The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging
Open accessAbstract
Autophagy has been linked to longevity in many species, but the underlying mechanisms are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we quantified autophagic vesicles and performed autophagic flux assays in multiple tissues of wild-type Caenorhabditis elegans and long-lived daf-2/insulin/IGF-1 and glp-1/Notch mutants throughout adulthood. Our data are consistent with an age-related decline in autophagic activity in the intestine, body-wall muscle, pharynx, and neurons of wild-type animals. In contrast, daf-2 and glp-1 mutants displayed unique age- and tissue-specific changes in autophagic activity, indicating that the two longevity paradigms have distinct effects on autophagy during aging. Although autophagy appeared active in the intestine of both long-lived mutants, inhibition of intestinal autophagy significantly abrogated lifespan extension only in glp-1 mutants. Collectively, our data suggest that autophagic activity normally decreases with age in C. elegans, whereas daf-2 and glp-1 long-lived mutants regulate autophagy in distinct spatiotemporal-specific manners to extend lifespan.
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Cites
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“However, age appears to affect neuronal autophagy more variably than other tissues (Chang et al. 2017).”
Background
Metadata
- Authors
- Chang, J. T., Kumsta, C., Hellman, A. B., Adams, L. M., & Hansen, M.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-07-04
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2732209041
- Cited by
- 266
- References
- 15
- FWCI
- 8.91
- Type
- journal article
- Language
- en
- Open access
- gold
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