Partial leptin deficiency and human adiposity
Abstract
The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic mutations in the leptin pathway can be a cause of human obesity.
“Mutations in the leptin pathway can be a cause of human obesity (5–7).”
From Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults (2004) · cites this paper as [5]
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works
Self-citationEffects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works
Self-citationHeymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422 · see citing works
Body mass index as a measure of body fatness: age- and sex-specific prediction formulas
Deurenberg, P., Weststrate, J., & Seidell, J. C. (1991) · British Journal of Nutrition · doi:10.1079/bjn19910073 · Cited by 1,397 · see citing works
What’s in a Name? In Search of Leptin’s Physiologic Role1
Flier, J. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4779 · Cited by 518 · see citing works
Havel, P. J. (2000) · Proceedings of The Nutrition Society · doi:10.1017/s0029665100000410 · Cited by 329 · see citing works
Relatively low plasma leptin concentrations precede weight gain in Pima Indians
Ravussin, É., Pratley, R. E., Maffei, M., Wang, H., Friedman, J. M., Bennett, P. H., & Bogardus, C. (1997) · Nature Medicine · doi:10.1038/nm0297-238 · Cited by 240 · see citing works
Metabolic fluctuation during a muscle contraction cycle
Chung, Y., Sharman, R. B., Carlsen, R. C., Unger, S. W., Larson, D. E., & Jue, T. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.3.c846 · Cited by 73 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990 · see citing works
The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review
Klok, M. D., Jakobsdottir, S., & Drent, M. L. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00270.x · Cited by 1,442 · see citing works
Obesity and the role of adipose tissue in inflammation and metabolism
Greenberg, A. S., & Obin, M. S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.461s · Cited by 1,271 · see citing works
Reversible Super-hydrophobicity to Super-hydrophilicity Transition of Aligned ZnO Nanorod Films
Feng, X., Feng, L., Jin, M., Zhai, J., Jiang, L., & Zhu, D. (2003) · Journal of the American Chemical Society · doi:10.1021/ja038636o · Cited by 1,179 · see citing works
Flier, J. S. (2004) · Cell · doi:10.1016/s0092-8674(03)01081-x · Cited by 1,105 · see citing works
Fructose, weight gain, and the insulin resistance syndrome,,
Elliott, S. S., Keim, N. L., Stern, J. S., Teff, K. L., & Havel, P. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.911 · Cited by 1,031 · see citing works
Mitochondrial dysfunction in Nash: causes, consequences and possible means to prevent it
Begriche, K., Igoudjil, A., Pessayre, D., & Fromenty, B. (2006) · Mitochondrion · doi:10.1016/j.mito.2005.10.004 · Cited by 753 · see citing works
Teff, K. L., Elliott, S. S., Tschöp, M. H., Kieffer, T. J., Rader, D. J., Heiman, M. L., Townsend, R. R., Keim, N. L., D’Alessio, D. D., & Havel, P. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031855 · Cited by 738 · see citing works
Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor.
