Risk for Arterial and Venous Thrombosis in Patients With Myeloproliferative Neoplasms: A Population-Based Cohort Study
Open accessAbstract
Background: Patients with myeloproliferative neoplasms (MPNs) are reported to be at increased risk for thrombotic events. However, no population-based study has estimated this excess risk compared with matched control participants. Objective: To assess risk for arterial and venous thrombosis in patients with MPNs compared with matched control participants. Design: Matched cohort study. Setting: Population-based setting in Sweden from 1987 to 2009, with follow-up to 2010. Patients: 9429 patients with MPNs and 35 820 matched control participants. Measurements: The primary outcomes were rates of arterial and venous thrombosis. Flexible parametric models were used to calculate hazard ratios (HRs) and cumulative incidence with 95% CIs. Results: The HRs for arterial thrombosis among patients with MPNs compared with control participants at 3 months, 1 year, and 5 years were 3.0 (95% CI, 2.7 to 3.4), 2.0 (CI, 1.8 to 2.2), and 1.5 (CI, 1.4 to 1.6), respectively. The corresponding HRs for venous thrombosis were 9.7 (CI, 7.8 to 12.0), 4.7 (CI, 4.0 to 5.4), and 3.2 (CI, 2.9 to 3.6). The rate was significantly elevated across all age groups and was similar among MPN subtypes. The 5-year cumulative incidence of thrombosis in patients with MPNs showed an initial rapid increase followed by gentler increases during follow-up. The HR for venous thrombosis decreased during more recent calendar periods. Limitation: No information on individual laboratory results or treatment. Conclusion: Patients with MPNs across all age groups have a significantly increased rate of arterial and venous thrombosis compared with matched control participants, with the highest rates at and shortly after diagnosis. Decreases in the rate of venous thrombosis over time likely reflect advances in clinical management. Primary Funding Source: The Cancer Research Foundations of Radiumhemmet, Blodcancerfonden, the Swedish Research Council, the regional agreement on medical training and clinical research between Stockholm County Council and Karolinska Institutet, the Adolf H. Lundin Charitable Foundation, and Memorial Sloan Kettering Cancer Center.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Myeloproliferative neoplasms are associated with an increased risk of thrombosis.
“Myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera, and myelofibrosis have been shown to be associated with an increased risk of thrombosis [114].”
From Estrogen and thrombosis: a bench to bedside review (2020) · cites this paper as [114]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sensitivity analysis in observational research: Introducing the E-value
VanderWeele, T. J., & Ding, P. (2017) · Annals of Internal Medicine · doi:10.7326/m16-2607 · Cited by 6,350 · see citing works
External review and validation of the Swedish national inpatient register
Ludvigsson, J. F., Andersson, E., Ekbom, A., Feychting, M., Kim, J.-L., Reuterwall, C., Heurgren, M., & Olausson, P. O. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-450 · Cited by 5,055 · see citing works
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
Baxter, E. J., Scott, L. M., Campbell, P. J., East, C., Fourouclas, N., Swanton, S., Vassiliou, G. S., Bench, A. J., Boyd, E. M., Curtin, N., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71142-9 · Cited by 3,548 · see citing works
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
James, C., Ugo, V., Couedic, J. P. L., Staerk, J., Delhommeau, F., Lacout, C., Garçon, L., Raslová, H., Berger, R., Griscelli, A. B., et al. (2005) · Nature · doi:10.1038/nature03546 · Cited by 3,542 · see citing works
A Gain-of-Function Mutation of <i>JAK2</i> in Myeloproliferative Disorders
Kralovics, R., Passamonti, F., Buser, A. S., Teo, S.-S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., & Skoda, R. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051113 · Cited by 3,470 · see citing works
Levine, R. L., Wadleigh, M., Cools, J., Ebert, B. L., Wernig, G., Huntly, B. J. P., Boggon, T. J., Wlodarska, I., Clark, J. J., Moore, S., et al. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.03.023 · Cited by 2,993 · see citing works
Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms
