Cited by 74

The Evolving Biology of Microglia in Alzheimer's Disease

Malm, Tarja M., Jay, Taylor R., Landreth, Gary E.·2015·Neurotherapeutics

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s13311-014-0316-8

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Dysregulation of microglia functions contributes to the pathogenesis of neurodegenerative diseases including Alzheimer's disease, Parkinson's disease and Huntington's disease.

    “Dysregulation of microglia functions contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD) (6–8), Parkinson’s disease (PD) (9–12) and Huntington’s disease (HD) (13–15).”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Part of this paper’s reference list could not be split into single entries.

Flagged first, then by citations

Research works printed but not linked: 66

  1. Alliot F, Godin I, Pessac B. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res 1999;117:145-152.
  2. Ginhoux F, Greter M, Leboeuf M, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 2010;330:841-845.
  3. Nimmerjahn A, Kirchhoff F, Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005;308:1314-1318.
  4. Davalos D, Grutzendler J, Yang G, et al. ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005;8:752-758.
  5. Ransohoff RM, Stevens B. Neuroscience. How many cell types does it take to wire a brain? Science 2011;333:1391-1392.
  6. Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009;29: 3974-3980.
  7. McGeer PL, Rogers J. Anti-inflammatory agents as a therapeutic approach to Alzheimer's disease. Neurology 1992;42:447-449.
  8. Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with alzheimer's disease. Glia 1999;25:324-331.
  9. Mackenzie IR, Hao C, Munoz DG. Role of microglia in senile plaque formation. Neurobiol Aging 1995;16:797-804.
  10. Ferrera D, Mazzaro N, Canale C, Gasparini L. Resting microglia react to Abeta42 fibrils but do not detect oligomers or oligomer- induced neuronal damage. Neurobiol Aging 2014;35:2444-2457.
  11. Hanzel CE, Pichet-Binette A, Pimentel LS, et al. Neuronal driven pre-plaque inflammation in a transgenic rat model of alzheimer's disease. Neurobiol Aging 2014;35:2249-2262.
  12. Bolmont T, Haiss F, Eicke D, et al. Dynamics of the microglial/ amyloid interaction indicate a role in plaque maintenance. J Neurosci 2008;28:4283-4292.
  13. Blasko I, Veerhuis R, Stampfer-Kountchev M, Saurwein-Teissl M, Eikelenboom P, Grubeck-Loebenstein B. Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes. Neurobiol Dis 2000;7:682-689.
  14. Hong HS, Hwang EM, Sim HJ, et al. Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes. Biochem Biophys Res Commun 2003;307:922-927.
  15. Chung H, Brazil MI, Soe TT, Maxfield FR. Uptake, degradation, and release of fibrillar and soluble forms of alzheimer's amyloid beta-peptide by microglial cells. J Biol Chem 1999;274:32301- 32308.
  16. Koenigsknecht-Talboo J, Landreth GE. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 2005;25:8240- 8249.
  17. Boddeke EW, Meigel I, Frentzel S, et al. Cultured rat microglia express functional beta-chemokine receptors. J Neuroimmunol 1999;98:176-184.
  18. Guillot-Sestier MV, Town T. Innate immunity in Alzheimer's disease: A complex affair. CNS Neurol Disord Drug Targets 2013;12:593-607.
  19. Oddo S, Caccamo A, Shepherd JD, et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular abeta and synaptic dysfunction. Neuron 2003;39:409-421.
  20. Jankowsky JL, Fadale DJ, Anderson J, et al. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: Evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet 2004;13:159-170.
  21. Ishizuka K, Kimura T, Igata-yi R, Katsuragi S, Takamatsu J, Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin Neurosci 1997;51:135-138.
