The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Integrating influenza antigenic dynamics with molecular evolution
Open accessAbstract
Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay. Here, we extend previous approaches to antigenic cartography, and simultaneously characterize antigenic and genetic evolution by modeling the diffusion of antigenic phenotype over a shared virus phylogeny. Using HI data from influenza lineages A/H3N2, A/H1N1, B/Victoria and B/Yamagata, we determine patterns of antigenic drift across viral lineages, showing that A/H3N2 evolves faster and in a more punctuated fashion than other influenza lineages. We also show that year-to-year antigenic drift appears to drive incidence patterns within each influenza lineage. This work makes possible substantial future advances in investigating the dynamics of influenza and other antigenically-variable pathogens by providing a model that intimately combines molecular and antigenic evolution.
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Self-citationMapping the Antigenic and Genetic Evolution of Influenza Virus
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Self-citationEcological and immunological determinants of influenza evolution.
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The Global Circulation of Seasonal Influenza A (H3N2) Viruses
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Self-citationPhylogeography Takes a Relaxed Random Walk in Continuous Space and Time
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Self-citationPermissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance
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Kistler, K. E., & Bedford, T. (2021) · eLife · doi:10.7554/elife.64509 · Cited by 94
Self-citationCobey, S., Wilson, P., & Matsen, F. A. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0235 · Cited by 40
de Vries, R. D., Nieuwkoop, N. J., van der Klis, F. R. M., Koopmans, M. P. G., Krammer, F., & Rimmelzwaan, G. F. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix546 · Cited by 39
Metadata
- Authors
- Bedford, T., Suchard, M. A., Lemey, P., Dudas, G., Gregory, V., Hay, A. J., McCauley, J. W., Russell, C. A., Smith, D. J., & Rambaut, A.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-02-04
- Volume
- 3
- Pages
- e01914-e01914
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2158189516
- Cited by
- 406
- References
- 56
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bedford, T., Suchard, M. A., Lemey, P., Dudas, G., Gregory, V., Hay, A. J., McCauley, J. W., Russell, C. A., Smith, D. J., & Rambaut, A. (2014). Integrating influenza antigenic dynamics with molecular evolution. eLife. https://doi.org/10.7554/elife.01914
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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