Klampfl, T., Gisslinger, H., Harutyunyan, A. S., Nivarthi, H., Rumi, E., Milosevic, J. D., Them, N. C. C., Berg, T., Gisslinger, B., Pietra, D., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1311347 · Cited by 2,003 · see citing works
Somatic <i>CALR</i> Mutations in Myeloproliferative Neoplasms with Nonmutated <i>JAK2</i>
Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1312542 · Cited by 1,756 · see citing works
Royston, P. J., & Parmar, M. (2002) · Statistics in Medicine · doi:10.1002/sim.1203 · Cited by 1,537 · see citing works
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
Pikman, Y., Lee, B. H., Mercher, T., McDowell, E. P., Ebert, B. L., Gozo, M. C., Cuker, A. C., Wernig, G., Moore, S. A., Galinsky, I. A., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030270 · Cited by 1,445 · see citing works
JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis
Scott, L. M., Tong, W., Levine, R. L., Scott, M., Beer, P., Stratton, M. R., Futreal, P., Erber, W., McMullin, M., Harrison, C. N., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065202 · Cited by 1,346 · see citing works
Cervantes, F., Dupriez, B., Pereira, A., Passamonti, F., Reilly, J. T., Morra, E., Vannucchi, A. M., Mesa, R. A., Demory, J., Barosi, G., et al. (2008) · Blood · doi:10.1182/blood-2008-07-170449 · Cited by 1,256 · see citing works
Efficacy and Safety of Low-Dose Aspirin in Polycythemia Vera
Landolfi, R., Marchioli, R., Kutti, J., Gisslinger, H., Tognoni, G., Patrono, C., & Barbui, T. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa035572 · Cited by 1,006 · see citing works
Hydroxyurea Compared with Anagrelide in High-Risk Essential Thrombocythemia
Harrison, C. N., Campbell, P. J., Buck, G. A. N., Wheatley, K., East, C. L., Bareford, D., Wilkins, B. S., van der Walt, J. D., Reilly, J. T., Grigg, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043800 · Cited by 921 · see citing works
Cardiovascular Events and Intensity of Treatment in Polycythemia Vera
Marchioli, R., Finazzi, G., Specchia, G., Cacciola, R. R., Cavazzina, R., Cilloni, D., Stefano, V. D., Elli, E. M., Iurlo, A., Latagliata, R., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1208500 · Cited by 848 · see citing works
Barbui, T., Barosi, G., Birgegård, G., Cervantes, F., Finazzi, G., Grießhammer, M., Harrison, C. N., Hasselbalch, H. C., Hehlmann, R., Hoffman, R., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.31.8436 · Cited by 846 · see citing works
Further Development of Flexible Parametric Models for Survival Analysis
Lambert, P. C., & Royston, P. J. (2009) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x0900900206 · Cited by 838 · see citing works
Vascular and Neoplastic Risk in a Large Cohort of Patients With Polycythemia Vera
Marchioli, R., Finazzi, G., Landolfi, R., Kutti, J., Gisslinger, H., Patrono, C., Marilus, R., Villegas, A., Tognoni, G., & Barbui, T. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.07.062 · Cited by 722 · see citing works
Tefferi, A., Rumi, E., Finazzi, G., Gisslinger, H., Vannucchi, A. M., Rodeghiero, F., Randi, M. L., Vaidya, R., Cazzola, M., Rambaldi, A., et al. (2013) · Leukemia · doi:10.1038/leu.2013.163 · Cited by 697 · see citing works
Barbui, T., Finazzi, G., Carobbio, A., Thiele, J., Passamonti, F., Rumi, E., Ruggeri, M., Rodeghiero, F., Randi, M. L., Bertozzi, I., et al. (2012) · Blood · doi:10.1182/blood-2012-07-444067 · Cited by 603 · see citing works
Kiladjian, J., Cassinat, B., Chevret, S., Turlure, P., Cambier, N., Roussel, M., Bellucci, S., Grandchamp, B., Chomienne, C., & Fenaux, P. (2008) · Blood · doi:10.1182/blood-2008-03-143537 · Cited by 582 · see citing works
Diagnosis and classification of the polycythemias.
Berlin, N. I. (1975) · PubMed · Cited by 557 · see citing works
Barbui, T., Thiele, J., Passamonti, F., Rumi, E., Boveri, E., Ruggeri, M., Rodeghiero, F., dʼAmore, E. S. G., Randi, M. L., Bertozzi, I., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.34.5298 · Cited by 534 · see citing works
Carobbio, A., Thiele, J., Passamonti, F., Rumi, E., Ruggeri, M., Rodeghiero, F., Randi, M. L., Bertozzi, I., Vannucchi, A. M., Antonioli, E., et al. (2011) · Blood · doi:10.1182/blood-2011-02-339002 · Cited by 456 · see citing works
Myeloproliferative neoplasms and thrombosis
Barbui, T., Finazzi, G., & Falanga, A. (2013) · Blood · doi:10.1182/blood-2013-03-460154 · Cited by 415 · see citing works
Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
