Cited by 53Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Early life adversity and adult social behavior: focus on arginine vasopressin and oxytocin as potential mediators

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Kompier, Nine F., Keysers, Christian, Gazzola, Valeria, Lucassen, Paul J., Krugers, Harmen J.·2019·Frontiers in Behavioral Neuroscience

Abstract

Exposure to stress during the early postnatal period (i.e., early life stress, ES) can impact brain physiology and modify individual variability in adult social behavior. Arginine vasopressin (AVP) and oxytocin (OXT) are two centrally released neuropeptides that are involved in shaping essential social behaviors, like aggression, social recognition, and social motivation. AVP and OXT modulate activity in brain regions important for the establishment of social behavior, and may be particularly sensitive to ES. In this review, we discuss whether ES alters the characteristics of the AVP- and OXT- systems in rodents, and whether these changes are associated with later alterations in aggression, social recognition, and social motivation. We have integrated causal studies indicating that (1) ES affects AVP/OXT, and (2) that changing AVP/OXT in affected regions alters social behavior. Although there is encouraging evidence that ES causes AVP- and OXT-system changes, and that these may mediate social behavior, a comprehensive understanding of the exact nature of AVP- and OXT changes and whether they are causal in establishing these behavioral disturbances needs further investigation. As there are indications that ES alters AVP- and OXT characteristics in humans as well, and that these may interact with adult predisposition to psychopathology with social dysfunction, future rodent studies may lay ground for a better understanding of such changes in humans. Ultimately, this may assist in developing therapeutic strategies to target ES effects on social behavior.

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  • Early life stress significantly impacted the oxytocinergic system in brain regions associated with social behavior, suggesting similar connections in humans.

    “Integrating causal animal studies, the researchers found that early life stress significantly impacted the oxytocinergic system in brain regions associated with social behavior and suggested similar connections in humans.”

    From The evolved nest, oxytocin functioning, and prosocial development (2023) · cites this paper as Kompier et al. (2019)

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Authors
Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J.
Affiliations
  • Netherlands Institute for Neuroscience (NL)
  • University of Amsterdam (NL)
Corresponding author
  • Kompier, Nine F.
  • Krugers, Harmen J.
Venue
Frontiers in Behavioral Neuroscience
Published
2019-07-26
Volume
13
Pages
143-143
ISSN
1662-5153 (ISSN-L)
OpenAlex
W2962706904
Cited by
53
References
181
Citations by year
2026: 4 · 2025: 7 · 2024: 1 · 2023: 9 · 2022: 11 · 2021: 14 · 2020: 7
FWCI
1.24
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
  • KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • UvA-DARE (University of Amsterdam) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
childhood adversity, early life stress, vasopressin, oxytocin, social behavior, aggression, social recognition, social motivation, neuropeptides, postpartum stress, rodent models, social dysfunction, psychopathology

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