Hekimi, Siegfried

Taking a good look at free radicals in the aging process

Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 606

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

Van Raamsdonk, J. M., & Hekimi, S. (2009) · PLoS Genetics

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 511

Genetics and the Specificity of the Aging Process

Hekimi, S., & Guarente, L. (2003) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 434

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing

Wong, A., Boutis, P., & Hekimi, S. (1995) · Genetics

Circadian rhythm and melatoninGenetics, Aging, and Longevity in Model Organisms

Cited by 416

The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans

Yee, C., Yang, W., & Hekimi, S. (2014) · Cell

Genetics, Aging, and Longevity in Model OrganismsCell death mechanisms and regulation

Cited by 356

Evolutionary conservation of the clk-1 -dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice

Liu, X., Jiang, N., Hughes, B., Bigras, E., Shoubridge, E., & Hekimi, S. (2005) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsCoenzyme Q10 studies and effects

Cited by 345

Understanding Ubiquinone

Wang, Y., & Hekimi, S. (2016) · Trends in Cell Biology

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 256

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Schaar, C. E., Dues, D. J., Spielbauer, K. K., Machiela, E., Cooper, J. F., Senchuk, M., Hekimi, S., & Van Raamsdonk, J. M. (2015) · PLOS Genetics

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 203

Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1α in Long-Lived Mclk1 +/− Mouse Mutants

Wang, D., Malo, D., & Hekimi, S. (2010) · The Journal of Immunology

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 123