Landolfi, R., Gennaro, L. D., Barbui, T., Stefano, V. D., Finazzi, G., Marfisi, R., Tognoni, G., & Marchioli, R. (2006) · Blood · doi:10.1182/blood-2006-08-042515 · Cited by 413 · see citing works
Murphy, S., Peterson, P., Iland, H., & Laszlo, J. (1997) · PubMed · Cited by 404 · see citing works
Thrombosis in primary myelofibrosis: incidence and risk factors
Barbui, T., Carobbio, A., Cervantes, F., Vannucchi, A. M., Guglielmelli, P., Antonioli, E., Álvarez‐Larrán, A., Rambaldi, A., Finazzi, G., & Barosi, G. (2009) · Blood · doi:10.1182/blood-2009-08-238956 · Cited by 266 · see citing works
Björkholm, M., Derolf, Å. R., Hultcrantz, M. L., Kristinsson, S. Y., Ekstrand, C., Goldin, L. R., Andréasson, B., Birgegård, G., Linder, O., Malm, C., et al. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2011.34.7542 · Cited by 244 · see citing works
Campbell, P. J., MacLean, C., Beer, P. A., Buck, G. A. N., Wheatley, K., Kiladjian, J., Forsyth, C. J., Harrison, C. N., & Green, A. R. (2012) · Blood · doi:10.1182/blood-2012-04-424911 · Cited by 220 · see citing works
Hultcrantz, M. L., Kristinsson, S. Y., Andersson, T., Landgren, O., Eloranta, S., Derolf, Å. R., Dickman, P. W., & Björkholm, M. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.1925 · Cited by 217 · see citing works
Falanga, A., Marchetti, M., Vignoli, A., Balducci, D., Russo, L., Guerini, V., & Barbui, T. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2007.01.053 · Cited by 194 · see citing works
Barbui, T., Carobbio, A., Rumi, E., Finazzi, G., Gisslinger, H., Rodeghiero, F., Randi, M. L., Rambaldi, A., Gisslinger, B., Pieri, L., et al. (2014) · Blood · doi:10.1182/blood-2014-07-591610 · Cited by 160 · see citing works
Verstovšek, S., Vannucchi, A. M., Grießhammer, M., Masszi, T., Durrant, S., Passamonti, F., Harrison, C. N., Pane, F., Zachée, P., Kirito, K., et al. (2016) · Haematologica · doi:10.3324/haematol.2016.143644 · Cited by 160 · see citing works
Flexible parametric modelling of cause-specific hazards to estimate cumulative incidence functions
Hinchliffe, S. R., & Lambert, P. C. (2013) · BMC Medical Research Methodology · doi:10.1186/1471-2288-13-13 · Cited by 157 · see citing works
Hultcrantz, M. L., Wilkes, S. R., Kristinsson, S. Y., Andersson, T., Derolf, Å. R., Eloranta, S., Samuelsson, J., Landgren, O., Dickman, P. W., Lambert, P. C., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.6652 · Cited by 145 · see citing works
Barbui, T., Thiele, J., Gisslinger, H., Finazzi, G., Vannucchi, A. M., & Tefferi, A. (2016) · Blood Reviews · doi:10.1016/j.blre.2016.06.001 · Cited by 127 · see citing works
Age-related differences in disease characteristics and clinical outcomes in polycythemia vera
Stein, B. L., Saraf, S. L., Sobol, U., Halpern, A. B., Shammo, J. M., Rondelli, D., Michaelis, L. C., Odenike, O. M., RADEMAKER, A. W., Zakarija, A., et al. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.759656 · Cited by 83 · see citing works
Robertson, B. J., Urquhart, C., Ford, I., Townend, J., Watson, H. G., Vickers, M. A., & Greaves, M. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02626.x · Cited by 75 · see citing works
The impact of ruxolitinib on thrombosis in patients with polycythemia vera and myelofibrosis
Samuelson, B. T., Vesely, S. K., Chai‐Adisaksopha, C., Scott, B. L., Crowther, M. A., & Garcia, D. A. (2015) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000446 · Cited by 71 · see citing works
Increased platelet, leukocyte, and coagulation activation in primary myelofibrosis
Álvarez‐Larrán, A., Arellano‐Rodrigo, E., Reverter, J. C., Domingo, A., Villamor, N., Colomer, D., & Cervantes, F. (2007) · Annals of Hematology · doi:10.1007/s00277-007-0386-3 · Cited by 61 · see citing works
JAK2 Mutation-Related Disease and Thrombosis
Guglielmelli, P., & Vannucchi, A. M. (2013) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1343890 · Cited by 51 · see citing works
Leukemic transformation in myeloproliferative neoplasms: Therapy-related or unrelated?
Björkholm, M., Hultcrantz, M. L., & Derolf, Å. R. (2014) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2014.07.003 · Cited by 46 · see citing works
Extending the Flexible Parametric Survival Model for Competing Risks
Hinchliffe, S. R., & Lambert, P. C. (2013) · The Stata Journal Promoting communications on statistics and Stata · doi:10.1177/1536867x1301300209 · Cited by 45 · see citing works
