Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters
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Roux-en-Y gastric bypass (RYGB) has become a prominent therapeutic option for long-term treatment of morbid obesity and type 2 diabetes mellitus (T2D). Cross talk and pathogenetic consequences of RYGB-induced profound effects on metabolism and gut microbiome are poorly understood. The aim of the present study therefore was to characterize intra-individual changes of gut microbial composition before and 3 months after RYGB by metagenomic sequencing in morbidly obese patients (body mass index (BMI)>40 kg m(-)(2)) with T2D. Subsequently, metagenomic data were correlated with clinical indices. Based on gene relative abundance profile, 1061 species, 729 genera, 44 phyla and 5127 KO (KEGG Orthology) were identified. Despite high diversity, bacteria could mostly be assigned to seven bacterial divisions. The overall metagenomic RYGB-induced shift was characterized by a reduction of Firmicutes and Bacteroidetes and an increase of Proteobacteria. Twenty-two microbial species and 11 genera were significantly altered by RYGB. Using principal component analysis, highly correlated species were assembled into two common components. Component 1 consisted of species that were mainly associated with BMI and C-reactive protein. This component was characterized by increased numbers of Proteobacterium Enterobacter cancerogenus and decreased Firmicutes Faecalibacterium prausnitzii and Coprococcus comes. Functional analysis of carbohydrate metabolism by KO revealed significant effects in 13 KOs assigned to phosphotransferase system. Spearmen's Rank correlation indicated an association of 10 species with plasma total- or low-density lipoprotein cholesterol, and 5 species with triglycerides. F. prausnitzii was directly correlated to fasting blood glucose. This is the first clinical demonstration of a profound and specific intra-individual modification of gut microbial composition by full metagenomic sequencing. A clear correlation exists of microbiome composition and gene function with an improvement in metabolic and inflammatory parameters. This will allow to develop new diagnostic and therapeutic strategies based on metagenomic sequencing of the human gut microbiome.
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The results are in agreement with previous findings showing an expansion of Proteobacteria shortly after RYGB in humans and mice.
“Moreover, our results are in agreement with previous findings showing an expansion of Proteobacteria shortly after RYGB, both in humans (Furet et al., 2010; Graessler et al., 2013; Kong et al., 2013; Zhang et al., 2009) and mice (Liou et al., 2013).”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Graessler et al., 2013
Changes in the composition and diversity of the gut microbiota have been observed in the short term after RYGB in humans.
“Recent work has also indicated that the gut microbiota may mediate some of the beneficial effects of bariatric surgery, and changes in the composition and diversity of the gut microbiota have been observed in the short term after RYGB in humans (Furet et al., 2010; Graessler et al., 2013; Kong et al., 2013; Zhang et al., 2009), as well as after vertical sleeve gastrectomy and RYGB in mice (Liou et”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Graessler et al., 2013
The gut microbiota may mediate some of the beneficial effects of bariatric surgery.
“Recent work has also indicated that the gut microbiota may mediate some of the beneficial effects of bariatric surgery, and changes in the composition and diversity of the gut microbiota have been observed in the short term after RYGB in humans (Furet et al., 2010; Graessler et al., 2013; Kong et al., 2013; Zhang et al., 2009), as well as after vertical sleeve gastrectomy and RYGB in mice (Liou et”
From Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015) · cites this paper as Graessler et al., 2013
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- Authors
- Graessler, J., Qin, Y., Zhong, H., Zhang, J., Licinio, J., Wong, M.-L., Xu, A., Chavakis, T., Bornstein, A. B., Ehrhart-Bornstein, M., Lamounier-Zepter, V, Lohmann, T., Wolf, T., & Bornstein, S. R.
- Affiliations
- Technische Universität Dresden (DE)
- BGI Group (China) (CN)
- Australian National University (AU)
- University of Hong Kong (HK)
- Corresponding author
- Bornstein, S R
- Venue
- The Pharmacogenomics Journal
- Published
- 2012-10-02
- Volume
- 13
- Issue
- 6
- Pages
- 514-522
- ISSN
- 1470-269X (ISSN-L)
- 1473-1150
- OpenAlex
- W1984993963
- Cited by
- 428
- References
- 28
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 21 · 2023: 24 · 2022: 34 · 2021: 46 · 2020: 53 · 2019: 50 · 2018: 35 · 2017: 40 · 2016: 33 · 2015: 33 · 2014: 22 · 2013: 19
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- Locations
- The Pharmacogenomics Journal (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- Site cant be reached (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, bariatric surgery, Roux-en-Y gastric bypass, morbid obesity, type 2 diabetes, Firmicutes, Bacteroidetes, Proteobacteria, Faecalibacterium prausnitzii, C-reactive protein, inflammatory parameters, carbohydrate metabolism, phosphotransferase system, lipid metabolism, fasting blood glucose
- MeSH terms
- Adult, Diabetes Mellitus, Type 2, Female, Humans, Inflammation, Male, Middle Aged, Obesity, Postoperative Period, Gastric Bypass, Metagenome, Microbiota
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