Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes

Untitled work

(2014) · Medical Entomology and Zoology · Cited by 9,400 · see citing works

Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes

Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321 · see citing works

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990 · see citing works

ACSM's guidelines for exercise testing and prescription

Franklin, B. A., WHALEY, M. H., Howley, E. T., Balady, G. J., & Grais, I. M. (2006) · Medical Entomology and Zoology · Cited by 1,344 · see citing works

Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research

Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,159 · see citing works

Fuel selection in human skeletal muscle in insulin resistance: a reexamination.

Kelley, D. E., & Mandarino, L. J. (2000) · Diabetes · doi:10.2337/diabetes.49.5.677 · Cited by 1,017 · see citing works

Effects of Aerobic and Resistance Training on Hemoglobin A _1c Levels in Patients With Type 2 Diabetes: A Randomized Controlled Trial

Church, T. S., Blair, S. N., Cocreham, S., Johannsen, N., Johnson, W., Kramer, K., Mikus, C. R., Myers, V., Nauta, M., Rodarte, R. Q., et al. (2010) · JAMA · doi:10.1001/jama.2010.1710 · Cited by 944 · see citing works

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes

Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887 · see citing works

What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes

McGarry, J. D. (1992) · Science · doi:10.1126/science.1439783 · Cited by 657 · see citing works

Lipid oxidation is reduced in obese human skeletal muscle

Kim, J.-Y., Hickner, R. C., Cortright, R. L., Dohm, G. L., & Houmard, J. A. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.5.e1039 · Cited by 634 · see citing works

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle

Sparks, L. M., Xie, H., Koza, R. A., Mynatt, R., Hulver, M. W., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1926 · Cited by 629 · see citing works

Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo

Bogacka, I., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1392 · Cited by 467 · see citing works

Impaired Mitochondrial Substrate Oxidation in Muscle of Insulin-Resistant Offspring of Type 2 Diabetic Patients

Befroy, D. E., Petersen, K. F., Dufour, S., Mason, G. F., de Graaf, R. A., Rothman, D. L., & Shulman, G. I. (2007) · Diabetes · doi:10.2337/db06-0783 · Cited by 453 · see citing works

Strength and skeletal muscle adaptations in heavy-resistance-trained women after detraining and retraining

Staron, R. S., Leonardi, M. J., Karapondo, D. L., Malicky, E. S., Falkel, J. E., Hagerman, F. C., & Hikida, R. S. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.70.2.631 · Cited by 400 · see citing works

Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients

Phielix, E., Schrauwen-Hinderling, V. B., Mensink, M., Lenaers, E., Meex, R., Hoeks, J., Kooi, M. E., Moonen-Kornips, E., Sels, J.-P., Hesselink, M. K. C., et al. (2008) · Diabetes · doi:10.2337/db08-0391 · Cited by 359 · see citing works

Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity

Meex, R. C. R., Schrauwen-Hinderling, V. B., Moonen-Kornips, E., Schaart, G., Mensink, M., Phielix, E., van de Weijer, T., Sels, J.-P., Schrauwen, P., & Hesselink, M. K. C. (2010) · Diabetes · doi:10.2337/db09-1322 · Cited by 355 · see citing works

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

Ritov, V. B., Menshikova, E. V., Azuma, K., Wood, R., Toledo, F. G. S., Goodpaster, B. H., Ruderman, N. B., & Kelley, D. E. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00317.2009 · Cited by 283 · see citing works

Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men

Alibegovic, A. C., Sonne, M. P., Højbjerre, L., Bork-Jensen, J., Jacobsen, S., Nilsson, E., Færch, K., Hiscock, N., Mortensen, B., Friedrichsen, M., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2009 · Cited by 247 · see citing works

Physical inactivity and obesity underlie the insulin resistance of aging

Amati, F., Dubé, J. J., Coen, P. M., Stefanovic-Racic, M., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes Care · doi:10.2337/dc09-0267 · Cited by 230 · see citing works

Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content

Toledo, F. G. S., Menshikova, E. V., Azuma, K., Radiková, Z., Kelley, C. A., Ritov, V. B., & Kelley, D. E. (2008) · Diabetes · doi:10.2337/db07-1429 · Cited by 218 · see citing works

Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor

Ukropcova, B., McNeil, M., Sereda, O., de Jonge, L., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24332 · Cited by 213 · see citing works

Large energetic adaptations of elderly muscle to resistance and endurance training

Jubrias, S. A., Esselman, P. C., Price, L. B., Cress, M. E., & Conley, K. E. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.1663 · Cited by 213 · see citing works

Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals

Phielix, E., Meex, R., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2010) · Diabetologia · doi:10.1007/s00125-010-1764-2 · Cited by 206 · see citing works

Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans

Pesta, D. H., Hoppel, F., Macek, C., Messner, H., Faulhaber, M., Kobel, C., Parson, W., Burtscher, M., Schocke, M. F. H., & Gnaiger, E. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00285.2011 · Cited by 181 · see citing works

Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance

Holloszy, J. O. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717c · Cited by 175 · see citing works

Reduced Glucose Tolerance and Insulin Resistance Induced by Steroid Treatment, Relative Physical Inactivity, and High-Calorie Diet Impairs the Incretin Effect in Healthy Subjects

Hansen, K. B., Vilsbøll, T., Bagger, J. I., Holst, J. J., & Knop, F. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0119 · Cited by 109 · see citing works

Skeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction

Finley, L. W. S., Lee, J., Souza, A., Desquiret-Dumas, V., Bullock, K., Rowe, G. C., Procaccio, V., Clish, C. B., Arany, Z., & Haigis, M. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1115813109 · Cited by 102 · see citing works

Acetate metabolism and aging: An emerging connection

Shimazu, T., Hirschey, M. D., Huang, J.-Y., Ho, L., & Verdin, E. M. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.05.001 · Cited by 79 · see citing works

Skeletal Muscle Fat Oxidation Is Increased in African‐American and White Women after 10 days of Endurance Exercise Training

Cortright, R. N., Sandhoff, K. M., Basilio, J. L., Berggren, J. R., Hickner, R. C., Hulver, M. W., Dohm, G. L., & Houmard, J. A. (2006) · Obesity · doi:10.1038/oby.2006.137 · Cited by 70 · see citing works

Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle

Jong-Yeon, K., Hickner, R. C., Dohm, G. L., & Houmard, J. A. (2002) · Metabolism · doi:10.1053/meta.2002.31326 · Cited by 66 · see citing works

Reduced tricarboxylic acid cycle flux in type 2 diabetes mellitus?

Schrauwen, P., & Hesselink, M. K. C. (2008) · Diabetologia · doi:10.1007/s00125-008-1069-x · Cited by 51 · see citing works

Rapid isolation of muscle and heart mitochondria, the lability of oxidative phosphorylation and attempts to stabilize the process in vitro by taurine, carnitine and other compounds

Scholte, H. R., Yu, Y., Ross, J. D. M., Oosterkamp, I. I., Boonman, A. M. C., & Busch, H. F. M. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006803807814 · Cited by 38 · see citing works

Exercise training modalities in patients with type 2 diabetes mellitus: a systematic review and network meta-analysis

Pan, B., Ge, L., Xun, Y.-Q., Chen, Y.-J., Gao, C.-Y., Han, X., Zuo, L.-Q., Shan, H.-Q., Yang, K.-H., Ding, G.-W., et al. (2018) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-018-0703-3 · Cited by 470 · see citing works

The immunomodulating role of exercise in metabolic disease

Lancaster, G. I., & Febbraio, M. A. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.02.008 · Cited by 193 · see citing works

Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis

Liu, Y., Ye, W., Chen, Q., Zhang, Y., Kuo, C.-H., & Korivi, M. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16010140 · Cited by 176 · see citing works

Inflammation, physical activity, and chronic disease: An evolutionary perspective

Burini, R. C., Anderson, E., Durstine, J. L., & Carson, J. A. (2020) · Sports Medicine and Health Science · doi:10.1016/j.smhs.2020.03.004 · Cited by 166 · see citing works

Impact of Resistance Training on Skeletal Muscle Mitochondrial Biogenesis, Content, and Function

Groennebaek, T., & Vissing, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00713 · Cited by 154 · see citing works

Mediators of Physical Activity Protection against ROS-Linked Skeletal Muscle Damage

Meo, S. D., Napolitano, G., & Venditti, P. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123024 · Cited by 146 · see citing works

Exercise training for patients with type 2 diabetes and cardiovascular disease: What to pursue and how to do it. A Position Paper of the European Association of Preventive Cardiology (EAPC)

Kemps, H., Kränkel, N., Dörr, M., Moholdt, T. T., Wilhelm, M., Paneni, F., Serratosa, L., Solberg, E. E., Hansen, D., Halle, M., et al. (2019) · European Journal of Preventive Cardiology · doi:10.1177/2047487318820420 · Cited by 147 · see citing works

Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

Glynn, E. L., Piner, L. W., Huffman, K. M., Slentz, C. A., Elliot‐Penry, L., AbouAssi, H., White, P. J., Bain, J. R., Muehlbauer, M. J., Ilkayeva, O., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3705-6 · Cited by 142 · see citing works

Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age

Irving, B. A., Lanza, I. R., Henderson, G. C., Rao, R. R., Spiegelman, B. M., & Nair, K. S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3081 · Cited by 139 · see citing works

