Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling
Open accessAbstract
The Insulin signaling pathway couples growth, development and lifespan to nutritional conditions. Here, we demonstrate a function for the Drosophila lipoprotein LTP in conveying information about dietary lipid composition to the brain to regulate Insulin signaling. When yeast lipids are present in the diet, free calcium levels rise in Blood Brain Barrier glial cells. This induces transport of LTP across the Blood Brain Barrier by two LDL receptor-related proteins: LRP1 and Megalin. LTP accumulates on specific neurons that connect to cells that produce Insulin-like peptides, and induces their release into the circulation. This increases systemic Insulin signaling and the rate of larval development on yeast-containing food compared with a plant-based food of similar nutritional content.
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Dietary sugars, proteins and lipids induce insulin release into circulation by directly or indirectly affecting insulin-producing cells.
“Dietary sugars, proteins and lipids induce insulin release into the circulation by directly or indirectly affecting insulin-producing cells [65,66].”
From An option space for early neural evolution (2015) · cites this paper as [66]
Insulin-related peptides produced by neurosecretory cells in flies and other metazoans regulate glucose levels in haemolymph and lipid and carbohydrate storage.
“Insulin-related peptides, produced by neurosecretory cells in flies and other metazoans, regulate glucose levels in the haemolymph, and lipid and carbohydrate storage.”
From An option space for early neural evolution (2015) · cites this paper as [66]
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An option space for early neural evolution
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- Authors
- Brankatschk, M., Dunst, S., Nemetschke, L., & Eaton, S.
- Affiliations
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Corresponding author
- Brankatschk, Marko
- Eaton, Suzanne
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-10-02
- Volume
- 3
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC4210815
- OpenAlex
- W2097340608
- Cited by
- 95
- References
- 44
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 3 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 12 · 2019: 11 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 1
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Molecular Biology Organization
- Deutsche Forschungsgemeinschaft (NV EA24)
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- lipoprotein transport, insulin signaling, Drosophila brain, blood-brain barrier, glial cells, calcium signaling, LDL receptor-related protein, LRP1, megalin, insulin-like peptides, dietary fat composition, yeast diet, larval development
- MeSH terms
- Animals, Biological Transport, Blood-Brain Barrier, Brain, Drosophila melanogaster, Insulin, Larva, Lipids, Lipoproteins, Neuroglia, Neurons, Saccharomyces cerevisiae, Signal Transduction, Gene Expression, Insect Proteins, Low Density Lipoprotein Receptor-Related Protein-1, Low Density Lipoprotein Receptor-Related Protein-2
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