Identification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors
Open accessAbstract
We identify the cell cycle-regulated mRNA transcripts genome-wide in the osteosarcoma-derived U2OS cell line. This results in 2140 transcripts mapping to 1871 unique cell cycle-regulated genes that show periodic oscillations across multiple synchronous cell cycles. We identify genomic loci bound by the G2/M transcription factor FOXM1 by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) and associate these with cell cycle-regulated genes. FOXM1 is bound to cell cycle-regulated genes with peak expression in both S phase and G2/M phases. We show that ChIP-seq genomic loci are responsive to FOXM1 using a real-time luciferase assay in live cells, showing that FOXM1 strongly activates promoters of G2/M phase genes and weakly activates those induced in S phase. Analysis of ChIP-seq data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) from the Encyclopedia of DNA Elements and ChIP-seq data for the DREAM complex finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors. These data identify the cell cycle-regulated genes in a second cancer-derived cell line and provide a comprehensive picture of the transcriptional regulatory systems controlling periodic gene expression in the human cell division cycle.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Machine-reported cell cycle gene lists were compared with four published datasets for experimentally characterized cell cycle genes.
“We compared these machine-reported gene lists with four published datasets for experimentally characterized cell cycle genes (including the HeLa data we used as seeds) (Grant et al., 2013)”
From Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing (2019) · cites this paper as Grant et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Wang, Z. P., Banerjee, S., Kong, D., Li, Y., & Sarkar, F. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1265 · Cited by 245 · see citing works
RetractedAhmad, A., Wang, Z. P., Kong, D., Ali, S. S., Li, Y., Banerjee, S., Raza, A., & Sarkar, F. H. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0572-1 · Cited by 135 · see citing works
RetractedSystematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Primer3 on the WWW for General Users and for Biologist Programmers
Rozen, S., & Skaletsky, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:365 · Cited by 14,952 · see citing works
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 12,617 · see citing works
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327 · see citing works
Spellman, P. T., Sherlock, G. J., Zhang, M. Q., Iyer, V. R., Anders, K. R., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,724 · see citing works
Self-citationMissing Value Estimation Methods for DNA Microarrays
Troyanskaya, O., Cantor, M., Sherlock, G., Brown, P., Hastie, T., Tibshirani, R., Botstein, D., & Altman, R. B. (2001) · Bioinformatics · doi:10.1093/bioinformatics/17.6.520 · Cited by 4,230 · see citing works
Self-citationA Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle
Cho, R. J., Campbell, M. J., Winzeler, E. A., Steinmetz, L. M., Conway, A. R., Wodicka, L. M., Wolfsberg, T. G., Gabrielian, A. E., Landsman, D., Lockhart, D. J., et al. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80114-8 · Cited by 2,024 · see citing works
Singular value decomposition for genome-wide expression data processing and modeling
Alter, O., Brown, P. O., & Botstein, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.18.10101 · Cited by 1,989 · see citing works
The Transcriptional Program in the Response of Human Fibroblasts to Serum
Iyer, V. R., Eisen, M. B., Ross, D. T., Schuler, G. D., Moore, T. A., Lee, J. C. F., Trent, J. M., Staudt, L. M., Hudson, J., Boguski, M. S., et al. (1999) · Science · doi:10.1126/science.283.5398.83 · Cited by 1,966 · see citing works
Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527 · see citing works
Self-citationArchitecture of the human regulatory network derived from ENCODE data
Gerstein, M., Kundaje, A. B., Hariharan, M., Landt, S. G., Yan, K., Cheng, C., Mu, X. J., Khurana, E., Rozowsky, J. S., Alexander, R. P., et al. (2012) · Nature · doi:10.1038/nature11245 · Cited by 1,418 · see citing works
Self-citationFoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983 · see citing works
FoxM1 is required for execution of the mitotic programme and chromosome stability
Laoukili, J., Kooistra, M. R. H., Brás, A., Kauw, J. J. W., Kerkhoven, R. M., Morrison, A. J., Clevers, H. C., & Medema, R. H. (2005) · Nature Cell Biology · doi:10.1038/ncb1217 · Cited by 808 · see citing works
Cistrome: an integrative platform for transcriptional regulation studies
Liu, T., Ortiz, J. A., Taing, L., Meyer, C. A., Lee, B. T. K., Zhang, Y., Shin, H., Wong, S. S., Ma, J., Lei, Y., et al. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r83 · Cited by 705 · see citing works
Ishida, S., Huang, E. S., Zuzan, H., Spang, R., Leone, G. W., West, M., & Nevins, J. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.14.4684-4699.2001 · Cited by 596 · see citing works
Global Analysis of the Genetic Network Controlling a Bacterial Cell Cycle
Laub, M. T., McAdams, H. H., Feldblyum, T. V., Fraser, C. M., & Shapiro, L. (2000) · Science · doi:10.1126/science.290.5499.2144 · Cited by 557 · see citing works
An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators
Takayama, S.-I. J., Xie, Z., & Reed, J. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.781 · Cited by 521 · see citing works
