Phagocytic ‘teeth’ and myosin-II ‘jaw’ power target constriction during phagocytosis
Open accessPublished version of a preprint
Abstract
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs membrane extensions to engulf such diverse targets remains unclear. Here, we combine lattice light-sheet microscopy (LLSM) with microparticle traction force microscopy (MP-TFM) to quantify actin dynamics and subcellular forces during macrophage phagocytosis. We show that spatially localized forces leading to target constriction are prominent during phagocytosis of antibody-opsonized targets. This constriction is largely driven by Arp2/3-mediated assembly of discrete actin protrusions containing myosin 1e and 1f (‘teeth’) that appear to be interconnected in a ring-like organization. Contractile myosin-II activity contributes to late-stage phagocytic force generation and progression, supporting a specific role in phagocytic cup closure. Observations of partial target eating attempts and sudden target release via a popping mechanism suggest that constriction may be critical for resolving complex in vivo target encounters. Overall, our findings present a phagocytic cup shaping mechanism that is distinct from cytoskeletal remodeling in 2D cell motility and may contribute to mechanosensing and phagocytic plasticity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A single stress filament could generate bending forces within the range of sub-nanonewton to nanonewton magnitudes.
“A single stress filament could generate bending forces within the range of sub-nanonewton to nanonewton magnitudes, comparable to pulling forces reported during early phagocytosis [31].”
From Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis (2026) · cites this paper as [31]
Forces for continuous inward transport of a fibre are generated by actin-myosin-I structures organized in a ring at the pseudopod tip.
“evidence from particle uptake studies suggests that forces are generated by actin–myosin-I structures organized in a ring at the pseudopod tip [31].”
From Macrophages bend long fibres with flexural rigidity lower than 3 mN·nm2 to avoid frustrated phagocytosis (2026) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Johnson, K. L. (1985) · Cambridge University Press eBooks · doi:10.1017/cbo9781139171731 · Cited by 7,821 · see citing works
Mechanisms of phagocytosis in macrophages
Aderem, A., & Underhill, D. M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.593 · Cited by 2,854 · see citing works
SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells
Sachs, P., Ding, D., Bergmaier, P., Lamp, B., Schlagheck, C., Finkernagel, F., Nist, A., Stiewe, T., & Mermoud, J. E. (2019) · Nature Communications · doi:10.1038/s41467-019-09078-0 · Cited by 2,388 · see citing works
Role of target geometry in phagocytosis
Champion, J. A., & Mitragotri, S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600997103 · Cited by 2,082 · see citing works
Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Chen, B., Legant, W. R., Wang, K., Shao, L., Milkie, D. E., Davidson, M. W., Janetopoulos, C., Wu, X., Hammer, J. A., Liu, Z. J., et al. (2014) · Science · doi:10.1126/science.1257998 · Cited by 1,932 · see citing works
Nanomechanical analysis of cells from cancer patients
Cross, S. E., Jin, Y., Rao, J., & Gimzewski, J. K. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.388 · Cited by 1,906 · see citing works
Actin Dynamics, Architecture, and Mechanics in Cell Motility
Blanchoin, L., Boujemaa‐Paterski, R., Sykes, C., & Plastino, J. (2014) · Physiological Reviews · doi:10.1152/physrev.00018.2013 · Cited by 1,468 · see citing works
Yang, B.-J., Han, X., Yin, L.-L., Xing, M., Xu, Z. H., & Xue, H. (2016) · Nature Communications · doi:10.1038/ncomms11388 · Cited by 1,210 · see citing works
Localizing Region-Based Active Contours
Lankton, S., & Tannenbaum, A. (2008) · IEEE Transactions on Image Processing · doi:10.1109/tip.2008.2004611 · Cited by 1,143 · see citing works
The lamellipodium: where motility begins
Small, J. V., Stradal, T. E. B., Vignal, E., & Rottner, K. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02237-1 · Cited by 924 · see citing works
The clearance of dead cells by efferocytosis
Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 893 · see citing works
Phagocytosis: Our Current Understanding of a Universal Biological Process
Uribe-Querol, E., & Rosales, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01066 · Cited by 651 · see citing works
The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
Linder, S. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.01.002 · Cited by 640 · see citing works
Phagocytosis: Receptors, signal integration, and the cytoskeleton
Freeman, S. A., & Grinstein, S. (2014) · Immunological Reviews · doi:10.1111/imr.12212 · Cited by 548 · see citing works
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520 · see citing works
Tsai, R. K., & Discher, D. E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708043 · Cited by 486 · see citing works
Chimeric antigen receptors that trigger phagocytosis
Morrissey, M. A., Williamson, A. P., Steinbach, A. M., Roberts, E. W., Kern, N., Headley, M. B., & Vale, R. D. (2018) · eLife · doi:10.7554/elife.36688 · Cited by 413 · see citing works
Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis
Matlung, H. L., Babes, L., Zhao, X. W., van Houdt, M., Treffers, L. W., van Rees, D. J., Franke, K., Schornagel, K., Verkuijlen, P., Janssen, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.082 · Cited by 406 · see citing works
Estimating curvatures and their derivatives on triangle meshes
Rusinkiewicz, S. M. (2004) · doi:10.1109/3dpvt.2004.54 · Cited by 390 · see citing works
Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target
Beningo, K. A., & Wang, Y.-L. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.849 · Cited by 389 · see citing works
Self-citationMyosin II contributes to cell-scale actin network treadmilling through network disassembly
Wilson, C. A., Tsuchida, M. A., Allen, G. M., Barnhart, E. L., Applegate, K. T., Yam, P. T., Ji, L., Keren, K., Danuser, G. M., & Theriot, J. A. (2010) · Nature · doi:10.1038/nature08994 · Cited by 383 · see citing works
Self-citationLiang, Y., Wang, M., Chien, C., Yarmishyn, A. A., Yang, Y.-P., Lai, W.-Y., Luo, Y., Lin, Y.-T., Chen, Y.-J., Chang, P., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01022 · Cited by 339 · see citing works
The coordination of signaling during Fc receptor-mediated phagocytosis
Swanson, J. A., & Hoppe, A. D. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0804439 · Cited by 326 · see citing works
Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3
May, R., Caron, E., Hall, A., & Machesky, L. (2000) · Nature Cell Biology · doi:10.1038/35008673 · Cited by 313 · see citing works
SHTools: Tools for Working with Spherical Harmonics
Wieczorek, M. A., & Meschede, M. (2018) · Geochemistry Geophysics Geosystems · doi:10.1029/2018gc007529 · Cited by 307 · see citing works
Estimating curvatures and their derivatives on triangle meshes
Rusinkiewicz, S. M. (2004) · International Symposium on 3D Data Processing, Visualization and Transmission · doi:10.1109/tdpvt.2004.1335277 · Cited by 302 · see citing works
A contractile activity that closes phagosomes in macrophages
Swanson, J. A., Johnson, M. T., Beningo, K. A., Post, P. L., Mooseker, M. S., & Araki, N. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.3.307 · Cited by 282 · see citing works
Legant, W. R., Choi, C. K., Miller, J. S., Shao, L., Gao, L., Betzig, E., & Chen, C. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1207997110 · Cited by 275 · see citing works
Bieling, P., Li, T., Weichsel, J., McGorty, R., Jreij, P., Huang, B., Fletcher, D. A., & Mullins, R. D. (2016) · Cell · doi:10.1016/j.cell.2015.11.057 · Cited by 257 · see citing works
Chabon, J. J., Simmons, A. D., Lovejoy, A. F., Esfahani, M. S., Newman, A. M., Haringsma, H. J., Kurtz, D. M., Stehr, H., Scherer, F., Karlovich, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13513 · Cited by 245 · see citing works
Rho-Kinase and Myosin-II Control Phagocytic Cup Formation during CR, but Not FcγR, Phagocytosis
Olazabal, I. M., Caron, E., May, R. C., Schilling, K., Knecht, D. A., & Machesky, L. M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01069-2 · Cited by 237 · see citing works
Manipulation of the Innate Immune Response by Varicella Zoster Virus
Gerada, C., Campbell, T., Kennedy, J. J., Mcsharry, B. P., Steain, M., Slobedman, B., & Abendroth, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00001 · Cited by 234 · see citing works
Freeman, S. A., Vega, A. R., Riedl, M., Collins, R. F., Ostrowski, P. P., Woods, E. C., Bertozzi, C. R., Tammi, M., Lidke, D. S., Johnson, P., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.023 · Cited by 232 · see citing works
Lim, J. J., Grinstein, S., & Roth, Z. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00191 · Cited by 217 · see citing works
Mechanics of neutrophil phagocytosis: experiments and quantitative models
Herant, M., Heinrich, V., & Dembo, M. (2006) · Journal of Cell Science · doi:10.1242/jcs.02876 · Cited by 215 · see citing works
Labernadie, A., Bouissou, A., Delobelle, P., Balor, S., Voituriez, R., Proag, A., Fourquaux, I., Thibault, C., Christophe Vieu, A., Poincloux, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms6343 · Cited by 203 · see citing works
Mechanosensing through immunoreceptors
Zhu, C., Chen, W., Lou, J., Rittase, W., & Li, K. (2019) · Nature Immunology · doi:10.1038/s41590-019-0491-1 · Cited by 203 · see citing works
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
Freeman, S. A., Goyette, J., Furuya, W., Woods, E. C., Bertozzi, C. R., Bergmeier, W., Hinz, B., van der Merwe, P. A., Das, R., & Grinstein, S. (2016) · Cell · doi:10.1016/j.cell.2015.11.048 · Cited by 192 · see citing works
Araki, N., Hatae, T., Furukawa, A., & Swanson, J. A. (2002) · Journal of Cell Science · doi:10.1242/jcs.00235 · Cited by 190 · see citing works
SEGMENTAL RESPONSE OF THE MACROPHAGE PLASMA MEMBRANE TO A PHAGOCYTIC STIMULUS
Griffin, F. M., & Silverstein, S. C. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.139.2.323 · Cited by 179 · see citing works
Mechanics of neutrophil phagocytosis: behavior of the cortical tension
Herant, M., Heinrich, V., & Dembo, M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02275 · Cited by 162 · see citing works
Dynamics of podosome stiffness revealed by atomic force microscopy
