Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality
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Abstract
Abstract Water balance, tracked by extracellular osmolality, is regulated by feedback and feedforward mechanisms. Feedback regulation is reactive, occurring as deviations in osmolality are detected . Feedforward or presystemic regulation is proactive, occurring when disturbances in osmolality are anticipated . Vasopressin (AVP) is a key hormone regulating water balance and is released during hyperosmolality to limit renal water excretion. AVP neurons are under feedback and feedforward regulation. Not only do they respond to disturbances in blood osmolality, but they are also rapidly suppressed and stimulated, respectively, by drinking and eating, which will ultimately decrease and increase osmolality. Here, we demonstrate that AVP neuron activity is regulated by multiple anatomically-and functionally-distinct neural circuits. Notably, presystemic regulation during drinking and eating are mediated by non-overlapping circuits that involve the lamina terminalis and hypothalamic arcuate nucleus, respectively. These findings reveal neural mechanisms that support differential regulation of AVP release by diverse behavioral and physiological stimuli.
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Few of the inputs to paraventricular vasopressin cells are vasopressin immunoreactive and may be oxytocinergic, suggesting functional crosstalk between oxytocin and vasopressin paraventricular cells.
“Few of the inputs to PVN AVP cells are AVP immunoreactive, and may, in fact, be OXT-ergic (61,62), suggesting functional crosstalk between OXT and AVP PVN cells.”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [62]
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Vijayan, M., & Rein, J. L. (2026) · Endocrinology · doi:10.1210/endocr/bqag014
A symmetric systemic challenge elicits a right‐biased response mediated by vasopressin signaling
Watanabe, H., Kobikov, Y., Mohamed, S. Y., Rich, K., Sarkisyan, D., Nosova, O., Grönbladh, A., Hallberg, M., Schouenborg, J., Bakalkin, G. Y., et al. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70257
Benhafri, N., Remana, S., Rouibate, A. D., Thirouin, Z. S., Dekar-Madoui, A., Bourque, C. W., & Ouali‐Hassenaoui, S. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70236
- Authors
- Kim, A., Madara, J. C., Wu, C., Andermann, M. L., & Lowell, B. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Lowell, Bradford B
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-09-29
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC8601670
- OpenAlex
- W3202496989
- Cited by
- 25
- References
- 67
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 1
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (F31 DK109575, R01 DK075632, R01 DK096010, R01 DK089044, R01 DK111401, P30 DK046200, DP2 DK105570, R01 DK109930, P30 DK057521)
- McKnight Foundation (McKnight Scholar Award)
- Pew Charitable Trusts (Pew Scholar Award)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Keywords
- vasopressin, osmolality, water balance, feedforward control, feedback regulation, lamina terminalis, arcuate nucleus, drinking behavior, dietary habits, neural circuits, hyperosmolarity, renal water excretion
- MeSH terms
- Animals, Arginine Vasopressin, Female, Hypothalamus, Male, Neurons, Osmolar Concentration, Osmotic Pressure, Vasopressins, Water-Electrolyte Balance, Mice
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