Johnson, D. G., Ohtani, K., & Nevins, J. R. (1994) · Genes & Development · doi:10.1101/gad.8.13.1514 · Cited by 494 · see citing works
Menges, M., de Jager, S. M., Gruissem, W., & Murray, J. A. H. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02319.x · Cited by 492 · see citing works
Regulation of cell proliferation by the E2F transcription factors
Helin, K. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80058-0 · Cited by 491 · see citing works
Periodic gene expression program of the fission yeast cell cycle
Rustici, G., Mata, J., Kivinen, K., Lió, P., Penkett, C. J., Burns, G., Hayles, J., Brāzma, A., Nurse, P., & Bähler, J. (2004) · Nature Genetics · doi:10.1038/ng1377 · Cited by 486 · see citing works
CEAS: <i>cis</i>-regulatory element annotation system
Shin, H., Liu, T., Manrai, A. K., & Liu, X. S. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp479 · Cited by 461 · see citing works
Transcriptional regulation and function during the human cell cycle
Cho, R. J., Huang, M., Campbell, M. J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S. J., Davis, R. W., & Lockhart, D. J. (2001) · Nature Genetics · doi:10.1038/83751 · Cited by 455 · see citing works
Litovchick, L., Sadasivam, S., Florens, L., Zhu, X., Swanson, S. K., Velmurugan, S., Chen, R., Washburn, M. P., Liu, X. S., & DeCaprio, J. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.015 · Cited by 396 · see citing works
Two established in vitro cell lines from human mesenchymal tumours
Pontén, J., & SAKSELA, E. (1967) · International Journal of Cancer · doi:10.1002/ijc.2910020505 · Cited by 347 · see citing works
Wonsey, D. R., & Follettie, M. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4059 · Cited by 346 · see citing works
Functions and regulation of the 70 kDa ribosomal S6 kinases
Fenton, T. R., & Gout, I. T. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.09.018 · Cited by 338 · see citing works
Liu, M., Dai, B., Kang, S.-H., Ban, K., Huang, F.-J., Lang, F. F., Aldape, K., Xie, T., Pelloski, C. E., Xie, K., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2912 · Cited by 314 · see citing works
FOXM1, a typical proliferation-associated transcription factor
Wierstra, I., & Alves, J. (2007) · Biological Chemistry · doi:10.1515/bc.2007.159 · Cited by 313 · see citing works
The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expressionPreprint
Sadasivam, S., Duan, S., & DeCaprio, J. A. (2012) · Genes & Development · doi:10.1101/gad.181933.111 · Cited by 311 · see citing works
Genome-scale RNAi profiling of cell division in human tissue culture cells
Kittler, R., Pelletier, L., Heninger, A., Slabicki, M. M., Theis, M., Mirosław, Ł., Poser, I., Lawo, S., Grabner, H., Kozak, K., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1659 · Cited by 299 · see citing works
Lynch, T. P., Ferrer, C. M., Jackson, S. R., Shahriari, K. S., Vosseller, K., & Reginato, M. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.302547 · Cited by 286 · see citing works
Wang, Z. F., Whitfield, M. L., Ingledue, T. C., Dominski, Z., & Marzluff, W. F. (1996) · Genes & Development · doi:10.1101/gad.10.23.3028 · Cited by 267 · see citing works
Self-citationMajor, M. L., Lepe, R., & Costa, R. H. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2649-2661.2004 · Cited by 267 · see citing works
Cell Cycle-regulated Gene Expression inArabidopsis
Menges, M., Hennig, L., Gruissem, W., & Murray, J. A. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207570200 · Cited by 251 · see citing works
Whitfield, M. L., Zheng, L.-X., Baldwin, A. E., Ohta, T., Hurt, M. M., & Marzluff, W. F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.12.4188-4198.2000 · Cited by 250 · see citing works
Self-citationS6 Kinase 1 Regulates Estrogen Receptor α in Control of Breast Cancer Cell Proliferation
Yamnik, R. L., Digilova, A., Davis, D. C., Brodt, Z. N., Murphy, C. J., & Holz, M. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807532200 · Cited by 247 · see citing works
Introduction to the E2F Family: Protein Structure and Gene Regulation
Slansky, J. E., & Farnham, P. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79910-5_1 · Cited by 245 · see citing works
Chen, X. X., Müller, G. A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A. D., & Engeland, K. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00881-12 · Cited by 226 · see citing works
FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells
Kwok, J. M.-M., Peck, B., Monteiro, L. J., Schwenen, H. D. C., Millour, J., Coombes, R. C., Myatt, S. S., & Lam, E. W. ‐. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0432 · Cited by 207 · see citing works
The Cell Cycle–Regulated Genes of Schizosaccharomyces pombe
Oliva, A., Rosebrock, A. P., Ferrezuelo, F., Pyne, S., Chen, H., Skiena, S., Futcher, B., & Leatherwood, J. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030225 · Cited by 204 · see citing works
Gemenetzidis, E., Bose, A., Riaz, A., Chaplin, T., Young, B. D., Ali, M., Sugden, D., Thurlow, J. K., Cheong, S., Teo, S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004849 · Cited by 189 · see citing works
Madureira, P. A., Varshochi, R., Constantinidou, D., Francis, R. E., Coombes, R. C., Yao, K., & Lam, E. W. ‐. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603906200 · Cited by 177 · see citing works
Dai, B., Kang, S.-H., Gong, W., Liu, M., Aldape, K., Sawaya, R. A., & Huang, S. (2007) · Oncogene · doi:10.1038/sj.onc.1210443 · Cited by 174 · see citing works
Identification of Cell Cycle-regulated Genes in Fission Yeast
