Srivastava, Deepak

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 2,454

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

Cordes, K. R., Sheehy, N. T., White, M. P., Berry, E. C., Morton, S. U., Muth, A. N., Lee, T.-H., Miano, J. M., Ivey, K. N., & Srivastava, D. (2009) · Nature

MicroRNA in disease regulationCongenital heart defects research

Cited by 1,585

Mutations in NOTCH1 cause aortic valve disease

Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature

Congenital heart defects researchCardiac Valve Diseases and Treatments

Cited by 1,509

Contribution of rare inherited and de novo variants in 2,871 congenital heart disease probands

Jin, S. C., Homsy, J., Zaidi, S., Lu, Q., Morton, S., DePalma, S. R., Zeng, X., Qi, H., Chang, W., Sierant, M. C., et al. (2017) · Nature Genetics

Congenital heart defects researchGenomics and Rare Diseases

Cited by 875

Molecular Pathways Controlling Heart Development

Olson, E. N., & Srivastava, D. (1996) · Science

Congenital heart defects researchDevelopmental Biology and Gene Regulation

Cited by 478

MicroRNAs as Regulators of Differentiation and Cell Fate Decisions

Ivey, K. N., & Srivastava, D. (2010) · Cell Stem Cell

MicroRNA in disease regulationDevelopmental Biology and Gene Regulation

Cited by 449

Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

Ang, Y.-S., Rivas, R. N., Ribeiro, A. J. S., Srivas, R., Rivera, J., Stone, N. R., Pratt, K., Mohamed, T. M. A., Fu, J.-D., Spencer, C. I., et al. (2016) · Cell

Congenital heart defects researchGenomics and Chromatin Dynamics

Cited by 294

In Vivo Cellular Reprogramming: The Next Generation

Srivastava, D., & DeWitt, N. (2016) · Cell

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 292

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

Duan, Q., McMahon, S., Anand, P., Shah, H., Thomas, S., Salunga, H. T., Huang, Y., Zhang, R., Sahadevan, A., Lemieux, M. E., et al. (2017) · Science Translational Medicine

Protein Degradation and InhibitorsCardiac Fibrosis and Remodeling

Cited by 262

A transcriptional switch governs fibroblast activation in heart disease

Alexanian, M., Przytycki, P. F., Micheletti, R., Padmanabhan, A., Ye, L., Travers, J. G., Gonzalez-Teran, B., Silva, A. C., Duan, Q., Ranade, S. S., et al. (2021) · Nature

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 238

Stromal cell-derived factor-1α is cardioprotective after myocardial infarction

Saxena, A., Fish, J. E., White, M. D., Yu, S., Smyth, J. W. P., Shaw, R. M., DiMaio, J. M., & Srivastava, D. (2008) · Circulation

Cardiac Ischemia and ReperfusionCardiac Fibrosis and Remodeling

Cited by 237

Human Disease Modeling Reveals Integrated Transcriptional and Epigenetic Mechanisms of NOTCH1 Haploinsufficiency

Theodoris, C. V., Li, M., White, M. P., Liu, L., He, D., Pollard, K. S., Bruneau, B. G., & Srivastava, D. (2015) · Cell

Genomics and Chromatin DynamicsCardiac Valve Diseases and Treatments

Cited by 210

Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation

Stratton, M. S., Bagchi, R. A., Felisbino, M. B., Hirsch, R. A., Smith, H. E., Riching, A. S., Enyart, B. Y., Koch, K. A., Cavasin, M. A., Alexanian, M., et al. (2019) · Circulation Research

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 179

Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics

Congenital heart defects researchCongenital limb and hand anomalies

Cited by 170

Chromatin remodelling drives immune cell–fibroblast communication in heart failure

Alexanian, M., Padmanabhan, A., Nishino, T., Travers, J. G., Ye, L., Pelonero, A., Lee, C. Y., Sadagopan, N., Huang, Y., Auclair, K., et al. (2024) · Nature

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 140

RNA Sequencing of Mouse Sinoatrial Node Reveals an Upstream Regulatory Role for Islet-1 in Cardiac Pacemaker Cells

Vedantham, V., Galang, G., Evangelista, M., Deo, R. C., & Srivastava, D. (2015) · Circulation Research

Cardiac electrophysiology and arrhythmiasCongenital heart defects research

Cited by 117

Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease

Theodoris, C. V., Zhou, P., Liu, L., Zhang, Y., Nishino, T., Huang, Y., Kostina, A., Ranade, S. S., Gifford, C. A., Uspenskiy, V., et al. (2021) · Science

Computational Drug Discovery MethodsGene Regulatory Network Analysis

Cited by 105

Fibronectin mediates mesendodermal cell fate decisions

Cheng, P., Andersen, P., Hassel, D., Kaynak, B. L., Limphong, P., Juergensen, L., Kwon, C., & Srivastava, D. (2013) · Development

Developmental Biology and Gene RegulationPluripotent Stem Cells Research

Cited by 65

Association of Damaging Variants in Genes With Increased Cancer Risk Among Patients With Congenital Heart Disease

Morton, S. U., Shimamura, A., Newburger, P. E., Opotowsky, A. R., Quiat, D., Pereira, A. C., Jin, S. C., Gurvitz, M., Brueckner, M., Chung, W. K., et al. (2021) · JAMA Cardiology

Congenital Heart Disease StudiesGenomics and Rare Diseases

Cited by 62

BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes

Padmanabhan, A., Alexanian, M., Linares-Saldana, R., González-Terán, B., Andreoletti, G., Huang, Y., Connolly, A. J., Kim, W., Hsu, A., Duan, Q., et al. (2020) · Circulation

Protein Degradation and InhibitorsCongenital heart defects research

Cited by 60

Japanese encephalitis (JE) part II: 14 Years’ follow-up of survivors

Sarkari, N. B. S., Thacker, A. K., Barthwal, S. P., Mishra, V. K., Prapann, S., Srivastava, D., & Sarkari, M. (2012) · Journal of Neurology

Infectious Encephalopathies and EncephalitisMosquito-borne diseases and control

Cited by 45

Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects

Edwards, J. J., Rouillard, A. D., Fernandez, N. F., Wang, Z., Lachmann, A., Shankaran, S. S., Bisgrove, B. W., Demarest, B., Turan, N., Srivastava, D., et al. (2020) · JACC: Basic to Translational Science

Congenital heart defects researchCardiomyopathy and Myosin Studies

Cited by 27