  22. El Khoury J, Toft M, Hickman SE, et al. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer- like disease. Nat Med 2007;13:432-438.
  23. El Khoury JB, Moore KJ, Means TK, et al. CD36 mediates the innate host response to beta-amyloid. J Exp Med 2003;197:1657- 1666.
  24. Wilkinson K, El Khoury J. Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. Int J Alzheimers Dis 2012;2012:489456.
  25. Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci 2003;23:2665-2674.
  26. McDonald DR, Bamberger ME, Combs CK, Landreth GE. Beta- amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J Neurosci 1998;18: 4451-4460.
  27. Alarcon R, Fuenzalida C, Santibanez M, von Bernhardi R. Expression of scavenger receptors in glial cells. comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid. J Biol Chem 2005;280:30406-30415.
  28. Chung H, Brazil MI, Irizarry MC, Hyman BT, Maxfield FR. Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice. Neuroreport 2001;12:1151-1154.
  29. Landreth GE, Reed-Geaghan EG. Toll-like receptors in Alzheimer's disease. Curr Top Microbiol Immunol 2009;336:137-153.
  30. Reed-Geaghan EG, Reed QW, Cramer PE, Landreth GE. Deletion of CD14 attenuates Alzheimer's disease pathology by influencing the brain's inflammatory milieu. J Neurosci 2010;30:15369-15373.
  31. Cameron B, Tse W, Lamb R, Li X, Lamb BT, Landreth GE. Loss of interleukin receptor-associated kinase 4 signaling suppresses amy- loid pathology and alters microglial phenotype in a mouse model of Alzheimer's disease. J Neurosci 2012;32:15112-15123.
  32. Koenigsknecht J, Landreth G. Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism. J Neurosci 2004;24:9838-9846.
  33. Gallardo-Soler A, Gomez-Nieto C, Campo ML, et al. Arginase I induction by modified lipoproteins in macrophages: A peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity. Mol Endocrinol 2008;22: 1394-1402.
  34. Szanto A, Balint BL, Nagy ZS, et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene ex- pression in macrophages and dendritic cells. Immunity 2010;33: 699-712.
  35. Escribano L, Simon AM, Gimeno E, et al. Rosiglitazone rescues memory impairment in alzheimer's transgenic mice: Mechanisms i n v o l v i n g a r e d u c e d a m y l o i d a n d t a u p a t y. Neuropsychopharmacology 2010;35:1593-1604.
  36. Pedersen WA, McMillan PJ, Kulstad JJ, Leverenz JB, Craft S, Haynatzki GR. Rosiglitazone attenuates learning and memory def- icits in Tg2576 Alzheimer mice. Exp Neurol 2006;199:265-273.
  37. Mukundan L, Odegaard JI, Morel CR, et al. PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med 2009;15:1266-1272.
  38. A-Gonzalez N, Bensinger SJ, Hong C, et al. Apoptotic cells pro- mote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 2009;31:245-258.
  39. Glass CK, Saijo K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol 2010;10:365-376.
  40. Kalinin S, Richardson JC, Feinstein DL. A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. Curr Alzheimer Res 2009;6: 431-437.
  41. Nixon RA, Wegiel J, Kumar A, et al. Extensive involvement of autophagy in alzheimer disease: An immuno-electron microscopy study. J Neuropathol Exp Neurol 2005;64:113-122.
  42. Pickford F, Masliah E, Britschgi M, et al. The autophagy-related protein beclin 1 shows reduced expression in early alzheimer dis- ease and regulates amyloid beta accumulation in mice. J Clin Invest 2008;118:2190-2199.
  43. Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE. CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimu- lated microglial activation. J Neurosci 2009;29:11982-11992.
  44. Richard KL, Filali M, Prefontaine P, Rivest S. Toll-like receptor 2 acts as a natural innate immune receptor to clear amyloid beta 1-42 and delay the cognitive decline in a mouse model of Alzheimer's disease. J Neurosci 2008;28:5784-5793.
