A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors
Open accessAbstract
The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female sociosexual behavior. Here, we show that, in male mice, OxtrINs regulate anxiety-related behaviors. We demonstrate that corticotropin-releasing-hormone-binding protein (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs. Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyramidal cell activity of male, but not female, mice, thus producing an anxiolytic effect. Our data identify OxtrINs as critical for modulation of social and emotional behaviors in both females and males and reveal a molecular mechanism that acts on local medial prefrontal cortex (mPFC) circuits to coordinate responses to OXT and CRH. They suggest that additional studies of the impact of the OXT/OXTR and CRHBP/CRH pathways in males and females will be important in development of gender-specific therapies.
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Sex-specific differences in the effects of activating oxytocin receptor positive medial prefrontal cortex interneurons have been reported, with activation inducing anxiety in males but promoting social behavior in females.
“For example, sex-specific differences in the effects of activating OXT receptor positive mPFC interneurons have been reported with activation inducing anxiety in males, but promoting social behavior in females [68,69].”
From Neural circuits regulating prosocial behaviors (2023) · cites this paper as [69]
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- Authors
- Li, K., Nakajima, M., Ibañez-Tallon, I., & Heintz, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Heintz, Nathaniel
- ORCID
- Heintz, Nathaniel
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 167
- Issue
- 1
- Pages
- 60-72.e11
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC5220951
- OpenAlex
- W2520003619
- Cited by
- 234
- References
- 45
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 21 · 2023: 26 · 2022: 27 · 2021: 31 · 2020: 20 · 2019: 25 · 2018: 22 · 2017: 18
- FWCI
- 34.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (P30DA035756)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- oxytocin, anxiety, corticotropin-releasing factor, medial prefrontal cortex, layer 2/3 pyramidal cells, sex differences, anxiolytic effects, social behavior, emotional behavior
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Carrier Proteins, Corticotropin-Releasing Hormone, Female, Interneurons, Male, Oxytocin, Sex Characteristics, Sex Factors, Prefrontal Cortex, Long-Term Potentiation, Receptors, Oxytocin, Mice, Metabolic Networks and Pathways
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