Metabolic cycles as an underlying basis of biological oscillations.
Abstract
The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.
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The results give support to hypothesized links between metabolic and circadian cycles generated and guided by the circadian pacemaker.
“As they all affect the circadian clockwork, our results herein give support to the hypothesized links between the metabolic and circadian cycles generated and guided by the circadian pacemaker [35].”
From Seasonal changes in mood and behavior are linked to metabolic syndrome (2008) · cites this paper as [35]
Cites
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works
Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P. J., Nishino, S., & Mignot, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81965-0 · Cited by 2,613 · see citing works
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Entrainment of the circadian clock in the liver by feeding
Stokkan, K.-A., Yamazaki, S., Tei, H., Sakaki, Y., & Menaker, M. (2001) · Science · doi:10.1126/science.291.5503.490 · Cited by 1,800 · see citing works
Orchestrated Transcription of Key Pathways in <i>Arabidopsis</i> by the Circadian Clock
Harmer, S. L., Hogenesch, J. B., Straume, M., Chang, H.-S., Han, B., Zhu, T., Wang, X., Kreps, J. A., & Kay, S. A. (2000) · Science · doi:10.1126/science.290.5499.2110 · Cited by 1,640 · see citing works
Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature
Carey, H. V., Andrews, M. T., & Martin, S. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00008.2003 · Cited by 1,145 · see citing works
Metabolic Rate and Body Temperature Reduction During Hibernation and Daily Torpor
Geiser, F. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.115105 · Cited by 1,135 · see citing works
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132 · see citing works
Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro
Nakajima, M., Imai, K., Ito, H., Nishiwaki, T., Murayama, Y., Iwasaki, H., Oyama, T., & Kondo, T. (2005) · Science · doi:10.1126/science.1108451 · Cited by 1,110 · see citing works
Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors
Rutter, J., Reick, M., Wu, L. C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060698 · Cited by 1,059 · see citing works
Self-citationClues to the functions of mammalian sleep
Siegel, J. M. (2005) · Nature · doi:10.1038/nature04285 · Cited by 1,040 · see citing works
Circadian Gene Expression in Individual Fibroblasts
Nagoshi, E., Saini, C., Bauer, C. R., Laroche, T., Naef, F., & Schibler, U. (2004) · Cell · doi:10.1016/j.cell.2004.11.015 · Cited by 1,003 · see citing works
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works
Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes
Tu, B. P., Kudlicki, A. S., Rowicka, M., & McKnight, S. L. (2005) · Science · doi:10.1126/science.1120499 · Cited by 889 · see citing works
Self-citationExtensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627 · see citing works
Microarray Analysis and Organization of Circadian Gene Expression in Drosophila
McDonald, M. J., & Rosbash, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00545-1 · Cited by 606 · see citing works
The Segmentation Clock: Converting Embryonic Time into Spatial Pattern
Pourquié, O. (2003) · Science · doi:10.1126/science.1085887 · Cited by 526 · see citing works
Circadian Regulation of Gene Expression Systems in the Drosophila Head
Claridge‐Chang, A., Wijnen, H., Naef, F., Boothroyd, C. E., Rajewsky, N., & Young, M. W. (2001) · Neuron · doi:10.1016/s0896-6273(01)00515-3 · Cited by 444 · see citing works
NPAS2: A Gas-Responsive Transcription Factor
Dioum, E. M., Rutter, J. P., Tuckerman, J. R., Gonzalez, G., Gilles‐Gonzalez, M., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432 · see citing works
