Auwerx, Johan

PPARδ Promotes Running Endurance by Preserving Glucose

Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M.-X., Wall, C. E., Li, H., Liddle, C., Yu, R. T., Atkins, A. R., et al. (2017) · Cell Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

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NAD + metabolism: A therapeutic target for age-related metabolic disease

Mouchiroud, L., Houtkooper, R. H., & Auwerx, J. (2013) · Critical Reviews in Biochemistry and Molecular Biology

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 193

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H.-C., Ikeda, K., Kanegae, Y., et al. (2019) · Nature Communications

Autophagy in Disease and TherapyPeroxisome Proliferator-Activated Receptors

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The bile acid membrane receptor TGR5: a valuable metabolic target

Pols, T. W. H., Noriega, L. G., Nomura, M., Auwerx, J., & Schoonjans, K. (2011) · Digestive Diseases

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 185

TGR5 regulates macrophage inflammation in nonalcoholic steatohepatitis by modulating NLRP3 inflammasome activation

Shi, Y., Su, W., Zhang, L., Shi, C., Zhou, J., Wang, P., Wang, H., Shi, X., Wei, S., Wang, Q., et al. (2021) · Frontiers in Immunology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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A platform for experimental precision medicine: The extended BXD mouse family

Ashbrook, D. G., Arends, D., Prins, P., Mulligan, M. K., Roy, S., Williams, E. G., Lutz, C. M., Valenzuela, A., Bohl, C. J., Ingels, J. F., et al. (2021) · Cell Systems

Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and Epidemiology

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Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

Gariani, K., Ryu, D., Menzies, K. J., Yi, H.-S., Stein, S., Zhang, H., Perino, A., Lemos, V., Katsyuba, E., Jha, P., et al. (2017) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentSirtuins and Resveratrol in Medicine

Cited by 167

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Remie, C. M., Roumans, K. H., Moonen, M. P., Connell, N. J., Havekes, B., Mevenkamp, J., Lindeboom, L., de Wit, V. H., van de Weijer, T., Aarts, S. A., et al. (2020) · The American Journal of Clinical Nutrition

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 160

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

D’Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., et al. (2019) · Molecular Cell

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 159

The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression

Miranda, M. X., van Tits, L. J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A. P., Suri, V., Ellis, J. L., et al. (2015) · European Heart Journal

Cholesterol and Lipid MetabolismSirtuins and Resveratrol in Medicine

Cited by 153

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass

Simonen, M., Dali-Youcef, N., Kaminska, D., Venesmaa, S., Käkelä, P., Pääkkönen, M., Hallikainen, M., Kolehmainen, M., Uusitupa, M., Moilanen, L., et al. (2012) · Obesity Surgery

Bariatric Surgery and OutcomesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 145

LRP1 Controls Intracellular Cholesterol Storage and Fatty Acid Synthesis through Modulation of Wnt Signaling

Terrand, J., Bruban, V., Zhou, L., Gong, W., El Asmar, Z., May, P., Zurhove, K., Haffner, P., Philippe, C., Woldt, E., et al. (2009) · Journal of Biological Chemistry

Cholesterol and Lipid MetabolismLipid metabolism and biosynthesis

Cited by 143

Growth differentiation factor 15 protects against the aging‐mediated systemic inflammatory response in humans and mice

Moon, J. S., Goeminne, L. J. E., Kim, J. T., Tian, J. W., Kim, S., Nga, H. T., Kang, S. G., Kang, B. E., Byun, J., Lee, Y., et al. (2020) · Aging Cell

GDF15 and Related BiomarkersGenetics, Aging, and Longevity in Model Organisms

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Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans

van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., Livingstone, R., Nowotny, P., Sparks, L. M., Paglialunga, S., et al. (2015) · Diabetes

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

Fernandez-Marcos, P. J., Jeninga, E. H., Canto, C., Harach, T., de Boer, V. C. J., Andreux, P., Moullan, N., Pirinen, E., Yamamoto, H., Houten, S. M., et al. (2012) · Scientific Reports

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

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The mitochondrial unfolded protein response–synchronizing genomes

Jovaisaite, V., & Auwerx, J. (2015) · Current Opinion in Cell Biology

Mitochondrial Function and PathologyEndoplasmic Reticulum Stress and Disease

Cited by 131

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

Rutanen, J., Yaluri, N., Modi, S., Pihlajamäki, J., Vänttinen, M., Itkonen, P., Kainulainen, S., Yamamoto, H., Lagouge, M., Sinclair, D. A., et al. (2010) · Diabetes

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

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Mitophagy in the pathogenesis and management of disease

Wang, Q., Sun, Y., Li, T. Y., & Auwerx, J. (2026) · Cell Research

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

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Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans

Binnert, C., Koistinen, H. A., Martin, G., Andreelli, F., Ebeling, P., Koivisto, V. A., Laville, M., Auwerx, J., & Vidal, H. (2000) · American Journal of Physiology-Endocrinology and Metabolism

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

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NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

Romani, M., Sorrentino, V., Oh, C.-M., Li, H., de Lima, T. I., Zhang, H., Shong, M., & Auwerx, J. (2021) · Cell Reports

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

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Metabolic Effects of Rexinoids: Tissue-Specific Regulation of Lipoprotein Lipase Activity

Davies, P. J. A., Berry, S. A., Shipley, G. L., Eckel, R. H., Hennuyer, N., Crombie, D. L., Ogilvie, K. M., Peinado-Onsurbe, J., Fievet, C., Leibowitz, M. D., et al. (2001) · Molecular Pharmacology

Lipid metabolism and disordersPeroxisome Proliferator-Activated Receptors

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The Corepressor NCoR1 Antagonizes PGC-1 α and Estrogen-Related Receptor α in the Regulation of Skeletal Muscle Function and Oxidative Metabolism

Pérez-Schindler, J., Summermatter, S., Salatino, S., Zorzato, F., Beer, M., Balwierz, P. J., van Nimwegen, E., Feige, J. N., Auwerx, J., & Handschin, C. (2012) · Molecular and Cellular Biology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

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The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress

Li, T. Y., Sleiman, M. B., Li, H., Gao, A. W., Mottis, A., Bachmann, A. M., Alam, G. E., Li, X., Goeminne, L. J. E., Schoonjans, K., et al. (2021) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

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Estrogen‐related receptor‐α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury

LaBarge, S., McDonald, M., Smith‐Powell, L., Auwerx, J., & Huss, J. M. (2014) · The FASEB Journal

Muscle Physiology and DisordersAdipose Tissue and Metabolism

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