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Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases

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Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures

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Tsix–Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function

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Death receptor 6 (DR6) antagonist antibody is neuroprotective in the mouse SOD1G93A model of amyotrophic lateral sclerosis

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A systems-approach to NAD+ restoration

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P7C3‐A20 alleviates fatty liver by shaping gut microbiota and inducing FGF21/FGF1, via the AMP‐activated protein kinase/CREB regulated transcription coactivator 2 pathway

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Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)

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P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo

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Systemic administration of 2‐hydroxypropyl‐β‐cyclodextrin to symptomatic Npc1‐deficient mice slows cholesterol sequestration in the major organs and improves liver function

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Neurotherapeutic capacity of P7C3 agents for the treatment of Traumatic Brain Injury

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Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis

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P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death in vitro and in vivo

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Stemistry: the control of stem cells in situ using chemistry.

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NAD+ Metabolism and Diseases with Motor Dysfunction

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P7C3 Attenuates the Scopolamine-Induced Memory Impairments in C57BL/6J Mice

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Multipharmacophore strategy in medicinal chemistry for the design of drugs for the treatment of Alzheimer’s and some other neurodegenerative diseases

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Chronic P7C3 treatment restores hippocampal neurogenesis

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Neuroregeneration Versus Neurodegeneration: Toward a Paradigm Shift in Alzheimer'S Disease Drug Discovery

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Modeling Retinal Dystrophies Using Patient-Derived Induced Pluripotent Stem Cells

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Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats

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Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1G93A Amyotrophic Lateral Sclerosis

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GSK-3 inhibition through GLP-1R allosteric activation mediates the neurogenesis promoting effect of P7C3 after cerebral ischemic/reperfusional injury in mice

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Application of P7C3 Compounds to Investigating and Treating Acute and Chronic Traumatic Brain Injury

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Discovery of a novel multifunctional carbazole–aminoquinoline dimer for Alzheimer's disease: copper selective chelation, anti-amyloid aggregation, and neuroprotection

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The effect of NAMPT deletion in projection neurons on the function and structure of neuromuscular junction (NMJ) in mice

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Cacna1c: Protecting young hippocampal neurons in the adult brain

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Effects of Carbazole Derivatives on Neurite Outgrowth and Hydrogen Peroxide-Induced Cytotoxicity in Neuro2a Cells

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Pharmacologic reversal of advanced Alzheimer’s disease in mice and identification of potential therapeutic nodes in human brain

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Anti-inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss

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Maternal P7C3-A20 Treatment Protects Offspring from Neuropsychiatric Sequelae of Prenatal Stress

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Nanotechnology‐empowered therapeutics targeting neurodegenerative diseases

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Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

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Growth Differentiation Factor 6 As a Putative Risk Factor in Neuromuscular Degeneration

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Gamma-Carbolines Derivatives As Promising Agents for the Development of Pathogenic Therapy for Proteinopathy

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The Neurogenic Compound P7C3 Regulates the Aerobic Glycolysis by Targeting Phosphoglycerate Kinase 1 in Glioma

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MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers

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Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain

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Nicotinamide Adenine Dinucleotide (NAD + )-Dependent Signaling in Neurological Disorders

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An Aminopropyl Carbazole Derivative Induces Neurogenesis by Increasing Final Cell Division in Neural Stem Cells

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P7C3 suppresses astrocytic senescence to protect dopaminergic neurons: Implication in the mouse model of Parkinson’s disease

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Neuroprotective effects of P7C3 against spinal cord injury in rats

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Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease

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Potential Therapeutic Interventions Targeting NAD+ Metabolism for ALS

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The Small Molecule P7C3-A20 Exerts Neuroprotective Effects in a Hypoxic–ischemic Encephalopathy Model via Activation of PI3K/AKT/GSK3β Signaling

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A bioisostere of Dimebon/Latrepirdine delays the onset and slows the progression of pathology in FUS transgenic mice

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Gait-level analysis of mouse open field behavior using deep learning-based pose estimationPreprint

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YangXueQingNaoWan attenuated blood brain barrier disruption after thrombolysis with tissue plasminogen activator in ischemia stroke

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Dietary NMN supplementation enhances motor and NMJ function in ALS

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Protective effect of P7C3 on retinal ganglion cells from optic nerve injury

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P7C3-A20 neuroprotection is independent of Wallerian degeneration in primary neuronal culture

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Potential Parkinson disease and ALS drug

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Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease

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Novel route to neuroprotection

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Discovery of a Neuroprotective Chemical, ( S )- N -(3-(3,6-Dibromo-9 H -carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

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A preliminary study of the neuroprotective effect of dl-3-n-butylphthalide in a transgenic mouse model of amyotrophic lateral sclerosis

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