Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
Open accessAbstract
The oxidative stress theory of aging postulates that aging results from the accumulation of molecular damage caused by reactive oxygen species (ROS) generated during normal metabolism. Superoxide dismutases (SODs) counteract this process by detoxifying superoxide. It has previously been shown that elimination of either cytoplasmic or mitochondrial SOD in yeast, flies, and mice results in decreased lifespan. In this experiment, we examine the effect of eliminating each of the five individual sod genes present in Caenorhabditis elegans. In contrast to what is observed in other model organisms, none of the sod deletion mutants shows decreased lifespan compared to wild-type worms, despite a clear increase in sensitivity to paraquat- and juglone-induced oxidative stress. In fact, even mutants lacking combinations of two or three sod genes survive at least as long as wild-type worms. Examination of gene expression in these mutants reveals mild compensatory up-regulation of other sod genes. Interestingly, we find that sod-2 mutants are long-lived despite a significant increase in oxidatively damaged proteins. Testing the effect of sod-2 deletion on known pathways of lifespan extension reveals a clear interaction with genes that affect mitochondrial function: sod-2 deletion markedly increases lifespan in clk-1 worms while clearly decreasing the lifespan of isp-1 worms. Combined with the mitochondrial localization of SOD-2 and the fact that sod-2 mutant worms exhibit phenotypes that are characteristic of long-lived mitochondrial mutants-including slow development, low brood size, and slow defecation-this suggests that deletion of sod-2 extends lifespan through a similar mechanism. This conclusion is supported by our demonstration of decreased oxygen consumption in sod-2 mutant worms. Overall, we show that increased oxidative stress caused by deletion of sod genes does not result in decreased lifespan in C. elegans and that deletion of sod-2 extends worm lifespan by altering mitochondrial function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Caenorhabditis elegans, inactivation of clk-1 or sod-2 is associated with increased lifespan.
“These results correlate with those from Caenorhabditis elegans, in which inactivation of clk-1 or sod-2 is associated with increased lifespan 95, 96.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [96]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Superoxide radical and superoxide dismutases
Fridovich, I. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000525 · Cited by 3,455 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works
The Biologic Clock: The Mitochondria?
Harman, D. (1972) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1972.tb00787.x · Cited by 1,991 · see citing works
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
Dillin, A., Hsu, A.-L., Arantes-Oliveira, N., Lehrer-Graiwer, J., Hsin, H., Fraser, A. G., Kamath, R. S., Ahringer, J., & Kenyon, C. (2002) · Science · doi:10.1126/science.1077780 · Cited by 1,121 · see citing works
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053 · see citing works
Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works
Signals from the reproductive system regulate the lifespan of C. elegans
Hsin, H., & Kenyon, C. J. (1999) · Nature · doi:10.1038/20694 · Cited by 1,015 · see citing works
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works
The genetics of caloric restriction in Caenorhabditis elegans
Lakowski, B., & Hekimi, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13091 · Cited by 967 · see citing works
Self-citationParaquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment
Dinis‐Oliveira, R. J., Duarte, J. A., Navarro, A. S., Remião, F., Bastos, M. D. L., & Carvalho, F. D. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440701669959 · Cited by 931 · see citing works
Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S. R., Alderson, N. L., Baynes, J. W., Epstein, C. J., Huang, T.-T., et al. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00122.2003 · Cited by 734 · see citing works
Aging and resistance to oxidative damage in Caenorhabditis elegans.
Larsen, P. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8905 · Cited by 722 · see citing works
Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans
Feng, J., Bussière, F., & Hekimi, S. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00071-5 · Cited by 675 · see citing works
Self-citationElchuri, S., Oberley, T. D., Qi, W., Eisenstein, R. S., Jackson Roberts, L., Van Remmen, H., Epstein, C. J., & Huang, T.-T. (2005) · Oncogene · doi:10.1038/sj.onc.1208207 · Cited by 667 · see citing works
Mitochondrial disease in superoxide dismutase 2 mutant mice
Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A. S., Zastawny, T. H., Dizdaroglu, M., Goodman, S. I., Huang, T.-T., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.846 · Cited by 581 · see citing works
Determination of Life-Span in Caenorhabditis elegans by Four Clock Genes
Lakowski, B., & Hekimi, S. (1996) · Science · doi:10.1126/science.272.5264.1010 · Cited by 539 · see citing works
Self-citationPHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
Panowski, S. H., Wolff, S., Aguilaniu, H., Durieux, J., & Dillin, A. G. (2007) · Nature · doi:10.1038/nature05837 · Cited by 538 · see citing works
Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae
Longo, V. D., Gralla, E. B., & Valentine, J. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12275 · Cited by 531 · see citing works
Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.
