Simon, M. Celeste

Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation

Imtiyaz, H. Z., Williams, E. P., Hickey, M. M., Patel, S. A., Durham, A. C., Yuan, L.-J., Hammond, R., Gimotty, P. A., Keith, B., & Simon, M. C. (2010) · Journal of Clinical Investigation

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 461

Acute postnatal ablation of Hif-2 α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 457

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 452

The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Lum, J. J., Bui, T., Gruber, M., Gordan, J. D., DeBerardinis, R. J., Covello, K. L., Simon, M. C., & Thompson, C. B. (2007) · Genes & Development

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 429

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B., & Simon, M. C. (2015) · Cancer Discovery

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 394

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Giaccia, A. J., Simon, M. C., & Johnson, R. (2004) · Genes & Development

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 380

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

Dahl, R., Walsh, J. C., Lancki, D., Laslo, P., Iyer, S. R., Singh, H., & Simon, M. C. (2003) · Nature Immunology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 380

Hypoxia-Inducible Factors as Essential Regulators of Inflammation

Imtiyaz, H. Z., & Simon, M. C. (2010) · Current Topics in Microbiology and Immunology

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 379

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell

Cell death mechanisms and regulationCancer, Hypoxia, and Metabolism

Cited by 375

The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 355

Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro

Pan, Y., Mansfield, K. D., Bertozzi, C. C., Rudenko, V., Chan, D. A., Giaccia, A. J., & Simon, M. C. (2007) · Molecular and Cellular Biology

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 332

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

Fang, H.-Y., Hughes, R., Murdoch, C., Coffelt, S. B., Biswas, S. K., Harris, A. L., Johnson, R. S., Imityaz, H. Z., Simon, M. C., Fredlund, E., et al. (2009) · Blood

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 319

PU.1 Functions in a Cell‐autonomous Manner to Control the Differentiation of Multipotential Lymphoid‐myeloid Progenitors

Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., & Singh, H. (1997) · Immunity

Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

Cited by 270

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

Glick, D., Zhang, W., Beaton, M., Marsboom, G., Gruber, M., Simon, M. C., Hart, J., Dorn, G. W., Brady, M. J., & Macleod, K. F. (2012) · Molecular and Cellular Biology

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 251

Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival

Liu, L., Wise, D. R., Diehl, J. A., & Simon, M. C. (2008) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseasePI3K/AKT/mTOR signaling in cancer

Cited by 206

HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

Bertout, J. A., Majmundar, A. J., Gordan, J. D., Lam, J. C., Ditsworth, D., Keith, B., Brown, E. J., Nathanson, K. L., & Simon, M. C. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 196

PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C. (1995) · Immunity

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 191

Multilineage embryonic hematopoiesis requires hypoxic ARNT activity

Adelman, D. M., Maltepe, E., & Simon, M. C. (1999) · Genes & Development

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 185

Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B

Su, G. H., Chen, H., Muthusamy, N., Garrett‐Sinha, L. A., Baunoch, D., Tenen, D. G., & Simon, M. C. (1997) · The EMBO Journal

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 182

Hypoxia-inducible factors: key regulators of myeloid cells during inflammation

Lin, N., & Simon, M. C. (2016) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 170

Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta

Maltepe, E., Krampitz, G. W., Okazaki, K. M., Red-Horse, K., Mak, W., Simon, M. C., & Fisher, S. J. (2005) · Development

Pregnancy and preeclampsia studiesReproductive System and Pregnancy

Cited by 169

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

Mack, F. A., Rathmell, W. K., Arsham, A. M., Gnarra, J., Keith, B., & Simon, M. C. (2003) · Cancer Cell

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 160

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α

Qing, G., Skuli, N., Mayes, P. A., Pawel, B., Martinez, D., Maris, J. M., & Simon, M. C. (2010) · Cancer Research

Neuroblastoma Research and TreatmentsCancer, Hypoxia, and Metabolism

Cited by 157

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

Hanna, S. C., Krishnan, B., Bailey, S. T., Moschos, S. J., Kuan, P.-F., Shimamura, T., Osborne, L. D., Siegel, M. B., Duncan, L. M., O’Brien, E. T., et al. (2013) · Journal of Clinical Investigation

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 147