Peng, X., Karuturi, R. K. M., Miller, L. D., Lin, K., Jia, Y., Akalın, P., Wang, L., Wong, L., Liu, E. T., Balasubramanian, M. K., et al. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0299 · Cited by 170 · see citing works
A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis
Huang, C., Qiu, Z., Wang, L., Peng, Z., Jia, Z., Logsdon, C. D., Le, X., Wei, D., Huang, S., & Xie, K. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-3102 · Cited by 168 · see citing works
Laoukili, J., Álvarez‐Fernández, M., Meijer, L. A. T., Stahl, M., Mohammed, S., Kleij, L., Heck, A. J. R., & Medema, R. H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01710-07 · Cited by 164 · see citing works
CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-γ and Hsp70/Hsc70
Doong, H., Price, J. T., Kim, Y. S., Gasbarre, C. C., Probst, J., Liotta, L. A., Blanchette, J., Rizzo, K., & Kohn, E. C. (2000) · Oncogene · doi:10.1038/sj.onc.1203797 · Cited by 163 · see citing works
Kim, I., Ramakrishna, S., Gusarova, G. A., Yoder, H. M., Costa, R. H., & Kalinichenko, V. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500936200 · Cited by 162 · see citing works
Bar‐Joseph, Z., Siegfried, Z., Brandeis, M., Brors, B., Lu, Y. C., Eils, R., Dynlacht, B. D., & Simon, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704723105 · Cited by 162 · see citing works
Liu, S., Guo, W., Shi, J., Li, N., Yu, X., Xue, J., Fu, X., Chu, K., Lu, C., Zhao, J., et al. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.08.008 · Cited by 159 · see citing works
Xia, L., Huang, W., Tian, D., Zhu, H., Zhang, Y., Hu, H., Fan, D., Nie, Y., & Wu, K. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.020 · Cited by 158 · see citing works
FoxM1 Regulates Transcription of JNK1 to Promote the G1/S Transition and Tumor Cell Invasiveness
Wang, I., Chen, Y., Hughes, D. E., Ackerson, T. J., Major, M. L., Kalinichenko, V. V., Costa, R. H., Raychaudhuri, P., Tyner, A. L., & Lau, L. F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709892200 · Cited by 141 · see citing works
The 17q23 Amplicon and Breast Cancer
Sinclair, C. S., Rowley, M., Naderi, A., & Couch, F. J. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1023081624133 · Cited by 138 · see citing works
FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair
Park, Y., Jung, S. Y., Jennings, N. B., Rodriguez‐Aguayo, C., Peng, G., Lee, S.-R., Kim, S. B., Kim, K., Leem, S.-H., Lin, S., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs167 · Cited by 135 · see citing works
Genome-wide functional analysis of human cell-cycle regulators
Mukherji, M., Bell, R. N., Supeková, Ľ., Wang, Y., Orth, A. P., Batalov, S., Miraglia, L. J., Huesken, D., Lange, J., Martin, C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604320103 · Cited by 130 · see citing works
Park, H. J., Costa, R. H., Lau, L. F., Tyner, A. L., & Raychaudhuri, P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00387-08 · Cited by 118 · see citing works
Kalinichenko, V. V., Gusarova, G. A., Tan, Y., Wang, I., Major, M. L., Wang, X., Yoder, H. M., & Costal, R. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305555200 · Cited by 111 · see citing works
Chen, Y.-J., Dominguez‐Brauer, C., Wang, Z., Asara, J. M., Costa, R. H., Tyner, A. L., Lau, L. F., & Raychaudhuri, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007997 · Cited by 106 · see citing works
BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis
Romano, M. F., Festa, M., Pagliuca, M. G., Lerose, R., Bisogni, R., Chiurazzi, F., Storti, G., Volpe, S., Venuta, S., Turco, M. C., et al. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401167 · Cited by 105 · see citing works
Nakamura, S., Hirano, I., Okinaka, K., Takemura, T., Yokota, D., Ono, T., Shigeno, K., SHIBATA, K., Fujisawa, S., & Ohnishi, K. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq185 · Cited by 104 · see citing works
FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner
Laoukili, J., Álvarez‐Fernández, M., Stahl, M., & Medema, R. H. (2008) · Cell Cycle · doi:10.4161/cc.7.17.6580 · Cited by 97 · see citing works
Waseem, A., Ali, M., Odell, E. W., Fortune, F., & Teh, M. (2010) · Oral Oncology · doi:10.1016/j.oraloncology.2010.03.022 · Cited by 96 · see citing works
Xue, Y., Xiao, R.-H., Long, D., Zou, X., Wang, X., Zhang, G., Yuan, Y., Wu, G., Yang, J., Wu, Y., et al. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-200 · Cited by 89 · see citing works
Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb
Down, C. F., Millour, J., Lam, E. W. ‐., & Watson, R. J. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.008 · Cited by 87 · see citing works
Chen, C., Chien, C.-Y., Huang, C., Hwang, C.-F., Chuang, H. C., Fang, F.-M., Huang, H.-Y., Chen, C.-M., Liu, H.-L., & Huang, C. F. (2009) · Oncogene · doi:10.1038/onc.2009.128 · Cited by 87 · see citing works
Calvisi, D. F., Pinna, F., Ladu, S., Pellegrino, R., Simile, M. M., Frau, M., Miglio, M. R. D., Tomasi, M. L., Sanna, V., Muroni, M. R., et al. (2009) · Gut · doi:10.1136/gut.2008.152652 · Cited by 87 · see citing works
Novel functions of FoxM1: from molecular mechanisms to cancer therapy
Alvarez-Fernández, M., & Medema, R. H. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00030 · Cited by 85 · see citing works
Bergamaschi, A., Christensen, B. L., & Katzenellenbogen, B. S. (2011) · Breast Cancer Research · doi:10.1186/bcr2913 · Cited by 82 · see citing works
The G2 DNA Damage Checkpoint Delays Expression of Genes Encoding Mitotic Regulators