Barbui, T., Vannucchi, A. M., Carobbio, A., Thiele, J., Rumi, E., Gisslinger, H., Rodeghiero, F., Randi, M. L., Rambaldi, A., Pieri, L., et al. (2015) · American Journal of Hematology · doi:10.1002/ajh.23970 · Cited by 22 · see citing works
Finazzi, G., Stefano, V. D., & Barbui, T. (2013) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-013-0176-z · Cited by 22 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cancer-associated venous thromboembolism
Khorana, A. A., Mackman, N., Falanga, A., Pabinger, I., Noble, S., Ageno, W., Moik, F., & Lee, A. Y. Y. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00336-y · Cited by 491 · see citing works
Estrogen and thrombosis: a bench to bedside review
Abou-Ismail, M. Y., Citla Sridhar, D., & Nayak, L. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.05.008 · Cited by 261 · see citing works
Polycythemia vera: 2024 update on diagnosis, risk‐stratification, and management
Tefferi, A., & Barbui, T. (2023) · American Journal of Hematology · doi:10.1002/ajh.27002 · Cited by 226 · see citing works
Baldini, C., Moriconi, F. R., Galimberti, S., Libby, P., & Caterina, R. D. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab447 · Cited by 168 · see citing works
Polycythemia vera: historical oversights, diagnostic details, and therapeutic views
Tefferi, A., Vannucchi, A. M., & Barbui, T. (2021) · Leukemia · doi:10.1038/s41375-021-01401-3 · Cited by 145 · see citing works
Thromboembolic events in polycythemia vera
Grießhammer, M., Kiladjian, J., & Besses, C. (2019) · Annals of Hematology · doi:10.1007/s00277-019-03625-x · Cited by 141 · see citing works
Guglielmelli, P., Loscocco, G. G., Mannarelli, C., Rossi, E., Mannelli, F., Ramundo, F., Coltro, G., Betti, S., Maccari, C., Ceglie, S., et al. (2021) · Blood Cancer Journal · doi:10.1038/s41408-021-00581-6 · Cited by 116 · see citing works
Thiele, J., Kvasnicka, H. M., Orazi, A., Gianelli, U., Gangat, N., Vannucchi, A. M., Barbui, T., Arber, D. A., & Tefferi, A. (2022) · American Journal of Hematology · doi:10.1002/ajh.26751 · Cited by 105 · see citing works
Hasselbalch, H. C., Elvers, M., & Schafer, A. I. (2021) · Blood · doi:10.1182/blood.2020008109 · Cited by 102 · see citing works
Shallis, R. M., Wang, R., Davidoff, A. J., Ma, X., Podoltsev, N. A., & Zeidan, A. M. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100706 · Cited by 87 · see citing works
Spivak, J. L. (2019) · Blood · doi:10.1182/blood.2018834044 · Cited by 84 · see citing works
Clinical insights into the origins of thrombosis in myeloproliferative neoplasms
Moliterno, A. R., Ginzburg, Y. Z., & Hoffman, R. (2020) · Blood · doi:10.1182/blood.2020008043 · Cited by 76 · see citing works
Stefano, V. D., Rossi, E., Carobbio, A., Ghirardi, A., Betti, S., Finazzi, G., Vannucchi, A. M., & Barbui, T. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0151-y · Cited by 76 · see citing works
Karantanos, T., Chaturvedi, S., Braunstein, E. M., Spivak, J. L., Resar, L. M. S., Karanika, S., Williams, D. M., Rogers, O. C., Gocke, C. D., & Moliterno, A. R. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019001407 · Cited by 70 · see citing works
Lai, H. Y., Brooks, S. A., Craver, B. M., Morse, S. J., Nguyen, T. K., Haghighi, N., Garbati, M. R., & Fleischman, A. G. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018026450 · Cited by 68 · see citing works
Verstovšek, S., Yu, J., Scherber, R. M., Verma, S., Dieyi, C., Chen, C.-C., & Parasuraman, S. V. (2021) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2021.1992756 · Cited by 65 · see citing works
Hamulyák, E. N., Daams, J. G., Leebeek, F. W. G., Biemond, B. J., Boekhorst, P. A. W. T., Middeldorp, S., & Lauw, M. N. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020003628 · Cited by 63 · see citing works
Zhang, Y., Zhou, Y., Wang, Y., Teng, G., Li, D., Wang, Y., Du, C., Chen, Y., Zhang, H., Li, Y., et al. (2020) · Cancer Medicine · doi:10.1002/cam4.2886 · Cited by 62 · see citing works
Gianelli, U., Thiele, J., Orazi, A., Gangat, N., Vannucchi, A. M., Tefferi, A., & Kvasnicka, H. M. (2022) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-022-03480-8 · Cited by 55 · see citing works
Landtblom, A. R., Andersson, T., Dickman, P. W., Smedby, K. E. E., Eloranta, S., Batyrbekova, N., Samuelsson, J., Björkholm, M., & Hultcrantz, M. L. (2020) · Leukemia · doi:10.1038/s41375-020-0909-7 · Cited by 55 · see citing works
Antithrombotic therapy for venous thromboembolism in myeloproliferative neoplasms
