Cited by 267Protein Degradation and InhibitorsCardiac Fibrosis and RemodelingHeart Failure Treatment and Management

BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure

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Duan, Qiming, McMahon, Sarah, Anand, Priti, Shah, Hirsh, Thomas, Sean, Salunga, Hazel T., Huang, Yu, Zhang, Rongli +7 more·2017·Science Translational Medicine

Abstract

BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.

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Crossref · 10.1126/scitranslmed.aah5084

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  1. [62]National Research Council Guide for the Care and Use of Laboratory Animals National Acadmies Press 8 2011 21595115

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Authors
Duan, Q., McMahon, S., Anand, P., Shah, H., Thomas, S., Salunga, H. T., Huang, Y., Zhang, R., Sahadevan, A., Lemieux, M. E., Brown, J. D., Srivastava, D., Bradner, J. E., McKinsey, T. A., & Haldar, S. M.
Affiliations
  • Gladstone Institutes (US)
  • University Hospitals of Cleveland (US)
  • 1QBit (CA)
  • Vanderbilt University (US)
  • Harvard University (US)
  • University of Colorado Anschutz (US)
Corresponding author
  • Duan, Qiming
  • McMahon, Sarah
  • Haldar, Saptarsi M.
Venue
Science Translational Medicine
Published
2017-05-17
Volume
9
Issue
390
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2616008841
Cited by
262
References
70
Citations by year
2026: 21 · 2025: 23 · 2024: 20 · 2023: 28 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 33 · 2018: 23 · 2017: 8
FWCI
11.16
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Heart, Lung, and Blood Institute (award298115, HL116848, award298112, HL127240)
  • National Institute of Diabetes and Digestive and Kidney Diseases (award298116, DK093821)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
Keywords
heart failure, BET bromodomain inhibition, BRD4, JQ1, epigenetic therapy, cardiac hypertrophy, NF-κB signaling, TGF-beta signaling, myocarditis, myocardial fibrosis, pressure overload, myocardial infarction, iPSC-derived cardiomyocytes, chromatin regulation, gene regulatory networks
MeSH terms
Bromodomain Containing Proteins, Animals, Azepines, Cardiomegaly, Heart Failure, Humans, Inflammation, Male, Mice, Inbred C57BL, Proteins, Triazoles, Signal Transduction, Transforming Growth Factor beta, NF-kappa B, Myocytes, Cardiac, Mice, Gene Regulatory Networks, Induced Pluripotent Stem Cells

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