The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain
Open accessAbstract
AMPA-type glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and are selectively recruited during activity-dependent plasticity to increase synaptic strength. A prerequisite for faithful signal transmission is the positioning and clustering of AMPARs at postsynaptic sites. The mechanisms underlying this positioning have largely been ascribed to the receptor cytoplasmic C-termini and to AMPAR-associated auxiliary subunits, both interacting with the postsynaptic scaffold. Here, using mouse organotypic hippocampal slices, we show that the extracellular AMPAR N-terminal domain (NTD), which projects midway into the synaptic cleft, plays a fundamental role in this process. This highly sequence-diverse domain mediates synaptic anchoring in a subunit-selective manner. Receptors lacking the NTD exhibit increased mobility in synapses, depress synaptic transmission and are unable to sustain long-term potentiation (LTP). Thus, synaptic transmission and the expression of LTP are dependent upon an AMPAR anchoring mechanism that is driven by the NTD.
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“Data show that the amino terminal domain is not necessary for the formation of functional ion channels, or delivery onto the cell surface, but is required for targeting and retention of GluA1 at synapses during LTP (Watson et al., 2017, Diaz-Alonso et al., 2017).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Watson et al., 2017
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“Third, most of these studies have tagged GluA1 on the NH2 terminus. This tagging severely impacts the trafficking of the GluA1-containing receptor (343, 344).”
From Synaptic memory and CaMKII (2023) · cites this paper as [343]
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NIH Image to ImageJ: 25 years of image analysis
Schneider, C. A., Rasband, W. S., & Eliceiri, K. W. (2012) · Nature Methods · doi:10.1038/nmeth.2089 · Cited by 64,638
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Ashkenazy, H., Abadi, S., Martz, E., Chay, O., Mayrose, I., Pupko, T., & Ben-Tal, N. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw408 · Cited by 3,163
A simple method for organotypic cultures of nervous tissue
Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,096
Hayashi, Y., Shi, S.-H., Esteban, J. A., Piccini, A., Poncer, J.-C., & Malinow, R. (2000) · Science · doi:10.1126/science.287.5461.2262 · Cited by 1,524
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Evidence for silent synapses: Implications for the expression of LTP
Isaac, J. T. R., Nicoll, R. A., & Malenka, R. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90046-2 · Cited by 1,233
Shi, S.-H., Hayashi, Y., Esteban, J. A., & Malinow, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00321-x · Cited by 1,094
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
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Qneibi, M., Issa, K., Bakhatan, A., Khaled, M. A., Bdir, S., Bdair, M., Sandouka, D., & Jaradat, N. A. (2024) · European Journal of Integrative Medicine · doi:10.1016/j.eujim.2024.102411 · Cited by 1
Kreir, M., Floren, W., Policarpo, R., Bondt, A. D., den Wyngaert, I. V., Teisman, A. C. H., Gallacher, D. J., & Lu, H. R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175189 · Cited by 1
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dou, T., Zhang, J., hong, Y., Chen, X., & Nicoll, R. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.28.708706 · Cited by 1
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Chipman, P. H., Fetter, R. D., Ragozzino, F. J., Lee, U., & Davis, G. W. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.12.711375 · Cited by 1
AMPA receptor trafficking in the developing and mature glutamatergic synapse
Catsburg, L. A. E., & MacGillavry, H. D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00023-5
Scheefhals, N. (2022) · Utrecht University Repository (Utrecht University) · doi:10.33540/1224
Schorova, L. (2018) · theses.fr (ABES) · doi:10.70675/a30a505az5e81z4089za24azcf43d27e33ce
Charles‐Messance, H. (2018) · theses.fr (ABES) · doi:10.70675/674377b7z4bf8z451cz9328zbe6648512747
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Bessa‐Neto, D. (2021) · theses.fr (ABES) · doi:10.70675/a68a26edzb1c6z414ez927czebc71c64fb29
Hunter, D. (2023) · theses.fr (ABES) · doi:10.70675/ae0cf321z922dz4431z8e9czca6cbf457b2e
Mapping the multi-domain allosteric network for CKAMP44 modulation of AMPA receptors
Bharti, P., Visal, S., Vinnakota, R., & Kumar, J. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113131
Padmanabhan, N., Twilley, R. E., Oku, S., Rabbi, M. S., Skeens, A., Jones, G. C., Acharya, S., Basha, M. A., Rajapakse, D., Koltek, C., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.06.018 · Cited by 2
Leana-Sandoval, G., Sandoval, M. A., Kolli, A. V., Saavedra, E., Li, K. H., Burlingame, A. L., Ramírez‐Franco, J., & Díaz-Alonso, J. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107553
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Ahn, J., Kim, S., Park, J., Woo, S., Sohn, H., & Lee, S. (2026) · Communications Biology · doi:10.1038/s42003-026-11082-2
Fan, Y., Ye, W., Sun, Y., Li, D., Liu, J., Li, Z., & Huang, Y. (2026) · Headache The Journal of Head and Face Pain · doi:10.1111/head.70259
Metadata
- Authors
- Watson, J. F., Ho, H., & Greger, I. H.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Greger, Ingo H
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-03-14
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5370185
- OpenAlex
- W2600278343
- Cited by
- 117
- References
- 74
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 14 · 2023: 14 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 8 · 2018: 13 · 2017: 9
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Medical Research Council (MC_U105174197)
- Biotechnology and Biological Sciences Research Council (BB/N002113/1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- AMPA receptors, synaptic transmission, long-term potentiation, synaptic plasticity, receptor mobility, postsynaptic scaffolds, hippocampus
- MeSH terms
- Animals, Hippocampus, Synaptic Transmission, Receptors, AMPA, Mice
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