The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Ventromedial hypothalamic neurons control a defensive emotion state
Open accessAbstract
Defensive behaviors reflect underlying emotion states, such as fear. The hypothalamus plays a role in such behaviors, but prevailing textbook views depict it as an effector of upstream emotion centers, such as the amygdala, rather than as an emotion center itself. We used optogenetic manipulations to probe the function of a specific hypothalamic cell type that mediates innate defensive responses. These neurons are sufficient to drive multiple defensive actions, and required for defensive behaviors in diverse contexts. The behavioral consequences of activating these neurons, moreover, exhibit properties characteristic of emotion states in general, including scalability, (negative) valence, generalization and persistence. Importantly, these neurons can also condition learned defensive behavior, further refuting long-standing claims that the hypothalamus is unable to support emotional learning and therefore is not an emotion center. These data indicate that the hypothalamus plays an integral role to instantiate emotion states, and is not simply a passive effector of upstream emotion centers.
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Cites
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InfluentialA mesoscale connectome of the mouse brain
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“…internal state), valence (positive or negative), generalization (a given state can be induced by multiple stimuli, and can control multiple behavioral responses) and persistence: they endure long after a threat is no longer present (Russell, 2003; Posner et al., 2005; Anderson and Adolphs, 2014).”
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“However, different subdivisions of the amygdala and hypothalamus are thought to control learned vs innate responses, in a parallel manner (Figure 1A; reviewed in [Davis, 1992; Fanselow, 1994; LeDoux, 1995, 2000; Gallagher and Chiba, 1996; Fanselow and LeDoux, 1999; Canteras, 2002; Rosen, 2004; Swanson, 2005; Gross and…”
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Cited by
Luczynski, P., McVey Neufeld, K.-A., Oriach, C. S., Clarke, G., Dinan, T. G., & Cryan, J. F. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw020 · Cited by 632
A synaptic threshold mechanism for computing escape decisions
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Organoid Cultures as Preclinical Models of Non–Small Cell Lung Cancer
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Multimodal analysis of cell types in a hypothalamic node controlling social behavior
Kim, D.-W., Yao, Z., Graybuck, L. T., Kim, T. K., Nguyen, T. N., Smith, K. A., Fong, O., Yi, L., Koulena, N., Pierson, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.09.020 · Cited by 259
Self-citationA Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors
Li, K., Nakajima, M., Ibañez-Tallon, I., & Heintz, N. (2016) · Cell · doi:10.1016/j.cell.2016.08.067 · Cited by 234
Metadata
- Authors
- Kunwar, P. S., Zelikowsky, M., Remedios, R., Cai, H., Yilmaz, M., Meister, M., & Anderson, D. J.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-03-06
- Volume
- 4
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2161093157
- Cited by
- 1,101
- References
- 27
- FWCI
- 43.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kunwar, P. S., Zelikowsky, M., Remedios, R., Cai, H., Yilmaz, M., Meister, M., & Anderson, D. J. (2015). Ventromedial hypothalamic neurons control a defensive emotion state. eLife. https://doi.org/10.7554/elife.06633
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