Innate Immune Cells in the Adipose Tissue in Health and Metabolic Disease

Michailidou, Z., Gomez-Salazar, M. A., & Alexaki, V. I. (2021) · Journal of Innate Immunity · doi:10.1159/000515117 · Cited by 137 · see citing works

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments

Espino-González, E., Dalbram, E., Mounier, R., Gondin, J., Farup, J., Jessen, N., & Treebak, J. T. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.02.014 · Cited by 132 · see citing works

Glucose Uptake by Skeletal Muscle within the Contexts of Type 2 Diabetes and Exercise: An Integrated Approach

Hulett, N. A., Scalzo, R. L., & Reusch, J. E. B. (2022) · Nutrients · doi:10.3390/nu14030647 · Cited by 125 · see citing works

Resistance training to improve type 2 diabetes: working toward a prescription for the future

Pesta, D. H., Goncalves, R. L. S., Madiraju, A. K., Strasser, B., & Sparks, L. M. (2017) · Nutrition & Metabolism · doi:10.1186/s12986-017-0173-7 · Cited by 120 · see citing works

Resistance Training for Diabetes Prevention and Therapy: Experimental Findings and Molecular Mechanisms

Strasser, B., & Pesta, D. H. (2013) · BioMed Research International · doi:10.1155/2013/805217 · Cited by 125 · see citing works

Impact of Endurance and Resistance Training on Skeletal Muscle Glucose Metabolism in Older Adults

Consitt, L. A., Dudley, C., & Saxena, G. (2019) · Nutrients · doi:10.3390/nu11112636 · Cited by 116 · see citing works

Resistance to the Beneficial Effects of Exercise in Type 2 Diabetes: Are Some Individuals Programmed to Fail?

Stephens, N. A., & Sparks, L. M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2545 · Cited by 97 · see citing works

Interventions to promote cardiometabolic health and slow cardiovascular ageing

Fontana, L. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0026-8 · Cited by 94 · see citing works

Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults

Moro, T., Brightwell, C. R., Phalen, D. E., McKenna, C. F., Lane, S. J., Porter, C., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110723 · Cited by 85 · see citing works

Exercise and diabetes: relevance and causes for response variability

Böhm, A., Weigert, C., Staiger, H., & Häring, H. (2015) · Endocrine · doi:10.1007/s12020-015-0792-6 · Cited by 79 · see citing works

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

Böhm, A., Hoffmann, C., Irmler, M., Schneeweiß, P., Schnauder, G., Sailer, C., Schmid, V., Hudemann, J., Machann, J., Schick, F., et al. (2016) · Diabetes · doi:10.2337/db15-1723 · Cited by 79 · see citing works

Endurance Exercise Training Up-Regulates Lipolytic Proteins and Reduces Triglyceride Content in Skeletal Muscle of Obese Subjects

Louche, K., Badin, P.-M., Montastier, É., Laurens, C., Bourlier, V., de Glisezinski, I., Thalamas, C., Viguerie, N., Langin, D., & Moro, C. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2058 · Cited by 78 · see citing works

Aerobic and Strength Training in Concomitant Metabolic Syndrome and Type 2 Diabetes

Earnest, C. P., Johannsen, N. M., Swift, D. L., Gillison, F., Mikus, C. R., Lucía, A., Kramer, K., Lavie, C. J., & Church, T. S. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000242 · Cited by 78 · see citing works

Diabetes-Induced Dysfunction of Mitochondria and Stem Cells in Skeletal Muscle and the Nervous System

Fujimaki, S., & Kuwabara, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102147 · Cited by 75 · see citing works

May the force be with you: Why resistance training is essential for subjects with type 2 diabetes mellitus without complications

Codella, R., Ialacqua, M., Terruzzi, I., & Luzi, L. (2018) · Endocrine · doi:10.1007/s12020-018-1603-7 · Cited by 72 · see citing works

Impact of exercise training on muscle mitochondria modifications in older adults: a systematic review of randomized controlled trials

Lippi, L., de Sire, A., Mezian, K., Curci, C., Perrero, L., Turco, A., Andaloro, S., Ammendolia, A., Fusco, N., & Invernizzi, M. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-02073-w · Cited by 65 · see citing works

Exercise and Muscle Lipid Content, Composition, and Localization: Influence on Muscle Insulin Sensitivity

Bergman, B. C., & Goodpaster, B. H. (2020) · Diabetes · doi:10.2337/dbi18-0042 · Cited by 71 · see citing works

Improvement of obesity-linked skeletal muscle insulin resistance by strength and endurance training

Meo, S. D., Iossa, S., & Venditti, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0186 · Cited by 62 · see citing works

