Lucassen, Paul J.

The stress system in the human brain in depression and neurodegeneration

Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews

Stress Responses and CortisolNeuroendocrine regulation and behavior

Cited by 984

Human Adult Neurogenesis: Evidence and Remaining Questions

Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., et al. (2018) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 790

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 516

Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action☆

Lucassen, P. J., Meerlo, P., Naylor, A. S., van Dam, A. M., Dayer, A. G., Fuchs, E., Oomen, C. A., & Czéh, B. (2010) · European Neuropsychopharmacology

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 449

What causes the hippocampal volume decrease in depression?: Are neurogenesis, glial changes and apoptosis implicated?

Czéh, B., & Lucassen, P. J. (2007) · European Archives of Psychiatry and Clinical Neuroscience

Stress Responses and CortisolNeurogenesis and neuroplasticity mechanisms

Cited by 419

Chronic stress: Implications for neuronal morphology, function and neurogenesis

Joëls, M., Karst, H., Krugers, H. J., & Lucassen, P. J. (2007) · Frontiers in Neuroendocrinology

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 381

Effects of Chronic Stress on Structure and Cell Function in Rat Hippocampus and Hypothalamus

Joëls, M., Karst, H., Alfarez, D., Heine, V. M., Qin, Y., Riel, E. V., Verkuyl, M., Lucassen, P. J., & Krugers, H. J. (2004) · Stress

Stress Responses and CortisolMemory and Neural Mechanisms

Cited by 330

Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activation

Heine, V. M., Maslam, S., Joëls, M., & Lucassen, P. J. (2004) · Neurobiology of Aging

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 318

Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible

Heine, V. M., Maslam, S., Zareno, J., Joëls, M., & Lucassen, P. J. (2004) · European Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 317

Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

Marlatt, M. W., Potter, M. C., Lucassen, P. J., & van Praag, H. (2012) · Developmental Neurobiology

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 314

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

Doorn, K. J., Moors, T., Drukarch, B., van de Berg, W. D., Lucassen, P. J., & van Dam, A.-M. (2014) · Acta Neuropathologica Communications

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 254

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus

Müller, M. B., Lucassen, P. J., Yassouridis, A., Hoogendijk, W. J. G., Holsboer, F., & Swaab, D. F. (2001) · European Journal of Neuroscience

Stress Responses and CortisolTreatment of Major Depression

Cited by 249

Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression

Heine, V. M., Zareno, J., Maslam, S., Joëls, M., & Lucassen, P. J. (2005) · European Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsAngiogenesis and VEGF in Cancer

Cited by 225

PrP Deposition, Microglial Activation, and Neuronal Apoptosis in Murine Scrapie

Williams, A., Lucassen, P. J., Ritchie, D., & Bruce, M. (1997) · Experimental Neurology

Prion Diseases and Protein MisfoldingNeuroinflammation and Neurodegeneration Mechanisms

Cited by 204

Early-life stress mediated modulation of adult neurogenesis and behavior

Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012) · Behavioural Brain Research

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 194

Opposite effects of early maternal deprivation on neurogenesis in male versus female rats

Oomen, C. A., Girardi, C. E. N., Cahyadi, R., Verbeek, E. C., Krugers, H., Joëls, M., & Lucassen, P. J. (2009) · PLoS ONE

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 190

Regulation of adult neurogenesis and plasticity by (early) stress, glucocorticoids, and inflammation.

Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015) · Cold Spring Harbor Perspectives in Biology

Neurogenesis and neuroplasticity mechanismsStress Responses and Cortisol

Cited by 166

Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment

Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 155

Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?

Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 150

Glucocorticoid receptor protein expression in human hippocampus; stability with age

Wang, Q., Van Heerikhuize, J., Aronica, E., Kawata, M., Seress, L., Joels, M., Swaab, D. F., & Lucassen, P. J. (2013) · Neurobiology of Aging

Stress Responses and CortisolNeuroscience and Neuropharmacology Research

Cited by 144

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model

Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2017) · Brain, Behavior, and Immunity

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 138

Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator

Zalachoras, I., Houtman, R., Atucha, E., Devos, R., Tijssen, A. M. I., Hu, P., Lockey, P. M., Datson, N. A., Belanoff, J. K., Lucassen, P. J., et al. (2013) · Proceedings of the National Academy of Sciences

Stress Responses and CortisolEstrogen and related hormone effects

Cited by 121

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

Christensen, D. Z., Schneider-Axmann, T., Lucassen, P. J., Bayer, T. A., & Wirths, O. (2010) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 120

Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin

Verwer, R. W. H., Sluiter, A. A., Balesar, R. A., Baayen, J. C., Noske, D. P., Dirven, C. M. F., Wouda, J., van Dam, A. M., Lucassen, P. J., & Swaab, D. F. (2007) · Brain

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 118