The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The Proportion of SARS-CoV-2 Infections That Are Asymptomatic: A Systematic Review
Open accessAbstract
BACKGROUND: Asymptomatic infection seems to be a notable feature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen that causes coronavirus disease 2019 (COVID-19), but the prevalence is uncertain. PURPOSE: To estimate the proportion of persons infected with SARS-CoV-2 who never develop symptoms. DATA SOURCES: . STUDY SELECTION: Observational, descriptive studies and reports of mass screening for SARS-CoV-2 that were either cross-sectional or longitudinal in design; were published through 17 November 2020; and involved SARS-CoV-2 nucleic acid or antibody testing of a target population, regardless of current symptomatic status, over a defined period. DATA EXTRACTION: The authors collaboratively extracted data on the study design, type of testing performed, number of participants, criteria for determining symptomatic status, testing results, and setting. DATA SYNTHESIS: = 61 075), which suggest that at least one third of SARS-CoV-2 infections are asymptomatic. LIMITATION: For PCR-based studies, data are limited to distinguish presymptomatic from asymptomatic infection. Heterogeneity precluded formal quantitative syntheses. CONCLUSION: Available data suggest that at least one third of SARS-CoV-2 infections are asymptomatic. Longitudinal studies suggest that nearly three quarters of persons who receive a positive PCR test result but have no symptoms at the time of testing will remain asymptomatic. Control strategies for COVID-19 should be altered, taking into account the prevalence and transmission risk of asymptomatic SARS-CoV-2 infection. PRIMARY FUNDING SOURCE: National Institutes of Health.
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Lauer, S. A., Grantz, K. H., Bi, Q., Jones, F. K., Zheng, Q., Meredith, H. R., Azman, A. S., Reich, N. G., & Lessler, J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-0504 · Cited by 5,970
Temporal dynamics in viral shedding and transmissibility of COVID-19
He, X., Lau, E. H. Y., Wu, P., Deng, X., Wang, J., Hao, X., Lau, Y. C., Wong, J. Y., Guan, Y., Tan, X., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0869-5 · Cited by 4,247
Prevalence of Asymptomatic SARS-CoV-2 Infection: A Narrative Review
Oran, D. P., & Topol, E. J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-3012 · Cited by 2,279
Self-citationPresymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
Arons, M. M., Hatfield, K. M., Reddy, S. C., Kimball, A., James, A., Jacobs, J. R., Taylor, J., Spicer, K., Bardossy, A. C., Oakley, L. P., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2008457 · Cited by 2,052
Pollán, M., Pérez-Gómez, B., Pastor-Barriuso, R., Oteo, J., Hernán, M. A., Pérez-Olmeda, M., Sanmartín, J. L., Fernández-García, A., Cruz, I., Fernández de Larrea, N., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31483-5 · Cited by 1,639
Spread of SARS-CoV-2 in the Icelandic population
Gudbjartsson, D. F., Helgason, A., Jonsson, H., Magnusson, O. T., Melsted, P., Norddahl, G. L., Saemundsdottir, J., Sigurdsson, A., Sulem, P., Agustsdottir, A. B., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2006100 · Cited by 1,248
Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’
Lavezzo, E., Franchin, E., Ciavarella, C., Cuomo-Dannenburg, G., Barzon, L., Del Vecchio, C., Rossi, L., Manganelli, R., Loregian, A., Navarin, N., et al. (2020) · Nature · doi:10.1038/s41586-020-2488-1 · Cited by 1,087
Universal Screening for SARS-CoV-2 in Women Admitted for Delivery
Sutton, D., Fuchs, K., D’Alton, M., & Goffman, D. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2009316 · Cited by 1,029
Rethinking Covid-19 Test Sensitivity — A Strategy for Containment
Mina, M. J., Parker, R., & Larremore, D. B. (2020) · New England Journal of Medicine · doi:10.1056/nejmp2025631 · Cited by 703
Zhang, B., Zhou, X., Zhu, C., Song, Y., Feng, F., Qiu, Y., Feng, J., Jia, Q., Song, Q., Zhu, B., et al. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00157 · Cited by 528
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CT of Post-Acute Lung Complications of COVID-19
Solomon, J. J., Heyman, B., Ko, J. P., Condos, R., & Lynch, D. A. (2021) · Radiology · doi:10.1148/radiol.2021211396 · Cited by 212
Ivermectin for preventing and treating COVID-19
Popp, M., Reis, S., Schießer, S., Hausinger, R. I., Stegemann, M., Metzendorf, M.-I., Kranke, P., Meybohm, P., Skoetz, N., & Weibel, S. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015017.pub3 · Cited by 169
Nkuba, A. N., Makiala, S. M., Guichet, E., Tshiminyi, P. M., Bazitama, Y. M., Yambayamba, M. K., Kazenza, B. M., Kabeya, T. M., Matungulu, E. B., Baketana, L. K., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciab515 · Cited by 51
Andrejko, K. L., Pry, J. M., Myers, J. F., Mehrotra, M., Lamba, K., Lim, E., Fukui, N., DeGuzman, J. L., Openshaw, J., Watt, J., et al. (2023) · American Journal of Epidemiology · doi:10.1093/aje/kwad017 · Cited by 28
Metadata
- Authors
- Oran, D. P., & Topol, E. J.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2021-05
- Volume
- 174
- Issue
- 5
- Pages
- 655-662
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W3122838760
- Cited by
- 533
- References
- 58
- FWCI
- 36.94
- Type
- journal article
- Language
- en
- Open access
- green
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