Bushell, Martin

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein

Sawicka, K., Bushell, M., Spriggs, K. A., & Willis, A. E. (2008) · Biochemical Society Transactions

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 332

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

Meijer, H. A., Kong, Y. W., Lu, W. T., Wilczynska, A., Spriggs, R. V., Robinson, S. W., Godfrey, J. D., Willis, A. E., & Bushell, M. (2013) · Science

MicroRNA in disease regulationRNA Research and Splicing

Cited by 326

Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice

Halliday, M., Radford, H., Zents, K. A. M., Molloy, C., Moreno, J. A., Verity, N. C., Smith, E., Ortori, C. A., Barrett, D. A., Bushell, M., et al. (2017) · Brain

Endoplasmic Reticulum Stress and DiseaseAlzheimer's disease research and treatments

Cited by 293

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes

Ferland-McCollough, D., Fernandez-Twinn, D. S., Cannell, I. G., David, H., Warner, M., Vaag, A. A., Bork-Jensen, J., Brøns, C., Gant, T. W., Willis, A. E., et al. (2012) · Cell Death & Differentiation

Birth, Development, and HealthMicroRNA in disease regulation

Cited by 149

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms

Fernandez-Twinn, D. S., Alfaradhi, M. Z., Martin-Gronert, M. S., Duque-Guimaraes, D. E., Piekarz, A., Ferland-McCollough, D., Bushell, M., & Ozanne, S. E. (2014) · Molecular Metabolism

Birth, Development, and HealthAdipokines, Inflammation, and Metabolic Diseases

Cited by 114

MNK Inhibition Sensitizes KRAS -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

Knight, J. R. P., Alexandrou, C., Skalka, G. L., Vlahov, N., Pennel, K., Officer, L., Teodosio, A., Kanellos, G., Gay, D. M., May-Wilson, S., et al. (2021) · Cancer Discovery

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 96

TOPs and their regulation

Hamilton, T. L., Stoneley, M., Spriggs, K. A., & Bushell, M. (2006) · Biochemical Society Transactions

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 91

DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids

Dearlove, E. L., Chatrin, C., Buetow, L., Ahmed, S. F., Schmidt, T., Bushell, M., Smith, B. O., & Huang, D. T. (2024) · eLife

Ubiquitin and proteasome pathwaysGenomics and Chromatin Dynamics

Cited by 23

Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

Pantaleão, L. C., Inzani, I., Furse, S., Loche, E., Hufnagel, A., Ashmore, T., Blackmore, H. L., Jenkins, B., Carpenter, A. A. M., Wilczynska, A., et al. (2022) · eLife

Birth, Development, and HealthLipid metabolism and biosynthesis

Cited by 19

Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration

May, S., Müller, M., Livingstone, C. R., Skalka, G. L., Walsh, P. J., Nixon, C., Hedley, A., Shaw, R., Clark, W., Vande Voorde, J., et al. (2023) · Journal of Hepatology

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 13

Optimisation of sample preparation from primary mouse tissue to maintain RNA integrity for methods examining translational control

Munro, J., Gillen, S. L., Mitchell, L., Laing, S., Karim, S. A., Rink, C., Waldron, J. A., & Bushell, M. (2023) · Cancers

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 5