Fuchs, Helmut

High-throughput discovery of novel developmental phenotypes

The International Mouse Phenotyping Consortium, Dickinson, M. E., Flenniken, A. M., Ji, X., Teboul, L., Wong, M. D., White, J. K., Meehan, T. F., Weninger, W. J., Westerberg, H., et al. (2016) · Nature

Genomics and Rare DiseasesZebrafish Biomedical Research Applications

Cited by 1,196

Cardioprotection and lifespan extension by the natural polyamine spermidine

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine

Polyamine Metabolism and ApplicationsGenetics, Aging, and Longevity in Model Organisms

Cited by 1,168

Genome-wide, large-scale production of mutant mice by ENU mutagenesis

de Angelis, M. H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., et al. (2000) · Nature Genetics

Plant Genetic and Mutation StudiesCarcinogens and Genotoxicity Assessment

Cited by 664

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

Enard, W., Gehre, S., Hammerschmidt, K., Hölter, S. M., Blass, T., Somel, M., Brückner, M. K., Schreiweis, C., Winter, C., Sohr, R., et al. (2009) · Cell

Genetics and Neurodevelopmental DisordersAnimal Vocal Communication and Behavior

Cited by 605

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology

Genetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals

Cited by 507

Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration

Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., et al. (2010) · PLoS Biology

Acute Ischemic Stroke ManagementNitric Oxide and Endothelin Effects

Cited by 447

Rapamycin extends murine lifespan but has limited effects on aging

Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

Cited by 374

An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice

Lewis, M. A., Quint, E., Glazier, A. M., Fuchs, H., De Angelis, M. H., Langford, C., van Dongen, S., Abreu-Goodger, C., Piipari, M., Redshaw, N., et al. (2009) · Nature Genetics

Hearing, Cochlea, Tinnitus, GeneticsMicroRNA in disease regulation

Cited by 302

Prevalence of sexual dimorphism in mammalian phenotypic traits

Karp, N. A., Mason, J., Beaudet, A. L., Benjamini, Y., Bower, L., Braun, R. E., Brown, S. D. M., Chesler, E. J., Dickinson, M. E., Flenniken, A. M., et al. (2017) · Nature Communications

Sex and Gender in HealthcareGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 257

Epigenetic inheritance of diet-induced and sperm-borne mitochondrial RNAs

Tomar, A., Gomez-Velazquez, M., Gerlini, R., Comas-Armangué, G., Makharadze, L., Kolbe, T., Boersma, A., Dahlhoff, M., Burgstaller, J. P., Lassi, M., et al. (2024) · Nature

Sperm and Testicular FunctionEpigenetics and DNA Methylation

Cited by 216

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Keller, J., Catala-Lehnen, P., Huebner, A. K., Jeschke, A., Heckt, T., Lueth, A., Krause, M., Koehne, T., Albers, J., Schulze, J., et al. (2014) · Nature Communications

Bone Metabolism and DiseasesSphingolipid Metabolism and Signaling

Cited by 211

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., et al. (2016) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 191

Autoimmunity and Inflammation Due to a Gain-of-Function Mutation in Phospholipase Cγ2 that Specifically Increases External Ca2+ Entry

Yu, P., Constien, R., Dear, N., Katan, M., Hanke, P., Bunney, T. D., Kunder, S., Quintanilla-Martinez, L., Huffstadt, U., Schröder, A., et al. (2005) · Immunity

T-cell and B-cell ImmunologyImmunodeficiency and Autoimmune Disorders

Cited by 177

Urocortin 3 Modulates Social Discrimination Abilities via Corticotropin-Releasing Hormone Receptor Type 2

Deussing, J. M., Breu, J., Kuhne, C., Kallnik, M., Bunck, M., Glasl, L., Yen, Y.-C., Schmidt, M. V., Zurmuhlen, R., Vogl, A. M., et al. (2010) · Journal of Neuroscience

Neuroendocrine regulation and behaviorOlfactory and Sensory Function Studies

Cited by 86

IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock

Siegfried, A., Berchtold, S., Manncke, B., Deuschle, E., Reber, J., Ott, T., Weber, M., Kalinke, U., Hofer, M. J., Hatesuer, B., et al. (2013) · The Journal of Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 70

Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations

Everett, K. L., Bunney, T. D., Yoon, Y., Rodrigues-Lima, F., Harris, R., Driscoll, P. C., Abe, K., Fuchs, H., Hrabé de Angelis, M., Yu, P., et al. (2009) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 63

Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

Galli, G. G., Honnens de Lichtenberg, K., Carrara, M., Hans, W., Wuelling, M., Mentz, B., Multhaupt, H. A., Fog, C. K., Jensen, K. T., Rappsilber, J., et al. (2012) · PLoS Genetics

Bone Metabolism and DiseasesBone and Dental Protein Studies

Cited by 61

A novel N‐ethyl‐N‐nitrosourea–induced mutation in phospholipase Cγ2 causes inflammatory arthritis, metabolic defects, and male infertility in vitro in a murine model

Abe, K., Fuchs, H., Boersma, A., Hans, W., Yu, P., Kalaydjiev, S., Klaften, M., Adler, T., Calzada‐Wack, J., Mossbrugger, I., et al. (2011) · Arthritis & Rheumatism

Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus Research

Cited by 46

Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-induced diabetic mice

Franko, A., Huypens, P., Neschen, S., Irmler, M., Rozman, J., Rathkolb, B., Neff, F., Prehn, C., Dubois, G., Baumann, M., et al. (2016) · Diabetes

Peroxisome Proliferator-Activated ReceptorsDiabetes Treatment and Management

Cited by 42

Conditional reduction of adult born doublecortin-positive neurons reversibly impairs selective behaviors

Garrett, L., Zhang, J., Zimprich, A., Niedermeier, K. M., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Vogt Weisenhorn, D., Wurst, W., & Hölter, S. M. (2015) · Frontiers in Behavioral Neuroscience

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 37

CIP2A promotes T-cell activation and immune response to Listeria monocytogenes infection

Côme, C., Cvrljevic, A., Khan, M. M., Treise, I., Adler, T., Aguilar-Pimentel, J. A., Au-Yeung, B., Sittig, E., Laajala, T. D., Chen, Y., et al. (2016) · PLoS ONE

T-cell and B-cell ImmunologySignaling Pathways in Disease

Cited by 20

RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation

Bartsch, K., Damme, M., Regen, T., Becker, L., Garrett, L., Hölter, S. M., Knittler, K., Borowski, C., Waisman, A., Glatzel, M., et al. (2018) · Frontiers in Immunology

interferon and immune responsesInflammasome and immune disorders

Cited by 20