Urocortin 3 Modulates Social Discrimination Abilities via Corticotropin-Releasing Hormone Receptor Type 2
Open accessAbstract
Urocortin 3 (UCN3) is strongly expressed in specific nuclei of the rodent brain, at sites distinct from those expressing urocortin 1 and urocortin 2, the other endogenous ligands of corticotropin-releasing hormone receptor type 2 (CRH-R2). To determine the physiological role of UCN3, we generated UCN3-deficient mice, in which the UCN3 open reading frame was replaced by a tau-lacZ reporter gene. By means of this reporter gene, the nucleus parabrachialis and the premammillary nucleus were identified as previously unknown sites of UCN3 expression. Additionally, the introduced reporter gene enabled the visualization of axonal projections of UCN3-expressing neurons from the superior paraolivary nucleus to the inferior colliculus and from the posterodorsal part of the medial amygdala to the principal nucleus of the bed nucleus of the stria terminalis, respectively. The examination of tau-lacZ reporter gene activity throughout the brain underscored a predominant expression of UCN3 in nuclei functionally connected to the accessory olfactory system. Male and female mice were comprehensively phenotyped but none of the applied tests provided indications for a role of UCN3 in the context of hypothalamic-pituitary-adrenocortical axis regulation, anxiety- or depression-related behavior. However, inspired by the prevalent expression throughout the accessory olfactory system, we identified alterations in social discrimination abilities of male and female UCN3 knock-out mice that were also present in male CRH-R2 knock-out mice. In conclusion, our results suggest a novel role for UCN3 and CRH-R2 related to the processing of social cues and to the establishment of social memories.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Ucn3 is the only highly selective ligand for CRF-R2.
“Ucn3, the only highly selective ligand for CRF-R2, is expressed in distinct brain nuclei including the MeA, the bed nucleus of stria terminalis (BNST), the median preoptic nucleus, and the perifornical area of the hypothalamus 7,8 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [8]
For all experiments, no statistical methods were used to predetermine sample sizes, but sample sizes are similar to those generally employed in the field.
“For all experiments, no statistical methods were used to predetermine sample sizes, but our sample sizes are similar to those generally employed in the field 8 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Generalized lacZ expression with the ROSA26 Cre reporter strain
Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237 · see citing works
Visualizing an Olfactory Sensory Map
Mombaerts, P., Wang, F., Dulac, C. G., Chao, S. K., Nemes, A., Mendelsohn, M. M., Edmondson, J., & Axel, R. (1996) · Cell · doi:10.1016/s0092-8674(00)81387-2 · Cited by 1,992 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Friedrich, G., & Soriano, P. M. (1991) · Genes & Development · doi:10.1101/gad.5.9.1513 · Cited by 1,403 · see citing works
NEWMAN, S. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09271.x · Cited by 1,189 · see citing works
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130 · see citing works
Landgraf, R., & Neumann, I. D. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.05.001 · Cited by 1,059 · see citing works
Self-citationOxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043 · see citing works
The MAP1 family of microtubule-associated proteins.
Dehmelt (2004) · Genome biology · doi:10.1186/gb-2004-6-1-204 · Cited by 972 · see citing works
Lewis, K., Li, C., Perrin, M. H., Blount, A., Kunitake, K., Donaldson, C., Vaughan, J., Reyes, T. M., Gulyas, J., Fischer, W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121165198 · Cited by 925 · see citing works
Reyes, T. M., Lewis, K., Perrin, M. H., Kunitake, K. S., Vaughan, J., Arias, C. A., Hogenesch, J. B., Gulyas, J., Rivier, J., Vale, W. W., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051626398 · Cited by 887 · see citing works
Organization of projections from the medial nucleus of the amygdala: A PHAL study in the rat
Canteras, N. S., Simerly, R. B., & Swanson, L. W. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903600203 · Cited by 884 · see citing works
Bale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850 · see citing works
CAN SOCIAL INTERACTION BE USED TO MEASURE ANXIETY?