Self-citationStrategy by which nitrogen-fixing unicellular cyanobacteria grow photoautotrophically
Mitsui, A., Kumazawa, S., Takahashi, A., Ikemoto, H., Cao, S., & Arai, T. (1986) · Nature · doi:10.1038/323720a0 · Cited by 416 · see citing works
Metabolism and the Control of Circadian Rhythms
Rutter, J. P., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 401 · see citing works
Self-citationSuprachiasmatic Nucleus: Use of <sup>14</sup> C-Labeled Deoxyglucose Uptake as a Functional Marker
Schwartz, W. J., & Gainer, H. (1977) · Science · doi:10.1126/science.887940 · Cited by 358 · cited 1× · see citing works
“The uptake of 2-deoxyglucose has long been known to be robustly periodic as a function of the day–night cycle in the SC”
BackgroundMori, T., Binder, B. J., & Johnson, C. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10183 · Cited by 332 · see citing works
A genomewide oscillation in transcription gates DNA replication and cell cycle
Klevecz, R. R., Bolen, J., Forrest, G., & Murray, D. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306490101 · Cited by 321 · see citing works
Oscillations of glycolytic intermediates in yeast cells
Ghosh, A. K., & Chance, B. (1964) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(64)90357-2 · Cited by 305 · see citing works
Kong, J., Shepel, P. N., Holden, C. P., Mackiewicz, M., Pack, A. I., & Geiger, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05581.2002 · Cited by 281 · see citing works
Energetics of the budding cycle of Saccharomyces cerevisiae during glucose limited aerobic growth
von Meyenburg, H. K. (1969) · Archives of Microbiology · doi:10.1007/bf00414585 · Cited by 252 · see citing works
DAMPED SINUSOIDAL OSCILLATIONS OF CYTOPLASMIC REDUCED PYRIDINE NUCLEOTIDE IN YEAST CELLS
Chance, B., Estabrook, R. W., & Ghosh, A. K. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.51.6.1244 · Cited by 220 · see citing works
Seasonally hibernating phenotype assessed through transcript screening
Williams, D. R., Epperson, L. E., Li, W., HUGHES, M. A., Taylor, R., Rogers, J., Martin, S. L., Cossins, A. R., & Gracey, A. Y. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00301.2004 · Cited by 185 · see citing works
NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: Genotype and sex interactions
Franken, P., Dudley, C. A., Estill, S. J., Barakat, M. T., Thomason, R. G., O’Hara, B. F., & McKnight, S. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602006103 · Cited by 183 · see citing works
Self-citationOscillatory metabolism ofSaccharomyces cerevisiaein continuous culture
Satroutdinov, A. D., Kuriyama, H., & Kobayashi, H. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05525.x · Cited by 162 · see citing works
Circadian Rhythms in Rapidly Dividing Cyanobacteria
Kondo, T., Mori, T., Lebedeva, N. V., Aoki, S., Ishiura, M., & Golden, S. S. (1997) · Science · doi:10.1126/science.275.5297.224 · Cited by 159 · see citing works
Sleep as neuronal detoxification and restitution
Inoué, S., Honda, K., & Komoda, Y. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00014-k · Cited by 151 · see citing works
Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation
Beuckmann, C. T., & Yanagisawa, M. (2002) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0322-x · Cited by 148 · see citing works
Circadian Rhythm of the Prokaryote Synechococcus sp. RF-1
Huang, T.-C., Tu, J., Chow, T., & Chen, T. (1990) · PLANT PHYSIOLOGY · doi:10.1104/pp.92.2.531 · Cited by 139 · see citing works
The Coevolution of Blue-Light Photoreception and Circadian Rhythms
Gehring, W., & Rosbash, M. (2003) · Journal of Molecular Evolution · doi:10.1007/s00239-003-0038-8 · Cited by 132 · see citing works
Sleep and Circadian Rhythms in Mammalian Torpor
Heller, H. C., & Ruby, N. F. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.115313 · Cited by 124 · see citing works
Mammalian hibernation. Transcriptional and translational controls.