Carlsson, L. M. S., Jonsson, J., Edlund, H., & Marklund, S. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6264 · Cited by 487 · see citing works
Superoxide dismutase evolution and life span regulation
Landis, G. N., & Tower, J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.08.012 · Cited by 474 · see citing works
Williams, M. D., Remmen, H. V., Conrad, C. C., Huang, T., Epstein, C. J., & Richardson, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28510 · Cited by 453 · see citing works
Müller, F. L., Song, W., Liu, Y., Chaudhuri, A. R., Pieke-Dahl, S., Strong, R., Huang, T., Epstein, C. J., Roberts, L. J., CSETE, M. E., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.01.036 · Cited by 447 · see citing works
Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
Wong, A., Boutis, P., & Hekimi, S. (1995) · Genetics · doi:10.1093/genetics/139.3.1247 · Cited by 416 · see citing works
Self-citationHoogewijs, D., Houthoofd, K., Matthijssens, F., Vandesompele, J., & Vanfleteren, J. R. (2008) · BMC Molecular Biology · doi:10.1186/1471-2199-9-9 · Cited by 400 · see citing works
Phillips, J. P., Campbell, S. D., Michaud, D., Charbonneau, M., & Hilliker, A. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2761 · Cited by 389 · see citing works
Oxidative stress and ageing in Caenorhabditis elegans
Vanfleteren, J. R. (1993) · Biochemical Journal · doi:10.1042/bj2920605 · Cited by 383 · see citing works
Rea, S. L., Ventura, N., & Johnson, T. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050259 · Cited by 383 · see citing works
Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1
Ewbank, J. J., Barnes, T. M., Lakowski, B., Lussier, M., Bussey, H., & Hekimi, S. (1997) · Science · doi:10.1126/science.275.5302.980 · Cited by 319 · see citing works
Self-citationCLK‐1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
Felkai, S., Ewbank, J. J., Lemieux, J., Labbé, J. ‐., Brown, G. G., & Hekimi, S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.7.1783 · Cited by 291 · see citing works
Self-citationKnockout mice heterozygous forSod2show alterations in cardiac mitochondrial function and apoptosis
Remmen, H. V., Williams, M. D., Guo, Z., Estlack, L. E., Yang, H. C., Carlson, E. J., Epstein, C. J., Huang, T., & Richardson, A. G. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.3.h1422 · Cited by 230 · see citing works
Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice
(2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.1.b5 · Cited by 216 · see citing works
Mitochondrial Superoxide Decreases Yeast Survival in Stationary Phase
Longo, V. D., Liou, L.-L., Valentine, J. S., & Gralla, E. B. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1158 · Cited by 215 · see citing works
A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans
Ishii, N., Takahashi, K., Tomita, S., Keino, T., Honda, S., Yoshino, K., & Suzuki, K. (1990) · Mutation Research/DNAging · doi:10.1016/0921-8734(90)90022-j · Cited by 213 · see citing works
Thermotolerance of a Long-lived Mutant of Caenorhabditis elegans
Lithgow, G. J., White, T. M., Hinerfeld, D. A., & Johnson, T. E. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.6.b270 · Cited by 213 · see citing works
Kirby, K., Hu, J., Hilliker, A. J., & Phillips, J. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252342899 · Cited by 208 · see citing works
Sentman, M.-L., Granström, M., Jakobson, H., Reaume, A. G., Basu, S., & Marklund, S. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510764200 · Cited by 181 · see citing works
Johnson, T. E., Henderson, S. T., Murakami, S., de Castro, E., de Castro, S. H., Cypser, J. R., Rikke, B. A., Tedesco, P., & Link, C. D. (2002) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1015677828407 · Cited by 174 · see citing works
Yang, W., Li, J., & Hekimi, S. (2007) · Genetics · doi:10.1534/genetics.107.080788 · Cited by 171 · see citing works
Self-citationKayser (1999) · doi:10.1097/00000542-199902000-00031 · Cited by 159 · see citing works
A Sod2 Null Mutation Confers Severely Reduced Adult Life Span in Drosophila
Duttaroy, A., Paul, A., Kundu, M., & Belton, A. (2003) · Genetics · doi:10.1093/genetics/165.4.2295 · Cited by 153 · see citing works
Remmen, H. V., Salvador, C., Yang, H. C., Huang, T., Epstein, C. J., & Richardson, A. G. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1060 · Cited by 151 · see citing works
Lack of Peroxisomal Catalase Causes a Progeric Phenotype in Caenorhabditis elegans
Petriv, O. I., & Rachubinski, R. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400207200 · Cited by 148 · see citing works
Hunter, T., BANNISTER, W. H., & Hunter, G. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28652 · Cited by 142 · see citing works