Crawford, D. F., & Piwnica-Worms, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103414200 · Cited by 79 · see citing works
Bonet, C., Giuliano, S., Ohanna, M., Bille, K., Allégra, M., Lacour, J. ‐., Bahadoran, P., Rocchi, S., Ballotti, R., & Bertolotto, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.371682 · Cited by 77 · see citing works
Lok, G. T. M., Chan, D. W., Liu, V. W. S., Hui, W. W. Y., Leung, T. H. Y., Yao, K., & Ngan, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023790 · Cited by 77 · see citing works
Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2F1 Pathways
Gao, D., Inuzuka, H., Korenjak, M., Tseng, A., Wu, T., Wan, L., Kirschner, M. W., Dyson, N. J., & Wei, W. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0092 · Cited by 70 · see citing works
Chetty, C., Bhoopathi, P., Rao, J. S., & Lakka, S. S. (2008) · International Journal of Cancer · doi:10.1002/ijc.24209 · Cited by 69 · see citing works
Transcription factor FOXM1c is repressed by RB and activated by cyclin D1/Cdk4
Wierstra, I., & Alves, J. (2006) · Biological Chemistry · doi:10.1515/bc.2006.119 · Cited by 68 · see citing works
BAG3 Protein Regulates Cell Survival in Childhood Acute Lymphoblastic Leukemia Cells
Romano, M. F., Festa, M., Petrella, A., Pascale, M. C., Bisogni, R., Poggi, V., Kohn, E. C., Venuta, S., Turco, M. C., & Leone, A. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.5.524 · Cited by 65 · see citing works
Recovery from a DNA‐damage‐induced G2 arrest requires Cdk‐dependent activation of FoxM1
Álvarez‐Fernández, M., Halim, V. A., Krenning, L., Aprelia, M., Mohammed, S., Heck, A. J. R., & Medema, R. H. (2010) · EMBO Reports · doi:10.1038/embor.2010.46 · Cited by 64 · see citing works
Ahmed, M., Shahab Uddin, M. S., Hussain, A. R., Alyan, A., Jehan, Z., Al‐Dayel, F., Al-Nuaim, A., Al-Sobhi, S. S., Amin, T. M., Bavi, P. P., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1506 · Cited by 60 · see citing works
Peña-Dı́az, J., Hegre, S. A., Anderssen, E., Aas, P. A., Mjelle, R., Gilfillan, G. D., Lyle, R., Drabløs, F., Krokan, H. E., & Sætrom, P. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1336 · Cited by 55 · see citing works
The suppression of FOXM1 and its targets in breast cancer xenograft tumors by siRNA
Wang, M., & Gartel, A. L. (2011) · Oncotarget · doi:10.18632/oncotarget.359 · Cited by 51 · see citing works
Wan, X., Yeung, C. L., Kim, S. Y., Dolan, J. G., Ngo, V. N., Burkett, S. S., Khan, J. I., Staudt, L. M., & Helman, L. J. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1991 · Cited by 47 · see citing works
Ahmad, A., Ali, S. S., Wang, Z., Ali, A. S., Sethi, S. N., Sakr, W., Raz, A., & Rahman, K. W. (2010) · International Journal of Cancer · doi:10.1002/ijc.25839 · Cited by 47 · see citing works
Teh, M., Hutchison, I. L., Costea, D. E., Neppelberg, E., Liavaag, P. G., Purdie, K. J., Harwood, C. A., Wan, H., Odell, E. W., Hackshaw, A. K., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27886 · Cited by 42 · see citing works
Hui, M. K. C., Chan, K. W., Luk, J. M., Lee, N. P. Y., Chung, Y., Cheung, L. C. M., Srivastava, G., Tsao, S. W., Tang, J. C. O., & Law, S. Y.-K. (2011) · World Journal of Surgery · doi:10.1007/s00268-011-1302-5 · Cited by 32 · see citing works
Grant, G. D., Gamsby, J. J., Martyanov, V., Brooks, L., George, L. K., Mahoney, J. M., Loros, J., Dunlap, J., & Whitfield, M. L. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-02-0170 · Cited by 32 · see citing works
Self-citationFOXM1c is activated by cyclin E/Cdk2, cyclin A/Cdk2, and cyclin A/Cdk1, but repressed by GSK-3α
Wierstra, I., & Alves, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.008 · Cited by 31 · see citing works
Cyclin E/Cdk2, P/CAF, and E1A regulate the transactivation of the c-myc promoter by FOXM1
Wierstra, I., & Alves, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.01.039 · Cited by 22 · see citing works
Chen, W., Yuan, K., Tao, Z., & Xiao, B. (2011) · PubMed · Cited by 16 · see citing works
Flagged first, then by citations
1 of the 92 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Li, Q., Cheng, Z., Zhou, L., Darmanis, S., Neff, N. F., Okamoto, J., Gulati, G., Bennett, M. L., Sun, L. O., Clarke, L. E., et al. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.006 · Cited by 1,129 · see citing works
Vitamin B 12 , folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation
Froese, D. S., Fowler, B., & Baumgartner, M. R. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12009 · Cited by 479 · see citing works
Fischer, M., Grossmann, P., Padi, M., & DeCaprio, J. A. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw523 · Cited by 330 · see citing works
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Fischer, M., & Müller, G. A. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1360836 · Cited by 255 · see citing works
FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistance
Zona, S., Bella, L., Burton, M. J., de Moraes, G. N., & Lam, E. W. ‐. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.09.016 · Cited by 220 · see citing works
Dolatabadi, S., Candia, J., Akrap, N., Vannas, C., Tomić, T. T., Losert, W., Landberg, G., Åman, P., & Ståhlberg, A. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00001 · Cited by 206 · see citing works
Cell cycle regulation of human DNA repair and chromatin remodeling genes
Mjelle, R., Hegre, S. A., Aas, P. A., Slupphaug, G., Drabløs, F., Sætrom, P., & Krokan, H. E. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.03.007 · Cited by 203 · see citing works
Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle
Park, J.-E., Yi, H., Kim, Y., Chang, H., & Kim, V. N. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.007 · Cited by 202 · see citing works
Regulation of mRNA translation during mitosis
Tanenbaum, M. E., Stern‐Ginossar, N., Weissman, J. S., & Vale, R. D. (2015) · eLife · doi:10.7554/elife.07957 · Cited by 191 · see citing works
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics
Mahdessian, D., Cesnik, A. J., Gnann, C., Danielsson, F., Stenström, L., Arif, M., Zhang, C., Le, T. H., Johansson, F., Schutten, R., et al. (2021) · Nature · doi:10.1038/s41586-021-03232-9 · Cited by 190 · see citing works
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
Li, X., Wang, W., Wang, J., Malovannaya, A., Xi, Y., Li, W., Guerra, R., Hawke, D. H., Qin, J., & Chen, J. (2015) · Molecular Systems Biology · doi:10.15252/msb.20145504 · Cited by 153 · see citing works
Transcriptional landscape of the human cell cycle
Liu, Y., Chen, S., Wang, S., Soares, F., Fischer, M., Meng, F., Du, Z., Lin, C. Y., Meyer, C. A., DeCaprio, J. A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617636114 · Cited by 150 · see citing works
Lu, R. J., Taylor, S., Contrepois, K., Kim, M., Bravo, J. I., Ellenberger, M., Sampathkumar, N. K., & Benayoun, B. A. (2021) · Nature Aging · doi:10.1038/s43587-021-00086-8 · Cited by 128 · see citing works
FOXM1: A small fox that makes more tracks for cancer progression and metastasis
Khan, M. A., Κhan, P., Ahmad, A., Fatima, M., & Nasser, M. W. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.007 · Cited by 128 · see citing works
Sun, X., Clermont, P., Jiao, W., Helgason, C. D., Gout, P. W., Wang, Y. Z., & Qu, S. (2016) · International Journal of Cancer · doi:10.1002/ijc.30133 · Cited by 125 · see citing works
Shostak, A., Ruppert, B., Ha, N., Bruns, P., Toprak, U. H., ICGC MMML-Seq Project, Lawerenz, C., Lichter, P., Radlwimmer, B., Eils, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11807 · Cited by 118 · see citing works
Cell cycle regulation of folate‐mediated one‐carbon metabolism
Lan, X., Field, M. S., & Stover, P. J. (2018) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1426 · Cited by 113 · see citing works
Dominguez, D., Tsai, Y., Gomez, N. C., Jha, D. K., Davis, I. J., & Wang, Z. (2016) · Cell Research · doi:10.1038/cr.2016.84 · Cited by 107 · see citing works
A map of protein dynamics during cell-cycle progression and cell-cycle exit
Gookin, S. E., Min, M., Phadke, H., Chung, M., Moser, J. C., Miller, I., Carter, D., & Spencer, S. L. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2003268 · Cited by 96 · see citing works
Arceci, A., Bonacci, T., Wang, X., Stewart, K. G., Damrauer, J. S., Hoadley, K. A., & Emanuele, M. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.054 · Cited by 101 · see citing works
The CHR site: definition and genome-wide identification of a cell cycle transcriptional element
Müller, G. A., Wintsche, A., Stangner, K., Prohaska, S. J., Stadler, P. F., & Engeland, K. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku696 · Cited by 97 · see citing works
Michael Margaliot, A., Sontag, E. D., & Tuller, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096039 · Cited by 90 · see citing works
Bonacci, T., Suzuki, A., Grant, G. D., Stanley, N., Cook, J. G., Brown, N. G., & Emanuele, M. J. (2018) · The EMBO Journal · doi:10.15252/embj.201798701 · Cited by 90 · see citing works
Self-citationPreparation for DNA replication: the key to a successful S phase
Limas, J. C., & Cook, J. G. (2019) · FEBS Letters · doi:10.1002/1873-3468.13619 · Cited by 88 · see citing works
Katzenellenbogen, B. S., Guillen, V. S., & Katzenellenbogen, J. A. (2023) · Breast Cancer Research · doi:10.1186/s13058-023-01675-8 · Cited by 88 · see citing works
Assembly of a parts list of the human mitotic cell cycle machinery
Giotti, B., Chen, S.-H., Barnett, M. W., Regan, T. W., Ly, T., Wiemann, S., Hume, D. A., & Freeman, T. C. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy063 · Cited by 85 · see citing works
APC/C and SCF cyclin F Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry
Choudhury, R., Bonacci, T., Arceci, A., Lahiri, D., Mills, C. A., Kernan, J. L., Branigan, T. B., DeCaprio, J. A., Burke, D. J., & Emanuele, M. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.058 · Cited by 80 · see citing works
Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA)
Zhang, R., Podtelezhnikov, A. A., Hogenesch, J. B., & Anafi, R. C. (2016) · Journal of Biological Rhythms · doi:10.1177/0748730416631895 · Cited by 76 · see citing works
de Moraes, G. N., Bella, L., Zona, S., Burton, M. J., & Lam, E. W. ‐. (2016) · Current Drug Targets · doi:10.2174/1389450115666141122211549 · Cited by 75 · see citing works
Essential role for centromeric factors following p53 loss and oncogenic transformationPreprint
Filipescu, D., Naughtin, M., Podsypanina, K., Lejour, V., Wilson, L., Gurard‐Levin, Z. A., Orsi, G. A., Simeonova, I., Toufektchan, E., Attardi, L. D., et al. (2017) · Genes & Development · doi:10.1101/gad.290924.116 · Cited by 77 · see citing works
Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin
Emanuele, M. J., Enrico, T. P., Mouery, R. D., Wasserman, D., Nachum, S., & Tzur, A. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.05.002 · Cited by 72 · see citing works
GABPA inhibits invasion/metastasis in papillary thyroid carcinoma by regulating DICER1 expression