Farooqi, I. S., Wangensteen, T., Collins, S., Kimber, W., Matarese, G., Keogh, J. M., Lank, E., Bottomley, B., Lopez-Fernandez, J., Ferraz-Amaro, I., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063988 · Cited by 732 · see citing works
Self-citationNarrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications
Kelesidis, T., Kelesidis, I., Chou, S. H.-H., & Mantzoros, C. S. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-2-201001190-00008 · Cited by 667 · see citing works
Bell, C. G., Walley, A. J., & Froguel, P. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1556 · Cited by 650 · see citing works
Havel, P. J. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s143 · Cited by 625 · see citing works
Havel, P. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00132.x · Cited by 607 · see citing works
Farooqi, I. S., & O’Rahilly, S. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0040 · Cited by 583 · see citing works
Self-citationHavel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575 · see citing works
How Obesity Causes Diabetes: Not a Tall Tale
Lazar, M. A. (2005) · Science · doi:10.1126/science.1104342 · Cited by 570 · see citing works
Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308767101 · Cited by 505 · see citing works
Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459 · see citing works
Wynne, K., Stanley, S., McGowan, B. M., & Bloom, S. R. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.05866 · Cited by 452 · see citing works
Hu, X. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.22.1704 · Cited by 451 · see citing works
Pigeyre, M., Yazdi, F., Kaur, Y., & Meyre, D. (2016) · Clinical Science · doi:10.1042/cs20160136 · Cited by 405 · see citing works
Insulin Resistance Syndrome in Children
Ten, S., & Maclaren, N. K. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0276 · Cited by 398 · see citing works
Chan, J. L., & Mantzoros, C. S. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66830-4 · Cited by 382 · see citing works
Intermittent Hypoxia Increases Insulin Resistance in Genetically Obese Mice
Polotsky, V. Y., Li, J., Punjabi, N. M., Rubin, A. E., Smith, P. L., Schwartz, A. R., & O'Donnell, C. P. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.048173 · Cited by 375 · see citing works
Genetics and Pathophysiology of Human Obesity
Cummings, D. E., & Schwartz, M. W. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152403 · Cited by 371 · see citing works
Modern science versus the stigma of obesity
Friedman, J. M. (2004) · Nature Medicine · doi:10.1038/nm0604-563 · Cited by 368 · see citing works
Binge Eating as a Major Phenotype of Melanocortin 4 Receptor Gene Mutations
Branson, R., Potoczna, N., Kral, J. G., Lentes, K., Hoehe, M. R., & Horber, F. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021971 · Cited by 367 · see citing works
Leptin: Structure, Function and Biology
Zhang, F. P. Y., Chen, Y., Heiman, M. L., & DiMarchi, R. D. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)71012-8 · Cited by 343 · see citing works
Satiation, satiety and their effects on eating behaviour
Benelam, B. (2009) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2009.01753.x · Cited by 338 · see citing works
Leptin: a pivotal regulator of human energy homeostasis
Farooqi, I. S., & O’Rahilly, S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788c · Cited by 333 · see citing works
Self-citationSpeakman, J. R., Levitsky, D. A., Allison, D. B., Bray, M. S., de Castro, J. M., Clegg, D. J., Clapham, J. C., Dulloo, A. G., Gruer, L. D., Haw, S. J., et al. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008698 · Cited by 316 · see citing works
Self-citationAhima, R. S., & Osei, S. Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.014 · Cited by 315 · see citing works
Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity
Farooqi, I. S., & O’Rahilly, S. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0966 · Cited by 295 · see citing works
Self-citationPartial Leptin Reduction as an Insulin Sensitization and Weight Loss Strategy
Zhao, S., Zhu, Y., Schultz, R. D., Li, N., He, Z., Zhang, Z., Caron, A., Zhu, Q., Sun, K., Xiong, W., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.005 · Cited by 295 · see citing works
20 YEARS OF LEPTIN: Human disorders of leptin action
Farooqi, I. S., & O'Rahilly, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0480 · Cited by 280 · see citing works
Self-citationFriedman, J. M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci91578 · Cited by 279 · see citing works
Antiobesity carbonic anhydrase inhibitors: a literature and patent review
Scozzafava, A., Supuran, C. T., & Carta, F. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.790957 · Cited by 276 · see citing works
Obesity: The Integrated Roles of Environment and Genetics
Speakman, J. R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.2090s · Cited by 275 · see citing works
The role of leptin in regulating bone metabolism
Upadhyay, J., Farr, O. M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.021 · Cited by 269 · see citing works
Obesity – is it a genetic disorder?
Loos, R. J. F., & Bouchard, C. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01242.x · Cited by 264 · see citing works
The role of mPer2 clock gene in glucocorticoid and feeding rhythms
Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263 · see citing works
Fat as an Endocrine Organ: Relationship to the Metabolic Syndrome
Hutley, L. J., & Prins, J. B. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200512000-00005 · Cited by 258 · see citing works
Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals
Moon, H., Dalamaga, Μ., Kim, S. Y., Pοlyzos, S. A., Hamnvik, O. R., Magkos, F., Paruthi, J., & Mantzoros, C. S. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1053 · Cited by 257 · see citing works
Analysis of paradoxical observations on the association between leptin and insulin resistance
Ceddia, R. B., Koistinen, H. A., Zierath, J. R., & Sweeney, G. (2002) · The FASEB Journal · doi:10.1096/fj.02-0158rev · Cited by 256 · see citing works
20 YEARS OF LEPTIN: Leptin at 20: an overview
Friedman, J. M. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0405 · Cited by 249 · see citing works
The thrifty epigenotype: An acquired and heritable predisposition for obesity and diabetes?
