Cerebellar and vestibular nuclear synapses in the inferior olive have distinct release kinetics and neurotransmitters
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Abstract
The inferior olive (IO) is composed of electrically-coupled neurons that make climbing fiber synapses onto Purkinje cells. Neurons in different IO subnuclei are inhibited by synapses with wide ranging release kinetics. Inhibition can be exclusively synchronous, asynchronous, or a mixture of both. Whether the same boutons, neurons or sources provide these kinetically distinct types of inhibition was not known. We find that in mice the deep cerebellar nuclei (DCN) and vestibular nuclei (VN) are two major sources of inhibition to the IO that are specialized to provide inhibitory input with distinct kinetics. DCN to IO synapses lack fast synaptotagmin isoforms, release neurotransmitter asynchronously, and are exclusively GABAergic. VN to IO synapses contain fast synaptotagmin isoforms, release neurotransmitter synchronously, and are mediated by combined GABAergic and glycinergic transmission. These findings indicate that VN and DCN inhibitory inputs to the IO are suited to control different aspects of IO activity.
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Glycine receptor kinetics are faster than GABA receptor kinetics, producing IPSCs with fast and slow components.
“The kinetics of glycine receptors are faster than those of GABA receptors, resulting in an inhibitory post synaptic current (IPSC) with fast and slow components.44,45,49”
From Synaptic and circuit functions of multitransmitter neurons in the mammalian brain (2023) · cites this paper as [45]
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- Authors
- Turecek, J., & Regehr, W. G.
- Affiliations
- Harvard University (US)
- Corresponding author
- Regehr, Wade G
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2020-12-01
- Volume
- 9
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC7707816
- OpenAlex
- W3107116985
- Cited by
- 13
- References
- 75
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 5 · 2022: 1 · 2021: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH Office of the Director (R35NS097284)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- inferior olive, deep cerebellar nuclei, vestibular nuclei, GABAergic neurotransmission, glycinergic transmission, climbing fibers, Purkinje cells, cerebellar inhibition, neurotransmitter release
- MeSH terms
- Animals, Cerebellum, Female, Kinetics, Male, Mice, Inbred C57BL, Neural Inhibition, Neurons, Olivary Nucleus, Synapses, Vestibular Nuclei, Neurotransmitter Agents, Synaptotagmins, Mice
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