The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies
Open accessAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small animals in large numbers. Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Here, we transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues. hACE2-transduced mice were productively infected with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight loss. Passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss. The development of an accessible mouse model of SARS-CoV-2 infection and pathogenesis will expedite the testing and deployment of therapeutics and vaccines.
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Cites
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246
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“Given that human but not mouse ACE2 can act as a cellular receptor for SARS-CoV-2 in vitro (Hoffmann et al., 2020; Letko et al., 2020; Wan et al., 2020), our findings in conventional laboratory mice were anticipated and indeed recently reported by others (Bao et al.”
BackgroundResultLi, R., Pei, S., Chen, B., Song, Y., Zhang, T., Yang, W., & Shaman, J. (2020) · Science · doi:10.1126/science.abb3221 · Cited by 3,633
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Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
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Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure
Giamarellos-Bourboulis, E. J., Netea, M. G., Rovina, N., Akinosoglou, K., Antoniadou, A., Antonakos, N., Damoraki, G., Gkavogianni, T., Adami, M.-E., Katsaounou, P., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.04.009 · Cited by 2,045
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Self-citationSARS-CoV-2 Vaccines: Status Report
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Cited by
SARS-CoV-2 vaccines in development
Krammer, F. (2020) · Nature · doi:10.1038/s41586-020-2798-3 · Cited by 2,098
Potently neutralizing and protective human antibodies against SARS-CoV-2
Zost, S. J., Gilchuk, P., Case, J. B., Binshtein, E., Chen, R. E., Nkolola, J. P., Schäfer, A., Reidy, J. X., Trivette, A., Nargi, R. S., et al. (2020) · Nature · doi:10.1038/s41586-020-2548-6 · Cited by 1,041
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“neutralizing antibodies protect against SARS-CoV-2 in animals (Alsoussi et al., 2020; Cao et al., 2020; Hassan et al., 2020; Rogers et al., 2020; Walls et al., 2020a; Wu et al., 2020; Zost et al., 2020a), and preliminary evidence suggests the presence of neutralizing antibodies also correlates with protection in hum…”
Winkler, E. S., Bailey, A. L., Kafai, N. M., Nair, S., McCune, B. T., Yu, J., Fox, J. M., Chen, R. E., Earnest, J. T., Keeler, S. P., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0778-2 · Cited by 901
Self-citationBeyerstedt, S., Casaro, E. B., & Rangel, É. B. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-04138-6 · Cited by 897
Metadata
- Authors
- Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., Turner, J. S., Schmitz, A. J., Lei, T., Shrihari, S., Keeler, S. P., Fremont, D. H., Greco, S., McCray, P. B., Perlman, S., Holtzman, M. J., Ellebedy, A. H., & Diamond, M. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 182
- Issue
- 3
- Pages
- 744-753.e4
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3033015248
- Cited by
- 494
- References
- 14
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hassan, A. O., Case, J. B., Winkler, E. S., Thackray, L. B., Kafai, N. M., Bailey, A. L., McCune, B. T., Fox, J. M., Chen, R. E., Alsoussi, W. B., Turner, J. S., Schmitz, A. J., Lei, T., Shrihari, S., Keeler, S. P., Fremont, D. H., Greco, S., McCray, P. B., Perlman, S., . . . Diamond, M. S. (2020). A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies. Cell. https://doi.org/10.1016/j.cell.2020.06.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