File, S. E., & Hyde, J. R. G. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07001.x · Cited by 808 · see citing works
Simerly, R. B. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142745 · Cited by 723 · see citing works
Topography of projections from amygdala to bed nuclei of the stria terminalis
Dong, H.-W., Petrovich, G. D., & Swanson, L. W. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00079-0 · Cited by 714 · see citing works
Hsu, S. Y., & Hsueh, A. J. W. (2001) · Nature Medicine · doi:10.1038/87936 · Cited by 651 · see citing works
Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S., Hill, J. K., Pantely, G. A., Hohimer, A. R., et al. (2000) · Nature Genetics · doi:10.1038/74255 · Cited by 588 · see citing works
Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300360 · Cited by 531 · see citing works
Sexual Differentiation of the Vertebrate Brain: Principles and Mechanisms
Cooke, B., Hegstrom, C. D., Villeneuve, L. S., & Breedlove, S. M. (1998) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0171 · Cited by 504 · see citing works
Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
Kishimoto, T., Radulović, J., Radulović, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502 · see citing works
Radulovic, J., Rühmann, A., Liepold, T., & Spiess, J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05016.1999 · Cited by 402 · see citing works
Engelmann, M., Wotjak, C. T., & Landgraf, R. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00053-l · Cited by 274 · see citing works
Self-citationEngelmann, M., Wotjak, C. T., Neumann, I. D., Ludwig, M., & Landgraf, R. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00059-3 · Cited by 267 · see citing works
Self-citationGenetic variation in cortico-amygdala serotonin function and risk for stress-related disease
Holmes, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.006 · Cited by 264 · see citing works
Li, C., Vaughan, J. M., Sawchenko, P. E., & Vale, W. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00991.2002 · Cited by 241 · see citing works
Targeting genes for self-excision in the germ linePreprint
Bunting, M., Bernstein, K. E., Greer, J. M., Capecchi, M. R., & Thomas, K. R. (1999) · Genes & Development · doi:10.1101/gad.13.12.1524 · Cited by 234 · see citing works
Baseline and fear-potentiated startle in panic disorder patients
Grillon, C., Ameli, R., Goddard, A., Woods, S. W., & Davis, M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90040-x · Cited by 212 · see citing works
Targeted gene mutation approaches to the study of anxiety-like behavior in mice
Holmes, A. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00012-4 · Cited by 198 · see citing works
Introducing the German Mouse Clinic: open access platform for standardized phenotyping
Gailus‐Durner, V., Fuchs, H., Becker, L., Bolle, I., Brielmeier, M., Calzada‐Wack, J., Elvert, R., Ehrhardt, N. M., Dalke, C., Franz, T. J., et al. (2005) · Nature Methods · doi:10.1038/nmeth0605-403 · Cited by 191 · see citing works
Self-citationNonassociative learning processes determine expression and extinction of conditioned fear in micePreprint
Kamprath, K., & Wotjak, C. T. (2004) · Learning & Memory · doi:10.1101/lm.86104 · Cited by 188 · see citing works
Self-citationNeuroendocrine basis of social recognition
Winslow, J. T., & Insel, T. R. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.03.009 · Cited by 180 · see citing works
Bakshi, V. P., Smith-Roe, S., Newman, S. M., Grigoriadis, D. E., & Kalin, N. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02926.2002 · Cited by 171 · see citing works
Bale, T. L., & Vale, W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05295.2003 · Cited by 169 · see citing works
Copulatory behavior in male rats following amygdaloid lesions
Harris, V. S., & Sachs, B. D. (1975) · Brain Research · doi:10.1016/0006-8993(75)90906-3 · Cited by 163 · see citing works
Tau-beta-galactosidase, an axon-targeted fusion protein.