Labernadie, A., Thibault, C., Christophe Vieu, A., Maridonneau‐Parini, I., & Charrière, G. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007835107 · Cited by 157 · see citing works
Vorselen, D., Wang, Y., de Jesus, M., Shah, P. K., Footer, M. J., Huse, M., Wei Cai, A., & Theriot, J. A. (2020) · Nature Communications · doi:10.1038/s41467-019-13804-z · Cited by 156 · see citing works
Self-citationSosale, N. G., Rouhiparkouhi, T., Bradshaw, A. M., Dimova, R., Lipowsky, R., & Discher, D. E. (2014) · Blood · doi:10.1182/blood-2014-06-585299 · Cited by 154 · see citing works
Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets
Bakalar, M. H., Joffe, A. M., Schmid, E. M., Son, S., Podolski, M., & Fletcher, D. A. (2018) · Cell · doi:10.1016/j.cell.2018.05.059 · Cited by 153 · see citing works
Zang, J.-H., Cavet, G., Sabry, J. H., Wagner, P., Moores, S. L., & Spudich, J. A. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2617 · Cited by 151 · see citing works
Myosin 1E interacts with synaptojanin‐1 and dynamin and is involved in endocytosis
Krendel, M., Osterweil, E. K., & Mooseker, M. S. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.021 · Cited by 149 · see citing works
Self-citationPhysical Constraints and Forces Involved in Phagocytosis
Jaumouillé, V., & Waterman, C. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01097 · Cited by 144 · see citing works
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance
Freeman, S. A., Uderhardt, S., Sarić, A., Collins, R. F., Buckley, C. M. F., Mylvaganam, S., Boroumand, P., Plumb, J. D., Germain, R. N., Ren, D., et al. (2019) · Science · doi:10.1126/science.aaw9544 · Cited by 141 · see citing works
Jaumouillé, V., Cartagena‐Rivera, A. X., & Waterman, C. M. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0414-2 · Cited by 140 · see citing works
Mohagheghian, E., Luo, J., Chen, J., Chaudhary, G., Chen, J., Sun, J., Ewoldt, R. H., & Wang, N. (2018) · Nature Communications · doi:10.1038/s41467-018-04245-1 · Cited by 134 · see citing works
Rotty, J. D., Brighton, H. E., Craig, S. L., Asokan, S. B., Cheng, N., Ting, J. P. ‐., & Bear, J. E. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.08.003 · Cited by 126 · see citing works
Balance of actively generated contractile and resistive forces controls cytokinesis dynamics
Zhang, W., & Robinson, D. N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502545102 · Cited by 123 · see citing works
Colucci‐Guyon, E., Tinévez, J.-Y., Renshaw, S. A., & Herbomel, P. (2011) · Journal of Cell Science · doi:10.1242/jcs.082792 · Cited by 120 · see citing works
Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages.
Greenberg, S., Burridge, K., & Silverstein, S. C. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1853 · Cited by 112 · see citing works
The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape
Tollis, S., Dart, A., Tzircotis, G., & Endres, R. G. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-149 · Cited by 103 · see citing works
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
Barger, S. R., Reilly, N., Shutova, M. S., Li, Q., Maiuri, P., Heddleston, J. M., Mooseker, M. S., Flavell, R. A., Svitkina, T., Oakes, P. W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09104-1 · Cited by 101 · see citing works
Self-citationMacrophage-Mediated Trogocytosis Leads to Death of Antibody-Opsonized Tumor Cells
Velmurugan, R., Challa, D. K., Ram, S., Ober, R. J., & Ward, E. S. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0335 · Cited by 98 · see citing works
Polyacrylamide Bead Sensors for in vivo Quantification of Cell-Scale Stress in Zebrafish Development
Träber, N., Uhlmann, K., Girardo, S., Kesavan, G., Wagner, K., Friedrichs, J., Goswami, R., Bai, K., Brand, M., Werner, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-53425-6 · Cited by 95 · see citing works
The formin inhibitor SMIFH2 inhibits members of the myosin superfamily
Nishimura, Y., Shi, S., Zhang, F., Liu, R., Takagi, Y., Bershadsky, A. D., Viasnoff, V., & Sellers, J. R. (2021) · Journal of Cell Science · doi:10.1242/jcs.253708 · Cited by 94 · see citing works
Bouissou, A., Proag, A., Bourg, N., Pingris, K., Cabriel, C., Balor, S., Mangeat, T., Thibault, C., Christophe Vieu, A., Dupuis, G., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b00622 · Cited by 87 · see citing works
Probing the mechanical landscape – new insights into podosome architecture and mechanics
van den Dries, K., Linder, S., Maridonneau‐Parini, I., & Poincloux, R. (2019) · Journal of Cell Science · doi:10.1242/jcs.236828 · Cited by 87 · see citing works
Liebl, D., & Griffiths, G. W. (2009) · Journal of Cell Science · doi:10.1242/jcs.048355 · Cited by 85 · see citing works
Modular actin nano-architecture enables podosome protrusion and mechanosensing
van den Dries, K., Nahidiazar, L., Slotman, J. A., Meddens, M. B. M., Pandžić, E., Joosten, B., Ansems, M., Schouwstra, J., Meijer, A., Steen, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13123-3 · Cited by 81 · see citing works
Meddens, M. B. M., Pandžić, E., Slotman, J. A., Guillet, D., Joosten, B., Mennens, S. F. B., Paardekooper, L. M., Houtsmuller, A. B., van den Dries, K., Wiseman, P. W., et al. (2016) · Nature Communications · doi:10.1038/ncomms13127 · Cited by 72 · see citing works
