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Cited by 30melanin and skin pigmentationDevelopmental Biology and Gene RegulationZebrafish Biomedical Research Applications

Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling

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Gramann, Alec K, Venkatesan, Arvind M, Guerin, Melissa, Ceol, Craig J·2019·eLife
DOI 10.7554/elife.50047PMC PMC6968919

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Abstract

Preventing terminal differentiation is important in the development and progression of many cancers including melanoma. Recent identification of the BMP ligand GDF6 as a novel melanoma oncogene showed GDF6-activated BMP signaling suppresses differentiation of melanoma cells. Previous studies have identified roles for GDF6 orthologs during early embryonic and neural crest development, but have not identified direct regulation of melanocyte development by GDF6. Here, we investigate the BMP ligand gdf6a, a zebrafish ortholog of human GDF6, during the development of melanocytes from the neural crest. We establish that the loss of gdf6a or inhibition of BMP signaling during neural crest development disrupts normal pigment cell development, leading to an increase in the number of melanocytes and a corresponding decrease in iridophores, another neural crest-derived pigment cell type in zebrafish. This shift occurs as pigment cells arise from the neural crest and depends on mitfa, an ortholog of MITF, a key regulator of melanocyte development that is also targeted by oncogenic BMP signaling. Together, these results indicate that the oncogenic role ligand-dependent BMP signaling plays in suppressing differentiation in melanoma is a reiteration of its physiological roles during melanocyte development.

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  • BMP signaling in zebrafish biases the fates of progenitor cells away from melanophores and toward iridophores, at least in part by repressing mitfa and other genes required for melanogenesis.

    “BMP signaling in zebrafish biases the fates of progenitor cells away from melanophores and toward iridophores, at least in part by repressing mitfa and other genes required for melanogenesis (38).”

    From Agouti and BMP signaling drive a naturally occurring fate conversion of melanophores to leucophores in zebrafish (2025) · cites this paper as [38]

    The Results section on lineage tracing reports that BMP signaling promotes iridophore rather than melanocyte fate in mitfa-expressing progenitors; the section on mitfa expression reports that BMP signaling suppresses mitfa. The Results also show higher expression of the melanocyte markers mc1r, tyr, and tyrp1b when BMP signaling is inhibited, but describe this as consistent with increased melanocyte numbers, not as evidence that BMP represses those genes to determine progenitor fate. The indexed passages have no page numbers. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Gramann, A. K., Venkatesan, A. M., Guerin, M., & Ceol, C. J.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Ceol, Craig J
ORCID
Venue
eLife
Publisher
eLife Sciences Publications, Ltd
Published
2019-12-23
Volume
8
ISSN
2050-084X (ISSN-L)
DOI
10.7554/elife.50047
PMC
PMC6968919
OpenAlex
W2996552501
Cited by
30
References
2
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2017: 1
FWCI
1.84
Type
journal article
Language
en
Open access
Licence
Locations
  • eLife (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship@UMassChan (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Melanoma Research Foundation
  • National Cancer Institute (1F31CA239478-01)
  • National Center for Advancing Translational Sciences (UL1-TR001453)
  • Congressionally Directed Medical Research Programs (W8IXWH-13-0107)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR063850)
  • Sidney Kimmel Foundation for Cancer Research (SKF-13-123)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Keywords
melanocyte development, BMP signaling, GDF6, zebrafish, neural crest, iridophores, MITF, mitfa, terminal differentiation, pigment cells, embryonic development
MeSH terms
Animals, Cell Differentiation, Humans, Ligands, Melanocytes, Neoplasms, Neural Crest, Pigmentation, Zebrafish, Signal Transduction, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Zebrafish Proteins, Microphthalmia-Associated Transcription Factor, Growth Differentiation Factor 6

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