Callahan, C. A., & Thomas, J. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.5972 · Cited by 157 · see citing works
Pelleymounter, M. A., Joppa, M. A., LING, N. C., & Foster, A. C. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.302.1.145 · Cited by 147 · see citing works
Valdez, G. R., Inoue, K., Koob, G. F., Rivier, J., Vale, W., & Zorrilla, E. P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02707-5 · Cited by 143 · see citing works
Valdez, G. R., Zorrilla, E. P., Rivier, J., Vale, W., & Koob, G. F. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02971-8 · Cited by 140 · see citing works
Urocortin III Is Expressed in Pancreatic β-Cells and Stimulates Insulin and Glucagon Secretion
Li, C., Chen, P., Vaughan, J. M., Blount, A. L., Chen, A., Jamieson, P. M., Rivier, J., Smith, M. S., & Vale, W. (2003) · Endocrinology · doi:10.1210/en.2002-0087 · Cited by 127 · see citing works
Risbrough, V. B., Hauger, R. L., Roberts, A. L., Vale, W., & Geyer, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5760-03.2004 · Cited by 123 · see citing works
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis
Li, C., Chen, P., Vaughan, J. M., Lee, K., & Vale, W. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611641104 · Cited by 119 · see citing works
Animal models of CRH excess and CRH receptor deficiency display altered adaptations to stress
Coste, S. C., Murray, S., & Stenzel‐Poore, M. P. (2001) · Peptides · doi:10.1016/s0196-9781(01)00386-2 · Cited by 117 · see citing works
Venihaki, M., Sakihara, S., Subramanian, S. B., Dikkes, P., Weninger, S. C., Liapakis, G., Graf, T., & Majzoub, J. A. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01170.x · Cited by 115 · see citing works
The modified hole board as a differential screen for behavior in rodents
Ohl, F., Holsboer, F., & Landgraf, R. (2001) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03195393 · Cited by 113 · see citing works
Self-citationPelleymounter, M. A., Joppa, M. A., Ling, N., & Foster, A. C. (2004) · Peptides · doi:10.1016/j.peptides.2004.01.008 · Cited by 110 · see citing works
Medial amygdala lesions in male rats reduce aggressive behavior: interference with experience
Vochteloo, J. D., & Koolhaas, J. M. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90137-5 · Cited by 109 · see citing works
Risbrough, V. B., Hauger, R. L., Pelleymounter, M. A., & Geyer, M. A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1535-6 · Cited by 107 · see citing works
Ebner, K., Wotjak, C. T., Landgraf, R., & Engelmann, M. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01869.x · Cited by 104 · see citing works
Self-citationEffects of urocortin 2 and 3 on motor activity and food intake in rats
Ohata, H., & Shibasaki, T. (2004) · Peptides · doi:10.1016/j.peptides.2004.05.023 · Cited by 91 · see citing works
Chen, A., Zorrilla, E. P., Smith, S., Rousso, D. L., Levy, C. L., Vaughan, J. M., Donaldson, C., Roberts, A. L., Lee, K., & Vale, W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3955-05.2006 · Cited by 91 · see citing works
Fekete, É. M., Inoue, K., Zhao, Y., Rivier, J., Vale, W., Szűcs, A. L., Koob, G. F., & Zorrilla, E. P. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301214 · Cited by 90 · see citing works
Pham, T.-T., Giesert, F., Röthig, A. H. J., Floss, T., Kallnik, M., Weindl, K., Hölter, S. M., Ahting, U., Prokisch, H., Becker, L., et al. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00559.x · Cited by 85 · see citing works
Self-citationJamieson, P. M., Li, C., Kukura, C., Vaughan, J. M., & Vale, W. (2006) · Endocrinology · doi:10.1210/en.2006-0545 · Cited by 83 · see citing works
Visualizing an olfactory sensory map
(1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)84641-0 · Cited by 83 · see citing works
Systemic First-Line Phenotyping
Gailus‐Durner, V., Fuchs, H., Adler, T., Aguilar‐Pimentel, J. A., Becker, L., Bolle, I., Calzada‐Wack, J., Dalke, C., Ehrhardt, N., Ferwagner, B., et al. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-471-1_25 · Cited by 80 · see citing works
Self-citationGolub, Y., Mauch, C. P., Dahlhoff, M., & Wotjak, C. T. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.08.019 · Cited by 80 · see citing works
Self-citationTodorovic, C., Sherrin, T., Pitts, M. W., Hippel, C., Rayner, M. D., & Spiess, J. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.178 · Cited by 76 · see citing works
Taming in wild rats following medial amygdaloid lesions
Kemble, E. D., Blanchard, D. C., Blanchard, R. J., & Takushi, R. Y. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90084-2 · Cited by 70 · see citing works
D'Anna‐Hernandez, K., & Gammie, S. C. (2009) · Behavioral Neuroscience · doi:10.1037/a0014987 · Cited by 64 · see citing works
Gammie, S. C., Hasen, N. S., Stevenson, S. A., Bale, T. L., & D'Anna‐Hernandez, K. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.11.026 · Cited by 60 · see citing works
AN OLFACTORY DISCRIMINATION PROCEDURE FOR MICE
Mihalick, S. M., Langlois, J. C., Krienke, J. D., & Dube, W. V. (2000) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.2000.73-305 · Cited by 54 · see citing works
Tanaka, M., & Telegdy, G. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.08.009 · Cited by 50 · see citing works
Urocortin 1 and 3 Impair Maternal Defense Behavior in Mice.