Stöger, R. J. (2008) · BioEssays · doi:10.1002/bies.20700 · Cited by 249 · see citing works
Independent circadian and sleep/wake regulation of adipokines and glucose in humans
Shea, S. A., Hilton, M. F., Orlova, C., Ayers, R. T., & Mantzoros, C. S. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2232 · Cited by 240 · see citing works
The melanocortin receptors: Lessons from knockout models
Butler, A. A., & Cone, R. D. (2002) · Neuropeptides · doi:10.1054/npep.2002.0890 · Cited by 222 · see citing works
Leptin treatment: Facts and expectations
Paz-Filho, G., Mastronardi, C. A., & Licinio, J. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.014 · Cited by 220 · see citing works
Genetics of Obesity: What We Have Learned Over Decades of Research
Bouchard, C. (2021) · Obesity · doi:10.1002/oby.23116 · Cited by 219 · see citing works
Minireview: Human Obesity—Lessons from Monogenic Disorders
O’Rahilly, S., Farooqi, I. S., Yeo, G. S. H., & Challis, B. (2003) · Endocrinology · doi:10.1210/en.2003-0373 · Cited by 218 · see citing works
Self-citationSelective leptin resistance: a new concept in leptin physiology with cardiovascular implications
Mark, A. L., Correia, M. L. G., Rahmouni, K., & Haynes, W. G. (2002) · Journal of Hypertension · doi:10.1097/00004872-200207000-00001 · Cited by 215 · see citing works
The glucoregulatory actions of leptin
D'souza, A. M., Neumann, U. H., Glavas, M. M., & Kieffer, T. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.04.011 · Cited by 214 · see citing works
Roles of Leptin and Ghrelin in the Loss of Body Weight Caused by a Low Fat, High Carbohydrate Diet
Weigle, D. S., Cummings, D. E., Newby, P. D., Breen, P. A., Frayo, R. S., Matthys, C. C., Callahan, H. S., & Purnell, J. Q. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021262 · Cited by 212 · see citing works
Sensory processing in the brain related to the control of food intake
Rolls, E. T. (2007) · Proceedings of The Nutrition Society · doi:10.1017/s0029665107005332 · Cited by 210 · see citing works
O'Rahilly, S., & Farooqi, I. S. (2008) · Diabetes · doi:10.2337/db08-0210 · Cited by 205 · see citing works
Self-citationDifferential Accessibility of Circulating Leptin to Individual Hypothalamic Sites
Faouzi, M., Leshan, R. L., Björnholm, M., Hennessey, T., Jones, J. C., & Münzberg, H. (2007) · Endocrinology · doi:10.1210/en.2007-0655 · Cited by 205 · see citing works
Revisiting leptin’s role in obesity and weight loss
Ahima, R. S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36284 · Cited by 204 · see citing works
Relationship between serum adiponectin and leptin concentrations and body fat distribution
Park, K., Park, K. S., Kim, M., Kim, H., Suh, Y. S., Ahn, J. D., Park, K., Chang, Y., & Lee, I. (2003) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2003.09.010 · Cited by 203 · see citing works
The Role of Leptin in the Control of Body Weight
Leibel, R. L. (2002) · Nutrition Reviews · doi:10.1301/002966402320634788 · Cited by 201 · see citing works
The importance of gene–environment interactions in human obesity
Reddon, H., Guéant, J., & Meyre, D. (2016) · Clinical Science · doi:10.1042/cs20160221 · Cited by 201 · see citing works
The role of NPY in hypothalamic mediated food intake
Mercer, R. E., Chee, M. J. S., & Colmers, W. F. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.06.001 · Cited by 194 · see citing works
Dietary-Induced Obesity and Hypothalamic Infertility in Female DBA/2J Mice
Tortoriello, D. V., McMinn, J. E., & Chua, S. C. (2003) · Endocrinology · doi:10.1210/en.2003-1406 · Cited by 192 · see citing works
Oussaada, S. M., van Galen, K. A., Cooiman, M. I., Kleinendorst, L., Hazebroek, E. J., van Haelst, M. M., ter Horst, K. W., & Serlie, M. J. (2019) · Metabolism · doi:10.1016/j.metabol.2018.12.012 · Cited by 180 · see citing works
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, Å. K., Drong, A., Hayes, J. E., Zhao, J., et al. (2016) · Nature Communications · doi:10.1038/ncomms10494 · Cited by 180 · see citing works
Wu, L., Zhang, Z., Ran, J., Zhou, D., Li, C., & Xu, T. (2013) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp50296a · Cited by 171 · see citing works
Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints
Speakman, J. R. (2013) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150711 · Cited by 163 · see citing works
Leptin's Physiologic Role: Does the Emperor of Energy Balance Have No Clothes?