Neutrophil FcγRIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases
Nishi, H., Furuhashi, K., Culleré, X., Saggu, G., Miller, M. J., Chen, Y., Rosetti, F., Hamilton, S., Yang, L., Pittman, S. P., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94039 · Cited by 72 · see citing works
Ancient recycled lower crust in the mantle source of recent Italian magmatism
Koornneef, J. M., Nikogosian, I. K., van Bergen, M. J., Vroon, P. Z., & Davies, G. R. (2019) · Nature Communications · doi:10.1038/s41467-019-11072-5 · Cited by 70 · see citing works
der Meeren, L. V., Verduijn, J., Krysko, D. V., & Skirtach, A. G. (2020) · iScience · doi:10.1016/j.isci.2020.101816 · Cited by 67 · see citing works
A mechanical perspective on phagocytic cup formation
Vorselen, D., Labitigan, R. L. D., & Theriot, J. A. (2020) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2020.05.011 · Cited by 66 · see citing works
Self-citationCooperative epithelial phagocytosis enables error correction in the early embryo
Hoijman, E., Häkkinen, H.-M., Tolosa-Ramon, Q., Jiménez‐Delgado, S., Wyatt, C. D. R., Miret-Cuesta, M., Irimia, M., Callan-Jones, A., Wieser, S., & Ruprecht, V. (2021) · Nature · doi:10.1038/s41586-021-03200-3 · Cited by 62 · see citing works
Commentary: Systems Biology Approach to Model the Life Cycle of Trypanosoma cruzi
Carrea, A., & Diambra, L. A. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00001 · Cited by 60 · see citing works
Horsthemke, M., Bachg, A. C., Groll, K., Moyzio, S., Müther, B., Hemkemeyer, S. A., Wedlich‐Söldner, R., Sixt, M., Tacke, S., Bähler, M., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.766923 · Cited by 60 · see citing works
Working Together: Spatial Synchrony in the Force and Actin Dynamics of Podosome First Neighbors
Proag, A., Bouissou, A., Mangeat, T., Voituriez, R., Delobelle, P., Thibault, C., Christophe Vieu, A., Maridonneau‐Parini, I., & Poincloux, R. (2015) · ACS Nano · doi:10.1021/nn506745r · Cited by 57 · see citing works
Robotically controlled microprey to resolve initial attack modes preceding phagocytosis
Schuerle, S., Vizcarra, I. A., Moeller, J., Sakar, M. S., Özkale, B., Lindo, A. M., Mushtaq, F., Schoen, I., Pané, S., Viola Vogel, B., et al. (2017) · Science Robotics · doi:10.1126/scirobotics.aah6094 · Cited by 57 · see citing works
Dynamic Podosome-Like Structures in Nascent Phagosomes Are Coordinated by Phosphoinositides
Ostrowski, P. P., Freeman, S. A., Fairn, G. D., & Grinstein, S. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.05.028 · Cited by 55 · see citing works
Squeezing in a Meal: Myosin Functions in Phagocytosis
Barger, S. R., Gauthier, N. C., & Krendel, M. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.11.002 · Cited by 49 · see citing works
Self-citationWalbaum, S., Ambrosy, B., Schütz, P., Bachg, A. C., Horsthemke, M., Leusen, J. H. W., Mócsai, A., & Hanley, P. J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100256 · Cited by 49 · see citing works
A mechanical bottleneck explains the variation in cup growth during FcγR phagocytosis
van Zon, J. S., Tzircotis, G., Caron, E., & Howard, M. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.59 · Cited by 48 · see citing works
Davidson, A. J., & Wood, W. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107692 · Cited by 48 · see citing works
Frustrated Phagocytic Spreading of J774A-1 Macrophages Ends in Myosin II-Dependent Contraction
Kovari, D. T., Wei, W., Chang, P., Toro, J.-S., Fogg, R., Chambers, D. M., Porter, K., Koo, D., & Curtis, J. E. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2016.11.009 · Cited by 45 · see citing works
The molecular mechanism of load adaptation by branched actin networks
Li, T., Bieling, P., Weichsel, J., Mullins, R. D., & Fletcher, D. A. (2022) · eLife · doi:10.7554/elife.73145 · Cited by 43 · see citing works
Controlled One-on-One Encounters between Immune Cells and Microbes Reveal Mechanisms of Phagocytosis
Heinrich, V. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.06.042 · Cited by 39 · see citing works
Design of Porous Micro-Structures Using Curvature Analysis for Additive-Manufacturing
Ben-Shabat, Y., & Fischer, A. (2015) · Procedia CIRP · doi:10.1016/j.procir.2015.01.057 · Cited by 30 · see citing works
Ikeda, Y., Kawai, K., Ikawa, A., Kawamoto, K., Egami, Y., & Araki, N. (2017) · Journal of Cell Science · doi:10.1242/jcs.201749 · Cited by 27 · see citing works
Myosin II‐dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis
Yamauchi, S., Kawauchi, K., & Sawada, Y. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.06.041 · Cited by 26 · see citing works
Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines
Kendig, D. M., Hurst, N. R., & Grider, J. R. (2016) · Journal of Visualized Experiments · doi:10.3791/53263 · Cited by 26 · see citing works
The podosome cap: past, present, perspective
Linder, S., & Cervero, P. (2020) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2020.151087 · Cited by 20 · see citing works
Tertrais, M., Bigot, C., Martin, E., Poincloux, R., Labrousse, A. M., & Maridonneau‐Parini, I. (2021) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2021.151161 · Cited by 17 · see citing works
Spherical harmonics method for computing the image stress due to a spherical void
