Cited by 256RNA Research and SplicingRNA and protein synthesis mechanismsRNA regulation and disease

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GC content shapes mRNA storage and decay in human cells

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Courel, Maïté, Clément, Yves, Bossevain, Clémentine, Foretek, Dominika, Vidal Cruchez, Olivia, Yi, Zhou, Bénard, Marianne, Benassy, Marie-Noëlle, Kress, Michel, Vindry, Caroline, Ernoult-Lange, Michèle, Antoniewski, Christophe, Morillon, Antonin, Brest, Patrick, Hubstenberger, Arnaud, Roest Crollius, Hugues, Standart, Nancy, Weil, Dominique·2019·eLife

DOI 10.7554/elife.49708PMC PMC6944446

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Abstract

mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of broadly acting mRNA decay and repression factors, and with available CLIP and related data. This revealed the central role of GC content in mRNA fate, in terms of P-body localization, mRNA translation and mRNA stability: P-bodies contain mostly AU-rich mRNAs, which have a particular codon usage associated with a low protein yield; AU-rich and GC-rich transcripts tend to follow distinct decay pathways; and the targets of sequence-specific RBPs and miRNAs are also biased in terms of GC content. Altogether, these results suggest an integrated view of post-transcriptional control in human cells where most translation regulation is dedicated to inefficiently translated AU-rich mRNAs, whereas control at the level of 5’ decay applies to optimally translated GC-rich mRNAs.

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Authors: Courel, M., Clément, Y., Bossevain, C., Foretek, D., Vidal Cruchez, O., Yi, Z., Bénard, M., Benassy, M.-N., Kress, M., Vindry, C., Ernoult-Lange, M., Antoniewski, C., Morillon, A., Brest, P., Hubstenberger, A., Roest Crollius, H., Standart, N., & Weil, D.
Affiliations: Centre National de la Recherche Scientifique (FR)
École Normale Supérieure - PSL (FR)
Université Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Nice, France
Université Côte d'Azur, CNRS, INSERM, iBV, Nice, France
University of Cambridge (GB)
Sorbonne Université, CNRS, Institut de Biologie Paris Seine (IBPS), Laboratoire de Biologie du Développement, Paris, France
Ecole Normale Supérieure, Institut de Biologie de l'ENS, IBENS, Paris, France
ORCID: Courel, Maïté
Clément, Yves
Foretek, Dominika
Bénard, Marianne
Vindry, Caroline
Antoniewski, Christophe
Morillon, Antonin
Brest, Patrick
Hubstenberger, Arnaud
Roest Crollius, Hugues
Standart, Nancy
Weil, Dominique
Venue: eLife
Publisher: eLife Sciences Publications, Ltd
Published: 2019-12-19
Volume: 8
Pages: e49708
ISSN: 2050-084X (ISSN-L)
DOI: 10.7554/elife.49708
PMC: PMC6944446
OpenAlex: W2994774550
Cited by: 250
References: 83
Citations by year: 2026: 38 · 2025: 40 · 2024: 44 · 2023: 35 · 2022: 25 · 2021: 44 · 2020: 17 · 2019: 7
FWCI: 7.98
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
creativecommons.org/licenses/by/4.0/ (am)
creativecommons.org/licenses/by/4.0/ (tdm)
Locations: eLife (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
HAL (submittedVersion)
HAL (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Apollo (University of Cambridge) (submittedVersion, cc-by)
Apollo (cc-by)
Funders: Association pour la Recherche sur le Cancer (Subvention Fixe)
Agence Nationale de la Recherche (ANR-14-CE09-0013-01, ANR-11-LABX-0028-01)
European Research Council (DARK consolidator grant)
Canceropôle PACA
Biotechnology and Biological Sciences Research Council
Isaac Newton Trust
Fondation Philippe Wiener - Maurice Anspach
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: GC content, mRNA stability, mRNA degradation, P-bodies, codon usage, translational regulation, post-transcriptional regulation, RNA-binding proteins, microRNA, human cells
MeSH terms: Base Composition, Gene Expression Regulation, Humans, RNA, Messenger, Protein Biosynthesis, RNA Stability, RNA, Messenger, Stored, MicroRNAs, Transcriptome

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