Flier, J. S., & Maratos–Flier, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.013 · Cited by 163 · see citing works
Leptin and the Control of Metabolism: Role for Stearoyl-CoA Desaturase-1 (SCD-1)
Cohen, P., & Friedman, J. M. (2004) · Journal of Nutrition · doi:10.1093/jn/134.9.2455s · Cited by 163 · see citing works
Cleary, M. P., Jacobson, M. K., Phillips, F. C., Getzin, S. C., Grande, J. P., & Maihle, N. J. (2002) · PubMed · Cited by 162 · see citing works
High fructose corn syrup: production, uses and public health concerns.
Parker, G., Salas, M., & Nwosu, V. C. (2010) · Biotechnology and Molecular Biology Reviews · doi:10.5897/bmbr2010.0009 · Cited by 161 · see citing works
Leptin and its metabolic interactions – an update
Anubhuti, A., & Arora, S. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00852.x · Cited by 156 · see citing works
Central nervous system regulation of organismal energy and glucose homeostasis
Myers, M. G., Affinati, A. H., Richardson, N. E., & Schwartz, M. W. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00408-5 · Cited by 154 · see citing works
Stratigopoulos, G., Carli, J. F. M., O’Day, D. R., Wang, L., LeDuc, C. A., Lanzano, P., Chung, W. K., ROSENBAUM, M. S., Egli, D. M., Doherty, D., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.04.009 · Cited by 152 · see citing works
Brain Adipocytokine Action and Metabolic Regulation
Ahima, R. S., Qi, Y., Singhal, N. S., Jackson, M. B., & Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-s018 · Cited by 150 · see citing works
O’Rahilly, S., & Farooqi, I. S. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1850 · Cited by 149 · see citing works
Self-citationUnderstanding the mechanisms of food intake and obesity
Rolls, E. T. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2007.00321.x · Cited by 148 · see citing works
Genetically Obese MMTV-TGF-α/Lep ob Lep ob Female Mice do not Develop Mammary Tumors
Cleary, M. P., Phillips, F. C., Getzin, S. C., Jacobson, T. L., Jacobson, M. K., Christensen, T. A., Juneja, S. C., Grande, J. P., & Maihle, N. J. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1021891825399 · Cited by 146 · see citing works
Ethnic and population differences in the genetic predisposition to human obesity
Stryjecki, C., Alyass, A., & Meyre, D. (2017) · Obesity Reviews · doi:10.1111/obr.12604 · Cited by 142 · see citing works
Molecular physiology of weight regulation in mice and humans
Leibel, R. L. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.245 · Cited by 138 · see citing works
Oelmann, E. M., Haghgu, S., Kulimova, E., Serve, H. L., Schmitmann, C., & Berdel, W. E. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg007 · Cited by 136 · see citing works
Lessons from Extreme Human Obesity: Monogenic Disorders
Ranadive, S. A., & Vaisse, C. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.07.003 · Cited by 135 · see citing works
Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
Pedro, J. M. B., Sica, V., Martins, I., Pol, J. G., Loos, F., Maiuri, M. C., Durand, S., Bossut, N., Aprahamian, F., Anagnostopoulos, G., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.07.010 · Cited by 127 · see citing works
Zhao, S., Kusminski, C. M., Elmquist, J. K., & Scherer, P. E. (2020) · Diabetes · doi:10.2337/dbi19-0018 · Cited by 127 · see citing works
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Smith, R. G., Betancourt, L., & Sun, Y. (2005) · Endocrine Reviews · doi:10.1210/er.2002-0017 · Cited by 127 · see citing works
