DePinho, Ronald A.

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Maser, R. S., Choudhury, B., Campbell, P. J., Feng, B., Wong, K.-K., Protopopov, A., O’Neil, J., Gutierrez, A., Ivanova, E., Perna, I., et al. (2007) · Nature

Cancer Genomics and DiagnosticsGenomic variations and chromosomal abnormalities

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Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

Wong, K.-K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W., & DePinho, R. A. (2003) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse

Greenberg, R. A., Chin, L., Femino, A., Lee, K.-H., Gottlieb, G. J., Singer, R. H., Greider, C. W., & DePinho, R. A. (1999) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 367

DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation

Raveh, T., Droguett, G., Horwitz, M. S., DePinho, R. A., & Kimchi, A. (2001) · Nature Cell Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

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Passenger deletions generate therapeutic vulnerabilities in cancer

Muller, F. L., Colla, S., Aquilanti, E., Manzo, V. E., Genovese, G., Lee, J., Eisenson, D., Narurkar, R., Deng, P., Nezi, L., et al. (2012) · Nature

Cancer Genomics and DiagnosticsGlioma Diagnosis and Treatment

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

de la Iglesia, N., Konopka, G., Puram, S. V., Chan, J. A., Bachoo, R. M., You, M. J., Levy, D. E., DePinho, R. A., & Bonni, A. (2008) · Genes & Development

Cytokine Signaling Pathways and InteractionsGlioma Diagnosis and Treatment

Cited by 336

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

Allsopp, R. C., Morin, G. B., DePinho, R., Harley, C. B., & Weissman, I. L. (2003) · Blood

Telomeres, Telomerase, and SenescenceHematopoietic Stem Cell Transplantation

Cited by 324

Foxo1 integrates insulin signaling with mitochondrial function in the liver

Cheng, Z., Guo, S., Copps, K., Dong, X., Kollipara, R., Rodgers, J. T., Depinho, R. A., Puigserver, P., & White, M. F. (2009) · Nature Medicine

FOXO transcription factor regulationMetabolism, Diabetes, and Cancer

Cited by 321

A critical role for telomeres in suppressing and facilitating carcinogenesis

Artandi, S. E., & DePinho, R. A. (2000) · Current Opinion in Genetics & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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Constitutive telomerase expression promotes mammary carcinomas in aging mice

Artandi, S. E., Alson, S., Tietze, M. K., Sharpless, N. E., Ye, S., Greenberg, R. A., Castrillon, D. H., Horner, J. W., Weiler, S. R., Carrasco, R. D., et al. (2002) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Wong, K.-K., Chang, S., Weiler, S. R., Ganesan, S., Chaudhuri, J., Zhu, C., Artandi, S. E., Rudolph, K. L., Gottlieb, G. J., Chin, L., et al. (2000) · Nature Genetics

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 309

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production

Safran, M., Kim, W. Y., O'Connell, F., Flippin, L., Günzler, V., Horner, J. W., DePinho, R. A., & Kaelin, W. G. (2006) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 305

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification

Kitamura, T., Kitamura, Y. I., Funahashi, Y., Shawber, C. J., Castrillon, D. H., Kollipara, R., DePinho, R. A., Kitajewski, J., & Accili, D. (2007) · Journal of Clinical Investigation

Muscle Physiology and DisordersFOXO transcription factor regulation

Cited by 285

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W.-T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., et al. (2017) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

Cited by 264

Telomere dysfunction provokes regional amplification and deletion in cancer genomes

O'Hagan, R. C., Chang, S., Maser, R. S., Mohan, R., Artandi, S. E., Chin, L., & DePinho, R. A. (2002) · Cancer Cell

Telomeres, Telomerase, and SenescenceGenomic variations and chromosomal abnormalities

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STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation

Lee, C.-K., Raz, R., Gimeno, R., Gertner, R., Wistinghausen, B., Takeshita, K., DePinho, R. A., & Levy, D. E. (2002) · Immunity

Cytokine Signaling Pathways and InteractionsBlood disorders and treatments

Cited by 242

SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities

David, G., Neptune, M. A., & DePinho, R. A. (2002) · Journal of Biological Chemistry

Histone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathways

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FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

O-Sullivan, I., Zhang, W., Wasserman, D. H., Liew, C. W., Liu, J., Paik, J., DePinho, R. A., Stolz, D. B., Kahn, C. R., Schwartz, M. W., et al. (2015) · Nature Communications

FOXO transcription factor regulationMetabolism, Diabetes, and Cancer

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The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

Sharpless, N. E., Ramsey, M. R., Balasubramanian, P., Castrillon, D. H., & DePinho, R. A. (2004) · Oncogene

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 224

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

Ding, Z., Wu, C.-J., Jaskelioff, M., Ivanova, E., Kost-Alimova, M., Protopopov, A., Chu, G. C., Wang, G., Lu, X., Labrot, E. S., et al. (2012) · Cell

Telomeres, Telomerase, and SenescenceProstate Cancer Treatment and Research

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Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

Yao, W., Rose, J. L., Wang, W., Seth, S., Jiang, H., Taguchi, A., Liu, J., Yan, L., Kapoor, A., Hou, P., et al. (2019) · Nature

Pancreatic and Hepatic Oncology ResearchProteoglycans and glycosaminoglycans research

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Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

Dey, P., Li, J., Zhang, J., Chaurasiya, S., Strom, A., Wang, H., Liao, W.-T., Cavallaro, F., Denz, P., Bernard, V., et al. (2020) · Cancer Discovery

Pancreatic and Hepatic Oncology ResearchCytokine Signaling Pathways and Interactions

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Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

Boutin, A. T., Liao, W.-T., Wang, M., Hwang, S. S., Karpinets, T. V., Cheung, H., Chu, G. C., Jiang, S., Hu, J., Chang, K., et al. (2017) · Genes & Development

Colorectal Cancer Treatments and StudiesProtein Kinase Regulation and GTPase Signaling

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Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway

Laud, P. R., Multani, A. S., Bailey, S. M., Wu, L., Ma, J., Kingsley, C., Lebel, M., Pathak, S., DePinho, R. A., & Chang, S. (2005) · Genes & Development

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

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