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Diagnostic Accuracy of Cerebrospinal Fluid Multiplex Polymerase Chain Reaction Panel Testing in Patients With Suspected Central Nervous System Infections: A Multi-Center Study in the United Arab Emirates

Ghoweba, Yousra, Safizadeh Shabestari, Seyed Ali, Malik, Zainab A·2024·Cureus
DOI 10.7759/cureus.51906PMC PMC10851033
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Crossref · 10.7759/cureus.51906

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7 of 7 references verified0 citation errors · 0 not checkable

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Figure 1 Age distribution of the study sample Children constituted 51% of the study sample, followed by 44% and 5% of adults and elderly, respectively.
Figure 1 Age distribution of the study sample Children constituted 51% of the study sample, followed by 44% and 5% of adults and elderly, respectively.CC BY · PubMed Central
Figure 2 Clinical diagnosis of the study sample Viral meningitis was diagnosed in 17.80% of the study sample, while 5.09% were diagnosed with bacterial meningitis and 76.20% with suspected meningitis.
Figure 2 Clinical diagnosis of the study sample Viral meningitis was diagnosed in 17.80% of the study sample, while 5.09% were diagnosed with bacterial meningitis and 76.20% with suspected meningitis.CC BY · PubMed Central
Figure 3 Number of detections of the cerebrospinal fluid polymerase chain reaction panel Out of the 78 positive PCR CSF samples, 61 viral pathogens were detected while 19 were bacterial pathogens. Two samples had two viral co-detections. No fungal pathogens were detected. Enteroviruses were the most prevalent CNS pathogen (32/80, 40.0%), followed by HSV-2 (10/80, 12.5%), S. pneumonia (8/80, 10.0%), and VZV (8/80, 10.0%). E. coli: Escherichia coli; S. agalactiae: Streptococcus agalactiae; H. influenzae: Haemophilus influenzae; HHV-6: Human herpesvirus 6; HSV-2: Herpes simplex virus 2; HPeV: Human parechovirus; Listeria monocytogenes: L. monocytogenes; Neisseria meningitidis: N. meningitidis; S. pneumoniae: Streptococcus pneumoniae; VZV: Varicella zoster virus; PCR: polymerase chain reaction; CSF: cerebrospinal fluid; CNS: central nervous system
Figure 3 Number of detections of the cerebrospinal fluid polymerase chain reaction panel Out of the 78 positive PCR CSF samples, 61 viral pathogens were detected while 19 were bacterial pathogens. Two samples had two viral co-detections. No fungal pathogens were detected. Enteroviruses were the most prevalent CNS pathogen (32/80, 40.0%), followed by HSV-2 (10/80, 12.5%), S. pneumonia (8/80, 10.0%), and VZV (8/80, 10.0%). E. coli: Escherichia coli; S. agalactiae: Streptococcus agalactiae; H. influenzae: Haemophilus influenzae; HHV-6: Human herpesvirus 6; HSV-2: Herpes simplex virus 2; HPeV: Human parechovirus; Listeria monocytogenes: L. monocytogenes; Neisseria meningitidis: N. meningitidis; S. pneumoniae: Streptococcus pneumoniae; VZV: Varicella zoster virus; PCR: polymerase chain reaction; CSF: cerebrospinal fluid; CNS: central nervous systemCC BY · PubMed Central
Figure 4 Age distribution of enterovirus, HSV-2, VZV, and S. pneumoniae Children constituted 69% of positive samples for enterovirus, while HSV-2 was exclusively detected among adults. The majority of VZV and S. pneumoniae-positive samples were detected in adults. HSV-2: Herpes simplex virus 2; VZV: Varicella zoster virus; S. pneumoniae: Streptococcus pneumoniae
Figure 4 Age distribution of enterovirus, HSV-2, VZV, and S. pneumoniae Children constituted 69% of positive samples for enterovirus, while HSV-2 was exclusively detected among adults. The majority of VZV and S. pneumoniae-positive samples were detected in adults. HSV-2: Herpes simplex virus 2; VZV: Varicella zoster virus; S. pneumoniae: Streptococcus pneumoniaeCC BY · PubMed Central