Obesity therapy: altering the energy intake-and-expenditure balance sheet
Crowley, V., Yeo, G. S. H., & O’Rahilly, S. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd770 · Cited by 116 · see citing works
Self-citationCreemers, J. W. M., Choquet, H., Stijnen, P., Vatin, V., Pigeyre, M., Beckers, S., Meulemans, S. M. P., Than, M. E., Yengo, L., Tauber, M., et al. (2011) · Diabetes · doi:10.2337/db11-0305 · Cited by 113 · see citing works
Mynarcik, D. C., Combs, T. P., McNurlan, M. A., Scherer, P. E., Komaroff, E., & Gelato, M. C. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200212150-00009 · Cited by 113 · see citing works
Leptin: At the crossroads of energy balance and systemic inflammation
Steiner, A. A., & Romanovsky, A. A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.11.001 · Cited by 111 · see citing works
Convergence between biological, behavioural and genetic determinants of obesity
Ghosh, S., & Bouchard, C. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.72 · Cited by 108 · see citing works
Fetal and perinatal programming of appetite
Cripps, R. L., Martin‐Gronert, M. S., & Ozanne, S. E. (2005) · Clinical Science · doi:10.1042/cs20040367 · Cited by 108 · see citing works
Bray, G. A. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm0680124 · Cited by 108 · see citing works
Adiposity signals, genetic and body weight regulation in humans
Cancello, R., Tounian, A., Poitou, C., & Clément, K. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70112-x · Cited by 107 · see citing works
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y.-H., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0370-1 · Cited by 106 · see citing works
Molecular Basis of Obesity: Current Status and Future Prospects
Choquet, H., & Meyre, D. (2011) · Current Genomics · doi:10.2174/138920211795677921 · Cited by 105 · see citing works
Intergenerational cost–benefit analysis and marine ecosystem restoration
Sumaila, U. R. (2004) · Fish and Fisheries · doi:10.1111/j.1467-2679.2004.00166.x · Cited by 102 · see citing works
β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency
Begriche, K., Massart, J., Abbey‐Toby, A., Igoudjil, A., Lettéron, P., & Fromenty, B. (2008) · Obesity · doi:10.1038/oby.2008.337 · Cited by 99 · see citing works
Obesity, Inflammation, and Vascular Disease
Calabrò, P., & Yeh, E. T. H. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_3 · Cited by 99 · see citing works
Pediatric Obesity: Etiology and Treatment
Crocker, M. K., & Yanovski, J. A. (2009) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2009.06.007 · Cited by 95 · see citing works
- Authors
- Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S.
- Affiliations
- University of Cambridge (GB)
- Birmingham City Hospital (GB)
- MRC Elsie Widdowson Laboratory (GB)
- Alberta Children's Hospital (CA)
- Venue
- Nature
- Published
- 2001-11
- Volume
- 414
- Issue
- 6859
- Pages
- 34-35
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1527986744
- Cited by
- 407
- References
- 9
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 16 · 2020: 18 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 7 · 2014: 11 · 2013: 18 · 2012: 14
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- leptin, adiposity, obesity, energy homeostasis, appetite
- MeSH terms
- Adipose Tissue, Adult, Energy Metabolism, Biological Evolution, Female, Heterozygote, Humans, Male, Middle Aged, Obesity, Body Mass Index, Frameshift Mutation, Leptin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