Stefano, V. D., Finazzi, G., & Barbui, T. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0101-8 · Cited by 52 · see citing works
Overview of Myeloproliferative Neoplasms
Tremblay, D. A., Yacoub, A., & Hoffman, R. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2020.12.001 · Cited by 52 · see citing works
Vascular Diseases In Patients With Chronic Myeloproliferative Neoplasms – Impact Of Comorbidity
Frederiksen, H., Szépligeti, S. K., Bak, M., Ghanima, W., Hasselbalch, H. C., & Christiansen, C. F. (2019) · Clinical Epidemiology · doi:10.2147/clep.s216787 · Cited by 50 · see citing works
Platelet Dysfunction and Thrombosis in JAK2 V617F -Mutated Primary Myelofibrotic Mice
Matsuura, S., Thompson, C. R., Belghasem, M., Bekendam, R. H., Piasecki, A. J., Leiva, O., Ray, A., Italiano, J. E., Yang, M., Merrill‐Skoloff, G., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314760 · Cited by 49 · see citing works
Pemmaraju, N., Gerds, A. T., Yu, J., Parasuraman, S. V., Shah, A., Xi, A., Kumar, S., Scherber, R. M., & Verstovšek, S. (2022) · Leukemia Research · doi:10.1016/j.leukres.2022.106809 · Cited by 47 · see citing works
Diagnosis and Treatment of Polycythemia Vera
Tremblay, D. A., Kremyanskaya, M., Mascarenhas, J. O., & Hoffman, R. (2024) · JAMA · doi:10.1001/jama.2024.20377 · Cited by 47 · see citing works
Next-generation sequencing in the diagnosis of non-cirrhotic splanchnic vein thrombosis
Magaz, M., Álvarez‐Larrán, A., Colomer, D., López‐Guerra, M., García‐Criado, Á., Gabriel Mezzano, P., Belmonte, E., Olivas, P., Soy, G., Cervantes, F., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.06.045 · Cited by 45 · see citing works
Thrombosis in myeloproliferative neoplasms during cytoreductive and antithrombotic drug treatment
Barbui, T., Carobbio, A., & Stefano, V. D. (2022) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12657 · Cited by 45 · see citing works
Larsen, M. K., Skov, V., Kjær, L., Eickhardt‐Dalbøge, C. S., Knudsen, T. A., Kristiansen, M. H., Sørensen, A. L., Wienecke, T., Andersen, M., Ottesen, J. T., et al. (2024) · Blood Cancer Journal · doi:10.1038/s41408-024-00994-z · Cited by 44 · see citing works
Thrombosis in myeloproliferative neoplasms: A clinical and pathophysiological perspective
Kelliher, S., & Falanga, A. (2021) · Thrombosis Update · doi:10.1016/j.tru.2021.100081 · Cited by 39 · see citing works
Crucial role of hematopoietic JAK2 V617F in the development of aortic aneurysms
Yokokawa, T., Misaka, T., Kimishima, Y., Wada, K., Minakawa, K., Sugimoto, K., Ishida, T., Morishita, S., Komatsu, N., Ikeda, K., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.264085 · Cited by 36 · see citing works
Barbui, T., Ghirardi, A., Carobbio, A., Stefano, V. D., Rambaldi, A., Tefferi, A., & Vannucchi, A. M. (2024) · Blood Cancer Journal · doi:10.1038/s41408-024-01169-6 · Cited by 35 · see citing works
Găman, M., Cozma, M.-A., Dobrică, E.-C., Creţoiu, S. M., Găman, A. M., & Diaconu, C. C. (2021) · Life · doi:10.3390/life11070677 · Cited by 34 · see citing works
Hultcrantz, M. L., Modlitba, A., Vasan, S. K., Sjölander, A., Rostgaard, K., Landgren, O., Hjalgrim, H., Ullum, H., Erikstrup, C., Kristinsson, S. Y., et al. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.12.011 · Cited by 33 · see citing works
Barbui, T., Stefano, V. D., Falanga, A., Finazzi, G., Martinelli, I., Rodeghiero, F., Vannucchi, A. M., & Barosi, G. (2019) · Blood Cancer Journal · doi:10.1038/s41408-019-0225-5 · Cited by 30 · see citing works
Venous thromboembolism in cancer patients: Still looking for answers (Review)
Iorga, R., Bratu, O. G., Marcu, R., Constantin, T. V., Mischianu, D. L. D., Socea, B., Găman, M., & Diaconu, C. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8019 · Cited by 32 · see citing works
Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms
Reeves, B., & Beckman, J. D. (2021) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-021-00630-8 · Cited by 31 · see citing works
Moving toward disease modification in polycythemia vera
Bewersdorf, J. P., How, J., Masárová, L., Bose, P., Pemmaraju, N., Mascarenhas, J. O., & Rampal, R. K. (2023) · Blood · doi:10.1182/blood.2023021503 · Cited by 31 · see citing works
Podoltsev, N. A., Zhu, M., Zeidan, A. M., Wang, R., Wang, X., Davidoff, A. J., Huntington, S. F., Giri, S., Gore, S. D., & Ma, X. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018021436 · Cited by 30 · see citing works
JAK2 allele burden is correlated with a risk of venous but not arterial thrombosis
