Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing

Wong, A; Boutis, P; Hekimi, S

doi:10.1093/genetics/139.3.1247

Cited by 416Circadian rhythm and melatoninGenetics, Aging, and Longevity in Model OrganismsDevelopmental Biology and Gene Regulation

Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing

Wong, A, Boutis, P, Hekimi, S·1995·Genetics

DOI 10.1093/genetics/139.3.1247

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Abstract

We have identified three allelic, maternal-effect mutations that affect developmental and behavioral timing in Caenorhabditis elegans. They result in a mean lengthening of embryonic and postembryonic development, the cell cycle period and life span, as well as the periods of the defecation, swimming and pumping cycles. These mutants also display a number of additional phenotypes related to timing. For example, the variability in the length of embryonic development is several times larger in the mutants than in the wild type, resulting in the occasional production of mutant embryos developing more rapidly than the most rapidly developing wild-type embryos. In addition, the duration of embryonic development of the mutants, but not of the wild type, depends on the temperature at which their parents were raised. Finally, individual variations in the severity of distinct mutant phenotypes are correlated in a counterintuitive way. For example, the animals with the shortest embryonic development have the longest defecation cycle and those with the longest embryonic development have the shortest defecation cycle. Most of the features affected by these mutations are believed to be controlled by biological clocks, and we therefore call the gene defined by these mutations clk-1, for "abnormal function of biological clocks."

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In Caenorhabditis elegans, inactivation of clk-1 or sod-2 is associated with increased lifespan.
“These results correlate with those from Caenorhabditis elegans, in which inactivation of clk-1 or sod-2 is associated with increased lifespan 95, 96.”
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Authors: Wong, A., Boutis, P., & Hekimi, S.
Affiliations: McGill University (CA)
ORCID: Hekimi, S
Venue: Genetics
Publisher: Oxford University Press (OUP)
Published: 1995-03-01
Volume: 139
Issue: 3
Pages: 1247-1259
ISSN: 0016-6731 (ISSN-L)
1943-2631
DOI: 10.1093/genetics/139.3.1247
OpenAlex: W1922034805
Cited by: 416
References: 42
Citations by year: 2026: 7 · 2025: 4 · 2024: 3 · 2023: 17 · 2022: 6 · 2021: 12 · 2020: 5 · 2019: 6 · 2018: 10 · 2017: 15 · 2016: 17 · 2015: 12 · 2014: 19 · 2013: 11 · 2012: 18
FWCI: 5.03
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations: Genetics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: biological clock, developmental timing, maternal-effect mutations, embryonic development, lifespan, pumping cycle, temperature-dependent development, developmental variation, Caenorhabditis elegans
MeSH terms: Alleles, Animals, Biological Clocks, Cell Cycle, Mutation, Phenotype, Temperature, Caenorhabditis elegans, Genes, Helminth, Gene Expression Regulation, Developmental

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Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing

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