Beyond general resistance training. Hypertrophy versus muscular endurance training as therapeutic interventions in adults with type 2 diabetes mellitus: A systematic review and meta-analysis

Acosta‐Manzano, P., Rodriguez‐Ayllon, M., Acosta, F. M., Niederseer, D., & Niebauer, J. (2020) · Obesity Reviews · doi:10.1111/obr.13007 · Cited by 59 · see citing works

Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women

Garneau, L., Parsons, S. A., Smith, S. R., Mulvihill, E. E., Sparks, L. M., & Aguer, C. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00018 · Cited by 53 · see citing works

Multivesicular body and exosome pathway responses to acute exercise

Garner, R. T., Solfest, J. S., Nie, Y., Kuang, S., Stout, J., & Gavin, T. P. (2020) · Experimental Physiology · doi:10.1113/ep088017 · Cited by 45 · see citing works

Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes

Stephens, N. A., Brouwers, B., Eroshkin, A. M., Yi, F., Cornnell, H. H., Meyer, C., Goodpaster, B. H., Pratley, R. E., Smith, S. R., & Sparks, L. M. (2018) · Diabetes Care · doi:10.2337/dc18-0296 · Cited by 48 · see citing works

Enhanced glucose metabolism is preserved in cultured primary myotubes from obese donors in response to exercise training.

Bourlier, V., Saint-Laurent, C., Louche, K., Badin, P.-M., Thalamas, C., de Glisezinski, I., Langin, D., Sengenès, C., & Moro, C. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-1727 · Cited by 51 · see citing works

Aerobic-Strength Exercise Improves Metabolism and Clinical State in Parkinson’s Disease Patients

Krumpolec, P., Vallova, S., Slobodová, L., Tirpáková, V., Vajda, M., Schön, M., Klepochová, R., Janakova, Z., Straka, I., Šutovský, S., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00698 · Cited by 44 · see citing works

Exercising for Insulin Sensitivity – Is There a Mechanistic Relationship With Quantitative Changes in Skeletal Muscle Mass?

Paquin, J., Lagacé, J., Brochu, M., & Dionne, I. J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.656909 · Cited by 42 · see citing works

Effects of resistance training on insulin sensitivity in the elderly: A meta-analysis of randomized controlled trials

Li, J., Li, J., & Lu, Y. (2021) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2021.08.002 · Cited by 41 · see citing works

A transcriptional signature of “exercise resistance” in skeletal muscle of individuals with type 2 diabetes mellitus

Stephens, N. A., Xie, H., Johannsen, N. M., Church, T., Smith, S. R., & Sparks, L. (2015) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2015.06.008 · Cited by 39 · see citing works

Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise

Feng, Y., Nikolić, N., Bakke, S. S., Kase, E. T., Guderud, K., Hjelmesaeth, J. S., Aas, V., Rustan, A. C., & Thoresen, G. H. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00314.2014 · Cited by 39 · see citing works

Combined Aerobic and Resistance Training Effects on Glucose Homeostasis, Fitness, and Other Major Health Indices: A Review of Current Guidelines

Johannsen, N. M., Swift, D. L., Lavie, C. J., Earnest, C. P., Blair, S. N., & Church, T. S. (2016) · Sports Medicine · doi:10.1007/s40279-016-0548-3 · Cited by 39 · see citing works

Painful Diabetic Peripheral Neuropathy: Presentations, Mechanisms, and Exercise Therapy

Yoo, M. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s10-005 · Cited by 39 · see citing works

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Bilet, L., Esther Phielix, E., van de Weijer, T., Gemmink, A., Bosma, M., Moonen‐Kornips, E., Jörgensen, J. A., Schaart, G., Zhang, D., Meijer, K., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05128-1 · Cited by 36 · see citing works

Implementing Low-Cost, Community-Based Exercise Programs for Middle-Aged and Older Patients with Type 2 Diabetes: What Are the Benefits for Glycemic Control and Cardiovascular Risk?

Mendes, R., Sousa, N., Reis, V. M., & Themudo-Barata, J. L. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14091057 · Cited by 35 · see citing works

Benefits of different combinations of aerobic and resistance exercise for improving plasma glucose and lipid metabolism and sleep quality among elderly patients with metabolic syndrome: a randomized controlled trial

Zhou, Y., Wu, W., Zou, Y., Huang, W., Lin, S., Ye, J., & Lan, Y. (2022) · Endocrine Journal · doi:10.1507/endocrj.ej21-0589 · Cited by 35 · see citing works

Exercise resistance across the prediabetes phenotypes: Impact on insulin sensitivity and substrate metabolism

Malin, S. K., Liu, Z., Barrett, E. J., & WELTMAN, A. L. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9352-5 · Cited by 34 · see citing works

Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with Type 2 diabetes

Pino, M. F., Stephens, N. A., Eroshkin, A. M., Yi, F., Hodges, A. P., Cornnell, H. H., Pratley, R. E., Smith, S. R., Wang, M., Han, X., et al. (2019) · Physiological Genomics · doi:10.1152/physiolgenomics.00014.2019 · Cited by 33 · see citing works

Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts

Ko, T. H., Marquez, J. C., Kim, H. K., Jeong, S. H., Lee, S., Youm, J. B., Song, I. S., Seo, D. Y., Kim, H. J., Won, D. N., et al. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2076-x · Cited by 32 · see citing works

Diabetes and Stem Cell Function

Fujimaki, S., Wakabayashi, T., Takemasa, T., Asashima, M., & Kuwabara, T. (2015) · BioMed Research International · doi:10.1155/2015/592915 · Cited by 32 · see citing works

The Effects of Concurrent Training Versus Aerobic or Resistance Training Alone on Body Composition in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis

Khalafi, M., Kheradmand, S., Maleki, A. H., Symonds, M. E., Rosenkranz, S. K., & Batrakoulis, A. (2025) · Healthcare · doi:10.3390/healthcare13070776 · Cited by 30 · see citing works

Mitochondrial Adaptations in Aging Skeletal Muscle: Implications for Resistance Exercise Training to Treat Sarcopenia

Jeong, I., Cho, E., Yook, J.-S., Choi, Y., Park, D., Kang, J., Lee, S.-H., Seo, D. Y., Jung, S., & Kwak, H. (2024) · Life · doi:10.3390/life14080962 · Cited by 33 · see citing works

Healthy ageing in older adults with cardiovascular disease

Schmanske, N., Ngo, J. M., Kalra, K., Nanna, M. G., & Damluji, A. A. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf231 · Cited by 28 · see citing works

Rehabilitation of Individuals With Diabetes Mellitus: Focus on Diabetic Myopathy

Dibai, D. B., Santos‐de‐Araújo, A. D., Dibai‐Filho, A. V., de Azevedo, L. F. S., Goulart, C. D. L., Luz, G. C. P., Burke, P. R., Garcia-Araújo, A. S., & Borghi‐Silva, A. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.869921 · Cited by 28 · see citing works

Reduced Incorporation of Fatty Acids Into Triacylglycerol in Myotubes From Obese Individuals With Type 2 Diabetes

Sparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., Moonen‐Kornips, E., Eichmann, T. O., Lass, A., Hesselink, M. K. C., et al. (2014) · Diabetes · doi:10.2337/db13-1123 · Cited by 27 · see citing works

ER–Mitochondria Contacts and Insulin Resistance Modulation through Exercise Intervention

Sun, Y., & Ding, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249587 · Cited by 27 · see citing works

Diabetic Peripheral Neuropathy: Epidemiology, Physiopathology, Diagnosis and Treatment

Akter, N. (2019) · Delta Medical College Journal · doi:10.3329/dmcj.v7i1.40619 · Cited by 28 · see citing works

Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production

Jangjo-Borazjani, S., Dastgheib, M., Kiyamarsi, E., Jamshidi, R., Rahmati-Ahmadabad, S., Helalizadeh, M., Iraji, R., Cornish, S. M., Mohammadi-Darestani, S., Khojasteh, Z., et al. (2021) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2021.1886117 · Cited by 28 · see citing works

Dose-response relationships of resistance training in Type 2 diabetes mellitus: a meta-analysis of randomized controlled trials

Su, W., Tao, M., Ma, L., Tang, K., Xiong, F., Dai, X., & Qin, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1224161 · Cited by 31 · see citing works

The Comparison between Effects of 12 weeks Combined Training and Vitamin D Supplement on Improvement of Sensory-motor Neuropathy in type 2 Diabetic Women

Nadi, M., Marandi, S. M., Esfarjani, F., Saleki, M., & Mohammadi, M. (2017) · Advanced Biomedical Research · doi:10.4103/2277-9175.205528 · Cited by 25 · see citing works

Lipid homeostasis in exercise

Bosma, M. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.03.007 · Cited by 23 · see citing works

The Impact of Resistance Exercise Training on Glycemic Control Among Adults with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Wan, Y., & Su, Z. (2024) · Biological Research For Nursing · doi:10.1177/10998004241246272 · Cited by 28 · see citing works

Skeletal Muscle Mitochondrial Adaptations to Maximal Strength Training in Older Adults

Berg, O. K., Kwon, O. S., Hureau, T. J., Clifton, H. L., Thurston, T. S., Fur, Y. L., Jeong, E., Trinity, J. D., Richardson, R. S., Wang, E., et al. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa082 · Cited by 21 · see citing works

