Wong, Ma-Li

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 969

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Zheng, P., Zeng, B., Liu, M., Chen, J., Pan, J., Han, Y., Liu, Y., Cheng, K., Zhou, C., Wang, H., et al. (2019) · Science Advances

Gut microbiota and healthTryptophan and brain disorders

Cited by 704

Research and treatment approaches to depression

Wong, M.-L., & Licinio, J. (2001) · Nature Reviews Neuroscience

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 656

Human Leptin Levels Are Pulsatile and Inversely Related to Pituitary–Ardenal Function

Licinio, J., Mantzoros, C., Negrão, A. B., Cizza, G., Wong, M.-L., Bongiorno, P. B., Chrousos, G. P., Karp, B., Allen, C., Flier, J. S., et al. (1997) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 632

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 568

Circadian Interleukin-6 Secretion and Quantity and Depth of Sleep

Vgontzas, A. N., Papanicolaou, D. A., Bixler, E. O., Lotsikas, A., Zachman, K., Kales, A., Prolo, P., Wong, M.-L., Licinio, J., Gold, P. W., et al. (1999) · The Journal of Clinical Endocrinology & Metabolism

Sleep and Wakefulness ResearchSleep and Work-Related Fatigue

Cited by 516

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 505

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

Graessler, J., Qin, Y., Zhong, H., Zhang, J., Licinio, J., Wong, M.-L., Xu, A., Chavakis, T., Bornstein, A. B., Ehrhart-Bornstein, M., et al. (2013) · The Pharmacogenomics Journal

Gut microbiota and healthBariatric Surgery and Outcomes

Cited by 428

The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

Licinio, J., & Wong, M.-L. (1999) · Molecular Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 380

Polymorphisms in Inflammation-Related Genes Are Associated with Susceptibility to Major Depression and Antidepressant Response

Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry

Tryptophan and brain disordersTreatment of Major Depression

Cited by 295

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women

Licinio, J., Negrão, A. B., Mantzoros, C., Kaklamani, V., Wong, M.-L., Bongiorno, P. B., Mulla, A., Cearnal, L., Veldhuis, J. D., Flier, J. S., et al. (1998) · Proceedings of the National Academy of Sciences

Hypothalamic control of reproductive hormonesOvarian function and disorders

Cited by 287

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

Wong, M.-L., Rettori, V., AL-Shekhlee, A., Bongiorno, P. B., Canteros, G., McCann, S. M., Gold, P. W., & Licinio, J. (1996) · Nature Medicine

Nitric Oxide and Endothelin EffectsSepsis Diagnosis and Treatment

Cited by 286

The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress**This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder.

Deak, T., Nguyen, K. T., Ehrlich, A. L., Watkins, L. R., Spencer, R. L., Maier, S. F., Licinio, J., Wong, M.-L., Chrousos, G. P., Webster, E., et al. (1999) · Endocrinology

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 242

Synchronicity of Frequently Sampled Thyrotropin (TSH) and Leptin Concentrations in Healthy Adults and Leptin-Deficient Subjects: Evidence for Possible Partial TSH Regulation by Leptin in Humans

Mantzoros, C. S., Ozata, M., Negrao, A. B., Suchard, M. A., Ziotopoulou, M., Caglayan, S., Elashoff, R. M., Cogswell, R. J., Negro, P., Liberty, V., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism

Thyroid Disorders and TreatmentsRegulation of Appetite and Obesity

Cited by 229

Pathways and mechanisms for cytokine signaling of the central nervous system.

Licinio, J., & Wong, M. L. (1997) · Journal of Clinical Investigation

Cytokine Signaling Pathways and InteractionsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 220

Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.

Baicy, K., London, E. D., Monterosso, J., Wong, M.-L., Delibasi, T., Sharma, A., & Licinio, J. (2007) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 212

Requirements for kissing-loop-mediated dimerization of human immunodeficiency virus RNA

Clever, J. L., Wong, M. L., & Parslow, T. G. (1996) · Journal of Virology

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 202

Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: Association with major depression and antidepressant response in Mexican-Americans

Dong, C., Wong, M.-L., & Licinio, J. (2009) · Molecular Psychiatry

Treatment of Major DepressionGenetic Associations and Epidemiology

Cited by 182

The Microbiota-Inflammasome Hypothesis of Major Depression

Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays

Tryptophan and brain disordersGut microbiota and health

Cited by 134

Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls

Hiroi, N., Wong, M. L., Licinio, J., Park, C., Young, M., Gold, P. W., Chrousos, G. P., & Bornstein, S. R. (2001) · Molecular Psychiatry

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 124

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease

Vélez, J. I., Lopera, F., Sepulveda-Falla, D., Patel, H. R., Johar, A. S., Chuah, A., Tobón, C., Rivera, D., Villegas, A., Cai, Y., et al. (2016) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 111

The gut microbiome modulates the transformation of microglial subtypes

Huang, Y., Wu, J., Zhang, H., Li, Y., Wen, L., Tan, X., Cheng, K., Liu, Y., Pu, J., Liu, L., et al. (2023) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Cited by 111

Pharmacogenomics of neuroimmune interactions in human psychiatric disorders

Licinio, J., Mastronardi, C., & Wong, M. (2007) · Experimental Physiology

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 23

Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight.

Licinio, J., Milane, M., Thakur, S., Whelan, F., Yildiz, B. O., Delibasi, T., de Miranda, P. B., Ozata, M., Bolu, E., DePaoli, A., et al. (2007) · Appetite

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 22