Yuan, X., Mu, N., Wang, N., Strååt, K., Sofiadis, A., Guo, Y., Stenman, A., Li, K., Cheng, G., Zhang, L., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0483-x · Cited by 71 · see citing works
E2F Transcription Factors Control the Roller Coaster Ride of Cell Cycle Gene Expression
Thurlings, I., & de Bruin, A. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2957-3_4 · Cited by 68 · see citing works
Pardo, I., Lillemoe, H. A., Blosser, R. J., Choi, M.-R., Sauder, C. A. M., Doxey, D. K., Mathieson, T., Hancock, B. A., Baptiste, D. F., Atale, R. V., et al. (2014) · Breast Cancer Research · doi:10.1186/bcr3627 · Cited by 61 · see citing works
Identification of Drivers of Aneuploidy in Breast Tumors
Pfister, K. E., Pipka, J. L., Chiang, C., Liu, Y., Clark, R. A., Keller, R. E., Skoglund, P., Guertin, M. J., Hall, I. M., & Stukenberg, P. T. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.102 · Cited by 65 · see citing works
Pham, T. H., Page, Y. L., Percevault, F., Ferrière, F., Flouriot, G., & Pakdel, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010470 · Cited by 60 · see citing works
Who guards the guardian? Mechanisms that restrain APC/C during the cell cycle
Kernan, J. L., Bonacci, T., & Emanuele, M. J. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.09.011 · Cited by 55 · see citing works
Thiru, P., Kern, D. M., McKinley, K. L., Monda, J. K., Rago, F., Su, K.-C., Tsinman, T. K., Yarar, D., Bell, G. W., & Cheeseman, I. M. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-03-0837 · Cited by 53 · see citing works
The Emerging Roles of Forkhead Box (FOX) Proteins in Osteosarcoma
Zhang, W., Duan, N., Song, T., Li, Z., Zhang, C., & Chen, X. (2017) · Journal of Cancer · doi:10.7150/jca.18778 · Cited by 52 · see citing works
Kelliher, C., Leman, A. R., Sierra, C. S., & Haase, S. B. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006453 · Cited by 47 · see citing works
Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma
Rihani, A., Vandesompele, J., Speleman, F., & Maerken, T. V. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0224-y · Cited by 51 · see citing works
CINSARC signature as a prognostic marker for clinical outcome in sarcomas and beyond
Chibon, F., Lesluyes, T., Valentin, T., & Guellec, S. L. (2018) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22703 · Cited by 52 · see citing works
Temporal separation of replication and transcription during S-phase progression
Meryet‐Figuière, M., Alaei-Mahabadi, B., Ali, M. M., Mitra, S., Subhash, S., Pandey, G. K., Larsson, E., & Kanduri, C. (2014) · Cell Cycle · doi:10.4161/15384101.2014.953876 · Cited by 48 · see citing works
Single cell transcriptomics reveals unanticipated features of early hematopoietic precursors
Yang, J., Tanaka, Y., Seay, M., Li, Z., Jin, J., Garmire, L. X., Zhu, X., Taylor, A., Li, W., Euskirchen, G. M., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1214 · Cited by 42 · see citing works
Filho, R. A. E.-A., Nicolas, A., Castro, T. L. D. P., Deplanche, M., Azevedo, V., Goossens, P. L., Taieb, F. E., Lina, G., Loir, Y. L., & Berkova, N. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00208 · Cited by 47 · see citing works
Retinoic acid regulates cell cycle genes and accelerates normal mouse liver regeneration
Liu, H., Ly, I., Hu, Y. C., & Wan, Y. Y. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.003 · Cited by 46 · see citing works
Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival
Elsing, A. N., Aspelin, C., Björk, J., Bergman, H., Himanen, S. V., Kallio, M. J., Roos‐Mattjus, P., & Sistonen, L. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201402002 · Cited by 46 · see citing works
Krenning, L., Sonneveld, S., & Tanenbaum, M. E. (2022) · eLife · doi:10.7554/elife.71356 · Cited by 41 · see citing works
Roçi, I., Watrous, J. D., Lagerborg, K. A., Lafranchi, L., Lindqvist, A., Jain, M., & Nilsson, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.059 · Cited by 44 · see citing works
Chen, F., Bai, G., Li, Y., Feng, Y., & Wang, L. (2017) · PubMed Central · Cited by 43 · see citing works
Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy
Zheng, L., Chen, Z., Kawakami, M., Chen, Y., Roszik, J., Mustachio, L. M., Kurie, J. M., Villalobos, P. A., Lü, W., Behrens, C., et al. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0864 · Cited by 43 · see citing works
Wang, X., Arceci, A., Bird, K. E., Mills, C. A., Choudhury, R., Kernan, J. L., Zhou, C., Bae-Jump, V. L., Bowers, A. A., & Emanuele, M. J. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00609-16 · Cited by 41 · see citing works
Enigmatic MELK: The controversy surrounding its complex role in cancer
McDonald, I. M., & Graves, L. M. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.013433 · Cited by 41 · see citing works
Proteome-scale movements and compartment connectivity during the eukaryotic cell cycle
Litsios, A., Grys, B., Kraus, O. Z., Friesen, H., Ross, C., Masinas, M. P. D., Forster, D. T., Couvillion, M., Timmermann, S., Billmann, M., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.014 · Cited by 41 · see citing works
Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein
Gauson, E. J., Windle, B., Donaldson, M., Caffarel, M. M., Dornan, E. S., Coleman, N., Herzyk, P., Henderson, S. C., Wang, X., & Morgan, I. M. (2014) · Virology · doi:10.1016/j.virol.2014.07.022 · Cited by 39 · see citing works
Aswad, L., Yenamandra, S. P., Ow, G. S., Grinchuk, O. V., Ivshina, A. V., & Kuznetsov, V. A. (2015) · Oncotarget · doi:10.18632/oncotarget.5543 · Cited by 35 · see citing works
