Manns, Michael P.

A Direct In Vivo RNAi Screen Identifies MKK4 as a Key Regulator of Liver Regeneration

Wuestefeld, T., Pesic, M., Rudalska, R., Dauch, D., Longerich, T., Kang, T.-W., Yevsa, T., Heinzmann, F., Hoenicke, L., Hohmeyer, A., et al. (2013) · Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 149

Concanavalin A—induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice☆☆☆

Trautwein, C., Rakemann, T., Brenner, D. A., Streetz, K., Licato, L., Manns, M. P., & Tiegs, G. (1998) · Gastroenterology

Cell death mechanisms and regulationLiver physiology and pathology

Cited by 147

Coffee Induces Expression of Glucuronosyltransferases by the Aryl Hydrocarbon Receptor and Nrf2 in Liver and Stomach

Kalthoff, S., Ehmer, U., Freiberg, N., Manns, M. P., & Strassburg, C. P. (2010) · Gastroenterology

Genomics, phytochemicals, and oxidative stressPharmacogenetics and Drug Metabolism

Cited by 124

Hyperstimulation With Interleukin 6 Inhibits Cell Cycle Progression After Hepatectomy in Mice

Wüstefeld, T., Rakemann, T., Kubicka, S., Manns, M. P., & Trautwein, C. (2000) · Hepatology

Liver physiology and pathologyCytokine Signaling Pathways and Interactions

Cited by 120

The challenges of primary biliary cholangitis: What is new and what needs to be done

Terziroli Beretta-Piccoli, B., Mieli-Vergani, G., Vergani, D., Vierling, J. M., Adams, D., Alpini, G., Banales, J. M., Beuers, U., Björnsson, E., Bowlus, C., et al. (2019) · Journal of Autoimmunity

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 114

A placebo-controlled randomised trial of budesonide for PBC following an insufficient response to UDCA

Hirschfield, G. M., Beuers, U., Kupcinskas, L., Ott, P., Bergquist, A., Färkkilä, M., Manns, M. P., Parés, A., Spengler, U., Stiess, M., et al. (2021) · Journal of Hepatology

Liver Diseases and ImmunityPediatric Hepatobiliary Diseases and Treatments

Cited by 108

Efficacy of rituximab in difficult-to-manage autoimmune hepatitis: Results from the International Autoimmune Hepatitis Group

Than, N. N., Hodson, J., Schmidt-Martin, D., Taubert, R., Wawman, R. E., Botter, M., Gautam, N., Bock, K., Jones, R., Appanna, G. D., et al. (2019) · JHEP Reports

Liver Diseases and ImmunityIgG4-Related and Inflammatory Diseases

Cited by 101

Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.

StreetZ, K. L., Wüstefeld, T., Klein, C., Kallen, K.-J., Tronche, F., Betz, U. A. K., Schütz, G., Manns, M. P., Müller, W., & Trautwein, C. (2003) · Gastroenterology

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 94

T cell receptor gene rearrangements of T lymphocytes infiltrating the liver in chronic active hepatitis B and primary biliary cirrhosis (PBC): Oligoclonality of PBC‐derived T cell clones

Moebius, U., Manns, M., Hess, G., Kober, G., zum Büschenfelde, K. M., & Meuer, S. C. (1990) · European Journal of Immunology

Liver Diseases and ImmunityHepatitis B Virus Studies

Cited by 93

Norursodeoxycholic acid versus placebo in the treatment of non-alcoholic fatty liver disease: a double-blind, randomised, placebo-controlled, phase 2 dose-finding trial

Traussnigg, S., Schattenberg, J. M., Demir, M., Wiegand, J., Geier, A., Teuber, G., Hofmann, W. P., Kremer, A. E., Spreda, F., Kluwe, J., et al. (2019) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 88

Concanavalin A-induced liver injury triggers hepatocyte proliferation.

