Lucassen, Paul J.

Effects of early-life stress on cognitive function and hippocampal structure in female rodents.

Loi, M., Mossink, J. C. L., Meerhoff, G. F., Den Blaauwen, J. L., Lucassen, P. J., & Joëls, M. (2017) · Neuroscience

Stress Responses and CortisolMemory and Neural Mechanisms

Cited by 109

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

Wirths, O., Bethge, T., Marcello, A., Harmeier, A., Jawhar, S., Lucassen, P. J., Multhaup, G., Brody, D. L., Esparza, T., Ingelsson, M., et al. (2010) · Journal of Neural Transmission

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 106

Prefrontal alterations in GABAergic and glutamatergic gene expression in relation to depression and suicide

Zhao, J., Verwer, R. W. H., Gao, S.-F., Qi, X.-R., Lucassen, P. J., Kessels, H. W., & Swaab, D. F. (2018) · Journal of Psychiatric Research

Treatment of Major DepressionSuicide and Self-Harm Studies

Cited by 102

Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice

Marlatt, M. W., Lucassen, P. J., & van Praag, H. (2010) · Brain Research

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 96

Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of Alzheimer’s disease

Marlatt, M. W., Potter, M. C., Bayer, T. A., van Praag, H., & Lucassen, P. J. (2013) · Current Topics in Behavioral Neurosciences

Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 92

Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice

Lesuis, S. L., Weggen, S., Baches, S., Lucassen, P. J., & Krugers, H. J. (2018) · Translational Psychiatry

Alzheimer's disease research and treatmentsStress Responses and Cortisol

Cited by 85

Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics?

Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 85

Prefrontal changes in the glutamate-glutamine cycle and neuronal/glial glutamate transporters in depression with and without suicide

Zhao, J., Verwer, R. W. H., van Wamelen, D. J., Qi, X.-R., Gao, S.-F., Lucassen, P. J., & Swaab, D. F. (2016) · Journal of Psychiatric Research

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 83

Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition

Marlatt, M. W., Bauer, J., Aronica, E., van Haastert, E. S., Hoozemans, J. J. M., Joels, M., & Lucassen, P. J. (2014) · Neural Plasticity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 83

Exposure to chronic early-life stress lastingly alters the adipose tissue, the leptin system and changes the vulnerability to western-style diet later in life in mice

Yam, K. Y., Naninck, E. F. G., Abbink, M. R., la Fleur, S. E., Schipper, L., van den Beukel, J. C., Grefhorst, A., Oosting, A., van der Beek, E. M., Lucassen, P. J., et al. (2017) · Psychoneuroendocrinology

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 78

Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial

Schrantee, A., Tamminga, H. G. H., Bouziane, C., Bottelier, M. A., Bron, E. E., Mutsaerts, H.-J. M. M., Zwinderman, A. H., Groote, I. R., Rombouts, S. A. R. B., Lindauer, R. J. L., et al. (2016) · JAMA Psychiatry

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 77

Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence?

Thompson, A., Boekhoorn, K., Van Dam, A. ‐., & Lucassen, P. J. (2008) · Genes, Brain and Behavior

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 73

Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis

Hu, P., Liu, J., Maita, I., Kwok, C., Gu, E., Gergues, M. M., Kelada, F., Phan, M., Zhou, J.-N., Swaab, D. F., et al. (2020) · The Journal of Neuroscience

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 71

Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats

Klomp, A., Václavů, L., Meerhoff, G. F., Reneman, L., & Lucassen, P. J. (2014) · PLoS ONE

Neurogenesis and neuroplasticity mechanismsTreatment of Major Depression

Cited by 65

Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators

Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience

Neuroendocrine regulation and behaviorStress Responses and Cortisol

Cited by 53

Early-life stress alters affective behaviors in adult mice through persistent activation of CRH-BDNF signaling in the oval bed nucleus of the stria terminalis

Hu, P., Maita, I., Phan, M. L., Gu, E., Kwok, C., Dieterich, A., Gergues, M. M., Yohn, C. N., Wang, Y., Zhou, J.-N., et al. (2020) · Translational Psychiatry

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 49

Long-term oral methylphenidate treatment in adolescent and adult rats: differential effects on brain morphology and function

van der Marel, K., Klomp, A., Meerhoff, G. F., Schipper, P., Lucassen, P. J., Homberg, J. R., Dijkhuizen, R. M., & Reneman, L. (2014) · Neuropsychopharmacology

Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on Behavior

Cited by 42

Exploration of the Gut–Brain Axis through Metabolomics Identifies Serum Propionic Acid Associated with Higher Cognitive Decline in Older Persons

Neuffer, J., González-Domínguez, R., Lefèvre-Arbogast, S., Low, D. Y., Driollet, B., Helmer, C., Du Preez, A., de Lucia, C., Ruigrok, S. R., Altendorfer, B., et al. (2022) · Nutrients

Gut microbiota and healthDementia and Cognitive Impairment Research

Cited by 40

Changes in glial gene expression in the prefrontal cortex in relation to major depressive disorder, suicide and psychotic features

Zhang, L., Verwer, R. W. H., Zhao, J., Huitinga, I., Lucassen, P. J., & Swaab, D. F. (2021) · Journal of Affective Disorders

Treatment of Major DepressionTryptophan and brain disorders

Cited by 40

Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer’s disease

Lemmens, M. A. M., Sierksma, A. S. R., Rutten, B. P. F., Dennissen, F., Steinbusch, H. W. M., Lucassen, P. J., & Schmitz, C. (2011) · Brain Structure and Function

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 37

Hippocampal proliferation is increased in presymptomatic Parkinson’s disease and due to microglia

Doorn, K. J., Drukarch, B., van Dam, A.-M., & Lucassen, P. J. (2014) · Neural Plasticity

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 24

microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients

Penning, A., Snoeck, S., Ormaechea, O. R., Ayyildiz, D., Polzer, O., Buitrago-Arango, M., Capobianco, R., de Winter, F., Balusu, S., Verhaagen, J., et al. (2026) · Acta Neuropathologica Communications

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 6