Soudet, S., Roy, G. L., Cadet, E., Michaud, A., Morel, P., Marolleau, J. P., & Sevestre, M. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.01.011 · Cited by 30 · see citing works
Pathogenesis of cardiovascular events in BCR-ABL1-negative myeloproliferative neoplasms
Guy, A., Poisson, J., & James, C. (2021) · Leukemia · doi:10.1038/s41375-021-01170-z · Cited by 28 · see citing works
Stein, B. L., & Martin, K. A. (2019) · Blood · doi:10.1182/blood.2019001318 · Cited by 28 · see citing works
Frequency of arterial thromboembolism in populations with malignancies: A systematic review
Yu, J., Li, A., Laureano, M., & Crowther, M. A. (2019) · Thrombosis Research · doi:10.1016/j.thromres.2019.10.004 · Cited by 26 · see citing works
Gecht, J., Tsoukakis, I., Kricheldorf, K., Stegelmann, F., Klausmann, M., Grießhammer, M., Schulz, H., Hollburg, W., Göthert, J. R., Sockel, K., et al. (2021) · Cancers · doi:10.3390/cancers13164086 · Cited by 25 · see citing works
Álvarez‐Larrán, A., Cuevas, B., Vélez, P., Noya, M. S., Caballero‐Navarro, G., Ferrer‐Marín, F., Carbonell, S., Pérez‐Encinas, M., Gómez‐Casares, M. T., Pérez-López, R., et al. (2023) · HemaSphere · doi:10.1097/hs9.0000000000000936 · Cited by 25 · see citing works
Rocca, B., Tosetto, A., Petrucci, G., Rossi, E., Betti, S., Soldati, D., Iurlo, A., Cattaneo, D., Bucelli, C., Dragani, A., et al. (2024) · American Journal of Hematology · doi:10.1002/ajh.27418 · Cited by 26 · see citing works
Splanchnic vein thrombosis associated with myeloproliferative neoplasms
Tremblay, D. A., Winters, A. C., Beckman, J. D., Naymagon, L., Patel, R. S., Mascarenhas, J. O., & Schiano, T. D. (2022) · Thrombosis Research · doi:10.1016/j.thromres.2022.08.003 · Cited by 24 · see citing works
Characteristics and outcomes of young adults with Philadelphia‐negative myeloproliferative neoplasms
Barzilai, M., Kirgner, I., Avivi, I. M., Ellis, M. H., Dally, N., Rozovski, U., & Lavi, N. (2019) · European Journal Of Haematology · doi:10.1111/ejh.13232 · Cited by 24 · see citing works
Stein, B. L., & Martin, K. A. (2019) · Hematology · doi:10.1182/hematology.2019001318 · Cited by 24 · see citing works
Characterization of myeloproliferative neoplasms in the paediatric and young adult population
Harris, Z. I., Kaizer, H., Wei, A., Karantanos, T., Williams, D. M., Chaturvedi, S., Jain, T., Resar, L. M. S., Moliterno, A. R., & Braunstein, E. M. (2023) · British Journal of Haematology · doi:10.1111/bjh.18650 · Cited by 23 · see citing works
Thrombosis in the Philadelphia Chromosome-Negative Myeloproliferative Neoplasms
Sankar, K. N., Stein, B. L., & Rampal, R. K. (2019) · Cancer treatment and research · doi:10.1007/978-3-030-20315-3_11 · Cited by 23 · see citing works
Serrao, A., Breccia, M., Napolitano, M., Fiori, L., Santoro, M., Scalzulli, E., Santopietro, M., Santoro, C., Raso, S., & Chistolini, A. (2020) · American Journal of Hematology · doi:10.1002/ajh.25990 · Cited by 22 · see citing works
Mora, B., Guglielmelli, P., Kuykendall, A. T., Rumi, E., Maffioli, M., Palandri, F., Stefano, V. D., Caramella, M., Salmoiraghi, S., Kiladjian, J., et al. (2022) · Leukemia · doi:10.1038/s41375-022-01673-3 · Cited by 22 · see citing works
Unmasking and aggravation of polycythemia vera by canagliflozin
Das, L., Bhansali, A. K., & Walia, R. (2018) · Diabetic Medicine · doi:10.1111/dme.13706 · Cited by 22 · see citing works
groups, O. B. O. G. A. R., Álvarez‐Larrán, A., Pereira, A., Magaz, M., Hernández‐Boluda, J. C., Garrote, M., Cuevas, B., Ferrer‐Marín, F., Gómez‐Casares, M. T., García‐Gutiérrez, V., et al. (2020) · Annals of Hematology · doi:10.1007/s00277-020-03965-z · Cited by 21 · see citing works
Increased levels of NETosis in myeloproliferative neoplasms are not linked to thrombotic events
Schmidt, S. U., Daniliants, D., Hiller, E., Gunsilius, E., Wolf, D. G. F., & Feistritzer, C. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020004061 · Cited by 21 · see citing works
Kelliher, S., Gamba, S., Weiß, L., Shen, Z., Marchetti, M., Schieppati, F., Scaife, C., Madden, S. F., Bennett, K., Fortune, A., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2023012016 · Cited by 21 · see citing works
Coltro, G., Loscocco, G. G., & Vannucchi, A. M. (2021) · International review of cytology · doi:10.1016/bs.ircmb.2021.09.001 · Cited by 21 · see citing works
Prevention and Management of Thrombosis in BCR/ABL-Negative Myeloproliferative Neoplasms