Storey, K. B. (2003) · PubMed · Cited by 123 · see citing works
van Breukelen, F., & Martin, S. L. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01007.2001 · Cited by 122 · see citing works
Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors
Mieda, M. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00331-8 · Cited by 122 · see citing works
Storey, K. B. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-8997-0_3 · Cited by 117 · see citing works
Cyanobacterial circadian clocks — timing is everything
Golden, S. S., & Canales, S. R. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro774 · Cited by 112 · see citing works
Ultradian metronome: timekeeper for orchestration of cellular coherence
Lloyd, D., & Murray, D. B. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.005 · Cited by 112 · see citing works
Epperson, L. E., Dahl, T. A., & Martin, S. L. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400042-mcp200 · Cited by 89 · see citing works
Brain oxidation is an initial process in sleep induction
Ikeda, M., Ikeda‐Sagara, M., Okada, T., Clément, P., Urade, Y., Nagai, T., Sugiyama, T., Yoshioka, T., Honda, K., & Inoue, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.09.057 · Cited by 80 · see citing works
Cyclic AMP mediates the cell cycle dynamics of energy metabolism in Saccharomyces cerevisiae
Müller, D., Exler, S., Aguilera‐Vázquez, L., Guerrero‐Martín, E., & Reuß, M. (2003) · Yeast · doi:10.1002/yea.967 · Cited by 79 · see citing works
Endogenous Timekeepers in Photosynthetic Organisms
Johnson, C. H. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.695 · Cited by 77 · see citing works
Oscillatory reductions of pyridine nucleotides during anaerobic glycolysis in brewers' yeast
Hommes, F. A. (1964) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(64)90352-2 · Cited by 67 · see citing works
Reversible Depression of Oxygen Consumption in Isolated Liver Mitochondria during Hibernation
Martin, S. L., Maniero, G. D., Carey, C., & Hand, S. C. (1999) · Physiological and Biochemical Zoology · doi:10.1086/316667 · Cited by 63 · see citing works
Silljé, H. H. W., ter Schure, E. G., Rommens, A. J. M., Huls, P. G., Woldringh, C. L., Verkleij, A. J., Boonstra, J., & Verrips, C. T. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.21.6560-6565.1997 · Cited by 62 · see citing works
Chance, B., Schoener, B., & Elsaesser, S. (1964) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.52.2.337 · Cited by 61 · see citing works
Glycogen in the brain of Drosophila melanogaster: diurnal rhythm and the effect of rest deprivation
Zimmerman, J. E., Mackiewicz, M., Galante, R. J., Zhang, L., Cater, J. R., Zoh, C., Rizzo, W., & Pack, A. I. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02126.x · Cited by 50 · see citing works
Onai, K., & Nakashima, H. (1997) · Genetics · doi:10.1093/genetics/146.1.101 · Cited by 23 · see citing works
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Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works
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Dyar, K. A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.042 · Cited by 335 · see citing works
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Partonen, T., Treutlein, J., Alpman, A., Frank, J., Johansson, C. H., Depner, M., Aron, L., Rietschel, M., Wellek, S., Soronen, P., et al. (2007) · Annals of Medicine · doi:10.1080/07853890701278795 · Cited by 264 · see citing works
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Tu, B. P., Mohler, R. E., Liu, J. C., Dombek, K. M., Young, E. T., Synovec, R. E., & McKnight, S. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708365104 · Cited by 260 · see citing works
Self-citationExploring phylogeny to find the function of sleep
Anafi, R. C., Kayser, M. S., & Raizen, D. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0098-9 · Cited by 259 · see citing works
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Gracey, A. Y., Chaney, M. L., Boomhower, J. P., Tyburczy, W. R., Connor, K. M., & Somero, G. N. (2008) · Current Biology · doi:10.1016/j.cub.2008.08.049 · Cited by 256 · see citing works
Geyfman, M., Kumar, V., Liu, Q., Ruiz, R., Gordon, W., Espitia, F., Cam, E., Millar, S. E., Smyth, P., Ihler, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209592109 · Cited by 252 · see citing works