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Citations

Cites

Show all 7 references

Research works printed but not linked: 11

  1. Hasbun R. Progress and challenges in bacterial meningitis: a review. JAMA. 2022, 328:2147-54. 10.1001/jama.2022.20521 · DOI
  2. Wall EC, Chan JM, Gil E, Heyderman RS. Acute bacterial meningitis. Curr Opin Neurol. 2021, 34:386-95. 10.1097/WCO.0000000000000934 · DOI
  3. Aleem S, Greenberg RG. When to include a lumbar puncture in the evaluation for neonatal sepsis. Neoreviews. 2019, 20:e124-34. 10.1542/neo.20-3-e124 · DOI
  4. Bryant PA, Li HY, Zaia A, Griffith J, Hogg G, Curtis N, Carapetis JR. Prospective study of a real-time PCR that is highly sensitive, specific, and clinically useful for diagnosis of meningococcal disease in children. J Clin Microbiol. 2004, 42:2919-25. 10.1128/JCM.42.7.2919-2925.2004 · DOI
  5. Du B, Hua C, Xia Y, et al.. Evaluation of the BioFire FilmArray meningitis/encephalitis panel for the detection of bacteria and yeast in Chinese children. Ann Transl Med. 2019, 7:437. 10.21037/atm.2019.08.103 · DOI
  6. Seth R, Murthy PS, Sistla S, Subramanian M, Tamilarasu K. Rapid and accurate diagnosis of acute pyogenic meningitis due to Streptococcus Pneumoniae, Haemophilus influenzae type B and Neisseria meningitidis using a multiplex PCR assay. J Clin Diagn Res. 2017, 11:FC01-4. 10.7860/JCDR/2017/28114.10532 · DOI
  7. Graf EH, Farquharson MV, Cárdenas AM. Comparative evaluation of the FilmArray meningitis/encephalitis molecular panel in a pediatric population. Diagn Microbiol Infect Dis. 2017, 87:92-4. 10.1016/j.diagmicrobio.2016.09.022 · DOI · Paper page
  8. Nigrovic LE, Malley R, Macias CG, et al.. Effect of antibiotic pretreatment on cerebrospinal fluid profiles of children with bacterial meningitis. Pediatrics. 2008, 122:726-30. 10.1542/peds.2007-3275 · DOI · Paper page
  9. Li W, Sun X, Yuan F, et al.. Diagnostic accuracy of cerebrospinal fluid procalcitonin in bacterial meningitis patients with empiric antibiotic pretreatment. J Clin Microbiol. 2017, 55:1193-204. 10.1128/JCM.02018-16 · DOI
  10. Kaplan SL, Smith EO, Wills C, Feigin RD. Association between preadmission oral antibiotic therapy and cerebrospinal fluid findings and sequelae caused by Haemophilus influenzae type B meningitis. Pediatr Infect Dis. 1986, 5:626-32. 10.1097/00006454-198611000-00005 · DOI
  11. DiDiodato G, Bradbury N. Cerebrospinal fluid analysis with the BioFire FilmArray meningitis/encephalitis molecular panel reduces length of hospital stay in patients with suspected central nervous system infections. Open Forum Infect Dis. 2019, 6:ofz119. 10.1093/ofid/ofz119 · DOI · Paper page

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Metadata

Authors
Ghoweba, Y., Safizadeh Shabestari, S. A., & Malik, Z. A.
Venue
Cureus
Publisher
Springer Science and Business Media LLC
Published
2024-01-08
ISSN
2168-8184
DOI
10.7759/cureus.51906
PMC
PMC10851033
Cited by
5
References
7
Language
en

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