Cited by 229Circadian rhythm and melatoninPhysiological and biochemical adaptationsGene Regulatory Network Analysis

Metabolic cycles as an underlying basis of biological oscillations.

Tu, Benjamin P., McKnight, Steven L.·2006·Nature Reviews Molecular Cell Biology

Abstract

The evolutionary origins of periodic phenomena in biology, such as the circadian cycle, the hibernation cycle and the sleep-wake cycle, remain a mystery. We discuss the concept of temporal compartmentalization of metabolism that takes place during such cycles, and suggest that cyclic changes in a cell's metabolic state might be a fundamental driving force for such biological oscillations.

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Crossref · 10.1038/nrm1980

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  • The results give support to hypothesized links between metabolic and circadian cycles generated and guided by the circadian pacemaker.

    “As they all affect the circadian clockwork, our results herein give support to the hypothesized links between the metabolic and circadian cycles generated and guided by the circadian pacemaker [35].”

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Authors
Tu, B. P., & McKnight, S. L.
Affiliations
The University of Texas Southwestern Medical Center (US)
Venue
Nature Reviews Molecular Cell Biology
Published
2006-07-05
Volume
7
Issue
9
Pages
696-701
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W2054233487
Cited by
229
References
55
Citations by year
2026: 5 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 13 · 2020: 4 · 2019: 17 · 2018: 9 · 2017: 10 · 2016: 10 · 2015: 11 · 2014: 12 · 2013: 11 · 2012: 10
FWCI
1.70
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Molecular Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • European Commission
  • Bundesministerium für Bildung und Forschung
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
Keywords
biological oscillations, circadian rhythm, hibernation, sleep-wake cycle, metabolic cycles, metabolic status, Saccharomyces cerevisiae
MeSH terms
Animals, Biological Clocks, Circadian Rhythm, Hibernation, Humans, Saccharomyces cerevisiae

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