D'Anna‐Hernandez, K., Stevenson, S. A., & Gammie, S. C. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.4.1061 · Cited by 50 · see citing works
Saruta, M., Takahashi, K., Suzuki, T., Fukuda, T., Torii, A., & Sasano, H. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.014 · Cited by 49 · see citing works
Usunoff, K. G., Schmitt, O., Itzev, D. E., Haas, S. J.-P., Lazarov, N., Rolfs, A., & Wree, A. (2009) · Cells Tissues Organs · doi:10.1159/000209233 · Cited by 49 · see citing works
Distribution of urocortin 3 neurons innervating the ventral premammillary nucleus in the rat brain
Cavalcante, J. C., Sita, L. V., Mascaro, M. B., Bittencourt, J. C., & Elias, C. F. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.043 · Cited by 41 · see citing works
Modulation of social learning in rats by brain corticotropin-releasing factor.
Heinrichs, S. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.028 · Cited by 41 · see citing works
Tanaka, M., & Telegdy, G. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.08.012 · Cited by 37 · see citing works
Sociability trait and serotonin metabolism in the rat social interaction test
Tõnissaar, M., Philips, M., Eller, M., & Harro, J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.023 · Cited by 35 · see citing works
Expression Profiling Identifies the CRH/CRH-R1 System as a Modulator of Neurovascular Gene Activity
Deussing, J. M., Kühne, C., Pütz, B., Panhuysen, M., Breu, J., Stenzel‐Poore, M. P., Holsboer, F., & Wurst, W. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600451 · Cited by 25 · see citing works
Self-citationcGMP-dependent protein kinase I, the circadian clock, sleep and learning
Feil, R., Hölter, S. M., Weindl, K., Wurst, W., Langmesser, S., Gerling, A., Feil, S. C., & Albrecht, U. (2009) · Communicative & Integrative Biology · doi:10.4161/cib.2.4.8220 · Cited by 24 · see citing works
Self-citationUrocortin II increases spontaneous parental behavior in prairie voles (Microtus ochrogaster)
SAMUEL, P., Hostetler, C. M., & Bales, K. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.08.015 · Cited by 14 · see citing works
PELLEYMOUNTER, M. (2004) · Peptides · doi:10.1016/s0196-9781(04)00041-5 · Cited by 5 · see citing works
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse
Van Pett, K., Viau, V., Bittencourt, J. C., Chan, R. K. W., Li, H.-Y., Arias, C., Prins, G. S., Perrin, M., Vale, W., & Sawchenko, P. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001211)428:2
Flagged first, then by citations
Cited by
Sorted by citations
Role of neuropeptides in anxiety, stress, and depression: From animals to humans
Kormos, V., & Gaszner, B. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.014 · Cited by 327 · see citing works
The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.
Deussing, J., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 234 · see citing works
Self-citationRegion-specific roles of the corticotropin-releasing factor–urocortin system in stress
Henckens, M. J. A. G., Deussing, J. M., & Chen, A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.94 · Cited by 245 · see citing works
Self-citationThe CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response
Dedic, N., Chen, A., & Deussing, J. M. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467210666170302104053 · Cited by 181 · see citing works
Self-citationWong, R. Y., Oxendine, S. E., & Godwin, J. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-348 · Cited by 128 · see citing works
The human olfactory transcriptome
Olender, T., Keydar, I., Pinto, J. M., Tatarskyy, P., Alkelai, A., Chien, M., Fishilevich, S., Restrepo, D., Matsunami, H., Gilad, Y., et al. (2016) · BMC Genomics · doi:10.1186/s12864-016-2960-3 · Cited by 122 · see citing works
The CRF system and social behavior: a review
Hostetler, C. M., & Ryabinin, A. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00092 · Cited by 105 · see citing works
Stress-Related Neuropeptides and Addictive Behaviors: Beyond the Usual Suspects
Schank, J. R., Ryabinin, A. E., Giardino, W. J., Ciccocioppo, R., & Heilig, M. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.026 · Cited by 106 · see citing works
Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics
Shemesh, Y., Forkosh, O., Mahn, M., Anpilov, S., Sztainberg, Y., Manashirov, S., Shlapobersky, T., Elliott, E., Tabouy, L., Ezra, G., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4346 · Cited by 99 · see citing works
Self-citationHölter, S. M., Garrett, L., Einicke, J., Sperling, B., Dirscherl, P., Zimprich, A., Fuchs, H., Gailus‐Durner, V., de Angelis, M. H., & Wurst, W. (2015) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo150068 · Cited by 100 · see citing works
Self-citationEvidence for the role of corticotropin-releasing factor in major depressive disorder
Waters, R. P., Rivalan, M., Bangasser, D. A., Deussing, J. M., Ising, M., Wood, S. K., Holsboer, F., & Summers, C. H. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.011 · Cited by 93 · see citing works
Self-citationA triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery
Neufeld-Cohen, A., Tsoory, M., Evans, A. K., Getselter, D., Gil, S., Lowry, C. A., Vale, W., & Chen, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013761107 · Cited by 96 · see citing works
Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior
Fox, J. H., & Lowry, C. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00169 · Cited by 93 · see citing works
Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
Autry, A. E., Wu, Z., Kapoor, V., Kohl, J., Bambah-Mukku, D., Rubinstein, N. D., Marin-Rodriguez, B., Carta, I., Sedwick, V. M., Tang, M., et al. (2021) · eLife · doi:10.7554/elife.64680 · Cited by 72 · see citing works
Janssen, D., & Kozicz, T. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00028 · Cited by 65 · see citing works
The Role of Hypothalamic Neuropeptides in Neurogenesis and Neuritogenesis
Bakoš, J., Zatkova, M., Bačová, Z., & Ostatníková, D. (2016) · Neural Plasticity · doi:10.1155/2016/3276383 · Cited by 61 · see citing works
Ryabinin, A. E., Tsoory, M., Kozicz, T., Thiele, T. E., Neufeld-Cohen, A., Chen, A., Lowery‐Gionta, E. G., Giardino, W. J., & Kaur, S. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.10.007 · Cited by 60 · see citing works
Laryea, G. N., Arnett, M. G., & Muglia, L. J. (2012) · Behavioral Sciences · doi:10.3390/bs2020135 · Cited by 56 · see citing works
Kühne, C., Puk, O., Graw, J., de Angelis, M. H., Schütz, G., Wurst, W., & Deussing, J. M. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23082 · Cited by 53 · see citing works
Self-citationWaltereit, R., Leimer, U., Halbach, O. V. B. U., Panke, J., Hölter, S. M., Garrett, L., Wittig, K., Schneider, M., Schmitt, C., Calzada‐Wack, J., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-202317 · Cited by 54 · see citing works
Self-citationTests for Anxiety‐Related Behavior in Mice
Hölter, S. M., Einicke, J., Sperling, B., Zimprich, A., Garrett, L., Fuchs, H., Gailus‐Durner, V., de Angelis, M. H., & Wurst, W. (2015) · Current Protocols in Mouse Biology · doi:10.1002/9780470942390.mo150010 · Cited by 49 · see citing works
Self-citationWolf, E. J., Mitchell, K. S., Logue, M. W., Baldwin, C. T., Reardon, A. F., Humphries, D. E., & Miller, M. W. (2013) · Depression and Anxiety · doi:10.1002/da.22176 · Cited by 49 · see citing works
Phillips, T. J., Reed, C. L., & Pastor, R. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12189 · Cited by 46 · see citing works
Dedic, N., Kühne, C., Gomes, K. S., Hartmann, J., Ressler, K. J., Schmidt, M. V., & Deussing, J. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00986 · Cited by 44 · see citing works
Self-citationGarrett, L., Zhang, J., Zimprich, A., Niedermeier, K. M., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Vogt Weisenhorn, D., Wurst, W., & Hölter, S. M. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00302 · Cited by 37 · see citing works
Self-citationDong, H., Qian, Y., Bhuiyan, P., Wang, Y., & Sha, H.-H. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.310608 · Cited by 39 · see citing works
Horii‐Hayashi, N., Nomoto, K., Endo, N., Yamanaka, A., Kikusui, T., & Nishi, M. (2020) · iScience · doi:10.1016/j.isci.2020.101908 · Cited by 35 · see citing works
Urocortin 2 modulates aspects of social behaviour in mice
