The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission
Open accessAbstract
Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which the virus is selectively administered to the upper airways, mimicking a natural respiratory virus infection. Mice lacking functional IFN-λ receptors (Ifnlr1−/−) no longer restricted virus dissemination from the upper airways to the lungs. Ifnlr1−/− mice shed significantly more infectious virus particles via the nostrils and transmitted the virus much more efficiently to naïve contacts compared with wild-type mice or mice lacking functional type I IFN receptors. Prophylactic treatment with IFN-α or IFN-λ inhibited initial virus replication in all parts of the respiratory tract, but only IFN-λ conferred long-lasting antiviral protection in the upper airways and blocked virus transmission. Thus, IFN-λ has a decisive and non-redundant function in the upper airways that greatly limits transmission of respiratory viruses to naïve contacts.
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Cites
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
Kotenko, S. V., Gallagher, G., Baurin, V. V., Lewis-Antes, A., Shen, M., Shah, N. K., Langer, J. A., Sheikh, F., Dickensheets, H., & Donnelly, R. P. (2003) · Nature Immunology · doi:10.1038/ni875 · Cited by 1,868
IL-28, IL-29 and their class II cytokine receptor IL-28R
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Type I interferon: friend or foe?
Trinchieri, G. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20101664 · Cited by 844
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Self-citationInterferon-λ: Immune Functions at Barrier Surfaces and Beyond
Lazear, H. M., Nice, T. J., & Diamond, M. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.001 · Cited by 480
Galani, I. E., Triantafyllia, V., Eleminiadou, E.-E., Koltsida, O., Stavropoulos, A., Manioudaki, M., Thanos, D., Doyle, S. E., Kotenko, S. V., Thanopoulou, K., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.025 · Cited by 477
Mx GTPases: dynamin-like antiviral machines of innate immunity
Haller, O., Staeheli, P., Schwemmle, M., & Kochs, G. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2014.12.003 · Cited by 456
Self-citationMordstein, M., Neugebauer, E., Ditt, V., Jessen, B., Rieger, T., Falcone, V., Sorgeloos, F., Ehl, S., Mayer, D., Kochs, G., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00272-10 · Cited by 443
Self-citationIFN-λ determines the intestinal epithelial antiviral host defense
Pott, J., Mahlakõiv, T., Mordstein, M., Duerr, C. U., Michiels, T., Stockinger, S., Staeheli, P., & Hornef, M. W. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100552108 · Cited by 416
Self-citationCommensal microbes and interferon-λ determine persistence of enteric murine norovirus infection
Baldridge, M. T., Nice, T. J., McCune, B. T., Yokoyama, C. C., Kambal, A., Wheadon, M., Diamond, M. S., Ivanova, Y., Artyomov, M., & Virgin, H. W. (2015) · Science · doi:10.1126/science.1258025 · Cited by 412
Cited by
Shared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19
Park, A., & Iwasaki, A. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.008 · Cited by 909
Decoding type I and III interferon signalling during viral infection
Mesev, E. V., LeDesma, R. A., & Ploss, A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0421-x · Cited by 538
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
Major, J., Crotta, S., Llorian, M., McCabe, T. M., Gad, H. H., Priestnall, S. L., Hartmann, R., & Wack, A. (2020) · Science · doi:10.1126/science.abc2061 · Cited by 503
Self-citationA SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.011 · Cited by 494
Metadata
- Authors
- Klinkhammer, J., Schnepf, D., Ye, L., Schwaderlapp, M., Gad, H. H., Hartmann, R., Garcin, D., Mahlakõiv, T., & Staeheli, P.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2018-04-13
- Volume
- 7
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2798242933
- Cited by
- 264
- References
- 39
- FWCI
- 11.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Klinkhammer, J., Schnepf, D., Ye, L., Schwaderlapp, M., Gad, H. H., Hartmann, R., Garcin, D., Mahlakõiv, T., & Staeheli, P. (2018). IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission. eLife. https://doi.org/10.7554/elife.33354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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