Impact of continuous vs. interval training on oxygen extraction and cardiac function during exercise in type 2 diabetes mellitus

Ryckeghem, L. V., Keytsman, C., Brandt, J. D., Verboven, K., Verbaanderd, E., Marinus, N., Franssen, W. M. A., Frederix, I., Bakelants, E., Petit, T., et al. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04884-9 · Cited by 21 · see citing works

Research Progress on Lipophagy-Mediated Exercise Intervention in Non-Alcoholic Fatty Liver Disease

Li, X., Yang, Y., Sun, Y., & Ding, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063153 · Cited by 20 · see citing works

Phenotypic Responses to a Lifestyle Intervention Do Not Account for Inter-Individual Variability in Glucose Tolerance for Individuals at High Risk of Type 2 Diabetes

O’Donoghue, G., Kennedy, A., Andersen, G. S., Carr, B., Cleary, S., Durkan, E., Davis, H., Færch, K., Fitzpatrick, P., Kenny, H., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00317 · Cited by 20 · see citing works

Resistance training enhances metabolic and muscular health and reduces systemic inflammation in middle-aged and older adults with type 2 diabetes: a meta-analysis

Wang, J., Fan, S., & Wang, J. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112941 · Cited by 19 · see citing works

Mediation analysis of the testosterone treatment effect to prevent type 2 diabetes in the Testosterone for Prevention of Type 2 Diabetes Mellitus trial

Robledo, K. P., Marschner, I. C., Handelsman, D. J., Bracken, K., Stuckey, B. G. A., Yeap, B. B., Inder, W. J., Grossmann, M., Jesudason, D. R., Allan, C. A., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad074 · Cited by 18 · see citing works

Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls

Ekman, C., Elgzyri, T., Ström, K., Almgren, P.-E., Parikh, H. M., Nitert, M. D., Rönn, T., Koivula, F. N. M., Ling, C., Tornberg, Å. B., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01067.2014 · Cited by 19 · see citing works

Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search

Havers, T., Held, S., Schönfelder, M., Geisler, S., & Wackerhage, H. (2025) · Sports Medicine · doi:10.1007/s40279-025-02263-w · Cited by 19 · see citing works

Strength training improves insulin resistance and differently affects mitochondria in skeletal muscle and visceral adipose tissue in high-fat fed mice

Costa, J. S. R., Fonseca, G. F. A. C., Ottone, N. C. D. S., Silva, P. A., Antonaccio, R. F., Silva, G., Rocha, M. D. S. A., Coimbra, C. C., Esteves, E. A., Mang, Z. A., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119639 · Cited by 17 · see citing works

Association between Changes in Muscle Quality with Exercise Training and Changes in Cardiorespiratory Fitness Measures in Individuals with Type 2 Diabetes Mellitus: Results from the HART-D Study

Sénéchal, M., Johannsen, N. M., Swift, D. L., Earnest, C. P., Lavie, C. J., Blair, S. N., & Church, T. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135057 · Cited by 17 · see citing works

Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

Boulinguiez, A., Staels, B., Duez, H., & Lancel, S. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.05.011 · Cited by 17 · see citing works

Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training

Brouwers, B., Stephens, N. A., Costford, S. R., Hopf, M. E., Ayala, J. E., Yi, F., Xie, H., Li, J., Gardell, S. J., Sparks, L. M., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00704 · Cited by 15 · see citing works

Influence of endurance training on skeletal muscle mitophagy regulatory proteins in type 2 diabetic men

Brinkmann, C. K., Przyklenk, A., Metten, A., Schiffer, T., Bloch, W., Brixius, K., & Gehlert, S. (2017) · Endocrine Research · doi:10.1080/07435800.2017.1323914 · Cited by 16 · see citing works

Do Changes in Innate Immunity Underlie the Cardiovascular Benefits of Exercise?

Chuong, P., Wysoczynski, M., & Hellmann, J. L. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00070 · Cited by 13 · see citing works

An improvement in skeletal muscle mitochondrial capacity with short‐term aerobic training is associated with changes in Tribbles 1 expression

Vega, R. B., Brouwers, B., Parsons, S. A., Stephens, N. A., Pino, M. F., Hodges, A. P., Yi, F., Yu, G., Pratley, R. E., Smith, S. R., et al. (2020) · Physiological Reports · doi:10.14814/phy2.14416 · Cited by 13 · see citing works

Altered dynamics of lipid metabolism in muscle cells from patients with idiopathic inflammatory myopathy is ameliorated by 6 months of training

Nemec, M., Vernerová, L., Laiferová, N. A., Balážová, M., Vokurková, M., Kurdiová, T., Oreská, S., Kubínová, K., Klein, M., Špiritović, M., et al. (2020) · The Journal of Physiology · doi:10.1113/jp280468 · Cited by 12 · see citing works