Breu, J., Touma, C., Hölter, S. M., Knapman, A., Wurst, W., & Deussing, J. M. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.031 · Cited by 30 · see citing works
Self-citationInvolvement of CRF2 receptor in the brain regions in restraint-induced anorexia
Ohata, H., & Shibasaki, T. (2011) · Neuroreport · doi:10.1097/wnr.0b013e3283487467 · Cited by 30 · see citing works
Structure and function of the medial amygdala
(2020) · Handbook of Behavioral Neuroscience · doi:10.1016/b978-0-12-815134-1.00002-7 · Cited by 29 · see citing works
Relevance of urocortins to cardiovascular disease
Emeto, T. I., Moxon, J. V., Rush, C. M., Woodward, L., & Golledge, J. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.06.002 · Cited by 28 · see citing works
Karlsson, S. A., Studer, E., Kettunen, P., & Westberg, L. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00041 · Cited by 26 · see citing works
Frankiensztajn, L. M., Gur-Pollack, R., & Wagner, S. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.006 · Cited by 27 · see citing works
Molecular Signaling and Translational Significance of the Corticotropin Releasing Factor System
Ronan, P. J., & Summers, C. H. (2011) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-385506-0.00006-5 · Cited by 24 · see citing works
Novoa, J., Rivero, C. J., Pérez‐Cardona, E. U., Freire, J. A., Zegers, J., Yarur, H. E., Santiago-Marrero, I. G., Agosto, J. L., González‐Pérez, J. L., Gysling, K., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15345 · Cited by 23 · see citing works
Urocortins in the mammalian endocrine system
Squillacioti, C., Pelagalli, A., Liguori, G., & Mirabella, N. (2019) · Acta veterinaria Scandinavica · doi:10.1186/s13028-019-0480-2 · Cited by 23 · see citing works
Sänchez, R. L., Reddy, A. P., & Bethea, C. L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.059 · Cited by 21 · see citing works
Three urocortins in medaka: identification and spatial expression in the central nervous system
Hosono, K., Yamashita, J., Kikuchi, Y., Hiraki‐Kajiyama, T., & Okubo, K. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12472 · Cited by 21 · see citing works
Morisot, N., Monier, R., Moine, C. L., Millan, M. J., & Contarino, A. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14159 · Cited by 26 · see citing works
Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity
Flisher, M. F., Shin, D., & Huising, M. O. (2022) · Peptides · doi:10.1016/j.peptides.2022.170748 · Cited by 20 · see citing works
Capps, M. E., Moyer, A. J., Conklin, C. L., Martina, V., Torija-Olson, E. G., Klein, M. C., Gannaway, W. C., Calhoun, C. C., Vivian, M. D., & Thyme, S. B. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402557122 · Cited by 20 · see citing works
Sex, social status, and CRF receptor densities in naked mole‐rats
Beery, A. K., Bicks, L. K., Mooney, S. J., Goodwin, N. L., & Holmes, M. M. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23834 · Cited by 18 · see citing works
Viggiano, A., Cacciola, G., Widmer, D. A. J., & Viggiano, D. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.032 · Cited by 17 · see citing works
Ivanova, D., Li, X.-F., McIntyre, C., Liu, Y., Kong, L., & O’Byrne, K. T. (2021) · Endocrinology · doi:10.1210/endocr/bqab206 · Cited by 18 · see citing works
Breese, G. R., & Knapp, D. J. (2016) · Alcohol · doi:10.1016/j.alcohol.2016.01.005 · Cited by 15 · see citing works
Stem Cells in Neuroendocrinology
Pfaff, D., & Christen, Y. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-41603-8 · Cited by 16 · see citing works
Sex‐linked roles of the CRF 1 and the CRF 2 receptor in social behavior
Piccin, A., & Contarino, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24629 · Cited by 22 · see citing works
The CRF 1 receptor mediates social behavior deficits induced by opiate withdrawal
Piccin, A., & Contarino, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24697 · Cited by 19 · see citing works
Smith, M. L., Li, J., & Ryabinin, A. E. (2014) · Alcohol and Alcoholism · doi:10.1093/alcalc/agu084 · Cited by 13 · see citing works
The effects of CRF and urocortins on the sociability of mice
Bagosi, Z., Karasz, G., Czébely-Lénárt, A., Csabafi, K., Jászberényi, M., & Telegdy, G. (2017) · Brain Research · doi:10.1016/j.brainres.2017.03.003 · Cited by 13 · see citing works