Arking, R., Buck, S. A., Berrios, A., Dwyer, S. B., & Baker, G. T. (1991) · Developmental Genetics · doi:10.1002/dvg.1020120505 · Cited by 139 · see citing works
The kinetic basis of threshold effects observed in mitochondrial diseases: a systemic approach
Letellier, T., Heinrich, R., Malgat, M., & Mazat, J. (1994) · Biochemical Journal · doi:10.1042/bj3020171 · Cited by 134 · see citing works
Kim, Y.-S., & Sun, H. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00302.x · Cited by 121 · see citing works
Solomon, A., Bandhakavi, S., Jabbar, S. F., Shah, R., Beitel, G. J., & Morimoto, R. I. (2004) · Genetics · doi:10.1534/genetics.167.1.161 · Cited by 118 · see citing works
Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone
de Castro, E., de Castro, S. H., & Johnson, T. E. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.021 · Cited by 117 · see citing works
Permeability of bilayer lipid membranes for superoxide (O2−) radicals
Gus'kova, R. A., Ivanov, I. I., Koltover, V. K., Akhobadze, V. V., & Rubin, A. (1984) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(84)90409-7 · Cited by 112 · see citing works
Compartment-specific Protection of Iron-Sulfur Proteins by Superoxide Dismutase
Missirlis, F., Hu, J., Kirby, K., Hilliker, A. J., Rouault, T. A., & Phillips, J. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307700200 · Cited by 111 · see citing works
Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging
Paul, A., Belton, A., Nag, S., Martin, I., Grotewiel, M. S., & Duttaroy, A. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.013 · Cited by 105 · see citing works
Deficiency in superoxide dismutases shortens life span of yeast cells.
Wawryn, J., Krzepiłko, A., Myszka, A., & Biliński, T. (1999) · Acta Biochimica Polonica · doi:10.18388/abp.1999_4158 · Cited by 103 · see citing works
Jensen, L. T., & Culotta, V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509142200 · Cited by 100 · see citing works
Superoxide, hydrogen peroxide, and oxygen toxicity in two free-living nematode species
Blum, J., & Fridovich, I. (1983) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(83)90499-x · Cited by 87 · see citing works
Fujii, M. (1998) · DNA Research · doi:10.1093/dnares/5.1.25 · Cited by 72 · see citing works
Effects of Deleting Mitochondrial Antioxidant Genes on Life Span
Ünlü, E. S., & Koç, A. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.055 · Cited by 71 · see citing works
Metabolism in the Caenorhabditis elegans Mit mutants
Rea, S. L. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.06.015 · Cited by 57 · see citing works
The manganese superoxide dismutase gene of Caenorhabditis elegans.
Giglio, M. P., Hunter, T., Bannister, J. V., Bannister, W. H., & Hunter, G. J. (1994) · PubMed · Cited by 51 · see citing works
The copper/zinc superoxide dismutase gene of Caenorhabditis elegans.
Am, G., Hunter, T., Jv, B., Wh, B., & Hunter, G. J. (1994) · PubMed · Cited by 40 · see citing works
Suzuki, N., Inokuma, K., Yasuda, K., & Ishii, N. (1996) · DNA Research · doi:10.1093/dnares/3.3.171 · Cited by 38 · see citing works
Complex II inactivation is lethal in the nematode Caenorhabditis elegans
Ichimiya, H., Huet, R. G., Hartman, P. S., Amino, H., Kita, K., & Ishii, N. (2002) · Mitochondrion · doi:10.1016/s1567-7249(02)00069-7 · Cited by 24 · see citing works
Khazaeli, A. A., Nuzhdin, S. V., & Curtsinger, J. W. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.06.005 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931 · see citing works
Signal transduction by reactive oxygen species
Finkel, T. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102095 · Cited by 2,322 · see citing works
The role of mitochondria in aging
Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087 · see citing works
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity
Durieux, J., Wolff, S., & Dillin, A. (2011) · Cell · doi:10.1016/j.cell.2010.12.016 · Cited by 1,059 · see citing works
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789 · see citing works
Human iPSC-based modeling of late-onset disease via progerin-induced aging
Miller, J. D., Ganat, Y. M., Kishinevsky, S., Bowman, R. L., Liu, B., Tu, E. Y., Mandal, P. K., Vera, E., Shim, J.-W., Kriks, S., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.11.006 · Cited by 777 · see citing works
Is the oxidative stress theory of aging dead?
Pérez, V. I., Bokov, A., Remmen, H. V., Mele, J., Ran, Q., Ikeno, Y., & Richardson, A. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.003 · Cited by 604 · see citing works
Taking a good look at free radicals in the aging process
Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.008 · Cited by 606 · see citing works
Ageing, age-related diseases and oxidative stress: What to do next?