Workaholism, Exercise, and Stress-Related Illness

Aziz, S., Wuensch, K. L., & Duffrin, C. (2015) · Journal of Workplace Behavioral Health · doi:10.1080/15555240.2015.1074053 · Cited by 12 · see citing works

Mechanisms of exercise intervention in type 2 diabetes: a bibliometric and visualization analysis based on CiteSpace

Jin, Y., Wan, K., Liu, C., Cheng, W., & Wang, R. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1401342 · Cited by 12 · see citing works

The Effects of Exercise Interventions on Ectopic and Subcutaneous Fat in Patients with Type 2 Diabetes Mellitus: A Systematic Review, Meta-Analysis, and Meta-Regression

Kazeminasab, F., Kerchi, A. B., Behzadnejad, N., Belyani, S., Rosenkranz, S. K., Bagheri, R., & Dutheil, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13175005 · Cited by 11 · see citing works

Vulnerability to diabetes in Chinese: an age–period–cohort analysis

Wong, I. O. L., Cowling, B. J., & Schooling, C. M. (2014) · Annals of Epidemiology · doi:10.1016/j.annepidem.2014.10.010 · Cited by 11 · see citing works

Mitochondria as a target for exercise-mitigated type 2 diabetes

Tian, J., Fan, J., & Zhang, T. (2023) · Journal of Molecular Histology · doi:10.1007/s10735-023-10158-1 · Cited by 11 · see citing works

Short Bouts of High-Intensity Resistance-Style Training Produce Similar Reductions in Fasting Blood Glucose of Diabetic Offspring and Controls

Russell, R., Nelson, A. G., & Kraemer, R. R. (2014) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000624 · Cited by 11 · see citing works

Energy balance dynamics during short-term high-intensity functional training

Schubert, M. M., & Palumbo, E. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0311 · Cited by 11 · see citing works

Effect of Exercise on Pancreatic Islets in Zucker Diabetic Fatty Rats

Rawal, S. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s10-007 · Cited by 11 · see citing works

Effects of exercise training on skeletal muscle mitochondrial outcomes in type 2 diabetes: a systematic review and meta-analysis

Zhu, W., Zhou, Z., Sun, J., & Si, J. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1671926 · Cited by 11 · see citing works

Tailored Exercise Intervention in Metabolic Syndrome: Cardiometabolic Improvements Beyond Weight Loss and Diet—A Prospective Observational Study

Cominacini, M., Braggio, M., Dorelli, G., Olivato, N., Lamberti, V., Valenti, M. T., & Carbonare, L. D. (2025) · Nutrients · doi:10.3390/nu17050872 · Cited by 9 · see citing works

The effect of 12 weeks aerobic, resistance and combined trainings on peripheral vascular disease in type 2 diabetes with peripheral neuropathy in men

Alni, M. A., & Nikookheslat, S. D. (2022) · Obesity Medicine · doi:10.1016/j.obmed.2022.100439 · Cited by 9 · see citing works

The relationship between the level of exercise and hemoglobin A1c in patients with type 2 diabetes mellitus: a systematic review and meta-analysis

Igarashi, Y., Akazawa, N., & Maeda, S. (2021) · Endocrine · doi:10.1007/s12020-021-02817-8 · Cited by 9 · see citing works

Creatine Supplementation Combined with Exercise in the Prevention of Type 2 Diabetes: Effects on Insulin Resistance and Sarcopenia

Młynarska, E., Leszto, K., Katańska, K., Prusak, A., Wieczorek, A., Jakubowska, P., Rysz, J., & Franczyk, B. (2025) · Nutrients · doi:10.3390/nu17172860 · Cited by 10 · see citing works

Targeting mitochondria: a great boon to fight type 2 diabetes

Marañón, A., Rovira‐Llopis, S., Rocha, M., & Víctor, V. M. (2022) · Redox Experimental Medicine · doi:10.1530/rem-22-0012 · Cited by 6 · see citing works

PGC1α−1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals

Henagan, T. M., Stewart, L. K., Forney, L. A., Sparks, L. M., Johannsen, N. M., & Church, T. S. (2014) · PPAR Research · doi:10.1155/2014/895734 · Cited by 6 · see citing works

Effects of home- and gym-based resistance training on glycemic control in patients with type 2 diabetes mellitus—a systematic review and meta-analysis

Bärg, M., Polotto, V. I.-B., Geiger, S., Held, S., & Brinkmann, C. K. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01793-7 · Cited by 9 · see citing works

Effectiveness of multi-component exercise in individuals with type 2 diabetes: a systematic review and meta-analysis