Meta-analysis reveals conserved cell cycle transcriptional network across multiple human cell types
Giotti, B., Joshi, A., & Freeman, T. C. (2017) · BMC Genomics · doi:10.1186/s12864-016-3435-2 · Cited by 35 · see citing works
Chromosome Missegregation as a Modulator of Radiation Sensitivity
Cosper, P. F., Copeland, S. E., Tucker, J. B., & Weaver, B. A. A. (2021) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2021.09.002 · Cited by 34 · see citing works
Rizzardi, L. F., Coleman, K. E., Varma, D., Matson, J. P., Oh, S., & Cook, J. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.614701 · Cited by 34 · see citing works
Garg, A., Futcher, B., & Leatherwood, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv274 · Cited by 33 · see citing works
Sokolova, M., Turunen, M. M., Mortusewicz, O., Kivioja, T., Herr, P., Vähärautio, A., Björklund, M., Taipale, M., Helleday, T., & Taipale, J. (2016) · Cell Cycle · doi:10.1080/15384101.2016.1261765 · Cited by 32 · see citing works
Wiseman, E. F., Chen, X. X., Han, N., Webber, A., Ji, Z., Sharrocks, A. D., & Ang, Y. S. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0339-8 · Cited by 32 · see citing works
Unbiased Boolean analysis of public gene expression data for cell cycle gene identification
Dabydeen, S. A., Desai, A. B., & Sahoo, D. (2019) · Molecular Biology of the Cell · doi:10.1091/mbc.e19-01-0013 · Cited by 28 · see citing works
Higareda‐Almaraz, J. C., Ruiz-Moreno, J. S., Klimentová, J., Barbieri, D., Salvador-Gallego, R., Ly, R., Valtierra-Gutiérrez, I. A., Dinsart, C., Rabinovich, G. A., Stulík, J., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2700-8 · Cited by 31 · see citing works
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
Apraiz, A., Mitxelena, J., & Zubiaga, A. M. (2017) · Journal of Visualized Experiments · doi:10.3791/55745 · Cited by 31 · see citing works
Otto, J., Verwaayen, A., Penners, C., Hundertmark, J., Lin, C., Kallen, C., Paffen, D., Otto, T., Berger, H., Tacke, F., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06077-4 · Cited by 29 · see citing works
Benanti, J. A. (2015) · Current Genetics · doi:10.1007/s00294-015-0535-5 · Cited by 29 · see citing works
Intuyod, K., Saavedra-García, P., Zona, S., Lai, C., Jiramongkol, Y., Vaeteewoottacharn, K., Pairojkul, C., Yao, S. J., Yong, J.-S., Trakansuebkul, S., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1235-0 · Cited by 29 · see citing works
RetractedThe p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence
Schmidt, A., Allmann, S., Schwarzenbach, C., Snyder, P., Chen, J., Nagel, G., Schöneis, A., Rasenberger, B., Beli, P., Loewer, A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae426 · Cited by 28 · see citing works
RNA sequencing identifies crucial genes in papillary thyroid carcinoma (PTC) progression
Qiu, J., Zhang, W., Xia, Q., Liu, F., Li, L., Zhao, S., Gao, X., Zang, C., Ge, R., & Sun, Y. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.12.011 · Cited by 28 · see citing works
Layers of regulation of cell-cycle gene expression in the budding yeastSaccharomyces cerevisiae
Kelliher, C., Foster, M. W., Motta, F. C., Deckard, A., Soderblom, E. J., Moseley, M. A., & Haase, S. B. (2018) · Molecular Biology of the Cell · doi:10.1091/mbc.e18-04-0255 · Cited by 24 · see citing works
McDonald, I. M., Grant, G. D., East, M. P., Gilbert, T. S. K., Wilkerson, E., Goldfarb, D., Beri, J., Herring, L. E., Vaziri, C., Cook, J. G., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.011083 · Cited by 28 · see citing works
Self-citationYadav, A. K., & Polasek-Sedlackova, H. (2024) · Communications Biology · doi:10.1038/s42003-024-05855-w · Cited by 27 · see citing works
The Temporal Regulation of S Phase Proteins During G1
Grant, G. D., & Cook, J. G. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6955-0_16 · Cited by 26 · see citing works
Self-citationBodrug, T., Welsh, K. A., Hinkle, M., Emanuele, M. J., & Brown, N. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.687515 · Cited by 26 · see citing works
Martín, E., Vivori, C., Rogalska, M. E., Herrero-Vicente, J., & Valcárcel, J. (2021) · RNA · doi:10.1261/rna.078935.121 · Cited by 26 · see citing works
Asthana, A., Ramanan, P., Hirschi, A., Guiley, K. Z., Wijeratne, T. U., Shelansky, R. I., Doody, M. J., Narasimhan, H., Boeger, H., Tripathi, S. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28094-1 · Cited by 25 · see citing works
Chávez, S. S., Eastman, G., Smircich, P., Becco, L., Oliveira‐Rizzo, C., Fort, R. S., Potenza, M., Garat, B., Sotelo-Silveira, J. R., & Duhagon, M. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188441 · Cited by 24 · see citing works
Rega, C., Tsitsa, I., Roumeliotis, T. I., Krystkowiak, I., Portillo, M. G., Yu, L., Vorhauser, J., Pines, J., Mansfeld, J., Choudhary, J. S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57537-8 · Cited by 22 · see citing works
Vashisth, M., Cho, S., Irianto, J., Xia, Y., Wang, M., Hayes, B. H., Wieland, D. R., Wells, R. G., Jafarpour, F., Liu, A. J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112940118 · Cited by 23 · see citing works
Franks, J. L., Martinez‐Chacin, R. C., Wang, X., Tiedemann, R. L., Bonacci, T., Choudhury, R., Bolhuis, D. L., Enrico, T. P., Mouery, R. D., Damrauer, J. S., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000975 · Cited by 22 · see citing works
FOXM1 expression in rhabdomyosarcoma: a novel prognostic factor and therapeutic target
Kuda, M., Kohashi, K., Yamada, Y., Maekawa, A., Kinoshita, Y., Nakatsura, T., Iwamoto, Y., Taguchi, T., & Oda, Y. (2015) · Tumor Biology · doi:10.1007/s13277-015-4351-9 · Cited by 22 · see citing works
