Cited by 212Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

CT of Post-Acute Lung Complications of COVID-19

Open access
Solomon, Joshua J., Heyman, Brooke, Ko, Jane P., Condos, Rany, Lynch, David A.·2021·Radiology

Abstract

The acute course of COVID-19 is variable and ranges from asymptomatic infection to fulminant respiratory failure. Patients recovering from COVID-19 can have persistent symptoms and CT abnormalities of variable severity. At 3 months after acute infection, a subset of patients will have CT abnormalities that include ground-glass opacity (GGO) and subpleural bands with concomitant pulmonary function abnormalities. At 6 months after acute infection, some patients have persistent CT changes to include the resolution of GGOs seen in the early recovery phase and the persistence or development of changes suggestive of fibrosis, such as reticulation with or without parenchymal distortion. The etiology of lung disease after COVID-19 may be a sequela of prolonged mechanical ventilation, COVID-19-induced acute respiratory distress syndrome (ARDS), or direct injury from the virus. Predictors of lung disease after COVID-19 include need for intensive care unit admission, mechanical ventilation, higher inflammatory markers, longer hospital stay, and a diagnosis of ARDS. Treatments of lung disease after COVID-19 are being investigated, including the potential of antifibrotic agents for prevention of lung fibrosis after COVID-19. Future research is needed to determine the long-term persistence of lung disease after COVID-19, its impact on patients, and methods to either prevent or treat it. © RSNA, 2021.

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  1. [50]Fabbri L, Moss S, Khan F, Chi W, Xia J, Robinson K, et al. Post-viral parenchymal lung disease of COVID-19 and viral pneumonitis: A systematic review and meta-analysis. medRxiv. 2021: 10.1101/2021.03.15.21253593 35338102 · DOI
  2. [110]Tabatabaei SMH, Rajebi H, Moghaddas F, Ghasemiadl M, Talari H. Chest CT in COVID-19 pneumonia: what are the findings in mid-term follow-up? Emergency Radiology. 2020; 27 (6): 711 – 9. 10.1007/s10140-020-01869-z 33165674 PMC7649573 · DOI

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Authors
Solomon, J. J., Heyman, B., Ko, J. P., Condos, R., & Lynch, D. A.
Affiliations
National Jewish Health (US)
Corresponding author
Lynch, David A.
Venue
Radiology
Published
2021-11
Volume
301
Issue
2
Pages
E383-E395
ISSN
  • 0033-8419 (ISSN-L)
  • 1527-1315
OpenAlex
W3187562125
Cited by
212
References
116
Citations by year
2026: 13 · 2025: 21 · 2024: 42 · 2023: 69 · 2022: 59 · 2021: 7
FWCI
5.67
Type
journal article
Language
en
Open access
Locations
  • Radiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
post-COVID-19 lung disease, COVID-19 pandemic, ground-glass opacities, pulmonary fibrosis, pulmonary function abnormalities, acute respiratory distress syndrome, prolonged mechanical ventilation, antifibrotic therapy, risk factors, chest CT findings
MeSH terms
COVID-19, SARS-CoV-2, Acute Disease, Humans, Lung, Lung Diseases, Tomography, X-Ray Computed

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