Neuropeptide Regulation of Stress-Induced Behavior
Sztainberg, Y., & Chen, A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10015-0 · Cited by 12 · see citing works
Stress and the Reproductive System
Li, X.-F., & O’Byrne, K. T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00036-3 · Cited by 13 · see citing works
Corticotropin-releasing factor: innocent until proven guilty
Giardino, W. J., & Ryabinin, A. E. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3110-c1 · Cited by 12 · see citing works
Genetic Dissection of the Neuroendocrine and Behavioral Responses to Stressful Challenges
Chen, A. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-41603-8_6 · Cited by 11 · see citing works
Grommen, S. V. H., Scott, M. K., Darras, V., & Groef, B. D. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24223 · Cited by 11 · see citing works
The effects of CRF and urocortins on the preference for social novelty of mice
Bagosi, Z., Czébely-Lénárt, A., Karasz, G., Csabafi, K., Jászberényi, M., & Telegdy, G. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.009 · Cited by 11 · see citing works
Urocortins and their unfolding role in mammalian social behavior
Wagner, S. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2962-3 · Cited by 11 · see citing works
Bagosi, Z., Megyesi, K., Ayman, J., Rudersdorf, H., Ayaz, M. K., & Csabafi, K. (2023) · Biomedicines · doi:10.3390/biomedicines11082217 · Cited by 10 · see citing works
Zheng, Y., Zhang, Y.-M., & Ni, X. (2015) · Endocrinology · doi:10.1210/en.2015-1812 · Cited by 10 · see citing works
High-Throughput Mouse Phenotyping
Hölter, S. M., & Glasl, L. (2011) · Neuromethods · doi:10.1007/978-1-61779-298-4_7 · Cited by 10 · see citing works
Self-citationThe Role of Urocortins in Intracerebral Hemorrhage
Choy, K. W., Tsai, A. P., Lin, P. B., Wu, M., Lee, C., Alias, A., Pang, C., & Liew, H. (2020) · Biomolecules · doi:10.3390/biom10010096 · Cited by 9 · see citing works
Ivanova, D., Li, X.-F., McIntyre, C., & O’Byrne, K. T. (2022) · Endocrinology · doi:10.1210/endocr/bqac196 · Cited by 10 · see citing works
Role of Posterodorsal Medial Amygdala Urocortin-3 in Pubertal Timing in Female Mice
Ivanova, D., Li, X.-F., Liu, Y., McIntyre, C., Fernandes, C., Lass, G., Kong, L., & O’Byrne, K. T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.893029 · Cited by 8 · see citing works
Jakubcakova, V., Flachskamm, C., Deussing, J. M., & Kimura, M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.06.008 · Cited by 9 · see citing works
Self-citationContribution of Urocortin to the Development of Excessive Drinking
Ryabinin, A. E., & Giardino, W. J. (2017) · International review of neurobiology · doi:10.1016/bs.irn.2017.06.007 · Cited by 9 · see citing works
Abdelmesih, B., Anderson, R., Bambah-Mukku, D., Carta, I., & Autry, A. E. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01902-2 · Cited by 10 · see citing works
The role of CRF family peptides in the regulation of food intake and anxiety-like behavior
Nakayama, N., Suzuki, H., Li, J.-B., Atsuchi, K., Tsai, M., Amitani, H., Asakawa, A., & Inui, A. (2011) · BioMolecular Concepts · doi:10.1515/bmc.2011.022 · Cited by 8 · see citing works
Fischl, M. J., Ueberfuhr, M. A., Drexl, M., Pagella, S., Sinclair, J. L., Alexandrova, O., Deussing, J. M., & Kopp‐Scheinpflug, C. (2019) · The Journal of Physiology · doi:10.1113/jp278132 · Cited by 8 · see citing works
Self-citationBattagello, D. S., Diniz, G. B., Cândido, P. L., da Silva, J. M., de Oliveira, A. R., da Silva, K. R. T., Lotfi, C. F. P., de Oliveira, J. A., Sita, L. V., Casatti, C. A., et al. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00057 · Cited by 6 · see citing works
The urocortin peptides: biological relevance and laboratory aspects of UCN3 and its receptor
Alghamdi, N. J., Burns, C. T., & Valdes, R. (2022) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2022.2080175 · Cited by 7 · see citing works
Bagosi, Z., Csabafi, K., Karasz, G., Jászberényi, M., Földesi, I., Siska, A., Szabó, G., & Telegdy, G. (2018) · Peptides · doi:10.1016/j.peptides.2018.10.014 · Cited by 6 · see citing works