Schwarzenbach, C., Rinke, J., Vilar, J. B., Sallbach, J., Tatsch, L., Schmidt, A., Schöneis, A., Rasenberger, B., Kaina, B., Tomicic, M. T., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07651-8 · Cited by 21 · see citing works
Maekawa, A., Kohashi, K., Kuda, M., Iura, K., Ishii, T., Endo, M., Nakatsura, T., Iwamoto, Y., & Oda, Y. (2016) · BMC Cancer · doi:10.1186/s12885-016-2542-4 · Cited by 21 · see citing works
Pease, L. I., Clegg, P., Proctor, C. J., Shanley, D. P., Cockell, S., & Peffers, M. J. (2017) · Scientific Reports · doi:10.1038/s41598-017-14650-z · Cited by 22 · see citing works
Aristizábal-Corrales, D., Yang, J., & Li, F. (2019) · Genetics · doi:10.1534/genetics.118.301745 · Cited by 20 · see citing works
Roubtsova, A., Garçon, D., Lacoste, S., Chamberland, A., Marcinkiewicz, J., Métivier, R., Sotin, T., Paquette, M., Bernard, S., Cariou, B., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159217 · Cited by 20 · see citing works
S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression
Yıldırım, Ö., Izgü, E. Ç., Damle, M., Chalei, V., Ji, F., Sadreyev, R. I., Szostak, J. W., & Kingston, R. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107629 · Cited by 22 · see citing works
Transcriptomic Characterization of the Human Cell Cycle in Individual Unsynchronized Cells
Karlsson, J. W., Kroneis, T., Jonasson, E., Larsson, E., & Ståhlberg, A. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.10.011 · Cited by 18 · see citing works
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth
Zhang, N., & Pati, D. (2018) · Journal of Cancer Science & Therapy · doi:10.4172/1948-5956.1000517 · Cited by 19 · see citing works
Cell Type Specific Alterations in Interchromosomal Networks across the Cell Cycle
Fritz, A. J., Stojkovic, B., Ding, H., Xu, J., Bhattacharya, S., & Berezney, R. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003857 · Cited by 18 · see citing works
Personalized Network Modeling of the Pan-Cancer Patient and Cell Line Interactome
Bhattacharyya, R., Ha, M. J., Liu, Q., Akbani, R., Liang, H., & Baladandayuthapani, V. (2020) · JCO Clinical Cancer Informatics · doi:10.1200/cci.19.00140 · Cited by 18 · see citing works
Zheng, Y., Dubois, W., Benham, C. J., Batchelor, E., & Levens, D. (2020) · Communications Biology · doi:10.1038/s42003-020-01264-x · Cited by 17 · see citing works
The human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
Hirschler‐Laszkiewicz, I., Festa, F., Huang, S., Moldovan, G., Nicolae, C. M., Dhoonmoon, A., Bao, L., Keefer, K. A., Chen, S., Wang, H., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10385-8 · Cited by 17 · see citing works
Qu, S., Ci, X., Xue, H., Dong, X., Hao, J., Lin, D., Clermont, P., Wu, R. C., Collins, C. C., Gout, P. W., et al. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.474 · Cited by 17 · see citing works
Li, Y., Liu, M., Zhai, Z., Deng, L., Lv, X., Liu, H., Wang, Y., Zhang, C., Xiong, J., & Shi, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.688798 · Cited by 16 · see citing works
Structure and function of MuvB complexes
Müller, G. A., Asthana, A., & Rubin, S. M. (2022) · Oncogene · doi:10.1038/s41388-022-02321-x · Cited by 17 · see citing works
Context-dependent CpG methylation directs cell-specific binding of transcription factor ZBTB38
Marchal, C., Defossez, P., & Miotto, B. (2022) · Epigenetics · doi:10.1080/15592294.2022.2111135 · Cited by 16 · see citing works
Zhang, L., Cervantes, M. D., Pan, S., Lindsley, J., Dabney, A. R., & Kapler, G. M. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-08-0326 · Cited by 13 · see citing works
Abundance of d ‐2‐hydroxyglutarate in G2/M is determined by FOXM1 in mutant IDH1‐expressing cells
Kancharana, B., Katragunta, K., Sarma, U. M., & Jain, N. (2019) · FEBS Letters · doi:10.1002/1873-3468.13500 · Cited by 16 · see citing works
- Authors
- Grant, G. D., Brooks, L., Zhang, X., Mahoney, J. M., Martyanov, V., Wood, T. A., Sherlock, G., Cheng, C., & Whitfield, M. L.
- Affiliations
- Dartmouth College (US)
- Stanford Medicine (US)
- Corresponding author
- Whitfield, Michael L.
- ORCID
- Venue
- Molecular Biology of the Cell
- Published
- 2013-12
- Volume
- 24
- Issue
- 23
- Pages
- 3634-3650
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC3842991
- OpenAlex
- W2102123859
- Cited by
- 179
- References
- 92
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 6 · 2022: 10 · 2021: 21 · 2020: 19 · 2019: 17 · 2018: 14 · 2017: 20 · 2016: 17 · 2015: 14 · 2014: 12
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- Molecular Biology of the Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Foundation for the National Institutes of Health
- V Foundation for Cancer Research
- National Human Genome Research Institute (R01HG004499)
- National Cancer Institute (R25CA134286, R01CA130795)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- cell cycle-regulated genes, periodic gene expression, FOXM1, E2F transcription factors, G2/M phase, S phase, osteosarcoma, U2OS cells, transcriptional regulation, DREAM complex, GABPA, E2F1, E2F4, E2F6, promoter activation
- MeSH terms
- Forkhead Box Protein M1, Cell Cycle, Multigene Family, HeLa Cells, Humans, Protein Binding, RNA, Messenger, Time Factors, Transcription, Genetic, Protein Biosynthesis, Gene Expression Regulation, Neoplastic, Genes, cdc, Gene Expression Profiling, Chromatin Immunoprecipitation, E2F Transcription Factors, Forkhead Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review