Margulies, Kenneth B.

Targeting cardiac fibrosis with engineered T cells

Aghajanian, H., Kimura, T., Rurik, J. G., Hancock, A. S., Leibowitz, M. S., Li, L., Scholler, J., Monslow, J., Lo, A., Han, W., et al. (2019) · Nature

Cardiac Fibrosis and RemodelingCongenital heart defects research

Cited by 801

Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial

Margulies, K. B., Hernandez, A. F., Redfield, M. M., Givertz, M. M., Oliveira, G. H., Cole, R., Mann, D. L., Whellan, D. J., Kiernan, M. S., Felker, G. M., et al. (2016) · JAMA

Heart Failure Treatment and ManagementDiabetes Treatment and Management

Cited by 706

Transcriptional and Cellular Diversity of the Human Heart

Tucker, N. R., Chaffin, M., Fleming, S. J., Hall, A. W., Parsons, V. A., Bedi, K. C., Akkad, A.-D., Herndon, C. N., Arduini, A., Papangeli, I., et al. (2020) · Circulation

Single-cell and spatial transcriptomicsCongenital heart defects research

Cited by 554

Cellular basis of abnormal calcium transients of failing human ventricular myocytes

Piacentino, V., Weber, C. R., Chen, X., Weisser-Thomas, J., Margulies, K. B., Bers, D. M., & Houser, S. R. (2003) · Circulation Research

Cardiac electrophysiology and arrhythmiasIon channel regulation and function

Cited by 477

Animal Models of Heart Failure: A Scientific Statement From the American Heart Association

Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research

Cardiac Fibrosis and RemodelingHeart Failure Treatment and Management

Cited by 435

Clinical Phenogroups in Heart Failure With Preserved Ejection Fraction

Cohen, J. B., Schrauben, S. J., Zhao, L., Basso, M. D., Cvijic, M. E., Li, Z., Yarde, M., Wang, Z., Bhattacharya, P. T., Chirinos, D. A., et al. (2020) · JACC Heart Failure

Heart Failure Treatment and ManagementCardiovascular Function and Risk Factors

Cited by 432

Dapagliflozin Effects on Biomarkers, Symptoms, and Functional Status in Patients With Heart Failure With Reduced Ejection Fraction: The DEFINE-HF Trial

Nassif, M. E., Windsor, S. L., Tang, F., Khariton, Y., Husain, M., Inzucchi, S. E., McGuire, D. K., Pitt, B., Scirica, B. M., Austin, B., et al. (2019) · Circulation

Heart Failure Treatment and ManagementDiabetes Treatment and Management

Cited by 424

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

Chaffin, M., Papangeli, I., Simonson, B., Akkad, A.-D., Hill, M. C., Arduini, A., Fleming, S. J., Melanson, M., Hayat, S., Kost-Alimova, M., et al. (2022) · Nature

Cardiac Fibrosis and RemodelingCardiomyopathy and Myosin Studies

Cited by 418

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues

Boudou, T., Legant, W. R., Mu, A., Borochin, M. A., Thavandiran, N., Radisic, M., Zandstra, P. W., Epstein, J. A., Margulies, K. B., & Chen, C. S. (2012) · Tissue Engineering Part A

Tissue Engineering and Regenerative MedicineCellular Mechanics and Interactions

Cited by 413

BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure

Anand, P., Brown, J. D., Lin, C. Y., Qi, J., Zhang, R., Artero, P. C., Alaiti, M. A., Bullard, J., Alazem, K., Margulies, K. B., et al. (2013) · Cell

Protein Degradation and InhibitorsGenomics and Chromatin Dynamics

Cited by 406

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

Lee, D. I., Zhu, G., Sasaki, T., Cho, G.-S., Hamdani, N., Holewinski, R., Jo, S.-H., Danner, T., Zhang, M., Rainer, P. P., et al. (2015) · Nature

Phosphodiesterase function and regulationCardiovascular Function and Risk Factors

Cited by 353

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

Robison, P., Caporizzo, M. A., Ahmadzadeh, H., Bogush, A. I., Chen, C. Y., Margulies, K. B., Shenoy, V. B., & Prosser, B. L. (2016) · Science

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 338

GLP-1 Receptor Expression Within the Human Heart

Baggio, L. L., Yusta, B., Mulvihill, E. E., Cao, X., Streutker, C. J., Butany, J., Cappola, T. P., Margulies, K. B., & Drucker, D. J. (2018) · Endocrinology

Diabetes Treatment and ManagementNeuropeptides and Animal Physiology

Cited by 312

Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure With Preserved Ejection Fraction

Zamani, P., Rawat, D., Shiva-Kumar, P., Geraci, S., Bhuva, R., Konda, P., Doulias, P.-T., Ischiropoulos, H., Townsend, R. R., Margulies, K. B., et al. (2015) · Circulation

Cardiovascular and exercise physiologyNitric Oxide and Endothelin Effects

Cited by 307

Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study

Givertz, M. M., Anstrom, K. J., Redfield, M. M., Deswal, A., Haddad, H., Butler, J., Tang, W. H. W., Dunlap, M. E., LeWinter, M. M., Mann, D. L., et al. (2015) · Circulation

Gout, Hyperuricemia, Uric AcidHeart Failure Treatment and Management

Cited by 296

Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction

Hahn, V. S., Knutsdottir, H., Luo, X., Bedi, K., Margulies, K. B., Haldar, S. M., Stolina, M., Yin, J., Khakoo, A. Y., Vaishnav, J., et al. (2021) · Circulation

Cardiovascular Function and Risk FactorsHeart Failure Treatment and Management

Cited by 291

Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart

Chaudhary, K. W., Rossman, E. I., Piacentino, V., Kenessey, A., Weber, C., Gaughan, J. P., Ojamaa, K., Klein, I., Bers, D. M., Houser, S. R., et al. (2004) · Journal of the American College of Cardiology

Mechanical Circulatory Support DevicesCardiac electrophysiology and arrhythmias

Cited by 95

Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers

Levin, M. D., Lu, M. M., Petrenko, N. B., Hawkins, B. J., Gupta, T. H., Lang, D., Buckley, P. T., Jochems, J., Liu, F., Spurney, C. F., et al. (2009) · Journal of Clinical Investigation

Cardiac electrophysiology and arrhythmiasCardiac Arrhythmias and Treatments

Cited by 92

Targeting MRTF/SRF in CAP2‐dependent dilated cardiomyopathy delays disease onset

Xiong, Y., Bedi, K., Berritt, S., Attipoe, B. K., Brooks, T. G., Wang, K., Margulies, K. B., & Field, J. (2019) · JCI Insight

Cardiomyopathy and Myosin StudiesCardiac electrophysiology and arrhythmias

Cited by 20