Jia, C., Gill, W. D., Lovins, C., Brown, R. W., & Hagg, T. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100435 · Cited by 6 · see citing works
Yuyan, F. E. N. G., Jie, L. I. U., Chen, X., Guo, B., Lei, M., Zhu, H., & Ni, Y. (2025) · Poultry Science · doi:10.1016/j.psj.2025.104883 · Cited by 5 · see citing works
von Mücke-Heim, I.-A., Oldekamp, J., Metzger, M. W., Kläffgen, S., Tang, H., Walser, S. M., Dedic, N., Rammes, G., Holsboer, F., Wurst, W., et al. (2025) · Purinergic Signalling · doi:10.1007/s11302-025-10074-x · Cited by 4 · see citing works
Self-citationRiester, A., Spyroglou, A., Neufeld-Cohen, A., Chen, A., & Beuschlein, F. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-11-0144 · Cited by 4 · see citing works
Jia, C., Gill, W. D., Lovins, C., Brown, R. W., & Hagg, T. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100621 · Cited by 3 · see citing works
Papp, R. S., Könczöl, K., Sípos, K., & Tóth, Z. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020739 · Cited by 3 · see citing works
Pagella, S., Deussing, J. M., & Kopp‐Scheinpflug, C. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.747472 · Cited by 3 · see citing works
Self-citationAli, A., Milman, S., Weiss, E. F., Gao, T., Napolioni, V., Barzilai, N., Zhang, Z. D., & Lin, J.-R. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14379 · Cited by 3 · see citing works
Action of CRF/Urocortin Peptides
Deussing, J. M., Ryabinin, A. E., Zuniga, A., & Kozicz, T. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00062-6 · Cited by 3 · see citing works
Self-citationExpression of Urocortin 3 mRNA in the Central Nervous System of the Sea Lamprey Petromyzon marinus
Sobrido‐Cameán, D., Anadón, R., & Barreiro‐Iglesias, A. (2021) · Biology · doi:10.3390/biology10100978 · Cited by 2 · see citing works
Contarino, A. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110480 · Cited by 1 · see citing works
Abdelmesih, B., Anderson, R., Carta, I., & Autry, A. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.19.481074 · Cited by 1 · see citing works
The Corticotropin Releasing Factor System and Alcohol Consumption
Ryabinin, A. E., & Giardino, W. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800773-0.00016-1
Jia, C., Gill, W. D., Lovins, C., Hagg, T., & Brown, R. W. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3991834
- Authors
- Deussing, J. M., Breu, J., Kuhne, C., Kallnik, M., Bunck, M., Glasl, L., Yen, Y.-C., Schmidt, M. V., Zurmuhlen, R., Vogl, A. M., Gailus-Durner, V., Fuchs, H., Holter, S. M., Wotjak, C. T., Landgraf, R., de Angelis, M. H., Holsboer, F., & Wurst, W.
- Affiliations
- Max Planck Society (DE)
- Max Planck Institute of Psychiatry (DE)
- Helmholtz Munich (DE)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-07-07
- Volume
- 30
- Issue
- 27
- Pages
- 9103-9116
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632482
- OpenAlex
- W1968320836
- Cited by
- 86
- References
- 74
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 2 · 2013: 6 · 2012: 8
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- other-oa
- Locations
- Journal of Neuroscience (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion)
- DZNE Pub (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Commission (LSHG-2006-037188)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- urocortin 3, social discrimination, social memory, accessory olfactory system, parabrachial nucleus, superior paraolivary nucleus, inferior colliculus, medial amygdala, bed nucleus of the stria terminalis, axonal projections, hypothalamic-pituitary-adrenal axis, anxiety, depression
- MeSH terms
- Acoustic Stimulation, Animals, Brain, Circadian Rhythm, Corticosterone, Discrimination, Psychological, Fear, Female, Gene Expression Regulation, Hypothalamo-Hypophyseal System, Inhibition, Psychological, Interpersonal Relations, Male, Mice, Inbred C57BL, Neurons, Odorants, Olfactory Pathways, Perception, Pituitary-Adrenal System, Radioimmunoassay, Reflex, Startle, Swimming, Receptors, Corticotropin-Releasing Hormone, Mice, Knockout, Statistics, Nonparametric, Maze Learning, Recognition, Psychology, Mice, Urocortins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