Falanga, A., Marchetti, M., & Schieppati, F. (2021) · Hämostaseologie · doi:10.1055/a-1334-3259 · Cited by 20 · see citing works
Molecular Genetics of Thrombotic Myeloproliferative Neoplasms: Implications in Precision Oncology
Chia, Y. C., Jusoh, S. A. M., Ramli, M., Woon, P. Y., Johan, M. F., Hassan, R., & Islam, M. A. (2023) · Diagnostics · doi:10.3390/diagnostics13010163 · Cited by 19 · see citing works
Massarenti, L., Knudsen, T. A., Enevold, C., Skov, V., Kjær, L., Larsen, M. K., Larsen, T. S., Hansen, D. L., Hasselbalch, H. C., & Nielsen, C. H. (2023) · British Journal of Haematology · doi:10.1111/bjh.18845 · Cited by 20 · see citing works
Red Blood Cell Morphodynamics in Patients with Polycythemia Vera and Stroke
Игоревна, К. П., Раскуражев, А. А., Шабалина, А. А., Melikhyan, A. L., Subortseva, I. N., & Tanashyan, M. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042247 · Cited by 19 · see citing works
Harrison, C. N., Barbui, T., Bose, P., Kiladjian, J., Mascarenhas, J. O., McMullin, M. F., Mesa, R. A., & Vannucchi, A. M. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00608-3 · Cited by 19 · see citing works
Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence
Lushchak, O. V., Piskovatska, V., Strilbytska, O. M., Kindrat, I., Stefanyshyn, N., Koliada, A. K., Bubalo, V., Storey, K. B., & Vaiserman, A. M. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-55035-6_11 · Cited by 18 · see citing works
Thrombotic and Hemorrhagic Issues Associated with Myeloproliferative Neoplasms
Papageorgiou, L., Elalamy, I., Dreden, P. V., & Gerotziafas, G. (2022) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296221097969 · Cited by 18 · see citing works
Lin, H., Lin, C., & Shen, M. (2021) · Thrombosis Journal · doi:10.1186/s12959-021-00296-5 · Cited by 18 · see citing works
Platelet Heterogeneity in Myeloproliferative Neoplasms
Thomas, S. J., & Krishnan, A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316373 · Cited by 18 · see citing works
Guo, C., & Li, Z. (2019) · Medical Science Monitor · doi:10.12659/msm.918719 · Cited by 17 · see citing works
Evaluation of platelet function in essential thrombocythemia under different analytical conditions
Lussana, F., Femia, E. A., Pugliano, M., Podda, G. M., Razzari, C., Maugeri, N., Lecchi, A., Caberlon, S., Gerli, G., & Cattaneo, M. (2019) · Platelets · doi:10.1080/09537104.2019.1584668 · Cited by 17 · see citing works
Hernández‐Boluda, J. C., Pastor‐Galán, I., Arellano‐Rodrigo, E., Raya, J. M., Pérez‐Encinas, M., Ayala, R. M., Ferrer‐Marín, F., Vélez, P., Mora, E., Fox, M. L., et al. (2022) · British Journal of Haematology · doi:10.1111/bjh.18440 · Cited by 16 · see citing works
Farge, D., Maignan, C. L., Doucet, L. S., & Frère, C. (2019) · Thrombosis Research · doi:10.1016/s0049-3848(19)30367-6 · Cited by 16 · see citing works
Buxhofer‐Ausch, V., Wolf, D. G. F., Sormann, S., Forjan, E., Schimetta, W., Gisslinger, B., Heibl, S., Krauth, M. T., Thiele, J., Ruckser, R., et al. (2020) · European Journal Of Haematology · doi:10.1111/ejh.13516 · Cited by 16 · see citing works
Applications of Artificial Intelligence in Philadelphia-Negative Myeloproliferative Neoplasms
Elsayed, B., Elshoeibi, A. M., Elhadary, M. R., Ferih, K., Elsabagh, A. A., Rahhal, A. A. A., Abu‐Tineh, M., Afana, M., Abdulgayoom, M., & Yassin, M. A. (2023) · Diagnostics · doi:10.3390/diagnostics13061123 · Cited by 16 · see citing works
Kamiunten, A., Shide, K., Kameda, T., Ito, M., Sekine, M., Kubuki, Y., Hidaka, T., Akizuki, K., Tahira, Y., Toyama, T., et al. (2018) · International Journal of Hematology · doi:10.1007/s12185-018-2495-2 · Cited by 16 · see citing works
Solli, C. N., Chamat‐Hedemand, S., Elming, H., Ngo, A., Kjær, L., Skov, V., Sørensen, A. L., Ellervik, C., Fuchs, A., Sigvardsen, P. E., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.06.029 · Cited by 15 · see citing works
Barbui, T., Ghirardi, A., Carobbio, A., Masciulli, A., Carioli, G., Rambaldi, A., Finazzi, M. C., Bellini, M., Rumi, E., Vanni, D., et al. (2022) · Blood Cancer Journal · doi:10.1038/s41408-022-00743-0 · Cited by 15 · see citing works
Myeloproliferative neoplasms – blurring the lines between cancer and chronic inflammatory disorder
Soyfer, E. M., & Fleischman, A. G. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1208089 · Cited by 17 · see citing works
Testosterone therapy-induced erythrocytosis: can phlebotomy be justified?
