Cited by 95Neurobiology and Insect Physiology ResearchGenetics, Aging, and Longevity in Model OrganismsBarrier Structure and Function Studies

Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling

Open access
Brankatschk, Marko, Dunst, Sebastian, Nemetschke, Linda, Eaton, Suzanne·2014·eLife

Abstract

The Insulin signaling pathway couples growth, development and lifespan to nutritional conditions. Here, we demonstrate a function for the Drosophila lipoprotein LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signaling. When yeast lipids are present in the diet, free calcium levels rise in Blood Brain Barrier glial cells. This induces transport of LTP across the Blood Brain Barrier by two LDL receptor-related proteins: LRP1 and Megalin. LTP accumulates on specific neurons that connect to cells that produce Insulin-like peptides, and induces their release into the circulation. This increases systemic Insulin signaling and the rate of larval development on yeast-containing food compared with a plant-based food of similar nutritional content.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.7554/elife.02862

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dietary sugars, proteins and lipids induce insulin release into circulation by directly or indirectly affecting insulin-producing cells.

    “Dietary sugars, proteins and lipids induce insulin release into the circulation by directly or indirectly affecting insulin-producing cells [65,66].”

    From An option space for early neural evolution (2015) · cites this paper as [66]

  • Insulin-related peptides produced by neurosecretory cells in flies and other metazoans regulate glucose levels in haemolymph and lipid and carbohydrate storage.

    “Insulin-related peptides, produced by neurosecretory cells in flies and other metazoans, regulate glucose levels in the haemolymph, and lipid and carbohydrate storage.”

    From An option space for early neural evolution (2015) · cites this paper as [66]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Brankatschk, M., Dunst, S., Nemetschke, L., & Eaton, S.
Affiliations
Max Planck Institute of Molecular Cell Biology and Genetics (DE)
Corresponding author
  • Brankatschk, Marko
  • Eaton, Suzanne
Venue
eLife
Published
2014-10-02
Volume
3
ISSN
2050-084X (ISSN-L)
OpenAlex
W2097340608
Cited by
95
References
44
Citations by year
2026: 3 · 2025: 11 · 2024: 3 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 1
FWCI
2.90
Type
journal article
Language
en
Open access
Locations
  • eLife (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • European Molecular Biology Organization
  • Deutsche Forschungsgemeinschaft (NV EA24)
  • Max-Planck-Gesellschaft
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
lipoprotein transport, insulin signaling, Drosophila brain, blood-brain barrier, glial cells, calcium signaling, LDL receptor-related protein, LRP1, megalin, insulin-like peptides, dietary fat composition, yeast diet, larval development
MeSH terms
Animals, Biological Transport, Blood-Brain Barrier, Brain, Drosophila melanogaster, Insulin, Larva, Lipids, Lipoproteins, Neuroglia, Neurons, Saccharomyces cerevisiae, Signal Transduction, Gene Expression, Insect Proteins, Low Density Lipoprotein Receptor-Related Protein-1, Low Density Lipoprotein Receptor-Related Protein-2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review