The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Regulation of mRNA translation during mitosis
Open accessAbstract
Passage through mitosis is driven by precisely-timed changes in transcriptional regulation and protein degradation. However, the importance of translational regulation during mitosis remains poorly understood. Here, using ribosome profiling, we find both a global translational repression and identified ∼200 mRNAs that undergo specific translational regulation at mitotic entry. In contrast, few changes in mRNA abundance are observed, indicating that regulation of translation is the primary mechanism of modulating protein expression during mitosis. Interestingly, 91% of the mRNAs that undergo gene-specific regulation in mitosis are translationally repressed, rather than activated. One of the most pronounced translationally-repressed genes is Emi1, an inhibitor of the anaphase promoting complex (APC) which is degraded during mitosis. We show that full APC activation requires translational repression of Emi1 in addition to its degradation. These results identify gene-specific translational repression as a means of controlling the mitotic proteome, which may complement post-translational mechanisms for inactivating protein function.
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Cites
Global quantification of mammalian gene expression control
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · cited 2×
“What might be the function of translational repression during mitosis? The average protein half-life is many hours (Schwanhausser et al., 2011), while mitosis takes less than an hour, so inhibition of protein synthesis for this short period of time is not expected to have a major impact on overall protein levels.”
BackgroundGenome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
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Self-citationIngolia, N. T., Lareau, L. F., & Weissman, J. S. (2011) · Cell · doi:10.1016/j.cell.2011.10.002 · Cited by 2,187
Self-citationThe anaphase promoting complex/cyclosome: a machine designed to destroy
Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315
Poly(A)-tail profiling reveals an embryonic switch in translational control
Subtelny, A. O., Eichhorn, S. W., Chen, G. R., Sive, H., & Bartel, D. P. (2014) · Nature · doi:10.1038/nature13007 · Cited by 664
Dynamic profiling of the protein life cycle in response to pathogens
Jovanovic, M., Rooney, M. S., Mertins, P., Przybylski, D., Chevrier, N., Satija, R., Rodriguez, E. H., Fields, A. P., Schwartz, S., Raychowdhury, R., et al. (2015) · Science · doi:10.1126/science.1259038 · Cited by 460
Self-citationTranscriptional regulation and function during the human cell cycle
Cho, R. J., Huang, M., Campbell, M. J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S. J., Davis, R. W., & Lockhart, D. J. (2001) · Nature Genetics · doi:10.1038/83751 · Cited by 455
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Cited by
On the Dependency of Cellular Protein Levels on mRNA Abundance
Liu, Y., Beyer, A., & Aebersold, R. (2016) · Cell · doi:10.1016/j.cell.2016.03.014 · Cited by 3,221
Monaco, G., Lee, B., Xu, W., Mustafah, S., Hwang, Y. Y., Carré, C., Burdin, N., Visan, L., Ceccarelli, M., Poidinger, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.041 · Cited by 958
Dynamics of Translation of Single mRNA Molecules In Vivo
Yan, X., Hoek, T. A., Vale, R. D., & Tanenbaum, M. E. (2016) · Cell · doi:10.1016/j.cell.2016.04.034 · Cited by 490
Self-citationThe mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity
Simsek, D., Tiu, G. C., Flynn, R. A., Byeon, G. W., Leppek, K., Xu, A. F., Chang, H. Y., & Barna, M. (2017) · Cell · doi:10.1016/j.cell.2017.05.022 · Cited by 439
Queiroz, R. M. L., Smith, T., Villanueva, E., Marti-Solano, M., Monti, M., Pizzinga, M., Mirea, D.-M., Ramakrishna, M., Harvey, R. F., Dezi, V., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-018-0001-2 · Cited by 365
Metadata
- Authors
- Tanenbaum, M. E., Stern-Ginossar, N., Weissman, J. S., & Vale, R. D.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-08-25
- Volume
- 4
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2157705406
- Cited by
- 198
- References
- 8
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- gold
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