Bond, P., Verdegaal, T. J., & Smit, D. L. (2024) · Endocrine Connections · doi:10.1530/ec-24-0283 · Cited by 15 · see citing works
Sacco, M., Ranalli, P., Lancellotti, S., Petrucci, G., Dragani, A., Rocca, B., & CRISTOFARO, R. D. (2020) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12315 · Cited by 15 · see citing works
Scavone, M., Rizzo, J., Femia, E. A., Podda, G. M., Bossi, E., Caberlon, S., Paroni, R. C., & Cattaneo, M. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1714351 · Cited by 15 · see citing works
Thrombotic, Vascular, and Bleeding Complications of the Myeloproliferative Neoplasms
Schafer, A. I. (2021) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2020.11.006 · Cited by 15 · see citing works
Vo, T. P., Kristiansen, M. H., Hasselbalch, H. C., & Wienecke, T. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1232557 · Cited by 16 · see citing works
Pescia, C., Lopez, G., Cattaneo, D., Bucelli, C., Gianelli, U., & Iurlo, A. (2023) · Leukemia Research · doi:10.1016/j.leukres.2023.107420 · Cited by 14 · see citing works
Breccia, M., Palandri, F., Polverelli, N., Caira, M., Berluti, M., Palumbo, G. A., & Stefano, V. D. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1382872 · Cited by 14 · see citing works
Splanchnic Vein Thrombosis in the Myeloproliferative Neoplasms
Akpan, I. J., & Stein, B. L. (2018) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-018-0446-x · Cited by 14 · see citing works
Fedorov, K., Goel, S., Kushnir, M., & Billett, H. H. (2021) · Research and Practice in Thrombosis and Haemostasis · doi:10.1002/rth2.12574 · Cited by 14 · see citing works
Crodel, C. C., Jentsch‐Ullrich, K., Reiser, M., Jacobasch, L., Sauer, A., Tesch, H., Ulshöfer, T., Wunschel, R., Palandri, F., & Heidel, F. H. (2021) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-021-03855-5 · Cited by 13 · see citing works
Song, J., Kim, S. J., Gollamudi, J., Thiagarajan, P., & Prchal, J. T. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022008052 · Cited by 13 · see citing works
Modelling multiple time-scales with flexible parametric survival models
Batyrbekova, N., Bower, H., Dickman, P. W., Landtblom, A. R., Hultcrantz, M. L., Szulkin, R., Lambert, P. C., & Andersson, T. (2022) · BMC Medical Research Methodology · doi:10.1186/s12874-022-01773-9 · Cited by 13 · see citing works
Shedding Light on the Pathogenesis of Splanchnic Vein Thrombosis
Camerlo, S., Ligato, J., Rosati, G., Carrà, G., Russo, I., Gobbi, M. D., & Morotti, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032262 · Cited by 13 · see citing works
Tremblay, D. A., Kosiorek, H., Dueck, A. C., & Hoffman, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.636675 · Cited by 13 · see citing works
Enblom‐Larsson, A., Renlund, H., Andréasson, B., Holmberg, H., Liljeholm, M., & Själander, A. (2024) · British Journal of Haematology · doi:10.1111/bjh.19337 · Cited by 13 · see citing works
Chrysafi, P., Barnum, K. J., Gerhard, G. M., Chiasakul, T., Narang, A., McNichol, M. C., Riva, N., Semmler, G., Scheiner, B., Acosta, S., et al. (2024) · Journal of Thrombosis and Haemostasis · doi:10.1016/j.jtha.2024.06.029 · Cited by 12 · see citing works
Masárová, L., Mascarenhas, J. O., Rampal, R. K., Hu, W., Livingston, R. A., & Pemmaraju, N. (2024) · Cancer · doi:10.1002/cncr.35661 · Cited by 12 · see citing works
Global dynamics of healthy and cancer cells competing in the hematopoietic system
Andersen, M., Hasselbalch, H. C., Kjær, L., Skov, V., & Ottesen, J. T. (2020) · Mathematical Biosciences · doi:10.1016/j.mbs.2020.108372 · Cited by 12 · see citing works
Dam, M. J. B., Pedersen, R. K., Knudsen, T. A., Andersen, M., Skov, V., Kjær, L., Hasselbalch, H. C., & Ottesen, J. T. (2021) · European Journal Of Haematology · doi:10.1111/ejh.13700 · Cited by 12 · see citing works
Chen, J., Dong, H., Fu, R., Liu, X., Feng, X., Liu, W., Chen, Y., Sun, T., Ju, M., Dai, X., et al. (2023) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-023-02833-7 · Cited by 11 · see citing works
Modi, N. B., Shames, R. S., Lickliter, J. D., & Gupta, S. (2024) · European Journal Of Haematology · doi:10.1111/ejh.14243 · Cited by 12 · see citing works
Guy, A., Morange, P., & James, C. (2024) · Blood · doi:10.1182/blood.2024025627 · Cited by 12 · see citing works
Krečak, I., Verstovšek, S., & Lucijanić, M. (2023) · Annals of Hematology · doi:10.1007/s00277-023-05426-9 · Cited by 11 · see citing works
- Authors
- Hultcrantz, M., Björkholm, M., Dickman, P. W., Landgren, O., Derolf, Å. R., Kristinsson, S. Y., & Andersson, T. M. L.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Karolinska Institutet, Stockholm, Sweden (P.W.D., T.M.A.)
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2018-03-06
- Volume
- 168
- Issue
- 5
- Pages
- 317-325
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- PMC
- PMC7533681
- OpenAlex
- W2783991821
- Cited by
- 268
- References
- 46
- Citations by year
- 2026: 26 · 2025: 28 · 2024: 38 · 2023: 39 · 2022: 41 · 2021: 43 · 2020: 25 · 2019: 19 · 2018: 9
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- Swedish Blood Cancer Foundation
- Radiumhemmets Forskningsfonder
- The regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institutet (SLL20150341)
- Adolf H Lundin Charitable Foundation
- Memorial Sloan-Kettering Cancer Center (P30 CA008748)
- Topics
- Health Sciences › Medicine › Genetics › Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- myeloproliferative neoplasms, arterial thrombosis, venous thrombosis, thrombosis risk, cumulative incidence
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Myeloproliferative Disorders, Registries, Risk, Risk Factors, Sweden, Thrombosis, Incidence, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
