The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
Open accessAbstract
Ubiquitin-dependent proteolysis can initiate at ribosomes for myriad reasons including misfolding of a nascent chain or stalling of the ribosome during translation of mRNA. Clearance of a stalled complex is required to recycle the ribosome for future use. Here we show that the ubiquitin (Ub) pathway segregase Cdc48/p97 and its adaptors Ufd1-Npl4 participate in ribosome-associated degradation (RAD) by mediating the clearance of ubiquitinated, tRNA-linked nascent peptides from ribosomes. Through characterization of both endogenously-generated and heterologous model substrates for the RAD pathway, we conclude that budding yeast Cdc48 functions downstream of the Ub ligases Ltn1 and Ubr1 to release nascent proteins from the ribosome so that they can be degraded by the proteasome. Defective RAD could contribute to the pathophysiology of human diseases caused by mutations in p97.
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Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
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Self-citation
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Mechanisms and functions of ribosome-associated protein quality control
Joazeiro, C. A. P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0118-2 · Cited by 456
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Cristofani, R., Rusmini, P., Galbiati, M., Cicardi, M. E., Ferrari, V., Tedesco, B., Casarotto, E., Chierichetti, M., Messi, E., Piccolella, M., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00796 · Cited by 35
Metadata
- Authors
- Verma, R., Oania, R. S., Kolawa, N. J., & Deshaies, R. J.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2013-01-22
- Volume
- 2
- Pages
- e00308-e00308
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2044353042
- Cited by
- 238
- References
- 10
- FWCI
- 7.80
- Type
- journal article
- Language
- en
- Open access
- gold
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