Sun, Z., Zeng, H., Liu, H., Hu, M., Tian, X., Mao, D., & Zhang, R. (2025) · PeerJ · doi:10.7717/peerj.20146 · Cited by 8 · see citing works

Meeting physical activity and resistance exercise guidelines associated with significantly reduced prevalence of diabetes in older adults

Kim, C., Park, D., Lee, Y.-J., Kim, E., Oh, C.-G., Lee, D. H., & Jeon, J. Y. (2025) · Age and Ageing · doi:10.1093/ageing/afaf109 · Cited by 5 · see citing works

Resistance and Aerobic Training in the Treatment of Type 2 Diabetes Mellitus

Nunes, R. B. (2017) · Journal of Diabetes Metabolic Disorders & Control · doi:10.15406/jdmdc.2017.04.00126 · Cited by 5 · see citing works

The Significant Role of Physical Activity and Exercise in Health and Metabolic Diseases

Dimitriadis, G., Chryssanthopοulos, C., Philippou, Α., & Koutsilieris, M. (2025) · Physiologia · doi:10.3390/physiologia5040057 · Cited by 9 · see citing works

Benefits of adding food education sessions to an exercise programme on cardiovascular risk factors in patients with type 2 diabetes

Vasconcelos, C. E. G. D. C., Cabral, M., Ramos, E., & Mendes, R. (2021) · Journal of Nutritional Science · doi:10.1017/jns.2021.50 · Cited by 4 · see citing works

Aerobic training increases mitochondrial respiratory capacity in human skeletal muscle stem cells from sedentary individuals

Yeo, R. X., Dijkstra, P. J., de Carvalho, F. G., Yi, F., Pino, M. F., Smith, S. R., & Sparks, L. M. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00146.2022 · Cited by 4 · see citing works

Photobiomodulation Enhances the Effect of Strength Training on Insulin Resistance Regardless of Exercise Volume in Mice Fed a High‐Fat Diet

Costa, J. S. R., Silva, G., Guimarães, I. C., Silva, L. F. R., da Silva, S. S., Almeida, J. P. D. P., Coimbra, C. C., Parizotto, N. A., Gripp, F., Dias‐Peixoto, M. F., et al. (2024) · Journal of Biophotonics · doi:10.1002/jbio.202400274 · Cited by 4 · see citing works

Effects of resistance training on cardiovascular risk factors in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Sun, Y. M., Sun, M., Zeng, X., Je, L. X., & Guo, Z. S. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02413-y · Cited by 4 · see citing works

Effects of the association of different volumes of strength training with photobiomodulation therapy on insulin resistance: A protocol for a randomized, triple-blind, placebo-controlled trial

Ferreira, P. P. R., Silva, L. F. R., Dias‐Peixoto, M. F., Cassilhas, R. C., Gripp, F., Amorim, F. T., Mang, Z. A., Esteves, E. A., Tricoli, V., Ferraresi, C., et al. (2022) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2022.100984 · Cited by 4 · see citing works

Multiple Factors Affecting Insulin Resistance

钟, 林. (2022) · Bioprocess · doi:10.12677/bp.2022.122005 · Cited by 3 · see citing works

Effects of exercise training on skeletal muscle mitochondrial outcomes in type 2 diabetes: a systematic review and meta-analysis

Zhu, W., Zhou, Z., Sun, J., & Si, J. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1671926 · Cited by 11 · see citing works

ARTICLE

Esther Phielix, E., Meex, R. C. R., Moonen‐Kornips, E., Hesselink, M. K. C., Schrauwen, P., Esther Phielix, E., & Schrauwen, P. (2010)

Training-induced improvement in lipid oxidation in type 2 diabetes mellitus is related to alterations in muscle mitochondrial activity. Effect of endurance training in type 2 diabetes

Bordenave, S., Metz, L., Flavier, S., Lambert, K., Ghanassia, É., Dupuy, A., Michel, F., Puech-Cathala, A.-M., de Mauverger, É. R., Brun, J. ‐., et al. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2007.11.006 · Cited by 66 · see citing works

Aerobic Exercise Training Improves Skeletal Muscle Mitochondrial Function In Type 2 Diabetic Model

Bae, J. H., Cho, E., Choi, Y., Kim, J., Kim, S., Park, D., Kang, J., & Kwak, H. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000883400.08355.ee

Skeletal muscle mitochondrial dysfunction is secondary to type 2 diabetes and can be improved by prolonged exercise training

van Tienen, F. H. J., Praet, S., Feyter, H. M. D., van den Broek, N. M. A., Lindsey, P. J., Schoonderwoerd, K., de Coo, I. F. M., Nicolay, K., Prompers, J. J., Smeets, H. J. M., et al. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.03.073