Trautwein, C., Rakemann, T., Malek, N. P., Plümpe, J., Tiegs, G., & Manns, M. P. (1998) · Journal of Clinical Investigation

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 87

Low risk of hepatocellular carcinoma in patients with primary sclerosing cholangitis with cirrhosis

Zenouzi, R., Weismüller, T. J., Hübener, P., Schulze, K., Bubenheim, M., Pannicke, N., Weiler–Normann, C., Lenzen, H., Manns, M. P., Lohse, A. W., et al. (2014) · Clinical Gastroenterology and Hepatology

Liver Diseases and ImmunityHepatocellular Carcinoma Treatment and Prognosis

Cited by 86

Treatment with metformin is associated with a prolonged survival in patients with hepatocellular carcinoma

Schulte, L., Scheiner, B., Voigtländer, T., Koch, S., Schweitzer, N., Marhenke, S., Ivanyi, P., Manns, M. P., Rodt, T., Hinrichs, J. B., et al. (2019) · Liver International

Metabolism, Diabetes, and CancerHepatocellular Carcinoma Treatment and Prognosis

Cited by 67

Telomerase-Dependent Virotherapy Overcomes Resistance of Hepatocellular Carcinomas against Chemotherapy and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand by Elimination of Mcl-1

Wirth, T., Kühnel, F., Fleischmann-Mundt, B., Woller, N., Djojosubroto, M., Rudolph, K. L., Manns, M., Zender, L., & Kubicka, S. (2005) · Cancer Research

Virus-based gene therapy researchTelomeres, Telomerase, and Senescence

Cited by 65

The Detrimental Role of Regulatory T Cells in Nonalcoholic Steatohepatitis

Dywicki, J., Buitrago‐Molina, L. E., Noyan, F., Davalos‐Misslitz, A. C., Hupa‐Breier, K. L., Lieber, M., Hapke, M., Schlue, J., Falk, C. S., Raha, S., et al. (2022) · Hepatology Communications

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 57

Inter- and intra-individual variation, and limited prognostic utility, of serum alkaline phosphatase in a trial of patients with primary sclerosing cholangitis

Trivedi, P. J., Muir, A. J., Levy, C., Bowlus, C. L., Manns, M. P., Lu, X., Crans, G., Chung, C., Subramanian, G. M., Myers, R. P., et al. (2021) · Clinical Gastroenterology and Hepatology

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Cited by 55

Nonocclusive Mesenteric Ischemia and Interventional Local Vasodilatory Therapy: A Meta-Analysis and Systematic Review of the Literature

Stahl, K., Rittgerodt, N., Busch, M., Maschke, S. K., Schneider, A., Manns, M. P., Fuge, J., Meyer, B. C., Hoeper, M. M., Hinrichs, J. B., et al. (2020) · Journal of Intensive Care Medicine

Abdominal vascular conditions and treatmentsOmental and Epiploic Conditions

Cited by 33

Increased seroprevalence of HAV and parvovirus B19 in children and of HEV in adults at diagnosis of autoimmune hepatitis

Taubert, R., Diestelhorst, J., Junge, N., Kirstein, M. M., Pischke, S., Vogel, A., Bantel, H., Baumann, U., Manns, M. P., Wedemeyer, H., et al. (2018) · Scientific Reports

Liver Diseases and ImmunityHepatitis B Virus Studies

Cited by 29

ME3738 protects from concanavalin A‐induced liver failure via an IL‐6‐dependent mechanism

Klein, C., Wüstefeld, T., Heinrich, P. C., Streetz, K. L., Manns, M. P., & Trautwein, C. (2003) · European Journal of Immunology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 27

Outcome stagnation of liver transplantation for primary sclerosing cholangitis in the Model for End-Stage Liver Disease era

Klose, J., Klose, M. A., Metz, C., Lehner, F., Manns, M. P., Klempnauer, J., Hoppe, N., Schrem, H., & Kaltenborn, A. (2014) · Langenbeck's Archives of Surgery

Organ Transplantation Techniques and OutcomesLiver Diseases and Immunity

Cited by 21

Antineutrophil cytoplasmic antibodies in bile are associated with disease activity in primary sclerosing cholangitis

Lenzen, H., Weismüller, T. J., Negm, A. A., Wlecke, J., Loges, S., Strassburg, C. P., Manns, M. P., & Lankisch, T. O. (2013) · Scandinavian Journal of Gastroenterology

Liver Diseases and ImmunityIgG4-Related and Inflammatory Diseases

Cited by 11