Manz, Markus G.

Development of Monocytes, Macrophages, and Dendritic Cells

Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science

Immune cells in cancerImmunotherapy and Immune Responses

Cited by 3,049

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

Jamieson, C. H. M., Ailles, L. E., Dylla, S. J., Muijtjens, M., Jones, C., Zehnder, J. L., Gotlib, J., Li, K., Manz, M. G., Keating, A., et al. (2004) · New England Journal of Medicine

Chronic Myeloid Leukemia TreatmentsHematopoietic Stem Cell Transplantation

Cited by 1,485

Emergency granulopoiesis

Manz, M. G., & Boettcher, S. (2014) · Nature Reviews Immunology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 855

Development and function of human innate immune cells in a humanized mouse model

Rongvaux, A., Willinger, T., Martinek, J., Strowig, T., Gearty, S. V., Teichmann, L. L., Saito, Y., Marches, F., Halene, S., Palucka, A. K., et al. (2014) · Nature Biotechnology

Hematopoietic Stem Cell TransplantationImmune cells in cancer

Cited by 789

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Pietras, E. M., Mirantes-Barbeito, C., Fong, S., Loeffler, D., Kovtonyuk, L. V., Zhang, S., Lakshminarasimhan, R., Chin, C. P., Techner, J.-M., Will, B., et al. (2016) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 689

Dendritic cell homeostasis

Merad, M., & Manz, M. G. (2009) · Blood

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

Cited by 395

Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment

Kovtonyuk, L. V., Fritsch, K., Feng, X., Manz, M. G., & Takizawa, H. (2016) · Frontiers in Immunology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 371

Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

Caiado, F., Pietras, E. M., & Manz, M. G. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 289

IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

Kovtonyuk, L. V., Caiado, F., Garcia-Martin, S., Manz, E.-M., Helbling, P., Takizawa, H., Boettcher, S., Al-Shahrour, F., Nombela-Arrieta, C., Slack, E., et al. (2022) · Blood

Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

Cited by 166

Aging drives Tet2 +/− clonal hematopoiesis via IL-1 signaling

Caiado, F., Kovtonyuk, L. V., Gonullu, N. G., Fullin, J., Boettcher, S., & Manz, M. G. (2023) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 161

Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon-producing and dendritic cell development

Onai, N., Obata-Onai, A., Tussiwand, R., Lanzavecchia, A., & Manz, M. G. (2006) · The Journal of Experimental Medicine

Immunotherapy and Immune ResponsesCytokine Signaling Pathways and Interactions

Cited by 156

Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation

Helbling, P. M., Piñeiro-Yáñez, E., Gerosa, R., Boettcher, S., Al-Shahrour, F., Manz, M. G., & Nombela-Arrieta, C. (2019) · Cell Reports

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 116

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Bigenwald, C., Le Berichel, J., Wilk, C. M., Chakraborty, R., Chen, S. T., Tabachnikova, A., Mancusi, R., Abhyankar, H., Casanova-Acebes, M., Laface, I., et al. (2021) · Nature Medicine

Histiocytic Disorders and TreatmentsTelomeres, Telomerase, and Senescence

Cited by 83

HTLV-1 Propels Thymic Human T Cell Development in “Human Immune System” Rag2-/- gamma c-/- Mice

Villaudy, J., Wencker, M., Gadot, N., Gillet, N. A., Scoazec, J.-Y., Gazzolo, L., Manz, M. G., Bangham, C. R. M., & Dodon, M. D. (2011) · PLoS Pathogens

T-cell and Retrovirus StudiesT-cell and B-cell Immunology

Cited by 66

Clonal dynamics after allogeneic haematopoietic cell transplantation

Spencer Chapman, M., Wilk, C. M., Boettcher, S., Mitchell, E., Dawson, K., Williams, N., Müller, J., Kovtonyuk, L., Jung, H., Caiado, F., et al. (2024) · Nature

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 60

Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders

Wilk, C. M., Cathomas, F., Török, O., Le Berichel, J., Park, M. D., Bigenwald, C., Heaton, G. R., Hamon, P., Troncoso, L., Scull, B. P., et al. (2023) · Immunity

Histiocytic Disorders and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 51

Effects of vitamin D3, omega-3s, and a simple strength training exercise program on bone health: the DO-HEALTH randomized controlled trial

Kistler-Fischbacher, M., Armbrecht, G., Gängler, S., Theiler, R., Rizzoli, R., Dawson-Hughes, B., Kanis, J. A., Hofbauer, L. C., Schimmer, R. C., Vellas, B., et al. (2024) · Journal of Bone and Mineral Research

Bone health and osteoporosis researchVitamin D Research Studies

Cited by 15