The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point
Open accessAbstract
Vascular remodeling under conditions of growth or exercise, or during recovery from arterial restriction or blockage is essential for health, but mechanisms are poorly understood. It has been proposed that endothelial cells have a preferred level of fluid shear stress, or ‘set point’, that determines remodeling. We show that human umbilical vein endothelial cells respond optimally within a range of fluid shear stress that approximate physiological shear. Lymphatic endothelial cells, which experience much lower flow in vivo, show similar effects but at lower value of shear stress. VEGFR3 levels, a component of a junctional mechanosensory complex, mediate these differences. Experiments in mice and zebrafish demonstrate that changing levels of VEGFR3/Flt4 modulates aortic lumen diameter consistent with flow-dependent remodeling. These data provide direct evidence for a fluid shear stress set point, identify a mechanism for varying the set point, and demonstrate its relevance to vessel remodeling in vivo.
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Mechanisms and regulation of endothelial VEGF receptor signalling
Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.87 · Cited by 1,498
Vascular heterogeneity and specialization in development and disease
Potente, M., & Mäkinen, T. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.36 · Cited by 653
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression
Vion, A.-C., Alt, S., Klaus-Bergmann, A., Szymborska, A., Zheng, T., Perovic, T., Hammoutene, A., Oliveira, M. B., Bartels-Klein, E., Hollfinger, I., et al. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201706151 · Cited by 113
Vion, A.-C., Perovic, T., Petit, C., Hollfinger, I., Bartels-Klein, E., Frampton, E., Gordon, E., Claesson-Welsh, L., & Gerhardt, H. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.623769 · Cited by 103
Development and aging of the lymphatic vascular system
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Metadata
- Authors
- Baeyens, N., Nicoli, S., Coon, B. G., Ross, T. D., Van den Dries, K., Han, J., Lauridsen, H. M., Mejean, C. O., Eichmann, A., Thomas, J.-L., Humphrey, J. D., & Schwartz, M. A.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-02-02
- Volume
- 4
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2158183156
- Cited by
- 265
- References
- 65
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- gold
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- Baeyens, N., Nicoli, S., Coon, B. G., Ross, T. D., Van den Dries, K., Han, J., Lauridsen, H. M., Mejean, C. O., Eichmann, A., Thomas, J.-L., Humphrey, J. D., & Schwartz, M. A. (2015). Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. eLife. https://doi.org/10.7554/elife.04645
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