Wang, Y., Zhang, X., & Cai, W. (2019) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2019.01.020 · Cited by 16 · see citing works
Self-citationThe Evolution of Silica Nanoparticle-polyester Coatings on Surfaces Exposed to Sunlight
Truong, V. K., Stefanovic, M., MacLaughlin, S. A., Tobin, M. J., Vongsvivut, J. P., Kobaisi, M. A., Crawford, R. J., & Ivanova, E. P. (2016) · Journal of Visualized Experiments · doi:10.3791/54309 · Cited by 12 · see citing works
Marie‐Anaïs, F., Mazzolini, J., Bourdoncle, P., & Niedergang, F. (2016) · Journal of Visualized Experiments · doi:10.3791/54470 · Cited by 8 · see citing works
Gosavi, R. A., Salwe, S., Mukherjee, S., Dahake, R., Kothari, S., Patel, V. V., Chowdhary, A. S., & Deshmukh, R. A. (2018) · Bone Marrow Research · doi:10.1155/2018/3495086 · Cited by 8 · see citing works
Rougerie, P., & Cox, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.14.041335 · Cited by 2 · see citing works
Jo, S., Cronin, N. M., Nurmalasari, N. P. D., Kerkvliet, J. G., Bailey, E. M., Anderson, R. B., Scott, B. L., & Hoppe, A. D. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.12.451665 · Cited by 2 · see citing works
Vorselen, D., Barger, S. R., Theriot, J. A., Gauthier, N. C., & Krendel, M. (2021) · Figshare · doi:10.6084/m9.figshare.16666864 · Cited by 1 · see citing works
Self-citationBarger, S. R., Vorselen, D., Krendel, M., Theriot, J. A., & Gauthier, N. C. (2021) · Figshare · doi:10.6084/m9.figshare.16677373 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Macrophages in immunoregulation and therapeutics
Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,348 · see citing works
Microglia as hunters or gatherers of brain synapses
Pereira‐Iglesias, M., Maldonado-Teixidó, J., Melero, A., Piriz, J., Galea, E., Ransohoff, R. M., & Sierra, A. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01818-w · Cited by 81 · see citing works
Praharaj, M., Shen, F., Lee, A. J., Zhao, L., Nirschl, T. R., Theodros, D., Singh, A. K., Wang, X., Adusei, K. M., Lombardo, K. A., et al. (2024) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-23-1105 · Cited by 61 · see citing works
Shimizu, T., Schutt, C. R., Izumi, Y., Tomiyasu, N., Omahdi, Z., Kano, K., Takamatsu, H., Aoki, J., Bamba, T., Kumanogoh, A., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.008 · Cited by 47 · see citing works
Sadhu, R. K., Barger, S. R., Penič, S., Iglič, A., Krendel, M., Gauthier, N. C., & Gov, N. S. (2022) · Soft Matter · doi:10.1039/d2sm01152b · Cited by 40 · see citing works
Self-citationβ2 integrins impose a mechanical checkpoint on macrophage phagocytosis
Settle, A. H., Winer, B. Y., de Jesus, M., Seeman, L., Wang, Z., Chan, E., Romin, Y., Li, Z., Miele, M. M., Hendrickson, R. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52453-9 · Cited by 40 · see citing works
Self-citationDynamics of phagocytosis mediated by phosphatidylserine
Vorselen, D. (2022) · Biochemical Society Transactions · doi:10.1042/bst20211254 · Cited by 39 · see citing works
Self-citationA minimal cell model for lamellipodia-based cellular dynamics and migration
Sadhu, R. K., Iglič, A., & Gov, N. S. (2023) · Journal of Cell Science · doi:10.1242/jcs.260744 · Cited by 36 · see citing works
de Jesus, M., Settle, A. H., Vorselen, D., Gaetjens, T. K., Galiano, M., Romin, Y., Lee, E. H. C., Wong, Y. Y., Tian-ming Fu, B., Santosa, E. K., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adj2898 · Cited by 32 · see citing works
Self-citationActin nano-architecture of phagocytic podosomes
Herron, J. C., Hu, S., Watanabe, T., Nogueira, A. T., Liu, B., Kern, M., Aaron, J., Taylor, A., Pablo, M., Chew, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32038-0 · Cited by 32 · see citing works
Hu, Y., Li, H., Wang, W., Sun, F. Y., Wu, C., Chen, W., & Liu, Z. (2023) · Nano Letters · doi:10.1021/acs.nanolett.3c00957 · Cited by 28 · see citing works
Building the phagocytic cup on an actin scaffold
Krendel, M., & Gauthier, N. C. (2022) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2022.102112 · Cited by 28 · see citing works
Self-citationPlasma membrane abundance dictates phagocytic capacity and functional cross-talk in myeloid cells
Winer, B. Y., Settle, A. H., Yakimov, A. M., Jeronimo, C., Lazarov, T., Tipping, M. J., Saoi, M., Sawh-Gopal, A., Sepp, A.-L. L., Galiano, M., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adl2388 · Cited by 24 · see citing works
Targeting phagocytosis checkpoints for cancer immunotherapy
Veillette, A., Li, J., Galindo, C. C., Davidson, D., & Tang, Z.-H. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00893-w · Cited by 26 · see citing works
Barger, S. R., Vorselen, D., Gauthier, N. C., Theriot, J. A., & Krendel, M. (2022) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-06-0210 · Cited by 22 · see citing works
Self-citationDepierre, M., Pompili, C., & Niedergang, F. (2025) · Journal of Cell Science · doi:10.1242/jcs.263833 · Cited by 21 · see citing works
Coral–algal endosymbiosis characterized using RNAi and single-cell RNA-seq
Hu, M., Bai, Y., Zheng, X., & Zheng, Y. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01397-9 · Cited by 21 · see citing works
Mechanisms of frustrated phagocytic spreading of human neutrophils on antibody-coated surfaces
