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Compact graphical representation of phylogenetic data and metadata with GraPhlAn

Open access
Asnicar, Francesco, Weingart, George, Tickle, Timothy L., Huttenhower, Curtis, Segata, Nicola·2015·PeerJ

Abstract

The increased availability of genomic and metagenomic data poses challenges at multiple analysis levels, including visualization of very large-scale microbial and microbial community data paired with rich metadata. We developed GraPhlAn (Graphical Phylogenetic Analysis), a computational tool that produces high-quality, compact visualizations of microbial genomes and metagenomes. This includes phylogenies spanning up to thousands of taxa, annotated with metadata ranging from microbial community abundances to microbial physiology or host and environmental phenotypes. GraPhlAn has been developed as an open-source command-driven tool in order to be easily integrated into complex, publication-quality bioinformatics pipelines. It can be executed either locally or through an online Galaxy web application. We present several examples including taxonomic and phylogenetic visualization of microbial communities, metabolic functions, and biomarker discovery that illustrate GraPhlAn's potential for modern microbial and community genomics.

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  1. Huttenhower, 2012, Structure, function and diversity of the healthy human microbiome, Nature, 486, 207, 10.1038/nature11234 · DOI · Paper page

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Metadata

Authors
Asnicar, F., Weingart, G., Tickle, T. L., Huttenhower, C., & Segata, N.
Venue
PeerJ
Publisher
PeerJ
Published
2015-06-18
Volume
3
Pages
e1029
ISSN
2167-8359 (ISSN-L)
OpenAlex
W1883997870
Cited by
817
References
41
FWCI
18.65
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Compact graphical representation of phylogenetic data and metadata with GraPhlAn. https://app.cochat.ai/papers/10.7717/peerj.1029
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Asnicar, F., Weingart, G., Tickle, T. L., Huttenhower, C., & Segata, N. (2015). Compact graphical representation of phylogenetic data and metadata with GraPhlAn. PeerJ. https://doi.org/10.7717/peerj.1029

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