BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure
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BET bromodomain inhibition treats heart failure by blocking innate inflammatory and profibrotic gene networks.
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In mice with pressure-overload heart failure, BET inhibition with JQ1 strongly protected left ventricular ejection fraction.
“BET inhibition exerted a strong protective effect on left ventricular ejection fraction (Fig. 1B)4,6-10.”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [8]
BET proteins act as transcriptional co-activators, and their inhibition is linked to protection in heart failure models.
“As BET proteins are transcriptional co-activators and their inhibition is associated with protection in heart failure models6-8”
From Chromatin remodelling drives immune cell–fibroblast communication in heart failure (2024) · cites this paper as [8]
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- Authors
- Duan, Q., McMahon, S., Anand, P., Shah, H., Thomas, S., Salunga, H. T., Huang, Y., Zhang, R., Sahadevan, A., Lemieux, M. E., Brown, J. D., Srivastava, D., Bradner, J. E., McKinsey, T. A., & Haldar, S. M.
- Affiliations
- Gladstone Institutes (US)
- University Hospitals of Cleveland (US)
- 1QBit (CA)
- Vanderbilt University (US)
- Harvard University (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Duan, Qiming
- McMahon, Sarah
- Haldar, Saptarsi M.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2017-05-17
- Volume
- 9
- Issue
- 390
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC5544253
- OpenAlex
- W2616008841
- Cited by
- 262
- References
- 70
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 20 · 2023: 28 · 2022: 32 · 2021: 36 · 2020: 36 · 2019: 33 · 2018: 23 · 2017: 8
- FWCI
- 11.16
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-02-19)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (award298115, HL116848, award298112, HL127240)
- National Institute of Diabetes and Digestive and Kidney Diseases (award298116, DK093821)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Keywords
- heart failure, BET bromodomain inhibition, BRD4, JQ1, epigenetic therapy, cardiac hypertrophy, NF-κB signaling, TGF-beta signaling, myocarditis, myocardial fibrosis, pressure overload, myocardial infarction, iPSC-derived cardiomyocytes, chromatin regulation, gene regulatory networks
- MeSH terms
- Bromodomain Containing Proteins, Animals, Azepines, Cardiomegaly, Heart Failure, Humans, Inflammation, Male, Mice, Inbred C57BL, Proteins, Triazoles, Signal Transduction, Transforming Growth Factor beta, NF-kappa B, Myocytes, Cardiac, Mice, Gene Regulatory Networks, Induced Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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