Francis, E. A., Xiao, H., Teng, L. H., & Heinrich, V. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.10.016 · Cited by 18 · see citing works
Metabolic heterogeneity in tumor microenvironment – A novel landmark for immunotherapy
Chen, C., Han, P., & Qing, Y. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103579 · Cited by 17 · see citing works
Mechanical actuators in microglia dynamics and function
Melo, P., Socodato, R., Silveira, M. S., Neves, M. A. D., Relvas, J. B., & Pinto, I. M. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151247 · Cited by 16 · see citing works
Target cell cortical tension regulates macrophage trogocytosis
Cornell, C. E., Chorlay, A., Krishnamurthy, D., Martin, N. R., Baldauf, L., & Fletcher, D. A. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01807-6 · Cited by 20 · see citing works
Clustered macrophages cooperate to eliminate tumors via coordinated intrudopodia
Dooling, L. J., Anlaş, A. A., Tobin, M. P., Ontko, N. M., Marchena, T., Wang, M., Andrechak, J. C., & Discher, D. E. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2425452122 · Cited by 14 · see citing works
Distinct timing of neutrophil spreading and stiffening during phagocytosis
Zak, A., Dupré‐Crochet, S., Hudik, E., Babataheri, A., Barakat, A. I., Nüße, O., & Husson, J. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.03.021 · Cited by 13 · see citing works
CD47 inhibits phagocytosis through Vav dephosphorylation
Miller, W. D., Manion, A., Mishra, A. K., Sheedy, C. J., Bond, A., Gardner, B. M., Montell, D. J., & Morrissey, M. A. (2025) · The Journal of Cell Biology · doi:10.1083/jcb.202502206 · Cited by 13 · see citing works
Get a grip: Podosomes as potential players in phagocytosis
Linder, S., & Barcelona, B. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151356 · Cited by 12 · see citing works
Spatial models of pattern formation during phagocytosis
Herron, J. C., Hu, S., Liu, B., Watanabe, T., Hahn, K. M., & Elston, T. C. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010092 · Cited by 12 · see citing works
Vorselen, D., Kamber, R. A., Labitigan, R. L. D., van Loon, A. P., Peterman, E., Delgado, M. K., Lin, S., Rasmussen, J. P., Bassik, M. C., & Theriot, J. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.30.502145 · Cited by 10 · see citing works
Self-citationThe third dimension of the actin cortex
Jawahar, A., Vermeil, J., Heuvingh, J., du Roure, O., & Piel, M. (2024) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2024.102381 · Cited by 11 · see citing works
Two-component macrophage model for active phagocytosis with pseudopod formation
Wang, S., Ma, S., Li, H., Dao, M., Li, X., & Karniadakis, G. E. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.03.026 · Cited by 10 · see citing works
MERTK coordinates efferocytosis by regulating integrin localization and activation
Dickson, B. H., Tasnim, T., Nicholson, R. A., Stanlake, N., Lam, A. L., Vrieze, A. M., Blythe, E. N., Dekaban, G. A., & Heit, B. (2026) · Journal of Cell Science · doi:10.1242/jcs.264792 · Cited by 9 · see citing works
Visualizing the Invisible: Advanced Optical Microscopy as a Tool to Measure Biomechanical Forces
Hobson, C. M., Aaron, J., Heddleston, J. M., & Chew, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.706126 · Cited by 9 · see citing works
Phagocytosis by the retinal pigment epithelium: New insights into polarized cell mechanics
Zihni, C. (2024) · BioEssays · doi:10.1002/bies.202300197 · Cited by 8 · see citing works
Omer, S., Li, J., Yang, C. X., & Harrison, R. E. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-06-0216 · Cited by 10 · see citing works
Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis
Jo, S., Fischer, B. R., Cronin, N. M., Nurmalasari, N. P. D., Loyd, Y. M., Kerkvliet, J. G., Bailey, E. M., Anderson, R. B., Scott, B. L., & Hoppe, A. D. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.01.036 · Cited by 8 · see citing works
Ma, X., Wang, C., Ji, C., Cao, X., & Dong, Y. (2024) · Biotechnology and Bioengineering · doi:10.1002/bit.28683 · Cited by 7 · see citing works
Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria
Introini, V., Govendir, M., Rayner, J. C., Cicuta, P., & Bernabeu, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.908241 · Cited by 7 · see citing works
de Jesus, M., Settle, A. H., Vorselen, D., Gaetjens, T. K., Galiano, M., Wong, Y. Y., Tian-ming Fu, B., Santosa, E. K., Winer, B. Y., Tamzalit, F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.16.537078 · Cited by 7 · see citing works
Self-citationMechanosensing in Dendritic Cells
Calmettes, V., Quintanilla, M. A., Mariano, L. L., Piel, M., Moreau, H. D., & Lennon‐Duménil, A. (2025) · Immunological Reviews · doi:10.1111/imr.70086 · Cited by 6 · see citing works
Ezrin, radixin, and moesin are dispensable for macrophage migration and cellular cortex mechanics
Verdys, P., Rey-Barroso, J., Girel, A., Vermeil, J., Bergert, M., Sanchez, T., Métais, A., Mangeat, T., Bellard, E., Bigot, C., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00173-7 · Cited by 6 · see citing works
3D multiscale shape analysis of nuclei and in vivo elastic stress sensors allows force inference
Jurado, A., Isensee, J., Hofemeier, A. D., Krüger, L. J., Wittkowski, R., Golestanian, R., Bittihn, P., & Betz, T. (2025) · Biophysical Journal · doi:10.1016/j.bpj.2025.07.015 · Cited by 6 · see citing works