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Rosbash, M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000062 · Cited by 239 · see citing works
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Silverman, S. J., Petti, A. A., Slavov, N., Parsons, L. R., Briehof, R., Thiberge, S. Y., Zenklusen, D., Gandhi, S. J., Larson, D. R., Singer, R. H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002422107 · Cited by 96 · see citing works
Radhakrishnan, S. K., Pritchard, S., & Viollier, P. H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.10.024 · Cited by 94 · see citing works
Lévi, F., Filipski, E., Iurisci, I., Li, X. M., & Innominato, P. F. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.030 · Cited by 93 · see citing works
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Cai, L., & Tu, B. P. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010769 · Cited by 84 · see citing works
Self-citationMiles, S., Li, L., Davison, J., & Breeden, L. L. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003854 · Cited by 81 · see citing works
Metabolic cycles in a circannual hibernator
Epperson, L. E., Karimpour‐Fard, A., Hunter, L., & Martin, S. L. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00028.2011 · Cited by 80 · see citing works
Bechtel, W., & Abrahamsen, A. A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-444-52076-0.50009-2 · Cited by 76 · see citing works
Compartmentalized, All-Aqueous Flow-Through-Coordinated Reaction Systems
Xie, G., Forth, J., Chai, Y., Ashby, P. D., Helms, B. A., & Russell, T. P. (2019) · Chem · doi:10.1016/j.chempr.2019.07.016 · Cited by 75 · see citing works
Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity
Fan, L., Hsieh, P. N., Sweet, D. R., & Jain, M. K. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.018 · Cited by 74 · see citing works
Quantum biological tunnel junction for electron transfer imaging in live cells
Xin, H., Sim, W. J., Namgung, B., Choi, Y., Li, B., & Lee, L. P. (2019) · Nature Communications · doi:10.1038/s41467-019-11212-x · Cited by 73 · see citing works
Analysis of the hibernation cycle using LC-MS-based metabolomics in ground squirrel liver
Nelson, C. J., Otis, J. P., Martin, S. L., & Carey, H. V. (2008) · Physiological Genomics · doi:10.1152/physiolgenomics.90323.2008 · Cited by 71 · see citing works
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
Nakada, D., Levi, B. P., & Morrison, S. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.011 · Cited by 70 · see citing works
Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes
Rey, G., Milev, N. B., Valekunja, U. K., Ch, R., Ray, S., dos Santos, M. S., Nagy, A. D., Antrobus, R., MacRae, J. I., & Reddy, A. B. (2018) · Molecular Systems Biology · doi:10.15252/msb.20188376 · Cited by 68 · see citing works
Curie, T., Maret, S., Emmenegger, Y., & Franken, P. (2015) · SLEEP · doi:10.5665/sleep.4974 · Cited by 67 · see citing works
A circadian clock in Saccharomyces cerevisiae
Eelderink-Chen, Z., Mazzotta, G. M., Sturre, M. J. G., Bosman, J., Roenneberg, T., & Merrow, M. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907902107 · Cited by 68 · see citing works
DecodingCaulobacterdevelopment
Kirkpatrick, C. L., & Viollier, P. H. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00309.x · Cited by 67 · see citing works
Marden, J. H. (2013) · Molecular Ecology · doi:10.1111/mec.12534 · Cited by 65 · see citing works
Harbour, V. L., Weigl, Y., Robinson, B., & Amir, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076391 · Cited by 66 · see citing works
Chen, C., Mahar, R., Merritt, M. E., Denlinger, D. L., & Hahn, D. A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017603118 · Cited by 66 · see citing works
Cellular Timekeeping: It’s Redox o’ClockPreprint
Milev, N. B., Rhee, S.-G., & Reddy, A. B. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027698 · Cited by 65 · see citing works
Sleep Counteracts Aging Phenotypes to Survive Starvation-Induced Developmental Arrest in C. elegans
Wu, Y., Masurat, F., Preis, J., & Bringmann, H. (2018) · Current Biology · doi:10.1016/j.cub.2018.10.009 · Cited by 62 · see citing works
