Auwerx, Johan

Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3

Khan, N. A., Auranen, M., Paetau, I., Pirinen, E., Euro, L., Forsström, S., Pasila, L., Velagapudi, V., Carroll, C. J., Auwerx, J., et al. (2014) · EMBO Molecular Medicine

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

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Pharmacological approaches to restore mitochondrial function

Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

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NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Ratajczak, J., Joffraud, M., Trammell, S. A. J., Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., et al. (2016) · Nature Communications

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

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Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

Gariani, K., Menzies, K. J., Ryu, D., Wegner, C. J., Wang, X., Ropelle, E. R., Moullan, N., Zhang, H., Perino, A., Lemos, V., et al. (2016) · Hepatology

Sirtuins and Resveratrol in MedicineLiver Disease Diagnosis and Treatment

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Two conserved histone demethylases regulate mitochondrial stress-induced longevity

Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E. G., Mouchiroud, L., Tronnes, S. U., et al. (2016) · Cell

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

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Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Chung, H. K., Ryu, D., Kim, K. S., Chang, J. Y., Kim, Y. K., Yi, H.-S., Kang, S. G., Choi, M. J., Lee, S. E., Jung, S.-B., et al. (2017) · Journal of Cell Biology

GDF15 and Related BiomarkersAdipose Tissue and Metabolism

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NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Cerutti, R., Pirinen, E., Lamperti, C., Marchet, S., Sauve, A. A., Li, W., Leoni, V., Schon, E. A., Dantzer, F., Auwerx, J., et al. (2014) · Cell Metabolism

Sirtuins and Resveratrol in MedicineMitochondrial Function and Pathology

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Repairing mitochondrial dysfunction in disease

Sorrentino, V., Menzies, K. J., & Auwerx, J. (2018) · Annual Review of Pharmacology and Toxicology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

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The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

Jovaisaite, V., Mouchiroud, L., & Auwerx, J. (2014) · Journal of Experimental Biology

Mitochondrial Function and PathologyEndoplasmic Reticulum Stress and Disease

Cited by 335

Protein acetylation in metabolism – metabolites and cofactors

Menzies, K. J., Zhang, H., Katsyuba, E., & Auwerx, J. (2016) · Nature Reviews Endocrinology

Histone Deacetylase Inhibitors ResearchSirtuins and Resveratrol in Medicine

Cited by 331

Transcriptional coregulators in the control of energy homeostasis

Feige, J. N., & Auwerx, J. (2007) · Trends in Cell Biology

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 325

Activation of PPARδ alters lipid metabolism in db/db mice

Leibowitz, M. D., Fiévet, C., Hennuyer, N., Peinado-Onsurbe, J., Duez, H., Berger, J., Cullinan, C. A., Sparrow, C. P., Baffic, J., Berger, G. D., et al. (2000) · FEBS Letters

Peroxisome Proliferator-Activated ReceptorsCholesterol and Lipid Metabolism

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Emerging roles of the corepressors NCoR1 and SMRT in homeostasis

Mottis, A., Mouchiroud, L., & Auwerx, J. (2013) · Genes & Development

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J. (2006) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 290

Systems proteomics of liver mitochondria function

Williams, E. G., Wu, Y., Jha, P., Dubuis, S., Blattmann, P., Argmann, C. A., Houten, S. M., Amariuta, T., Wolski, W., Zamboni, N., et al. (2016) · Science

Advanced Proteomics Techniques and ApplicationsBioinformatics and Genomic Networks

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Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle

Greggio, C., Jha, P., Kulkarni, S. S., Lagarrigue, S., Broskey, N. T., Boutant, M., Wang, X., Conde Alonso, S., Ofori, E., Auwerx, J., et al. (2017) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

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Calorie Restriction: Is AMPK a Key Sensor and Effector

Cantó, C., & Auwerx, J. (2011) · Physiology

Metabolism, Diabetes, and CancerGenetics, Aging, and Longevity in Model Organisms

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Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

Bouitbir, J., Charles, A.-L., Echaniz-Laguna, A., Kindo, M., Daussin, F., Auwerx, J., Piquard, F., Geny, B., & Zoll, J. (2012) · European Heart Journal

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 256

NAD + repletion improves muscle function in muscular dystrophy and counters global PARylation

Ryu, D., Zhang, H., Ropelle, E. R., Sorrentino, V., Mázala, D. A. G., Mouchiroud, L., Marshall, P. L., Campbell, M. D., Ali, A. S., Knowels, G. M., et al. (2016) · Science Translational Medicine

Sirtuins and Resveratrol in MedicineMuscle Physiology and Disorders

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Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle

Pirinen, E., Cantó, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., et al. (2014) · Cell Metabolism

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

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Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

Wu, Y., Williams, E. G., Dubuis, S., Mottis, A., Jovaisaite, V., Houten, S. M., Argmann, C. A., Faridi, P., Wolski, W., Kutalik, Z., et al. (2014) · Cell

Bioinformatics and Genomic NetworksGenetic Mapping and Diversity in Plants and Animals

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The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance

Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., et al. (2019) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationSirtuins and Resveratrol in Medicine

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Metabolic networks of longevity

Houtkooper, R. H., Williams, R. W., & Auwerx, J. (2010) · Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

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The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1α

Coste, A., Louet, J.-F., Lagouge, M., Lerin, C., Antal, M. C., Meziane, H., Schoonjans, K., Puigserver, P., O'Malley, B. W., & Auwerx, J. (2008) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

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