Ivshina, M. P., Spijker, H. M. V. ‘., Jung, S., Ponny, S. R., Schafer, D. P., & Richter, J. D. (2022) · Glia · doi:10.1002/glia.24222 · Cited by 6 · see citing works
Xu, X., Liu, C., Bo, J., Wang, H., Zhang, Y., Xu, Y., Fu, J., Pi, J., & Wang, H. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.01.005 · Cited by 5 · see citing works
Mustapha, F., Sengupta, K., & Puech, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.898558 · Cited by 5 · see citing works
Roles of myosin 1e and the actin cytoskeleton in kidney functions and familial kidney disease
Liu, P., Sayeeda, K., Zhuang, C., & Krendel, M. (2024) · Cytoskeleton · doi:10.1002/cm.21861 · Cited by 5 · see citing works
Self-citationUsing tunable hydrogel microparticles to measure cellular forces
Mali, A., Peeters, Y., de Mercado, R. R., Settle, A. H., Footer, M. J., Srinivas, M., Theriot, J. A., & Vorselen, D. (2025) · Nature Protocols · doi:10.1038/s41596-025-01281-2 · Cited by 4 · see citing works
Self-citationHong, J., Wang, W., Hsu, Y., Tee, S. Y., Wu, Y., Huang, W., Lai, S., & Lin, S. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2023.07.012 · Cited by 4 · see citing works
Verdys, P., Rey-Barroso, J., Vermeil, J., Bergert, M., Sanchez, T., Métais, A., Mangeat, T., Bellard, E., Bigot, C., Girard, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.27.550674 · Cited by 4 · see citing works
Epithelial cells provide immunocompetence to the early embryo for bacterial clearance
Roncero-Carol, J., Olaizola-Muñoa, J., Arán, B., Mularoni, L., Miret-Cuesta, M., Blanco‐Cabra, N., Casals, M., Rumbo, M., Solé, M., Ojosnegros, S., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.05.025 · Cited by 3 · see citing works
Spatio-temporal Force Patterns Reveal a Mechanical Set Point in Early T Cell ActivationPreprint
Mustapha, F., Biarnes‐Pelicot, M., Husseiny, J. E., Torro, R., Sengupta, K., & Puech, P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.11.480084 · Cited by 3 · see citing works
Broßell, D., Meyer-Plath, A., Gräb, O., Heunisch, E., Kämpf, K., Haase, A., & Wiemann, M. (2026) · Particle and Fibre Toxicology · doi:10.1186/s12989-026-00666-9 · Cited by 2 · see citing works
Korpela, S., Kauppila, M., Karema-Jokinen, V., Sukki, L., Kallio, P. J., Skottman, H., Nymark, S., & Ihalainen, T. O. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.002 · Cited by 2 · see citing works
Arden, S. D., Pennink, E., Lakatos, A., Griffiths, G. M., Lippert, A. H., & Buß, F. (2024) · Journal of Cell Science · doi:10.1242/jcs.264357 · Cited by 2 · see citing works
Goswami, R., Kim, K., Boccaccini, A. R., Guck, J., & Girardo, S. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.115450 · Cited by 2 · see citing works
Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages
Sopelniak, K., Batlouni, R., Sun, Q., Cervero, P., & Linder, S. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117167 · Cited by 2 · see citing works
Mechanobiology of inflammation: Pulling the strings of innate immunity
Maniak, M. K., Jenkins, S. J., & Hansen, C. G. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20252269 · Cited by 4 · see citing works
Ghasempour, S., Muise, A. M., & Freeman, S. A. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2400031 · Cited by 2 · see citing works
Panah, A. K., & Jaumouillé, V. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00199-x · Cited by 1 · see citing works
Takito, J., & Nonaka, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104759 · Cited by 1 · see citing works
Häkkinen, H.-M., Palau, M. B., Bianchi, L. F., Jiménez‐Delgado, S., Pezzano, F., Wieser, S., Ciampa, L., Hoijman, E., Vibe, C. B., Wijma, S., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76710-1 · Cited by 1 · see citing works
Resident phagocytes promote non–cell-autonomous fragmentation of apoptotic cells
Santavanond, J. P., Atkin‐Smith, G. K., Lozano-González, I., Roncero-Carol, J., Jiang, L., Hodge, A. L., Ozkocak, D. C., Zhao, K., Gray, D. H. D., Herold, M. J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adz5264 · Cited by 1 · see citing works
Macrophage mechanobiology: from sensing to disease
D’Ambrosio, M., Warasnhe, K., Eldesouki, M. H., Joshi, V., Beyder, A., & Cipriani, G. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1812501 · Cited by 2 · see citing works
Quantifying the energetic costs and growth benefits of phagocytosis
Schavemaker, P. E., Tam, K. S., & Lynch, M. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.118105 · Cited by 2 · see citing works
Sadhu, R. K., Barger, S. R., Penič, S., Iglič, A., Krendel, M., Gauthier, N. C., & Gov, N. S. (2023) · Advances in biomembranes and lipid self-assembly · doi:10.1016/bs.abl.2023.04.001 · Cited by 1 · see citing works
Self-citationHarris, T. (2025) · BioEssays · doi:10.1002/bies.70004 · Cited by 1 · see citing works
TRPM7 regulates phagocytosis and clearance of Candida albicansPreprint
Stremska, M. E., Stipes, E. J., Jang, J. J., Busey, G. W., Iobst, W. H., Seegren, P. V., Kennedy, J. A., & Desai, B. N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.26.554944 · Cited by 1 · see citing works
3D dynamic multiscale force and shape analysis of in-vivo elastic stress sensorsPreprint