Interaction and Regulation Between Lipid Mediator Phosphatidic Acid and Circadian Clock Regulators
Kim, S., Nusinow, D. A., Sorkin, M. L., Pruneda-Paz, J. L., & Wang, X. (2019) · The Plant Cell · doi:10.1105/tpc.18.00675 · Cited by 63 · see citing works
Seasonal changes in mood and behavior are linked to metabolic syndrome
Rintamäki, R., Grimaldi, S., Englund, A., Haukka, J., Partonen, T., Reunanen, A., Aromaa, A., & Lönnqvist, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001482 · Cited by 61 · see citing works
Connecting cellular metabolism to circadian clocks
Rey, G., & Reddy, A. B. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.01.003 · Cited by 60 · see citing works
Kwon, I., Choe, H. K., Son, G. H., & Kim, K. (2011) · Experimental Neurobiology · doi:10.5607/en.2011.20.1.18 · Cited by 56 · see citing works
Ultradian Rhythms from Molecules to Mind
Lloyd, D., & Rossi, E. L. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8352-5 · Cited by 58 · see citing works
Puszynska, A. M., & O’Shea, E. K. (2017) · eLife · doi:10.7554/elife.23210 · Cited by 59 · see citing works
Burnetti, A., Aydın, M., & Buchler, N. E. G. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-07-0454 · Cited by 58 · see citing works
Minireview: Circadian Control of Metabolism by the Suprachiasmatic Nuclei
Kalsbeek, A., Kreier, F., Fliers, E., Sauerwein, H. P., Romijn, J. A., & Buijs, R. M. (2007) · Endocrinology · doi:10.1210/en.2007-0776 · Cited by 58 · see citing works
Genetic Basis of Metabolome Variation in Yeast
Breunig, J. S., Hackett, S. R., Rabinowitz, J. D., & Kruglyak, L. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004142 · Cited by 57 · see citing works
Seizure occurrence is linked to multiday cycles in diverse physiological signals
Gregg, N. M., Attia, T. P., Nasseri, M., Joseph, B., Karoly, P. J., Cui, J., Stirling, R. E., Viana, P. F., Richner, T. J., Nurse, E. S., et al. (2023) · Epilepsia · doi:10.1111/epi.17607 · Cited by 51 · see citing works
Chronic sleep deprivation and seasonality: implications for the obesity epidemic.
Cizza, G., Requena, M., Galli, G., & de Jonge, L. (2011) · PubMed · doi:10.3275/7808 · Cited by 55 · see citing works
The mitochondrial bioenergetic capacity of carcinomas
Formentini, L., Martínez‐Reyes, I., & Cuezva, J. M. (2010) · IUBMB Life · doi:10.1002/iub.352 · Cited by 54 · see citing works
Diversity of KaiC-based timing systems in marine Cyanobacteria
Axmann, I. M. I., Hertel, S., Wiegard, A., Dörrich, A. K., & Wilde, A. (2014) · Marine Genomics · doi:10.1016/j.margen.2013.12.006 · Cited by 55 · see citing works
Beck, C., Hertel, S., Rediger, A., Lehmann, R., Wiegard, A., Kölsch, A., Heilmann, B., Georg, J., Hess, W. R., & Axmann, I. M. I. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01086-14 · Cited by 51 · see citing works
Genetic sleep deprivation: using sleep mutants to study sleep functions
Bringmann, H. (2019) · EMBO Reports · doi:10.15252/embr.201846807 · Cited by 49 · see citing works
Emergence of self-organised oscillatory domains in fungal mycelia
Tlalka, M., Bebber, D. P., Darrah, P. R., Watkinson, S. C., & Fricker, M. D. (2007) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2007.02.013 · Cited by 49 · see citing works
Ultradian metabolic rhythm in the diazotrophic cyanobacterium Cyanothece sp. ATCC 51142
Červený, J., Sinetova, M. A., Valledor, L., Sherman, L. A., & Nedbal, L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301171110 · Cited by 46 · see citing works
Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)**
Rosbash, M. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202015199 · Cited by 46 · see citing works
Brennan, L. M., Widder, M. W., Lee, L. E. J., & van der Schalie, W. H. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.03.010 · Cited by 44 · see citing works
Mellor, J., Woloszczuk, R., & Howe, F. S. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.10.006 · Cited by 44 · see citing works
Hydrogen Peroxide Stimulates Activity and Alters Behavior in Drosophila melanogaster
Grover, D., Ford, D., Brown, C., Hoe, N., Erdem, A. L., Tavaré, S., & Tower, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007580 · Cited by 44 · see citing works
XRCC2 Regulates Replication Fork Progression during dNTP Alterations
