The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Long non-coding RNAs as a source of new peptides
Open accessAbstract
Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolution.
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Towards a complete map of the human long non-coding RNA transcriptome
Uszczynska-Ratajczak, B., Lagarde, J., Frankish, A., Guigó, R., & Johnson, R. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0017-y · Cited by 616
Cytoplasmic functions of long noncoding RNAs
Noh, J. H., Kim, K. M., McClusky, W. G., Abdelmohsen, K., & Gorospe, M. (2018) · WIREs RNA · doi:10.1002/wrna.1471 · Cited by 432
Extensive identification and analysis of conserved small ORFs in animals
Mackowiak, S. D., Zauber, H., Bielow, C., Thiel, D., Kutz, K., Calviello, L., Mastrobuoni, G., Rajewsky, N., Kempa, S., Selbach, M., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0742-x · Cited by 227
Metadata
- Authors
- Ruiz-Orera, J., Messeguer, X., Subirana, J. A., & Alba, M. M.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-09-16
- Volume
- 3
- Pages
- e03523-e03523
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2129883957
- Cited by
- 543
- References
- 98
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- gold
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