  45. Yang CN, Shiao YJ, Shie FS, et al. Mechanism mediating oligo- meric Abeta clearance by naive primary microglia. Neurobiol Dis 2011;42:221-230.
  46. Knauer MF, Soreghan B, Burdick D, Kosmoski J, Glabe CG. Intracellular accumulation and resistance to degradation of the alzheimer amyloid A4/beta protein. Proc Natl Acad Sci U S A 1992;89:7437-7441.
  47. Konishi A, Arakawa S, Yue Z, Shimizu S. Involvement of beclin 1 in engulfment of apoptotic cells. J Biol Chem 2012;287:13919- 13929.
  48. Deretic V, Levine B. Autophagy, immunity, and microbial adapta- tions. Cell Host Microbe 2009;5:527-549.
  49. Todde V, Veenhuis M, van der Klei IJ. Autophagy: Principles and significance in health and disease. Biochim Biophys Acta 2009;1792:3-13.
  50. Suzuki K, Kirisako T, Kamada Y, Mizushima N, Noda T, Ohsumi Y. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J 2001;20:5971-5981.
  51. Jounai N, Kobiyama K, Shiina M, Ogata K, Ishii KJ, Takeshita F. NLRP4 negatively regulates autophagic processes through an asso- ciation with beclin1. J Immunol 2011;186:1646-1655.
  52. Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T. Regulation of amyloid precursor protein processing by the beclin 1 complex. PLoS One 2010;5:e11102.
  53. Parton RG, Richards AA. Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms. Traffic 2003;4:724-738.
  54. Conner SD, Schmid SL. Regulated portals of entry into the cell. Nature 2003;422:37-44.
  55. Mandrekar S, Jiang Q, Lee CY, Koenigsknecht-Talboo J, Holtzman DM, Landreth GE. Microglia mediate the clearance of soluble abeta through fluid phase macropinocytosis. J Neurosci 2009;29:4252- 4262.
  56. Varvel NH, Grathwohl SA, Baumann F, et al. Microglial repopula- tion model reveals a robust homeostatic process for replacing CNS myeloid cells. Proc Natl Acad Sci U S A 2012;109:18150-18155.
  57. Parkhurst CN, Yang G, Ninan I, et al. Microglia promote learning- dependent synapse formation through brain-derived neurotrophic factor. Cell 2013;155:1596-1609.
  58. Giulian D, Haverkamp LJ, Yu JH, et al. Specific domains of beta- amyloid from alzheimer plaque elicit neuron killing in human microglia. J Neurosci 1996;16:6021-6037.
  59. Bhaskar K, Maphis N, Xu G, et al. Microglial derived tumor necrosis factor-alpha drives Alzheimer's disease-related neuronal cell cycle events. Neurobiol Dis 2014;62:273-285.
  60. Jung S, Aliberti J, Graemmel P, et al. Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluo- rescent protein reporter gene insertion. Mol Cell Biol. 2000;20: 4106-4114
  61. Nishiyori A, Minami M, Ohtani Y, et al. Localization of fractalkine and CX3CR1 mRNAs in rat brain: Does fractalkine play a role in signaling from neuron to microglia? FEBS Lett 1998;429:167-172.
  62. Harrison JK, Jiang Y, Chen S, et al. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci U S A 1998;95:10896-10901.
  63. Haskell CA, Cleary MD, Charo IF. Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. rapid flow arrest of CX3CR1-expressing cells is independent of G- protein activation. J Biol Chem 1999;274:10053-10058.
  64. Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB. Characterization of fractalkine in rat brain cells: Migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 1999;163:1628-1635.
  65. Hatori K, Nagai A, Heisel R, Ryu JK, Kim SU. Fractalkine and fractalkine receptors in human neurons and glial cells. J Neurosci Res 2002;69:418-426.
  66. Fuhrmann M, Bittner T, Jung CK, et al. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci 2010;13:411-413.

Cited by

Sorted by citations

Authors
Malm, T. M., Jay, T. R., & Landreth, G. E.
Venue
Neurotherapeutics
Publisher
Elsevier BV
Published
2015-01
Volume
12
Issue
1
Pages
81-93
ISSN
1878-7479
Cited by
74
References
43
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review