Jurado, A., Isensee, J., Hofemeier, A. D., Krüger, L. J., Wittkowski, R., Golestanian, R., Bittihn, P., & Betz, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.22.633835 · Cited by 1 · see citing works
Goswami, R., Kim, K., Boccaccini, A. R., Guck, J. R., & Girardo, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.24.666603 · Cited by 1 · see citing works
Mechanistic dissection of alga recognition and uptake in coral-algal endosymbiosisPreprint
Hu, M., Bai, Y., Zheng, X., & Zheng, Y. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.13.520278
Analysis of Efferocytic Receptor Dynamics and Synapse Formation in a Frustrated Efferocytosis Model
Dickson, B. H., & Heit, B. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3338-0_5
Praharaj, M., Shen, F., Lee, A. J., Zhao, L., Nirschl, T. R., Theodros, D., Singh, A. K., Wang, X., Adusei, K. M., Lombardo, K. A., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4506054
MYO1F interactome reveals the SH3-domain linked CASS complex at podosomes and the phagocytic cupPreprint
Arden, S. D., Pennink, E., Lakatos, A., Griffiths, G. M., Lippert, A. H., & Buß, F. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.04.663186
Goswami, R., Kim, K., Boccaccini, A. R., Guck, J. R., & Girardo, S. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5393417
Roy, S., Subramaniam, A. G., Chakraborty, S., Goswami, J., Ariraman, S., Swain, K. K., Sudhakar, S., Singh, R., & Roy, B. (2025) · npj Biological Physics and Mechanics. · doi:10.1038/s44341-025-00030-6 · Cited by 1 · see citing works
Ras signalling at the actin cortex: Coordinating local and global changes to cell morphology
Tyler, J. J., & Matthews, H. K. (2025) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2025.102600
Mechanical switch from nibbling to engulfment
Wu, C., & Liu, Z. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01818-3
Tobin, M. P., Ivanovska, I. L., Phan, S. H., Bai, T., Deans, J., Nader, G. P. F., & Discher, D. E. (2026) · Molecular Biology of the Cell · doi:10.1091/mbc.e25-06-0294 · Cited by 1 · see citing works
Schiefermeier-Mach, N., Polleux, J., Heinrich, L., Lechner, L., Levytska, I., Lass‐Flörl, C., & Perkhofer, S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0341448
Sadhukhan, S., Cornell, C. E., Sandhu, M. K., Palau, M. B., Peeters, Y., Hanssen, S., Penič, S., Iglič, A., Vorselen, D., Fletcher, D. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.28.702248
Self-citationEarly recruitment of membrane-bound DNaseX to phagocytic cups in macrophagesPreprint
Pyne, A., Pandey, V., Kundu, S., Ikegami, S., & Wang, X. (2026) · eLife · doi:10.7554/elife.110907
Myo1e/f regulate phagocytic podosomes to promote efficient cup closure in macrophagesPreprint
Paul, T., Loyd, Y. M., Chase, S. E., O'Connor, T. W., Hobson, C. M., Lee, R., Vorselen, D., & Krendel, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721640
Self-citationDigest before Ingest: Early Recruitment of Membrane-bound DNaseX to Phagocytic Cups in MacrophagesPreprint
Pyne, A., Pandey, V., Kundu, S., Ikegami, S., & Wang, X. (2026) · eLife · doi:10.7554/elife.110907.1
Podosomes and Mechanical Force
Kloc, M., Thabet, S. A., Ranmale, S., & Wosik, J. (2026) · Results and problems in cell differentiation · doi:10.1007/978-3-032-19509-8_4
Brauburger, S., Kraus, B. K., Walther, T., Mense, C., Abele, T., Göpfrich, K., & Schwarz, U. S. (2026) · Soft Matter · doi:10.1039/d6sm00242k
Digest before Ingest: Early Recruitment of Membrane-bound DNaseX to Phagocytic Cups in MacrophagesPreprint
Pyne, A., Pandey, V., Kundu, S., Ikegami, S., & Wang, X. (2026) · eLife · doi:10.7554/elife.110907.2
Chen, R., Lin, J., Yan, L., Huang, N., Yang, W., Lin, L., Zhang, L., & Ke, K. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.111014
- Authors
- Vorselen, D., Barger, S. R., Wang, Y., Cai, W., Theriot, J. A., Gauthier, N. C., & Krendel, M.
- Affiliations
- Howard Hughes Medical Institute (US)
- SUNY Upstate Medical University (US)
- Stanford University (US)
- Department of Mechanical Engineering, Stanford University
- IFOM (IT)
- Corresponding author
- Theriot, Julie A
- Krendel, Mira
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2021-10-28
- Volume
- 10
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC8585483
- OpenAlex
- W3210478861
- Cited by
- 85
- References
- 96
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 15 · 2023: 14 · 2022: 15 · 2021: 1
- FWCI
- 5.87
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- American Heart Association (Predoctoral fellowship 18PRE34070066)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083345)
- Associazione Italiana per la Ricerca sul Cancro (Investigator Grant 20716)
- Howard Hughes Medical Institute
- Cancer Research Institute (CRI Irvington fellowship)
- National Institute of General Medical Sciences (R01GM138652)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- phagocytosis, myosin II, Arp2/3 complex, actin protrusions, macrophages, membrane tension, lattice light-sheet microscopy, mechanosensing
- MeSH terms
- RAW 264.7 Cells, Actins, Animals, Bone Marrow Cells, Cytoskeleton, Humans, Macrophages, Mice, Inbred C57BL, Microscopy, Phagocytosis, Stem Cells, HL-60 Cells, Myosin Type II, Mice, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
