Resistance exercise protects mice from protein-induced fat accretion
Open accessPublished version of a preprint
Abstract
Low-protein (LP) diets extend the lifespan of diverse species and are associated with improved metabolic health in both rodents and humans. Paradoxically, many athletes and bodybuilders consume high-protein (HP) diets and protein supplements, yet are both fit and metabolically healthy. Here, we examine this paradox using weight pulling, a validated progressive resistance exercise training regimen, in mice fed either an LP diet or an isocaloric HP diet. We find that despite having lower food consumption than the LP group, HP-fed mice gain significantly more fat mass than LP-fed mice when not exercising, while weight pulling protected HP-fed mice from this excess fat accretion. The HP diet augmented exercise-induced hypertrophy of the forearm flexor complex, and weight pulling ability increased more rapidly in the exercised HP-fed mice. Surprisingly, exercise did not protect from HP-induced changes in glycemic control. Our results confirm that HP diets can augment muscle hypertrophy and accelerate strength gain induced by resistance exercise without negative effects on fat mass, and also demonstrate that LP diets may be advantageous in the sedentary. Our results highlight the need to consider both dietary composition and activity, not simply calories, when taking a precision nutrition approach to health.
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- Authors
- Trautman, M. E., Braucher, L. N., Elliehausen, C., Zhu, W. G., Zelenovskiy, E., Green, M., Sonsalla, M. M., Yeh, C.-Y., Hornberger, T. A., Konopka, A. R., & Lamming, D. W.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Lamming, Dudley W
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2023-11-29
- Volume
- 12
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC10686620
- OpenAlex
- W4387707410
- Cited by
- 8
- References
- 65
- Citations by year
- 2026: 3 · 2025: 5
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Aging (AG056771, AG067464, AG083290, AG077916, 3RF1AG056771-06S1, AG062328, AG061635, AG081482, AG084156, AG076941)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057347, AR074932)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- resistance training, high-protein diet, low-protein diet, muscle hypertrophy, strength gain, glycemic control, sedentary lifestyle, personalized nutrition, lifespan extension
- MeSH terms
- Diet, High-Protein, Glycemic Control, Animals, Humans, Hypertrophy, Cadherins, Mice, Resistance Training
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