Sparks, Lauren M.

Metabolic Flexibility in Health and Disease

Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 995

Effects of Aerobic and Resistance Training on Hemoglobin A 1c Levels in Patients With Type 2 Diabetes: A Randomized Controlled Trial

Church, T. S., Blair, S. N., Cocreham, S., Johannsen, N., Johnson, W., Kramer, K., Mikus, C. R., Myers, V., Nauta, M., Rodarte, R. Q., et al. (2010) · JAMA

Physical Activity and HealthDiabetes Management and Research

Cited by 944

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Sparks, L. M., Xie, H., Koza, R. A., Mynatt, R., Hulver, M. W., Bray, G. A., & Smith, S. R. (2005) · Diabetes

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 629

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

Patel, S., Alvarez-Guaita, A., Melvin, A., Rimmington, D., Dattilo, A., Miedzybrodzka, E. L., Cimino, I., Maurin, A.-C., Roberts, G. P., Meek, C. L., et al. (2019) · Cell Metabolism

GDF15 and Related BiomarkersRegulation of Appetite and Obesity

Cited by 509

Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue.

Kaaman, M., Sparks, L. M., van Harmelen, V., Smith, S. R., Sjölin, E., Dahlman, I., & Arner, P. (2007) · Diabetologia

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 217

Exercise training response heterogeneity: physiological and molecular insights.

Sparks, L. M. (2017) · Diabetologia

Cardiovascular and exercise physiologyGenetics and Physical Performance

Cited by 160

A Novel Endocrine Role for the BAT-Released Lipokine 12,13-diHOME to Mediate Cardiac Function

Pinckard, K. M., Shettigar, V. K., Wright, K. R., Abay, E., Baer, L. A., Vidal, P., Dewal, R. S., Das, D., Duarte-Sanmiguel, S., Hernández-Saavedra, D., et al. (2021) · Circulation

Adipose Tissue and MetabolismCardiovascular Disease and Adiposity

Cited by 157

Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels

Bosma, M., Hesselink, M. K. C., Sparks, L. M., Timmers, S., Ferraz, M. J., Mattijssen, F., van Beurden, D., Schaart, G., de Baets, M. H., Verheyen, F. K., et al. (2012) · Diabetes

Lipid metabolism and biosynthesisAdipose Tissue and Metabolism

Cited by 149

Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S., et al. (2015) · Diabetes

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 139

Understanding the variation in exercise responses to guide personalized physical activity prescriptions

Noone, J., Mucinski, J. M., DeLany, J. P., Sparks, L. M., & Goodpaster, B. H. (2024) · Cell Metabolism

Genetics and Physical PerformancePhysical Activity and Health

Cited by 128

Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes

Sparks, L. M., Johannsen, N. M., Church, T. S., Earnest, C. P., Moonen-Kornips, E., Moro, C., Hesselink, M. K. C., Smith, S. R., & Schrauwen, P. (2013) · The Journal of Clinical Endocrinology & Metabolism

Cardiovascular and exercise physiologyAdipose Tissue and Metabolism

Cited by 123

Resistance training to improve type 2 diabetes: working toward a prescription for the future

Pesta, D. H., Goncalves, R. L. S., Madiraju, A. K., Strasser, B., & Sparks, L. M. (2017) · Nutrition & Metabolism

Physical Activity and HealthCardiovascular and exercise physiology

Cited by 120

HDAC11 suppresses the thermogenic program of adipose tissue via BRD2

Bagchi, R. A., Ferguson, B. S., Stratton, M. S., Hu, T., Cavasin, M. A., Sun, L., Lin, Y.-H., Liu, D., Londono, P., Song, K., et al. (2018) · JCI Insight

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 110

High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance

Phielix, E., Meex, R., Ouwens, D. M., Sparks, L., Hoeks, J., Schaart, G., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2012) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 99

Relationships between Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes Mellitus

van de Weijer, T., Sparks, L. M., Phielix, E., Meex, R. C., van Herpen, N. A., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2013) · PLoS ONE

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 87

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Erickson, M. L., Allen, J. M., Beavers, D. P., Collins, L. M., Davidson, K. W., Erickson, K. I., Esser, K. A., Hesselink, M. K. C., Moreau, K. L., Laber, E. B., et al. (2023) · GeroScience

Cardiovascular and exercise physiologyPhysical Activity and Health

Cited by 47

EFFECTS OF 12 MONTHS OF CALORIC RESTRICTION ON MUSCLE MITOCHONDRIAL FUNCTION IN HEALTHY INDIVIDUALS

Sparks, L. M., Redman, L. M., Conley, K. E., Harper, M.-E., Yi, F., Hodges, A., Eroshkin, A., Costford, S. R., Gabriel, M. E., Shook, C., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 45

The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?

Sparks, L. M., Goodpaster, B. H., & Bergman, B. C. (2021) · Diabetes

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 35

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

Sparks, L. M., Gemmink, A., Phielix, E., Bosma, M., Schaart, G., Moonen-Kornips, E., Jörgensen, J. A., Nascimento, E. B. M., Hesselink, M. K. C., Schrauwen, P., et al. (2016) · Diabetologia

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 34

Prolonged Glucagon Infusion Does Not Affect Energy Expenditure in Individuals with Overweight/Obesity: A Randomized Trial

Whytock, K. L., Carnero, E. A., Vega, R. B., Tillner, J., Bock, C., Chivukula, K., Yi, F., Meyer, C., Smith, S. R., & Sparks, L. M. (2021) · Obesity

Regulation of Appetite and ObesityPancreatic function and diabetes

Cited by 30

A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity

Vega, R. B., Whytock, K. L., Gassenhuber, J., Goebel, B., Tillner, J., Agueusop, I., Truax, A. D., Yu, G., Carnero, E., Kapoor, N., et al. (2021) · Journal of the Endocrine Society

Pancreatic function and diabetesMetabolomics and Mass Spectrometry Studies

Cited by 24