Luo, J., Mills, K., le Cessie, S., Noordam, R., & van Heemst, D. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100982 · Cited by 581 · see citing works
Shields, H. J., Traa, A., & Van Raamsdonk, J. M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628157 · Cited by 478 · see citing works
Zarse, K., Schmeisser, S., Groth, M., Priebe, S., Beuster, G., Kuhlow, D., Guthke, R., Platzer, M., Kahn, C. R., & Ristow, M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.02.013 · Cited by 430 · see citing works
Cell biology of the mitochondrion
van der Bliek, A. M., Sedensky, M. M., & Morgan, P. G. (2017) · Genetics · doi:10.1534/genetics.117.300262 · Cited by 388 · see citing works
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works
Yee, C., Yang, W., & Hekimi, S. (2014) · Cell · doi:10.1016/j.cell.2014.02.055 · Cited by 356 · see citing works
Self-citationCardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334 · see citing works
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works
Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan
Schaar, C. E., Dues, D. J., Spielbauer, K. K., Machiela, E., Cooper, J. F., Senchuk, M., Hekimi, S., & Van Raamsdonk, J. M. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004972 · Cited by 203 · see citing works
Self-citationSantos, A. L., Sinha, S., & Lindner, A. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1941285 · Cited by 168 · see citing works
Signaling networks determining life span
Riera, C. E., Merkwirth, C., De Magalhaes Filho, C. D., & Dillin, A. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014451 · Cited by 161 · see citing works
Mitochondrial and sex steroid hormone crosstalk during aging
Velarde, M. C. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-2 · Cited by 96 · see citing works
Brys, K., Castelein, N., Matthijssens, F., Vanfleteren, J. R., & Braeckman, B. P. (2010) · BMC Biology · doi:10.1186/1741-7007-8-91 · Cited by 74 · see citing works
Revisiting an age-old question regarding oxidative stress
Edrey, Y. H., & Salmon, A. B. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.038 · Cited by 64 · see citing works
The role of mitochondria in <scp>mTOR</scp>‐regulated longevity
Wei, Y., Zhang, Y., Cai, Y., & Xu, M. (2015) · Biological Reviews · doi:10.1111/brv.12103 · Cited by 56 · see citing works
Cheah, I. K., Ong, R. L. S., Gruber, J., Yew, T. S. K., Ng, L. F., Chen, C. B., & Halliwell, B. (2013) · Free Radical Research · doi:10.3109/10715762.2013.848354 · Cited by 44 · see citing works
Osiewacz, H. D., Brust, D., Hamann, A., Kunstmann, B., Luce, K., Müller‐Ohldach, M., Scheckhuber, C. Q., Servos, J., & Strobel, I. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05190.x · Cited by 33 · see citing works
SOD2 deficiency promotes aging phenotypes in mouse skin
Weyemi, U., Parekh, P. R., Redon, C. E., & Bonner, W. M. (2012) · Aging · doi:10.18632/aging.100433 · Cited by 30 · see citing works
Mitochondrial free radical theory of aging: Who moved my premise?: MFRTA: Who moved my premise?
Liu, Y., Long, J., & Liu, J. (2014) · Geriatrics & Gerontology International · doi:10.1111/ggi.12296 · Cited by 27 · see citing works
Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans
Chang, H.-W., Shtessel, L., & Lee, S. S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.10.576 · Cited by 15 · see citing works
- Authors
- Van Raamsdonk, J. M., & Hekimi, S.
- Affiliations
- McGill University (CA)
- Corresponding author
- Hekimi, Siegfried
- ORCID
- Hekimi, Siegfried
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-02-06
- Volume
- 5
- Issue
- 2
- Pages
- e1000361
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC2628729
- OpenAlex
- W2074783650
- Cited by
- 511
- References
- 65
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 15 · 2023: 20 · 2022: 29 · 2021: 24 · 2020: 29 · 2019: 24 · 2018: 33 · 2017: 21 · 2016: 40 · 2015: 29 · 2014: 45 · 2013: 34 · 2012: 40
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Hereditary Disease Foundation
- McGill University
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- mitochondrial superoxide dismutase, manganese superoxide dismutase, lifespan extension, Caenorhabditis elegans, oxidative stress, aging, reactive oxygen species, clk-1, isp-1, mitochondrial function, oxygen consumption, compensatory gene expression, paraquat sensitivity
- MeSH terms
- Superoxide Dismutase 2, Animals, Longevity, Mitochondria, Osmotic Pressure, Oxygen Consumption, Phenotype, RNA, Messenger, Superoxide Dismutase, Caenorhabditis elegans, Genes, Helminth, Sequence Deletion, Oxidative Stress, Caenorhabditis elegans Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