Saxena, S., Somyajit, K., & Nagaraju, G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.085 · Cited by 42 · see citing works
Bechtold, D. A. (2008) · Journal of Genetics · doi:10.1007/s12041-008-0067-6 · Cited by 42 · see citing works
EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription
Tao, W., Wu, J., Zhang, Q., Lai, S., Jiang, S., Chen, J., Xu, Y., Xue, B., Du, J., & Li, C. (2015) · Scientific Reports · doi:10.1038/srep15212 · Cited by 41 · see citing works
The Symphony of Life [Chronobiological Investigations]
Moser, M., Frühwirth, M., & Kenner, T. (2008) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/memb.2007.907365 · Cited by 41 · see citing works
The yeast metabolic cycle: insights into the life of a eukaryotic cell
Tu, B. P., & McKnight, S. L. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.019 · Cited by 38 · see citing works
Self-citationTranscription mediated insulation and interference direct gene cluster expression switches
Nguyen, T., Fischl, H., Howe, F. S., Woloszczuk, R., Barros, A. S., Xu, Z., Brown, D., Murray, S. C., Haenni, S., Halstead, J. M., et al. (2014) · eLife · doi:10.7554/elife.03635 · Cited by 40 · see citing works
Tao, W., Chen, S., Shi, G., Guo, J., Xu, Y., & Liu, C. (2011) · Hepatology · doi:10.1002/hep.24514 · Cited by 40 · see citing works
Reinberg, A., Dejardin, L., Smolensky, M. H., & Touitou, Y. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1236807 · Cited by 37 · see citing works
Yeşilkent, E. N., & Ceylan, H. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110111 · Cited by 37 · see citing works
Zhang, W., Wang, P., Chen, S., Zhang, Z., Liang, T., & Liu, C. (2016) · The FASEB Journal · doi:10.1096/fj.201500120 · Cited by 37 · see citing works
Nuclear Receptors: Small Molecule Sensors that Coordinate Growth, Metabolism and Reproduction
Pardee, K., Necakov, A., & Krause, H. M. (2011) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-9069-0_6 · Cited by 37 · see citing works
Tsuchyia, M., Wong, S. T., Yeo, Z. X., Colosimo, A., Palumbo, M. C., Farina, L., Crescenzi, M., Mazzola, A., Negri, R., Bianchi, M. M., et al. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05822.x · Cited by 37 · see citing works
van Alphen, P., & Hellingwerf, K. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127715 · Cited by 34 · see citing works
The molecular basis of metabolic cycles and their relationship to circadian rhythms
Mellor, J. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3311 · Cited by 35 · see citing works
Coordination of cardiac rhythmic output and circadian metabolic regulation in the heart
Hsieh, P. N., Zhang, L., & Jain, M. K. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2606-x · Cited by 34 · see citing works
Mitochondrial control of sleep
Hartmann, C., & Kempf, A. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102733 · Cited by 34 · see citing works
The systemic control of circadian gene expression
Gerber, A., Saini, C., Curie, T., Emmenegger, Y., Rando, G., Gosselin, P., Gotić, I., Gos, P., Franken, P., & Schibler, U. (2015) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12512 · Cited by 33 · see citing works
Global Self-Regulation of the Cellular Metabolic Structure
la Fuente, I. M. D., Vadillo, F., Pérez‐Samartín, A., Pérez-Pinilla, M.-B., Bidaurrazaga, J., & López, A. V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009484 · Cited by 33 · see citing works
- Authors
- Tu, B. P., & McKnight, S. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2006-07-05
- Volume
- 7
- Issue
- 9
- Pages
- 696-701
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2054233487
- Cited by
- 229
- References
- 55
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 13 · 2020: 4 · 2019: 17 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 10
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Bundesministerium für Bildung und Forschung
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- biological oscillations, circadian rhythm, hibernation, sleep-wake cycle, metabolic cycles, metabolic status, Saccharomyces cerevisiae
- MeSH terms
- Animals, Biological Clocks, Circadian Rhythm, Hibernation, Humans, Saccharomyces cerevisiae
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